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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063473
UUCD1 version UUC-MuM-00908
Ensembl Protein ID ENSMUSP00000028351.3
UniProt Accession Q9CYU6; A2AJ86; Q5RJV7; Q8BIT9; DPH7_MOUSE
Genbank Protein ID BAB28775.1; BAC37279.1; BAC40084.1; CAM17983.1; ENSMUSP00000028351
Protein Name Diphthine methyltransferase; Diphthamide biosynthesis protein 7; WD repeat-containing protein 85
Genbank Nucleotide ID AK013297; AK078448; AK087998; AL732585; BC086486
Gene Name Dph7; Wdr85
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026975.10 ENSMUST00000028351.8 ENSMUSP00000028351.3
ENSMUSG00000026975.10 ENSMUST00000135339.7 ENSMUSP00000142067.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.20e-10 39.7 436 458
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 11   fsd.tllvsGs.dDgtikvWDlrt 32
           f d  ll+++s +D+++++W + t
   Q: 436  F-DnSLLATCSfYDHVLHLWKWET 458
           5.33799*************9876 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).
 Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).
Protein Sequence
(Fasta)
MAGSHAGTLR VLQAVDTELT ADSVEWCPVE GYQHLLACGT YQLRAPRDQP ALDGSEPQVR 60
LGRLYLFSFS EHNTAKPLLE VQRRDSSAVL DMKWCHIPVS GHVLLGLANA SGSIGLLRLM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063473|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGGAATCTT CGGAGGGTCG GCAGTGACTG AGGGAAGTGG AGAGAGAGTG TGGCGCATGC 60
ATCCTTTGGT TCTGGCTCAA TGGCGGGTAG CCACGCAGGG ACGTTGCGAG TCCTGCAGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063473|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR023302--Pept_S9A_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
SMART

SM00320--WD40
Gene Ontology

GO:0061685--F:diphthine methylesterase activity
GO:0017183--P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine
KEGG mmu:67228
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000566 Aegilops tauschii 39.77 2.00e-31 128.00
IUUC-Aml-001799 Ailuropoda melanoleuca 62.31 1.00e-164 573.00
IUUC-Atr-002540 Amborella trichopoda 41.09 3.00e-38 151.00
IUUC-Apl-003582 Anas platyrhynchos 47.19 4.00e-103 368.00
IUUC-Aca-004275 Anolis carolinensis 50.80 1.00e-98 353.00
IUUC-Aly-005425 Arabidopsis lyrata 34.76 9.00e-45 174.00
IUUC-Ath-007434 Arabidopsis thaliana 35.78 1.00e-46 179.00
IUUC-Ago-007782 Ashbya gossypii 33.14 3.00e-14 72.80
IUUC-Ang-009512 Aspergillus niger 25.20 9.00e-04 38.10
IUUC-Ame-011276 Astyanax mexicanus 45.99 4.00e-63 234.00
IUUC-Bta-012985 Bos taurus 60.53 1.00e-153 536.00
IUUC-Bdi-014568 Brachypodium distachyon 33.13 5.00e-36 145.00
IUUC-Bol-016236 Brassica oleracea 34.65 1.00e-44 173.00
IUUC-Bra-017012 Brassica rapa 34.25 1.00e-42 167.00
IUUC-Cel-018435 Caenorhabditis elegans 29.67 4.00e-15 75.50
IUUC-Cja-018952 Callithrix jacchus 62.34 5.00e-156 544.00
IUUC-Cfa-021210 Canis familiaris 62.20 7.00e-161 560.00
IUUC-Cpo-022017 Cavia porcellus 60.17 1.00e-146 512.00
IUUC-Cre-022584 Chlamydomonas reinhardtii 45.32 2.00e-31 128.00
IUUC-Csa-023897 Chlorocebus sabaeus 65.37 5.00e-154 537.00
IUUC-Cho-024708 Choloepus hoffmanni 50.60 2.00e-57 215.00
IUUC-Cin-025485 Ciona intestinalis 41.06 8.00e-64 237.00
IUUC-Cne-026845 Cryptococcus neoformans 34.28 9.00e-44 170.00
IUUC-Cme-027194 Cyanidioschyzon merolae 29.01 9.00e-19 87.40
IUUC-Dre-028581 Danio rerio 45.70 7.00e-100 357.00
IUUC-Dno-029285 Dasypus novemcinctus 61.11 1.00e-153 536.00
IUUC-Dor-030566 Dipodomys ordii 64.07 2.00e-160 558.00
IUUC-Dme-031714 Drosophila melanogaster 37.87 2.00e-51 196.00
IUUC-Ete-032317 Echinops telfairi 51.85 3.00e-107 381.00
IUUC-Eca-033341 Equus caballus 81.06 5.00e-63 232.00
IUUC-Eeu-034890 Erinaceus europaeus 57.33 3.00e-147 514.00
IUUC-Fca-035966 Felis catus 60.94 1.00e-161 563.00
IUUC-Fal-037338 Ficedula albicollis 48.41 2.00e-118 419.00
IUUC-Gmo-039487 Gadus morhua 44.00 8.00e-93 333.00
IUUC-Gga-040691 Gallus gallus 45.57 2.00e-103 369.00
IUUC-Gac-041912 Gasterosteus aculeatus 44.32 7.00e-100 357.00
IUUC-Gma-042905 Glycine max 35.67 7.00e-44 171.00
IUUC-Ggo-045003 Gorilla gorilla 65.94 4.00e-170 590.00
IUUC-Hsa-046840 Homo sapiens 65.94 1.00e-170 592.00
IUUC-Hvu-047291 Hordeum vulgare 34.04 3.00e-40 159.00
IUUC-Itr-048072 Ictidomys tridecemlineatus 62.74 5.00e-160 557.00
IUUC-Kpa-049296 Komagataella pastoris 29.64 7.00e-17 81.60
IUUC-Lch-049627 Latimeria chalumnae 47.29 1.00e-115 410.00
IUUC-Lpe-051462 Leersia perrieri 32.93 4.00e-40 158.00
IUUC-Loc-052917 Lepisosteus oculatus 45.87 2.00e-104 373.00
IUUC-Laf-054268 Loxodonta africana 60.81 7.00e-153 533.00
IUUC-Mcc-055309 Macaca mulatta 65.72 1.00e-170 592.00
IUUC-Meu-055985 Macropus eugenii 63.28 9.00e-117 412.00
IUUC-Mtr-058767 Medicago truncatula 36.14 3.00e-44 172.00
IUUC-Mla-059032 Melampsora laricipopulina 35.18 2.00e-49 189.00
IUUC-Mga-059799 Meleagris gallopavo 47.73 2.00e-91 329.00
IUUC-Mvi-060258 Microbotryum violaceum 36.64 1.00e-51 196.00
IUUC-Mmr-061425 Microcebus murinus 63.15 1.00e-166 579.00
IUUC-Mdo-062620 Monodelphis domestica 51.91 2.00e-132 465.00
IUUC-Mac-065376 Musa acuminata 34.76 2.00e-46 179.00
IUUC-Mpu-066124 Mustela putorius furo 62.37 2.00e-165 575.00
IUUC-Mlu-067844 Myotis lucifugus 56.37 4.00e-148 517.00
IUUC-Ont-071523 Oreochromis niloticus 44.49 1.00e-101 363.00
IUUC-Oan-072754 Ornithorhynchus anatinus 45.98 2.00e-89 322.00
IUUC-Ocu-074659 Oryctolagus cuniculus 61.61 7.00e-107 380.00
IUUC-Oba-075786 Oryza barthii 40.37 4.00e-30 124.00
IUUC-Obr-076077 Oryza brachyantha 32.52 3.00e-39 155.00
IUUC-Ogl-077449 Oryza glaberrima 32.83 1.00e-39 156.00
IUUC-Ogu-078217 Oryza glumaepatula 32.93 4.00e-39 155.00
IUUC-Oin-079292 Oryza indica 32.83 2.00e-39 156.00
IUUC-Olo-080599 Oryza longistaminata 40.37 3.00e-30 125.00
IUUC-Ome-081740 Oryza meridionalis 32.93 3.00e-39 155.00
IUUC-Oni-082582 Oryza nivara 32.93 3.00e-39 155.00
IUUC-Opu-083166 Oryza punctata 32.22 7.00e-37 147.00
IUUC-Oru-084514 Oryza rufipogon 32.08 2.00e-35 143.00
IUUC-Osa-086226 Oryza sativa 32.83 2.00e-39 156.00
IUUC-Olu-087798 Ostreococcus lucimarinus 38.26 2.00e-28 118.00
IUUC-Oga-088820 Otolemur garnettii 65.36 6.00e-167 580.00
IUUC-Oar-089825 Ovis aries 55.23 5.00e-136 478.00
IUUC-Pan-091766 Papio anubis 61.37 1.00e-152 532.00
IUUC-Psi-093167 Pelodiscus sinensis 50.21 3.00e-130 458.00
IUUC-Pno-095089 Phaeosphaeria nodorum 25.79 1.00e-14 74.30
IUUC-Ppa-095299 Physcomitrella patens 39.76 1.00e-50 193.00
IUUC-Pfo-096456 Poecilia formosa 44.25 3.00e-96 345.00
IUUC-Pab-097864 Pongo abelii 65.38 8.00e-101 359.00
IUUC-Pop-100043 Populus trichocarpa 37.36 4.00e-36 144.00
IUUC-Ppe-101556 Prunus persica 34.94 9.00e-45 174.00
IUUC-Pva-102281 Pteropus vampyrus 60.96 3.00e-153 535.00
IUUC-Pgr-103459 Puccinia graminis 35.21 6.00e-31 127.00
IUUC-Rno-105659 Rattus norvegicus 84.58 0.00e+00 818.00
IUUC-Sha-107077 Sarcophilus harrisii 51.82 3.00e-130 458.00
IUUC-Smo-109371 Selaginella moellendorffii 38.21 3.00e-56 212.00
IUUC-Sit-109789 Setaria italica 41.25 5.00e-31 128.00
IUUC-Sly-110953 Solanum lycopersicum 40.74 2.00e-32 132.00
IUUC-Stu-112698 Solanum tuberosum 34.74 7.00e-44 171.00
IUUC-Sbi-114197 Sorghum bicolor 31.82 5.00e-37 148.00
IUUC-Sre-115167 Sporisorium reilianum 43.53 6.00e-31 128.00
IUUC-Tgu-116657 Taeniopygia guttata 59.45 1.00e-71 261.00
IUUC-Tru-118578 Takifugu rubripes 45.26 4.00e-101 361.00
IUUC-Tca-121611 Theobroma cacao 39.05 2.00e-45 176.00
IUUC-Tae-124972 Triticum aestivum 33.54 8.00e-40 157.00
IUUC-Tur-126298 Triticum urartu 40.34 6.00e-32 130.00
IUUC-Ttr-128302 Tursiops truncatus 64.01 1.00e-116 412.00
IUUC-Uma-129644 Ustilago maydis 40.72 3.00e-30 126.00
IUUC-Vvi-131363 Vitis vinifera 34.52 1.00e-40 160.00
IUUC-Xtr-132976 Xenopus tropicalis 43.70 2.00e-103 369.00
IUUC-Xma-133286 Xiphophorus maculatus 45.00 2.00e-101 362.00
IUUC-Yli-134664 Yarrowia lipolytica 29.12 3.00e-17 82.80
Created Date 25-Jun-2017

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