iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033502

Ensembl Protein ID

ENSECAP00000000911.1

UniProt Accession

F7D721; F7D721_HORSE

Protein Name

Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47

Gene Name

EIF3F; EIF3S5; LOC100071582

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000001218.1	ENSECAT00000001158.1	ENSECAP00000000911.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/JAMM	94.66	3.00e-154	542.00	IUUC-Hsa-046860

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Equus caballus

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

MATPTVPASA PPAAPAPAPA SPTAPAPGSA PAAAPVLVPT AAPASSSDPA AAATATAAPG 60
QPPTSAPAPA QTPAQSLPGP ALPGHFPGGR VVRLHLVILA SIVDSYERRN EGAAHVIGTL 120

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Nucleotide Sequence
(Fasta)

GACAAGATGG CCACACCGAC GGTACCGGCG AGTGCTCCTC CTGCAGCTCC AGCCCCAGCC 60
CCAGCCTCAC CCACAGCTCC GGCCCCAGGC TCAGCGCCGG CTGCAGCGCC GGTTCTGGTC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome

Interpro

IPR027531--eIF3f
IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0016020--C:membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003743--F:translation initiation factor activity
GO:0031369--F:translation initiation factor binding
GO:0001731--P:formation of translation preinitiation complex
GO:0075522--P:IRES-dependent viral translational initiation
GO:0016579--P:protein deubiquitination
GO:0006446--P:regulation of translational initiation
GO:0006413--P:translational initiation

KEGG

ecb:100071582

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001150	Aegilops tauschii	34.55	3.00e-42	165.00
IUUC-Aml-001527	Ailuropoda melanoleuca	94.78	6.00e-147	513.00
IUUC-Atr-002686	Amborella trichopoda	39.16	3.00e-44	171.00
IUUC-Apl-003977	Anas platyrhynchos	85.71	9.00e-112	395.00
IUUC-Aca-004335	Anolis carolinensis	85.56	5.00e-136	476.00
IUUC-Aly-005945	Arabidopsis lyrata	36.50	3.00e-44	172.00
IUUC-Ath-007045	Arabidopsis thaliana	36.88	2.00e-44	172.00
IUUC-Acl-008365	Aspergillus clavatus	33.71	2.00e-38	153.00
IUUC-Afl-008742	Aspergillus flavus	33.70	8.00e-36	144.00
IUUC-Afu-009030	Aspergillus fumigatus	32.95	9.00e-38	150.00
IUUC-Ani-009212	Aspergillus nidulans	34.02	2.00e-39	155.00
IUUC-Ang-009712	Aspergillus niger	32.96	4.00e-37	148.00
IUUC-Aor-009885	Aspergillus oryzae	33.58	2.00e-38	152.00
IUUC-Ate-010315	Aspergillus terreus	34.21	7.00e-36	144.00
IUUC-Ame-010801	Astyanax mexicanus	48.99	3.00e-61	228.00
IUUC-Bgr-011982	Blumeria graminis	33.83	6.00e-37	147.00
IUUC-Bta-012804	Bos taurus	93.59	8.00e-153	533.00
IUUC-Bci-013891	Botrytis cinerea	33.08	8.00e-32	130.00
IUUC-Bdi-014328	Brachypodium distachyon	37.11	2.00e-44	172.00
IUUC-Bol-015446	Brassica oleracea	36.88	3.00e-45	175.00
IUUC-Bra-016862	Brassica rapa	37.26	9.00e-46	176.00
IUUC-Cel-018171	Caenorhabditis elegans	34.49	1.00e-41	162.00
IUUC-Cja-019335	Callithrix jacchus	94.85	9.00e-150	522.00
IUUC-Cfa-020138	Canis familiaris	94.40	3.00e-146	510.00
IUUC-Cpo-022109	Cavia porcellus	82.91	2.00e-125	442.00
IUUC-Cre-022664	Chlamydomonas reinhardtii	36.57	5.00e-53	201.00
IUUC-Csa-023994	Chlorocebus sabaeus	94.85	1.00e-149	522.00
IUUC-Cho-024351	Choloepus hoffmanni	72.06	6.00e-104	370.00
IUUC-Cin-025801	Ciona intestinalis	54.28	1.00e-80	292.00
IUUC-Csv-025805	Ciona savignyi	53.16	2.00e-78	285.00
IUUC-Cgl-026643	Colletotrichum gloeosporioides	30.53	7.00e-33	134.00
IUUC-Cne-026868	Cryptococcus neoformans	28.41	4.00e-24	105.00
IUUC-Cme-027328	Cyanidioschyzon merolae	25.95	5.00e-20	91.70
IUUC-Dre-028085	Danio rerio	77.32	9.00e-122	429.00
IUUC-Dno-030099	Dasypus novemcinctus	94.40	2.00e-146	511.00
IUUC-Dor-030324	Dipodomys ordii	85.82	3.00e-128	451.00
IUUC-Dse-031314	Dothistroma septosporum	34.21	4.00e-40	158.00
IUUC-Dme-031926	Drosophila melanogaster	46.13	2.00e-68	251.00
IUUC-Ete-032569	Echinops telfairi	88.85	2.00e-141	494.00
IUUC-Eeu-034883	Erinaceus europaeus	77.30	2.00e-75	274.00
IUUC-Fca-035873	Felis catus	94.78	1.00e-146	512.00
IUUC-Fal-036921	Ficedula albicollis	87.04	3.00e-137	480.00
IUUC-Fox-037765	Fusarium oxysporum	31.60	2.00e-27	116.00
IUUC-Fso-038240	Fusarium solani	31.97	8.00e-30	124.00
IUUC-Gmo-038864	Gadus morhua	75.84	2.00e-121	427.00
IUUC-Ggr-039862	Gaeumannomyces graminis	30.22	5.00e-28	118.00
IUUC-Gga-040952	Gallus gallus	87.13	1.00e-138	485.00
IUUC-Gac-041677	Gasterosteus aculeatus	76.95	1.00e-121	429.00
IUUC-Gma-043061	Glycine max	38.78	2.00e-43	169.00
IUUC-Ggo-045591	Gorilla gorilla	94.85	4.00e-150	523.00
IUUC-Hsa-046860	Homo sapiens	94.85	1.00e-149	522.00
IUUC-Hvu-047410	Hordeum vulgare	29.05	1.00e-17	81.60
IUUC-Itr-048211	Ictidomys tridecemlineatus	94.40	3.00e-146	511.00
IUUC-Lch-049410	Latimeria chalumnae	69.90	2.00e-79	288.00
IUUC-Lpe-051102	Leersia perrieri	38.04	6.00e-42	164.00
IUUC-Loc-052016	Lepisosteus oculatus	69.52	2.00e-105	375.00
IUUC-Lma-053157	Leptosphaeria maculans	33.71	7.00e-40	157.00
IUUC-Laf-054568	Loxodonta africana	94.12	4.00e-149	520.00
IUUC-Mcc-054613	Macaca mulatta	94.85	5.00e-150	523.00
IUUC-Meu-056832	Macropus eugenii	68.10	3.00e-74	270.00
IUUC-Mor-057104	Magnaporthe oryzae	30.88	1.00e-27	116.00
IUUC-Mtr-058445	Medicago truncatula	38.78	2.00e-52	199.00
IUUC-Mla-059038	Melampsora laricipopulina	30.36	3.00e-30	125.00
IUUC-Mga-059548	Meleagris gallopavo	86.86	2.00e-119	421.00
IUUC-Mvi-060520	Microbotryum violaceum	26.26	1.00e-18	86.70
IUUC-Mdo-062376	Monodelphis domestica	89.18	2.00e-138	484.00
IUUC-Mmu-063254	Mus musculus	94.03	2.00e-145	508.00
IUUC-Mac-065635	Musa acuminata	38.91	4.00e-46	177.00
IUUC-Mpu-066314	Mustela putorius furo	94.78	8.00e-147	512.00
IUUC-Mlu-067512	Myotis lucifugus	93.28	2.00e-144	505.00
IUUC-Nfi-068262	Neosartorya fischeri	32.95	1.00e-37	150.00
IUUC-Ncr-068872	Neurospora crassa	30.83	1.00e-29	123.00
IUUC-Nle-070118	Nomascus leucogenys	94.78	1.00e-146	512.00
IUUC-Opr-071228	Ochotona princeps	94.47	9.00e-129	452.00
IUUC-Ont-072600	Oreochromis niloticus	77.70	2.00e-124	437.00
IUUC-Oan-073584	Ornithorhynchus anatinus	88.56	6.00e-123	432.00
IUUC-Ocu-074542	Oryctolagus cuniculus	94.40	5.00e-146	510.00
IUUC-Oba-075923	Oryza barthii	36.82	2.00e-44	172.00
IUUC-Obr-076313	Oryza brachyantha	38.04	8.00e-44	170.00
IUUC-Ogl-076932	Oryza glaberrima	36.82	2.00e-44	172.00
IUUC-Ogu-078152	Oryza glumaepatula	36.82	2.00e-44	172.00
IUUC-Oin-079528	Oryza indica	36.82	2.00e-44	172.00
IUUC-Olo-080401	Oryza longistaminata	36.82	2.00e-44	172.00
IUUC-Ome-081553	Oryza meridionalis	36.46	7.00e-44	170.00
IUUC-Oni-082090	Oryza nivara	36.82	3.00e-44	171.00
IUUC-Opu-083583	Oryza punctata	38.04	2.00e-43	169.00
IUUC-Oru-084492	Oryza rufipogon	36.82	2.00e-44	172.00
IUUC-Osa-085383	Oryza sativa	36.82	2.00e-44	172.00
IUUC-Ola-086835	Oryzias latipes	76.58	4.00e-121	427.00
IUUC-Olu-087716	Ostreococcus lucimarinus	28.79	1.00e-24	106.00
IUUC-Oga-088886	Otolemur garnettii	94.03	4.00e-146	510.00
IUUC-Oar-090079	Ovis aries	93.62	3.00e-153	533.00
IUUC-Ptr-091457	Pan troglodytes	94.85	1.00e-149	522.00
IUUC-Pan-092317	Papio anubis	94.05	9.00e-98	348.00
IUUC-Psi-093129	Pelodiscus sinensis	80.69	2.00e-119	421.00
IUUC-Pma-094488	Petromyzon marinus	69.05	2.00e-116	411.00
IUUC-Pno-095049	Phaeosphaeria nodorum	33.33	1.00e-39	156.00
IUUC-Ppa-095341	Physcomitrella patens	38.69	5.00e-58	217.00
IUUC-Pfo-096286	Poecilia formosa	76.21	5.00e-122	429.00
IUUC-Pab-097765	Pongo abelii	94.85	1.00e-149	522.00
IUUC-Pop-099131	Populus trichocarpa	38.40	3.00e-48	185.00
IUUC-Pca-100524	Procavia capensis	78.63	4.00e-100	357.00
IUUC-Ppe-101934	Prunus persica	39.54	8.00e-53	200.00
IUUC-Pva-102577	Pteropus vampyrus	94.40	5.00e-146	510.00
IUUC-Pgr-103521	Puccinia graminis	28.28	6.00e-29	120.00
IUUC-Pte-104304	Pyrenophora teres	34.09	2.00e-40	159.00
IUUC-Pyt-104563	Pyrenophora triticirepentis	34.09	1.00e-40	159.00
IUUC-Rno-105717	Rattus norvegicus	94.40	4.00e-146	510.00
IUUC-Sha-107190	Sarcophilus harrisii	89.66	5.00e-136	477.00
IUUC-Sja-107918	Schizosaccharomyces japonicus	36.13	3.00e-42	165.00
IUUC-Spo-108355	Schizosaccharomyces pombe	34.14	5.00e-42	164.00
IUUC-Smo-109374	Selaginella moellendorffii	41.26	2.00e-61	228.00
IUUC-Sit-110119	Setaria italica	37.64	2.00e-44	172.00
IUUC-Sly-111570	Solanum lycopersicum	35.86	5.00e-40	157.00
IUUC-Stu-112308	Solanum tuberosum	37.66	3.00e-46	178.00
IUUC-Sar-113515	Sorex araneus	92.47	1.00e-46	178.00
IUUC-Sbi-114605	Sorghum bicolor	37.26	2.00e-44	172.00
IUUC-Sre-114906	Sporisorium reilianum	38.69	3.00e-49	188.00
IUUC-Tgu-117087	Taeniopygia guttata	85.17	4.00e-117	413.00
IUUC-Tru-117700	Takifugu rubripes	76.58	7.00e-122	429.00
IUUC-Tni-120470	Tetraodon nigroviridis	77.32	1.00e-122	431.00
IUUC-Tca-121109	Theobroma cacao	38.22	3.00e-42	164.00
IUUC-Tre-122095	Trichoderma reesei	33.58	2.00e-30	126.00
IUUC-Tvi-122580	Trichoderma virens	33.21	8.00e-30	124.00
IUUC-Tae-125129	Triticum aestivum	37.37	1.00e-46	180.00
IUUC-Tur-126658	Triticum urartu	33.83	2.00e-38	152.00
IUUC-Tme-127043	Tuber melanosporum	35.96	7.00e-44	171.00
IUUC-Tbe-127927	Tupaia belangeri	94.78	1.00e-146	512.00
IUUC-Ttr-129231	Tursiops truncatus	94.40	3.00e-146	510.00
IUUC-Uma-129578	Ustilago maydis	38.32	2.00e-48	185.00
IUUC-Vda-129730	Verticillium dahliae	31.60	4.00e-35	141.00
IUUC-Vpa-130677	Vicugna pacos	58.99	2.00e-35	142.00
IUUC-Vvi-130968	Vitis vinifera	38.40	2.00e-47	182.00
IUUC-Xtr-132203	Xenopus tropicalis	80.67	1.00e-125	442.00
IUUC-Xma-133972	Xiphophorus maculatus	75.84	2.00e-121	427.00
IUUC-Yli-134553	Yarrowia lipolytica	36.33	1.00e-38	153.00
IUUC-Zma-134941	Zea mays	36.88	1.00e-39	156.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence