iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006834

UUCD1 version

UUC-ArT-00257

Ensembl Protein ID

AT1G65430.1

UniProt Accession

Q8W468; O80814; Q84JP9; Q84VL9; ARI8_ARATH

Genbank Protein ID

CAD52890.1; AAZ14067.1; AAC27149.1; AEE34372.1; AAL32886.1; AAM91148.1; AAO43365.1; AAO43366.1; AAO43367.1; AAO43368.1; AAO43369.1; AAO43370.1; AAO43371.1; AAO43372.1; AAO43373.1

Protein Name

Probable E3 ubiquitin-protein ligase ARI8; ARIADNE-like protein ARI8; Protein ariadne homolog 8; RING-type E3 ubiquitin transferase ARI8

Genbank Nucleotide ID

AJ510211; DQ086843; AC004512; CP002684; AY062808; AY128748; AF528630; AF528631; AF528632; AF528633; AF528634; AF528635; AF528636; AF528637; AF528638

Gene Name

ARI8; At1g65430; T8F5.21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G65430	AT1G65430.1	AT1G65430.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16339806

Classification

Family	E-value	Score	Start	End
E3 activity/RBR	6.50e-44	150.8	128	316

Active Site

Position(s)	Description	Evidence
299	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqv.teiscpaaecpekleeseikellveeelykryekllleevveadaalk 89
           C +C+ ++  ++l   ++C h fC +C++ y++++i++g    ++ cp+++c + + ++ i+  l+ ++ +++y+ + ++++ve ++++k
   Q: 128  CGICFETFLSDKLH-AAACGHPFCDSCWEGYITTAINDGPGcLTLRCPDPSCRAAVGQDMINL-LAPDKDKQKYTSYFVRSYVEDNRKTK 215
           99***999887776.67*********************987699*****************99.6888999******************* PP
   S: 90   wcpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnh 179
           wcpap+C+++v +   + +  v+c +c   fC++C ee+H++++C+++++++ k++    e+e+++++ ansk+CpkCk +iekn+gC+h
   Q: 216  WCPAPGCDYAVNFVVGSGNYDVNC-RCCYSFCWNCAEEAHRPVDCDTVSKWVLKNS---AESENMNWILANSKPCPKCKRPIEKNQGCMH 301
           ***********99999999*****.8999*************************99...89***************************** PP
   S: 180  mtC.akCkaefCwlC 193
           +tC   Ck efCwlC
   Q: 302  ITCtPPCKFEFCWLC 316
           ***778********* PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.

Protein Sequence
(Fasta)

MEADDDFYSG TENYSDYADS DEDDADGEYE FVDDAADDSD DLIFRRRQQN YSVLSEADIC 60
KLQEDDISRI STVLSISRNS SAILLRHYNW CVSRVHDEWF ADEEKVRDAV GLLEKPVVDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTTGGGATA AAATTGGAAG GGGATTTAGT GGCTAAGCTT AATTTACCAT TTTGCCATTA 60
TTCCTTTTTC GATTAAAACG TTTTCCCTTC CAAACGTCTT CTTACGAGAG AGAGAGAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00547--ZnF_RBZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

ath:AT1G65430

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000693	Aegilops tauschii	64.85	0.00e+00	698.00
IUUC-Atr-002495	Amborella trichopoda	70.80	0.00e+00	819.00
IUUC-Aly-005668	Arabidopsis lyrata	96.83	0.00e+00	1038.00
IUUC-Afl-008468	Aspergillus flavus	33.81	8.00e-62	230.00
IUUC-Aor-010009	Aspergillus oryzae	33.95	2.00e-61	229.00
IUUC-Bdi-014714	Brachypodium distachyon	71.61	0.00e+00	795.00
IUUC-Bol-015311	Brassica oleracea	85.41	0.00e+00	928.00
IUUC-Bra-018031	Brassica rapa	85.24	0.00e+00	932.00
IUUC-Cre-022815	Chlamydomonas reinhardtii	49.90	7.00e-138	483.00
IUUC-Cne-026861	Cryptococcus neoformans	31.89	1.00e-57	216.00
IUUC-Hvu-047322	Hordeum vulgare	70.95	0.00e+00	788.00
IUUC-Lpe-051080	Leersia perrieri	71.32	0.00e+00	795.00
IUUC-Mac-065497	Musa acuminata	71.32	0.00e+00	805.00
IUUC-Oba-075918	Oryza barthii	61.61	0.00e+00	668.00
IUUC-Obr-076649	Oryza brachyantha	71.31	0.00e+00	702.00
IUUC-Ogl-077640	Oryza glaberrima	72.07	0.00e+00	802.00
IUUC-Ogu-078785	Oryza glumaepatula	70.20	0.00e+00	769.00
IUUC-Oin-079448	Oryza indica	72.07	0.00e+00	802.00
IUUC-Olo-080626	Oryza longistaminata	69.82	0.00e+00	682.00
IUUC-Ome-081470	Oryza meridionalis	72.07	0.00e+00	805.00
IUUC-Oni-082202	Oryza nivara	70.39	0.00e+00	772.00
IUUC-Opu-084143	Oryza punctata	69.89	0.00e+00	764.00
IUUC-Oru-084778	Oryza rufipogon	70.39	0.00e+00	772.00
IUUC-Osa-086044	Oryza sativa	72.55	0.00e+00	702.00
IUUC-Ppa-095554	Physcomitrella patens	65.24	0.00e+00	724.00
IUUC-Pop-099195	Populus trichocarpa	75.51	0.00e+00	836.00
IUUC-Ppe-101468	Prunus persica	75.41	0.00e+00	873.00
IUUC-Smo-109424	Selaginella moellendorffii	64.07	0.00e+00	717.00
IUUC-Sit-110645	Setaria italica	71.32	0.00e+00	814.00
IUUC-Sly-111226	Solanum lycopersicum	74.35	0.00e+00	821.00
IUUC-Sbi-114839	Sorghum bicolor	71.93	0.00e+00	799.00
IUUC-Tca-121539	Theobroma cacao	76.95	0.00e+00	867.00
IUUC-Tae-123155	Triticum aestivum	71.61	0.00e+00	805.00
IUUC-Tur-126546	Triticum urartu	64.97	0.00e+00	696.00
IUUC-Tme-127089	Tuber melanosporum	34.92	4.00e-62	231.00
IUUC-Vvi-131543	Vitis vinifera	74.44	0.00e+00	867.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence