iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007462

UUCD1 version

UUC-ArT-01417

Ensembl Protein ID

AT2G44950.1

UniProt Accession

Q8RXD6; O22156; O22157; BRE1A_ARATH

Genbank Protein ID

AAM14833.1; AAM14834.1; AEC10489.1; AAQ56803.1; AAL91211.1

Protein Name

E3 ubiquitin-protein ligase BRE1-like 1; Protein HISTONE MONOUBIQUITINATION 1; Protein REDUCED DORMANCY 4; RING-type E3 ubiquitin transferase BRE1-like 1

Genbank Nucleotide ID

AC002388; AC002388; CP002685; BT010360; AY081322

Gene Name

HUB1; BRE1A; RDO4; At2g44950/At2g44960; T13E15.24/T13E15.23; T14P1.25/T14P1.24

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G44950	AT2G44950.1	AT2G44950.1
AT2G44950	AT2G44950.2	AT2G44950.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18798874; 19286969

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00035	21.9	826	864

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C  C +++k+ ++++ C H+f+  C+qk+        ++ +CP+C
   Q: 826  CKACNDRPKE-VVITKCYHLFCNPCVQKL-----TGTRQKKCPTC 864
           889*****99.***************999.....6888899**** PP

Organism

Arabidopsis thaliana

Functional Description
(View)

E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me. It thereby plays a central role in histone code and gene regulation. Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6. Required for the regulation of flowering time and defense against necrotrophic fungal pathogens (PubMed:12535538, PubMed:17329565, PubMed:17329563, PubMed:19286969). Involved in the control of seed dormancy and germination (PubMed:21799800).

Protein Sequence
(Fasta)

MASTGEPDRK RRHFSSISPS EAAAAVKKQP FFWPSSEDKL DTAVLQFQNL KLSQKLEAQQ 60
VECSILEDKL SQIKEKQLPY NSSLKTVHKS WEKLTASVES CSVRVSDSSS GAHRFVNKED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACAAAATTA CGCCATCGTA CTCGAATTAA CTTCAACTCT CTCTTCTCTC TCTCTTTCTT 60
TTCACTCTTG TTTTTGTTTC TGTGAGTGCT GTGTGTGTTC TCGGTTTGTA ATATCTAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0042803--F:protein homodimerization activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016049--P:cell growth
GO:0009817--P:defense response to fungus, incompatible interaction
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0045087--P:innate immune response
GO:0009965--P:leaf morphogenesis
GO:0006513--P:protein monoubiquitination
GO:0010389--P:regulation of G2/M transition of mitotic cell cycle
GO:0010162--P:seed dormancy process
GO:0010228--P:vegetative to reproductive phase transition of meristem

KEGG

ath:AT2G44950

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000994	Aegilops tauschii	34.89	3.00e-124	439.00
IUUC-Aml-002295	Ailuropoda melanoleuca	29.76	1.00e-31	131.00
IUUC-Atr-002836	Amborella trichopoda	47.83	0.00e+00	720.00
IUUC-Aca-004850	Anolis carolinensis	28.90	3.00e-28	120.00
IUUC-Aly-006055	Arabidopsis lyrata	96.92	0.00e+00	1659.00
IUUC-Ani-009488	Aspergillus nidulans	41.18	4.00e-07	48.50
IUUC-Ame-011745	Astyanax mexicanus	28.26	2.00e-29	124.00
IUUC-Bgr-012245	Blumeria graminis	39.62	2.00e-09	57.00
IUUC-Bta-013173	Bos taurus	29.56	3.00e-31	130.00
IUUC-Bdi-014799	Brachypodium distachyon	42.94	1.00e-177	616.00
IUUC-Bol-015421	Brassica oleracea	86.67	0.00e+00	1434.00
IUUC-Bra-016664	Brassica rapa	87.26	0.00e+00	1431.00
IUUC-Cel-018659	Caenorhabditis elegans	27.27	3.00e-25	109.00
IUUC-Cja-019042	Callithrix jacchus	30.03	2.00e-30	127.00
IUUC-Cfa-020318	Canis familiaris	29.76	1.00e-31	131.00
IUUC-Cpo-021539	Cavia porcellus	30.11	3.00e-31	130.00
IUUC-Csa-024051	Chlorocebus sabaeus	30.03	7.00e-32	132.00
IUUC-Dno-028892	Dasypus novemcinctus	29.76	1.00e-31	131.00
IUUC-Dor-030268	Dipodomys ordii	29.73	2.00e-31	130.00
IUUC-Dse-031300	Dothistroma septosporum	32.63	4.00e-12	66.20
IUUC-Dme-032034	Drosophila melanogaster	25.47	4.00e-29	123.00
IUUC-Eca-033436	Equus caballus	29.76	1.00e-31	131.00
IUUC-Eeu-034801	Erinaceus europaeus	42.70	8.00e-18	85.10
IUUC-Fca-035720	Felis catus	29.49	8.00e-32	132.00
IUUC-Fal-037622	Ficedula albicollis	41.28	5.00e-19	89.70
IUUC-Fox-038017	Fusarium oxysporum	32.65	2.00e-10	60.10
IUUC-Fso-038414	Fusarium solani	37.50	1.00e-09	57.80
IUUC-Gmo-039269	Gadus morhua	27.89	5.00e-30	125.00
IUUC-Gga-040412	Gallus gallus	28.68	2.00e-26	114.00
IUUC-Gac-041303	Gasterosteus aculeatus	28.02	7.00e-30	125.00
IUUC-Gma-043027	Glycine max	50.96	0.00e+00	839.00
IUUC-Ggo-045426	Gorilla gorilla	30.03	8.00e-32	132.00
IUUC-Hsa-045732	Homo sapiens	30.03	9.00e-32	132.00
IUUC-Hvu-047689	Hordeum vulgare	42.92	0.00e+00	630.00
IUUC-Itr-048724	Ictidomys tridecemlineatus	29.76	2.00e-31	130.00
IUUC-Kpa-049345	Komagataella pastoris	32.26	2.00e-09	57.40
IUUC-Lch-049429	Latimeria chalumnae	29.71	9.00e-31	128.00
IUUC-Lpe-051253	Leersia perrieri	41.24	9.00e-169	586.00
IUUC-Loc-052847	Lepisosteus oculatus	35.29	1.00e-21	96.30
IUUC-Laf-054267	Loxodonta africana	29.76	1.00e-31	131.00
IUUC-Mcc-055240	Macaca mulatta	30.03	7.00e-32	132.00
IUUC-Meu-056750	Macropus eugenii	30.14	2.00e-31	130.00
IUUC-Mor-057068	Magnaporthe oryzae	31.53	4.00e-12	66.20
IUUC-Mtr-057632	Medicago truncatula	50.96	0.00e+00	840.00
IUUC-Mga-059731	Meleagris gallopavo	28.68	2.00e-26	114.00
IUUC-Mvi-060341	Microbotryum violaceum	34.48	6.00e-17	82.40
IUUC-Mmr-061177	Microcebus murinus	30.03	8.00e-32	132.00
IUUC-Mdo-062415	Monodelphis domestica	28.89	3.00e-32	133.00
IUUC-Mmu-063981	Mus musculus	29.76	1.00e-31	131.00
IUUC-Mac-065103	Musa acuminata	44.64	0.00e+00	700.00
IUUC-Mpu-066498	Mustela putorius furo	29.49	8.00e-32	132.00
IUUC-Mlu-067242	Myotis lucifugus	29.76	1.00e-31	131.00
IUUC-Opr-071149	Ochotona princeps	38.78	1.00e-18	87.80
IUUC-Ont-071299	Oreochromis niloticus	28.02	5.00e-30	126.00
IUUC-Oan-072996	Ornithorhynchus anatinus	27.91	2.00e-26	114.00
IUUC-Ocu-073799	Oryctolagus cuniculus	29.76	8.00e-32	132.00
IUUC-Oba-075000	Oryza barthii	40.48	2.00e-171	595.00
IUUC-Obr-076532	Oryza brachyantha	43.39	0.00e+00	635.00
IUUC-Ogl-077200	Oryza glaberrima	42.62	0.00e+00	639.00
IUUC-Ogu-078279	Oryza glumaepatula	44.44	1.00e-144	506.00
IUUC-Oin-079097	Oryza indica	42.62	0.00e+00	639.00
IUUC-Olo-080447	Oryza longistaminata	38.34	2.00e-142	499.00
IUUC-Ome-081304	Oryza meridionalis	42.84	0.00e+00	630.00
IUUC-Oni-082162	Oryza nivara	38.96	1.00e-160	559.00
IUUC-Opu-083812	Oryza punctata	40.21	2.00e-150	526.00
IUUC-Oru-084382	Oryza rufipogon	38.96	1.00e-160	559.00
IUUC-Ola-086435	Oryzias latipes	27.75	5.00e-30	125.00
IUUC-Olu-087683	Ostreococcus lucimarinus	37.50	1.00e-15	74.30
IUUC-Oga-089016	Otolemur garnettii	30.03	7.00e-32	132.00
IUUC-Oar-089589	Ovis aries	29.22	3.00e-31	130.00
IUUC-Pan-092502	Papio anubis	30.03	7.00e-32	132.00
IUUC-Psi-093348	Pelodiscus sinensis	35.88	5.00e-20	89.70
IUUC-Pfo-097527	Poecilia formosa	27.63	1.00e-25	111.00
IUUC-Pab-098619	Pongo abelii	30.03	8.00e-32	132.00
IUUC-Pop-099376	Populus trichocarpa	56.98	0.00e+00	923.00
IUUC-Pca-100544	Procavia capensis	29.76	1.00e-31	131.00
IUUC-Ppe-102065	Prunus persica	56.41	0.00e+00	882.00
IUUC-Pva-102479	Pteropus vampyrus	29.22	3.00e-31	130.00
IUUC-Pgr-103536	Puccinia graminis	40.86	2.00e-17	84.00
IUUC-Rno-105165	Rattus norvegicus	29.49	1.00e-31	131.00
IUUC-Sce-106384	Saccharomyces cerevisiae	27.27	1.00e-11	64.70
IUUC-Sha-107602	Sarcophilus harrisii	28.89	3.00e-32	133.00
IUUC-Sit-109889	Setaria italica	41.89	1.00e-180	626.00
IUUC-Sly-111490	Solanum lycopersicum	50.95	0.00e+00	778.00
IUUC-Sar-113349	Sorex araneus	38.78	2.00e-18	87.40
IUUC-Sbi-114734	Sorghum bicolor	44.83	9.00e-59	219.00
IUUC-Sre-115087	Sporisorium reilianum	32.04	2.00e-15	77.80
IUUC-Ssc-116134	Sus scrofa	30.00	3.00e-30	126.00
IUUC-Tgu-116549	Taeniopygia guttata	41.28	3.00e-19	90.10
IUUC-Tru-117867	Takifugu rubripes	28.02	6.00e-30	125.00
IUUC-Tni-120802	Tetraodon nigroviridis	28.02	5.00e-30	125.00
IUUC-Tca-121060	Theobroma cacao	59.77	0.00e+00	993.00
IUUC-Tre-122150	Trichoderma reesei	35.85	7.00e-09	55.50
IUUC-Tvi-122431	Trichoderma virens	35.85	5.00e-09	55.80
IUUC-Tae-125456	Triticum aestivum	43.00	2.00e-174	605.00
IUUC-Tur-126786	Triticum urartu	38.15	1.00e-149	523.00
IUUC-Tbe-127597	Tupaia belangeri	31.09	1.00e-27	117.00
IUUC-Ttr-128303	Tursiops truncatus	29.18	1.00e-30	128.00
IUUC-Uma-129488	Ustilago maydis	41.07	3.00e-15	76.60
IUUC-Vvi-131316	Vitis vinifera	56.24	0.00e+00	915.00
IUUC-Xtr-132906	Xenopus tropicalis	27.22	1.00e-29	124.00
IUUC-Xma-133607	Xiphophorus maculatus	29.67	3.00e-29	123.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence