iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007166

UUCD1 version

UUC-ArT-00350

Ensembl Protein ID

AT2G16090.4

UniProt Accession

Q84RR2; Q8VZE0; Q9XII0; ARI2_ARATH

Genbank Protein ID

CAD52884.1; AAD26951.1; AEC06466.1; AAL57664.1; AAM26640.1

Protein Name

Probable E3 ubiquitin-protein ligase ARI2; ARIADNE-like protein ARI2; Protein ariadne homolog 2; RING-type E3 ubiquitin transferase ARI2

Genbank Nucleotide ID

AJ510205; AC007134; CP002685; AY065022; AY101519

Gene Name

ARI2; At2g16090; F7H1.11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G16090	AT2G16090.3	AT2G16090.3
AT2G16090	AT2G16090.4	AT2G16090.4
AT2G16090	AT2G16090.1	AT2G16090.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	4.10e-41	141.7	124	312

Active Site

Position(s)	Description	Evidence
297	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikel..lveeelykryekllleevveadaal 88
           C++C+  ++  +lt  + C h fC++C++ ++++ki+egq ++i c+a++c + ++e+ +++l   ++++l ++++++lle+++e ++ +
   Q: 124  CDICVEDVPGYQLT-RMDCGHSFCNNCWTGHFTVKINEGQSKRIICMAHKCNAICDEDVVRALvsKSQPDLAEKFDRFLLESYIEDNKMV 212
           *****999997766.77*********************************************944457899******************* PP
   S: 89   kwcp.apdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegC 177
           kwcp +p+C  ++++e++ e  evec +cg +fC++C++++H+++sC +++ +++k+    +e+e+ ++++ ++k+CpkC+ ++ekn+gC
   Q: 213  KWCPsTPHCGNAIRVEDD-ELCEVEC-SCGLQFCFSCSSQAHSPCSCVMWELWRKKCF---DESETVNWITVHTKPCPKCHKPVEKNGGC 297
           ***9458**********6.999****.9******************************...99*************************** PP
   S: 178  nhmtCakCkaefCwlC 193
           n +tC  C+++fCwlC
   Q: 298  NLVTC-LCRQSFCWLC 312
           *****.9********* PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.

Protein Sequence
(Fasta)

MDDNLSGEEE DYYYSSDQES LNGIDNDESV SIPVSSRSNT VKVITKESLL AAQREDLRRV 60
MELLSVKEHH ARTLLIHYRW DVEKLFAVLV EKGKDSLFSG AGVTLLENQS CDSSVSGSSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGTAAATAA CGATGTCCTC TTTCTCTTCT CCTCCGGTTG ATTCAGTCCT TTTAACACTC 60
CTCTTTTGAT CTCGCCGGCA AATATCATCC CACATCCTTC ATGTCTCAAA ATCTCCGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

ath:AT2G16090

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001385	Ailuropoda melanoleuca	33.10	1.00e-59	223.00
IUUC-Atr-002480	Amborella trichopoda	62.48	0.00e+00	744.00
IUUC-Apl-004184	Anas platyrhynchos	33.17	2.00e-56	212.00
IUUC-Aca-004976	Anolis carolinensis	33.17	9.00e-57	213.00
IUUC-Aly-005807	Arabidopsis lyrata	90.32	0.00e+00	1105.00
IUUC-Ame-011264	Astyanax mexicanus	33.04	3.00e-65	242.00
IUUC-Bta-013518	Bos taurus	33.10	2.00e-59	223.00
IUUC-Bdi-014685	Brachypodium distachyon	62.77	0.00e+00	714.00
IUUC-Bol-016507	Brassica oleracea	77.52	0.00e+00	902.00
IUUC-Bra-018038	Brassica rapa	81.53	0.00e+00	935.00
IUUC-Cfa-020812	Canis familiaris	32.81	2.00e-58	219.00
IUUC-Cpo-021627	Cavia porcellus	33.10	2.00e-59	223.00
IUUC-Csa-023034	Chlorocebus sabaeus	33.17	2.00e-56	213.00
IUUC-Cho-024444	Choloepus hoffmanni	31.95	1.00e-54	206.00
IUUC-Dre-027785	Danio rerio	33.04	3.00e-65	242.00
IUUC-Dno-029205	Dasypus novemcinctus	33.10	2.00e-59	223.00
IUUC-Dor-030769	Dipodomys ordii	29.44	4.00e-42	164.00
IUUC-Eca-033431	Equus caballus	33.18	1.00e-57	216.00
IUUC-Fca-035882	Felis catus	34.25	2.00e-53	202.00
IUUC-Fal-037068	Ficedula albicollis	33.41	1.00e-57	216.00
IUUC-Fox-037790	Fusarium oxysporum	31.70	6.00e-44	170.00
IUUC-Gmo-038703	Gadus morhua	33.03	7.00e-65	240.00
IUUC-Gga-040319	Gallus gallus	34.36	3.00e-47	181.00
IUUC-Gac-041708	Gasterosteus aculeatus	33.10	8.00e-65	240.00
IUUC-Ggo-045178	Gorilla gorilla	33.10	2.00e-59	223.00
IUUC-Hsa-045718	Homo sapiens	33.10	2.00e-59	223.00
IUUC-Lpe-051110	Leersia perrieri	63.75	0.00e+00	732.00
IUUC-Loc-052442	Lepisosteus oculatus	33.04	3.00e-65	242.00
IUUC-Laf-054351	Loxodonta africana	33.17	2.00e-56	213.00
IUUC-Mcc-054670	Macaca mulatta	31.90	3.00e-57	215.00
IUUC-Mla-058889	Melampsora laricipopulina	29.03	1.00e-47	183.00
IUUC-Mga-059385	Meleagris gallopavo	33.17	1.00e-56	213.00
IUUC-Mmr-061439	Microcebus murinus	31.12	1.00e-46	180.00
IUUC-Mdo-062890	Monodelphis domestica	33.10	3.00e-59	222.00
IUUC-Mmu-063433	Mus musculus	33.10	2.00e-59	223.00
IUUC-Mac-064550	Musa acuminata	63.41	0.00e+00	742.00
IUUC-Mpu-066288	Mustela putorius furo	32.81	2.00e-59	223.00
IUUC-Mlu-067187	Myotis lucifugus	32.95	4.00e-59	221.00
IUUC-Nle-069263	Nomascus leucogenys	33.10	2.00e-59	223.00
IUUC-Ont-072309	Oreochromis niloticus	32.80	1.00e-64	239.00
IUUC-Oan-073731	Ornithorhynchus anatinus	34.25	2.00e-53	202.00
IUUC-Ocu-074000	Oryctolagus cuniculus	33.17	1.00e-56	213.00
IUUC-Oba-075628	Oryza barthii	58.03	0.00e+00	653.00
IUUC-Ogl-077447	Oryza glaberrima	63.48	0.00e+00	731.00
IUUC-Ogu-078881	Oryza glumaepatula	64.96	0.00e+00	734.00
IUUC-Oin-079573	Oryza indica	64.37	0.00e+00	714.00
IUUC-Olo-080774	Oryza longistaminata	64.11	0.00e+00	736.00
IUUC-Ome-081275	Oryza meridionalis	58.73	0.00e+00	651.00
IUUC-Oni-082267	Oryza nivara	58.73	0.00e+00	651.00
IUUC-Opu-084135	Oryza punctata	63.48	0.00e+00	731.00
IUUC-Oru-084849	Oryza rufipogon	64.78	0.00e+00	732.00
IUUC-Osa-085435	Oryza sativa	63.48	0.00e+00	730.00
IUUC-Ola-086792	Oryzias latipes	32.80	1.00e-64	239.00
IUUC-Oga-088706	Otolemur garnettii	33.10	2.00e-59	223.00
IUUC-Oar-089354	Ovis aries	33.79	2.00e-59	223.00
IUUC-Ptr-091287	Pan troglodytes	33.10	2.00e-59	223.00
IUUC-Pan-091701	Papio anubis	33.17	1.00e-56	213.00
IUUC-Psi-093814	Pelodiscus sinensis	33.17	1.00e-56	213.00
IUUC-Pfo-096449	Poecilia formosa	32.80	9.00e-65	240.00
IUUC-Pab-098132	Pongo abelii	33.10	2.00e-59	223.00
IUUC-Pca-100303	Procavia capensis	33.77	1.00e-42	167.00
IUUC-Pva-102457	Pteropus vampyrus	33.10	2.00e-59	223.00
IUUC-Ptt-103795	Puccinia triticina	34.68	3.00e-53	202.00
IUUC-Rno-106083	Rattus norvegicus	33.10	2.00e-59	223.00
IUUC-Sha-106765	Sarcophilus harrisii	33.17	2.00e-56	212.00
IUUC-Sit-110348	Setaria italica	64.40	0.00e+00	733.00
IUUC-Sly-111182	Solanum lycopersicum	61.71	0.00e+00	635.00
IUUC-Stu-112599	Solanum tuberosum	72.37	0.00e+00	768.00
IUUC-Sar-113023	Sorex araneus	33.17	2.00e-55	209.00
IUUC-Sbi-114262	Sorghum bicolor	64.97	0.00e+00	738.00
IUUC-Ssc-115667	Sus scrofa	37.68	1.00e-46	179.00
IUUC-Tgu-117273	Taeniopygia guttata	33.41	1.00e-56	213.00
IUUC-Tru-118338	Takifugu rubripes	32.57	3.00e-63	235.00
IUUC-Tsy-119096	Tarsius syrichta	29.59	1.00e-40	159.00
IUUC-Tni-120238	Tetraodon nigroviridis	32.57	5.00e-64	238.00
IUUC-Tca-121037	Theobroma cacao	76.83	0.00e+00	798.00
IUUC-Tae-124132	Triticum aestivum	63.36	0.00e+00	725.00
IUUC-Tur-126320	Triticum urartu	59.78	0.00e+00	650.00
IUUC-Vpa-130259	Vicugna pacos	32.33	8.00e-55	207.00
IUUC-Xtr-132219	Xenopus tropicalis	33.04	5.00e-60	224.00
IUUC-Xma-133423	Xiphophorus maculatus	32.80	9.00e-65	240.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence