iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028337

UUCD1 version

UUC-DaR-01372

Ensembl Protein ID

ENSDARP00000108827.2

UniProt Accession

Q4VBH4; B0V2U1; UB2WA_DANRE

Genbank Protein ID

CAQ15478.1; AAH95816.1

Protein Name

Probable ubiquitin-conjugating enzyme E2 W-A; E2 ubiquitin-conjugating enzyme W-A; N-terminal E2 ubiquitin-conjugating enzyme; Ubiquitin carrier protein W-A; Ubiquitin-protein ligase W-A

Genbank Nucleotide ID

CT027743; BC095816

Gene Name

ube2w; ube2wa; im:6905459; si:ch211-193n21.4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000044923.7	ENSDART00000130142.2	ENSDARP00000108827.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.20e-35	123.2	7	141

Active Site

Position(s)	Description	Evidence
91	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdppegisakpvdesd.ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk..ifhPnvyenGkvClsil 86
           Rl+kel +l++dpp+g++++  + ++ +tew + ++G ++t+Yeg++F+l ++f+++YPf++P+v+f+ +    hP+vy+nG++Clsil
   Q: 7    RLQKELLALQNDPPAGMTLNERSVQNtITEWFIDMEGAQGTVYEGEKFQLLFKFSSRYPFESPQVMFTGEniPVHPHVYSNGHICLSIL 95
           9********************999988*****************************************99989**************** PP
   S: 87   keeekWspalsvesvllsiqsll..aepnpesplneeaaellkknree 132
           +  e+Wspalsv+sv+lsi+s+l  ++ + + p n+  +++++kn+++
   Q: 96   T--EDWSPALSVQSVCLSIISMLssCKEKRRPPDNSFYVKTCNKNPKK 141
           9..********************6556777889999999999999874 PP

Organism

Danio rerio

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrate and DNA repair.

Protein Sequence
(Fasta)

MASMQKRLQK ELLALQNDPP AGMTLNERSV QNTITEWFID MEGAQGTVYE GEKFQLLFKF 60
SSRYPFESPQ VMFTGENIPV HPHVYSNGHI CLSILTEDWS PALSVQSVCL SIISMLSSCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGTCTTCT CATTCAAATA ACCAATGCCT ATGCGTAGAT TGCACAAAAC GTTATAATAT 60
TTTTATTTAA AATGTTTGAT TCGAGATGAT TTTAGGGTTT GAGCAGTAAA GCATATTCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0071218--P:cellular response to misfolded protein
GO:0006281--P:DNA repair
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

KEGG

dre:553013

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000363	Aegilops tauschii	42.86	4.00e-31	128.00
IUUC-Aly-006450	Arabidopsis lyrata	51.72	1.00e-40	158.00
IUUC-Ath-007383	Arabidopsis thaliana	51.72	4.00e-34	137.00
IUUC-Acl-008034	Aspergillus clavatus	35.53	1.00e-23	102.00
IUUC-Afl-008476	Aspergillus flavus	37.82	9.00e-27	112.00
IUUC-Afu-008827	Aspergillus fumigatus	36.54	2.00e-25	108.00
IUUC-Ani-009244	Aspergillus nidulans	35.97	1.00e-20	92.00
IUUC-Aor-009924	Aspergillus oryzae	36.62	2.00e-23	101.00
IUUC-Ate-010478	Aspergillus terreus	30.17	1.00e-19	89.40
IUUC-Bgr-012004	Blumeria graminis	39.74	8.00e-28	115.00
IUUC-Bdi-014373	Brachypodium distachyon	52.41	1.00e-41	161.00
IUUC-Bol-016083	Brassica oleracea	52.41	1.00e-40	159.00
IUUC-Bra-017578	Brassica rapa	52.05	2.00e-34	138.00
IUUC-Cel-018273	Caenorhabditis elegans	60.00	4.00e-54	203.00
IUUC-Cme-027157	Cyanidioschyzon merolae	58.12	3.00e-39	154.00
IUUC-Fox-038001	Fusarium oxysporum	39.74	9.00e-28	115.00
IUUC-Fso-038237	Fusarium solani	39.10	2.00e-27	114.00
IUUC-Gma-043703	Glycine max	50.34	2.00e-33	135.00
IUUC-Lpe-051342	Leersia perrieri	51.72	3.00e-41	160.00
IUUC-Mtr-058781	Medicago truncatula	51.72	1.00e-40	159.00
IUUC-Mla-059112	Melampsora laricipopulina	50.93	8.00e-33	132.00
IUUC-Mac-064973	Musa acuminata	51.72	6.00e-41	159.00
IUUC-Nfi-068242	Neosartorya fischeri	34.87	3.00e-23	101.00
IUUC-Oba-075077	Oryza barthii	51.72	2.00e-41	161.00
IUUC-Ogl-077944	Oryza glaberrima	51.72	2.00e-41	161.00
IUUC-Ogu-078453	Oryza glumaepatula	51.72	2.00e-41	161.00
IUUC-Oin-079726	Oryza indica	51.72	4.00e-41	160.00
IUUC-Olo-080356	Oryza longistaminata	51.72	2.00e-41	161.00
IUUC-Ome-081601	Oryza meridionalis	51.72	2.00e-41	161.00
IUUC-Oni-082554	Oryza nivara	51.72	2.00e-41	161.00
IUUC-Opu-083614	Oryza punctata	51.72	2.00e-41	161.00
IUUC-Oru-085028	Oryza rufipogon	51.72	2.00e-41	161.00
IUUC-Osa-085386	Oryza sativa	51.72	2.00e-41	161.00
IUUC-Pop-099724	Populus trichocarpa	50.34	9.00e-33	132.00
IUUC-Ppe-101296	Prunus persica	52.41	2.00e-34	138.00
IUUC-Pgr-103668	Puccinia graminis	44.17	1.00e-32	132.00
IUUC-Smo-109161	Selaginella moellendorffii	55.86	3.00e-44	171.00
IUUC-Sit-110749	Setaria italica	53.42	1.00e-42	165.00
IUUC-Sly-111213	Solanum lycopersicum	51.72	2.00e-34	138.00
IUUC-Stu-112148	Solanum tuberosum	51.72	5.00e-34	136.00
IUUC-Sbi-114650	Sorghum bicolor	52.74	2.00e-42	165.00
IUUC-Sre-114974	Sporisorium reilianum	45.16	3.00e-34	137.00
IUUC-Tca-121226	Theobroma cacao	51.03	2.00e-33	134.00
IUUC-Tae-124081	Triticum aestivum	52.41	8.00e-42	162.00
IUUC-Tur-126577	Triticum urartu	51.88	2.00e-38	150.00
IUUC-Tme-127110	Tuber melanosporum	40.13	3.00e-27	114.00
IUUC-Uma-129371	Ustilago maydis	45.16	9.00e-34	135.00
IUUC-Vda-129698	Verticillium dahliae	39.07	4.00e-28	117.00
IUUC-Vvi-131675	Vitis vinifera	51.72	2.00e-34	137.00
IUUC-Yli-134332	Yarrowia lipolytica	46.75	2.00e-30	125.00
IUUC-Zma-135814	Zea mays	52.74	4.00e-42	163.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence