iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000005374.13	ENSMUST00000153183.7	ENSMUSP00000115011.1
ENSMUSG00000005374.13	ENSMUST00000139565.7	ENSMUSP00000120685.1
ENSMUSG00000005374.13	ENSMUST00000005508.13	ENSMUSP00000005508.7
ENSMUSG00000005374.13	ENSMUST00000152013.1	ENSMUSP00000118691.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.40e-19	69.3	85	118
UBD/Beta-Prp	1.70e-42	146.8	72	305

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           H++ ++c++f s+ ++l++++dD t+++W+++++
   Q: 85   HSGNISCMDFsSNgKYLATCADDRTVRIWSTKDF 118
           9**********777***************98775 PP

UBD/Beta-Prp

   S: 38   dvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls....tgkcvhtlkghedsvlslsfspsg.dklvsGshdrtirvw 121
           ++t + l + l++h++ +++++fs++gk+l+t+++Drt+++w+ +         +  + + d +++++fsp+   ++v   + +t+rv+
   Q: 72   SFTHPLLAAALKSHSGNISCMDFSSNGKYLATCADDRTVRIWSTKdflqREHRSMRANVELDHATLVRFSPDCrAFIVWLANGDTLRVF 160
           56677788999*******************************777343333333333467899999*****655*************** PP
   S: 122  dletgqclee........tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldg 202
           ++ +++            + ++h++ +  + + ++g+ ++++s D+tv +W+l  g++l t    ++    +  +++ ++++ s++   
   Q: 161  KMTKREDGGFtftatpedFPKKHKAPIINIGIADTGKFIMTASSDTTVLIWNL-KGQVLSTINT-NQMNNSHAVISPCSRFVGSCGFTP 247
           99988766547888999999********************************9.7888888877.66777777789999********** PP
   S: 203  tvklwdlqtgec........vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlr 252
           +vk+w++  g+           +l+gh++ v s +fs+++ r++s+s+Dg+ ++Wd++
   Q: 248  DVKVWEVCFGKKgefqevlrAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTD 305
           *******94444444777778999*******************************865 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MELPQMPELM GLSLLVGLLA LVATAAVARG WLRAEEKPSQ PVCQKENEPK KSGSKKQKQN 60
QRVRKEKPQQ HSFTHPLLAA ALKSHSGNIS CMDFSSNGKY LATCADDRTV RIWSTKDFLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACTGTCCTC CCCCGCCCCC TCGTGCGCCG AGACGTGAGG ACGCCGGCGT CGTAGGCTGA 60
GGTGGCAGCT GTCCCGCAGT CATGGAGCTG CCGCAGATGC CGGAGCTGAT GGGGTTGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0051219--F:phosphoprotein binding
GO:0019901--F:protein kinase binding
GO:0003723--F:RNA binding
GO:0031369--F:translation initiation factor binding
GO:0042149--P:cellular response to glucose starvation
GO:0071456--P:cellular response to hypoxia
GO:0030968--P:endoplasmic reticulum unfolded protein response

KEGG

mmu:27368

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000109	Aegilops tauschii	31.12	4.00e-21	94.70
IUUC-Aml-002212	Ailuropoda melanoleuca	91.91	0.00e+00	704.00
IUUC-Atr-002903	Amborella trichopoda	30.35	2.00e-35	143.00
IUUC-Apl-003635	Anas platyrhynchos	73.84	1.00e-163	568.00
IUUC-Aca-004472	Anolis carolinensis	73.95	3.00e-165	574.00
IUUC-Aly-005761	Arabidopsis lyrata	29.23	2.00e-36	146.00
IUUC-Ath-007476	Arabidopsis thaliana	29.38	1.00e-36	147.00
IUUC-Ame-011221	Astyanax mexicanus	68.48	1.00e-149	523.00
IUUC-Bta-013186	Bos taurus	87.67	0.00e+00	713.00
IUUC-Bdi-014298	Brachypodium distachyon	30.35	1.00e-37	150.00
IUUC-Bol-015192	Brassica oleracea	28.62	6.00e-35	141.00
IUUC-Bra-017078	Brassica rapa	29.25	6.00e-36	145.00
IUUC-Cel-018602	Caenorhabditis elegans	32.45	8.00e-60	224.00
IUUC-Cja-018909	Callithrix jacchus	87.44	0.00e+00	709.00
IUUC-Cfa-020970	Canis familiaris	88.12	0.00e+00	717.00
IUUC-Cpo-022215	Cavia porcellus	90.84	0.00e+00	712.00
IUUC-Cre-022949	Chlamydomonas reinhardtii	32.19	2.00e-18	85.10
IUUC-Csa-023530	Chlorocebus sabaeus	86.32	0.00e+00	721.00
IUUC-Cho-024598	Choloepus hoffmanni	92.58	9.00e-130	456.00
IUUC-Cin-025486	Ciona intestinalis	46.34	3.00e-105	375.00
IUUC-Csv-025930	Ciona savignyi	46.89	8.00e-95	340.00
IUUC-Dre-027507	Danio rerio	66.49	2.00e-150	525.00
IUUC-Dno-029726	Dasypus novemcinctus	87.08	0.00e+00	697.00
IUUC-Dor-030501	Dipodomys ordii	80.36	1.00e-180	625.00
IUUC-Ete-032794	Echinops telfairi	86.13	2.00e-131	461.00
IUUC-Eca-033982	Equus caballus	88.34	0.00e+00	677.00
IUUC-Eeu-035090	Erinaceus europaeus	87.73	6.00e-134	470.00
IUUC-Fca-035944	Felis catus	89.23	0.00e+00	721.00
IUUC-Fal-036992	Ficedula albicollis	66.67	1.00e-149	522.00
IUUC-Gmo-038710	Gadus morhua	64.91	3.00e-149	521.00
IUUC-Gga-040885	Gallus gallus	70.82	1.00e-115	409.00
IUUC-Gac-041922	Gasterosteus aculeatus	65.62	2.00e-153	535.00
IUUC-Gma-044233	Glycine max	29.85	6.00e-37	148.00
IUUC-Ggo-045172	Gorilla gorilla	89.53	0.00e+00	697.00
IUUC-Hsa-045711	Homo sapiens	87.25	0.00e+00	720.00
IUUC-Itr-048196	Ictidomys tridecemlineatus	92.33	0.00e+00	738.00
IUUC-Lch-049739	Latimeria chalumnae	71.77	3.00e-164	571.00
IUUC-Lpe-050795	Leersia perrieri	24.86	8.00e-21	94.70
IUUC-Loc-052113	Lepisosteus oculatus	73.56	6.00e-157	546.00
IUUC-Laf-053751	Loxodonta africana	87.00	0.00e+00	714.00
IUUC-Mcc-055022	Macaca mulatta	86.79	0.00e+00	715.00
IUUC-Meu-056003	Macropus eugenii	73.98	1.00e-164	572.00
IUUC-Mtr-058500	Medicago truncatula	29.28	3.00e-34	139.00
IUUC-Mga-059278	Meleagris gallopavo	69.30	1.00e-126	446.00
IUUC-Mmr-061148	Microcebus murinus	87.00	0.00e+00	712.00
IUUC-Mdo-063002	Monodelphis domestica	70.27	4.00e-161	560.00
IUUC-Mac-065359	Musa acuminata	26.72	1.00e-33	137.00
IUUC-Mpu-066323	Mustela putorius furo	90.27	3.00e-166	577.00
IUUC-Mlu-067946	Myotis lucifugus	89.24	0.00e+00	736.00
IUUC-Nle-069019	Nomascus leucogenys	87.02	0.00e+00	715.00
IUUC-Opr-071047	Ochotona princeps	85.43	0.00e+00	687.00
IUUC-Ont-071694	Oreochromis niloticus	67.20	1.00e-152	532.00
IUUC-Oan-073474	Ornithorhynchus anatinus	56.61	5.00e-102	364.00
IUUC-Ocu-074493	Oryctolagus cuniculus	87.67	0.00e+00	691.00
IUUC-Oba-075468	Oryza barthii	26.95	8.00e-31	128.00
IUUC-Obr-076681	Oryza brachyantha	26.35	4.00e-32	132.00
IUUC-Ogl-077870	Oryza glaberrima	26.95	8.00e-31	128.00
IUUC-Ogu-078536	Oryza glumaepatula	26.95	7.00e-31	128.00
IUUC-Oin-080175	Oryza indica	26.95	8.00e-31	128.00
IUUC-Olo-080796	Oryza longistaminata	26.91	6.00e-30	125.00
IUUC-Oni-082076	Oryza nivara	26.95	8.00e-31	128.00
IUUC-Opu-083267	Oryza punctata	27.05	4.00e-30	125.00
IUUC-Oru-084553	Oryza rufipogon	26.95	1.00e-30	127.00
IUUC-Osa-085389	Oryza sativa	26.95	8.00e-31	128.00
IUUC-Ola-086414	Oryzias latipes	66.67	2.00e-152	531.00
IUUC-Oga-088656	Otolemur garnettii	86.55	0.00e+00	715.00
IUUC-Oar-089719	Ovis aries	90.03	0.00e+00	693.00
IUUC-Ptr-091087	Pan troglodytes	87.02	0.00e+00	718.00
IUUC-Pan-091709	Papio anubis	87.22	0.00e+00	729.00
IUUC-Psi-093265	Pelodiscus sinensis	72.58	3.00e-166	577.00
IUUC-Pma-094482	Petromyzon marinus	61.18	2.00e-57	214.00
IUUC-Ppa-095365	Physcomitrella patens	28.74	2.00e-36	147.00
IUUC-Pfo-097494	Poecilia formosa	67.23	7.00e-152	530.00
IUUC-Pab-098362	Pongo abelii	87.02	0.00e+00	719.00
IUUC-Pop-099163	Populus trichocarpa	29.02	1.00e-31	131.00
IUUC-Pca-101019	Procavia capensis	85.52	2.00e-150	525.00
IUUC-Ppe-102101	Prunus persica	28.17	4.00e-36	145.00
IUUC-Pva-102849	Pteropus vampyrus	88.33	0.00e+00	692.00
IUUC-Rno-105511	Rattus norvegicus	98.42	0.00e+00	779.00
IUUC-Sha-107265	Sarcophilus harrisii	72.70	9.00e-167	580.00
IUUC-Smo-108866	Selaginella moellendorffii	30.61	4.00e-33	135.00
IUUC-Sit-110806	Setaria italica	26.88	5.00e-33	135.00
IUUC-Sly-110994	Solanum lycopersicum	29.48	2.00e-34	140.00
IUUC-Stu-112493	Solanum tuberosum	34.90	1.00e-29	123.00
IUUC-Sar-113628	Sorex araneus	84.30	0.00e+00	685.00
IUUC-Sbi-114397	Sorghum bicolor	27.74	3.00e-33	135.00
IUUC-Ssc-116418	Sus scrofa	88.49	0.00e+00	736.00
IUUC-Tgu-117054	Taeniopygia guttata	67.55	8.00e-156	543.00
IUUC-Tru-118504	Takifugu rubripes	69.39	1.00e-159	555.00
IUUC-Tni-120254	Tetraodon nigroviridis	69.05	2.00e-157	548.00
IUUC-Tca-121085	Theobroma cacao	30.28	2.00e-36	146.00
IUUC-Tae-124320	Triticum aestivum	28.53	8.00e-37	147.00
IUUC-Tur-126756	Triticum urartu	26.63	3.00e-31	129.00
IUUC-Tbe-127903	Tupaia belangeri	83.82	0.00e+00	681.00
IUUC-Ttr-129118	Tursiops truncatus	86.36	0.00e+00	701.00
IUUC-Vvi-131125	Vitis vinifera	29.25	1.00e-35	144.00
IUUC-Xtr-132287	Xenopus tropicalis	73.02	8.00e-163	566.00
IUUC-Xma-134246	Xiphophorus maculatus	67.52	6.00e-152	530.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence