iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oan-073636

Ensembl Protein ID

ENSOANP00000015610.1

UniProt Accession

F7AKD8; F7AKD8_ORNAN

Protein Name

Uncharacterized protein

Gene Name

WDR48

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000009844.2	ENSOANT00000015613.2	ENSOANP00000015610.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-33	113.3	193	230
UBD/Beta-Prp	7.90e-47	160.1	16	271
ULD/UDP/UFD/RAWUL	3.30e-23	82.2	553	658
ULD/UBL/SUMO	7.80e-54	180.6	544	651

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gHtd v +l +  d t  +sGs Dgti++W+l +++++
   Q: 193  GHTDNVKALLLnRDgTQCLSGSSDGTIRLWSLGQQRCI 230
           8********88*888*****************999997 PP

UBD/Beta-Prp

   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkl...lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgheds 96
           + +++++  p  + l+t++rd+ i++w+v + k    ++s++ h++ v+++ +  +gk+l+++s D t+kvw+  +g c++tl+ h+d+
   Q: 16   NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASADTTVKVWNAHKGFCMSTLRTHKDY 104
           45666777778888899999999999999998888889999999999999999999999999999999999999999999999999999 PP
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqclee........tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           v +l++ ++++ ++s++ dr i +wd++t + l +         lsg+++++ ++++++ g ++vsGs+ +++r+Wd +t   l +l+g
   Q: 105  VKALAYARDKELVASAGLDRQIFLWDVNTLTALTAsnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKG 193
           99999999999999999999999999999999988889999888999999999999999999999999999999999988888888888 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdl 256
            htd v+ l ++++g++++sgs dgt++lw+l +++c+ t++ h++ v+ +++ +  ++++sg+ D+ +++ dlr+ d+
   Q: 194  -HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQANEAFTHVYSGGRDRKVYCTDLRNPDI 271
           .999999999999999999999999999999999999999999999999999999999999999999999988887665 PP

ULD/UDP/UFD/RAWUL

   S: 4    sLeplesnkakddsklkkkylrcsarltVkhlkkflaeklkl........sssy.....................evdllcedevLedn 63
            L+p++s++ak+   lkk++l++s++l+V++++++++ek++         s                        +++llc+d+vL++n
   Q: 553  YLQPHSSSGAKT---LKKDRLSASDMLQVRKVMEHVYEKIITgtkhsqttS--SsnnekpgeqekdedisglaeeKIELLCQDQVLDPN 636
           69**********...***************************777655552..05589999999************************* PP
   S: 64   etLeeikyifiwkkegpLvLqYr 86
           ++L+++ ++fiwk++g+L+L+Yr
   Q: 637  MDLRTV-KHFIWKSGGDLTLHYR 658
           ******.***************9 PP

ULD/UBL/SUMO

   S: 1    eskffkapvslkvagqdGsevlfklklsa....qlkklmeavYvkrinldensvrfv.fngqkireqetpeelevededkiellcq... 81
           ++kf+k+p++l++++++G+++l+k++lsa    q++k+me+vY+k+i   + s++++ +n++k++eqe++e++  ++e+kiellcq   
   Q: 544  MPKFNKIPFYLQPHSSSGAKTLKKDRLSAsdmlQVRKVMEHVYEKIITGTKHSQTTSsSNNEKPGEQEKDEDISGLAEEKIELLCQdqv 632
           8*******************************************************99****************************777 PP
   S: 82   ...............ksGG 85
                          ksGG
   Q: 633  ldpnmdlrtvkhfiwKSGG 651
           7777777777777777776 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

QVSYVIRDEV EKYNRNGVNA LQLDPALNRL FTAGRDSIIR IWSVNQHKQD PYIASMEHHT 60
DWVNDIVLCC NGKTLISASA DTTVKVWNAH KGFCMSTLRT HKDYVKALAY ARDKELVASA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCATACACT TCTCCTCCAC CCCTGGCGTT GGTGGTGGGG ATGGAAAAGC TGACAGTTTT 60
AATGGTTTCA GGTCTCCTAC GTGATTCGTG ATGAAGTCGA GAAGTATAAT CGGAATGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021772--DUF3337
IPR020472--G-protein_beta_WD-40_rep
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF11816--DUF3337
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0000724--P:double-strand break repair via homologous recombination
GO:0048568--P:embryonic organ development
GO:0048872--P:homeostasis of number of cells
GO:0035264--P:multicellular organism growth
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0016579--P:protein deubiquitination
GO:1902525--P:regulation of protein monoubiquitination
GO:0072520--P:seminiferous tubule development
GO:0007338--P:single fertilization
GO:0048705--P:skeletal system morphogenesis
GO:0043588--P:skin development
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001160	Aegilops tauschii	40.00	1.00e-95	343.00
IUUC-Aml-001533	Ailuropoda melanoleuca	94.41	0.00e+00	1197.00
IUUC-Atr-003009	Amborella trichopoda	33.86	3.00e-109	388.00
IUUC-Apl-003709	Anas platyrhynchos	96.50	0.00e+00	656.00
IUUC-Aca-004875	Anolis carolinensis	95.47	0.00e+00	1236.00
IUUC-Aly-005464	Arabidopsis lyrata	40.12	2.00e-91	329.00
IUUC-Ath-006969	Arabidopsis thaliana	39.27	6.00e-88	318.00
IUUC-Acl-008203	Aspergillus clavatus	29.19	1.00e-56	214.00
IUUC-Afl-008571	Aspergillus flavus	34.72	2.00e-46	180.00
IUUC-Afu-009072	Aspergillus fumigatus	34.73	1.00e-44	174.00
IUUC-Ani-009413	Aspergillus nidulans	30.10	3.00e-51	196.00
IUUC-Ang-009571	Aspergillus niger	35.33	2.00e-45	177.00
IUUC-Aor-010064	Aspergillus oryzae	35.33	9.00e-47	181.00
IUUC-Ate-010463	Aspergillus terreus	34.43	4.00e-46	179.00
IUUC-Ame-010875	Astyanax mexicanus	92.26	0.00e+00	1071.00
IUUC-Bgr-012288	Blumeria graminis	33.83	6.00e-41	162.00
IUUC-Bta-013379	Bos taurus	94.71	0.00e+00	1201.00
IUUC-Bci-013859	Botrytis cinerea	28.38	1.00e-48	187.00
IUUC-Bdi-014645	Brachypodium distachyon	35.05	3.00e-109	388.00
IUUC-Bol-016450	Brassica oleracea	34.73	2.00e-98	352.00
IUUC-Bra-017253	Brassica rapa	34.18	1.00e-100	360.00
IUUC-Cel-018656	Caenorhabditis elegans	44.16	7.00e-155	540.00
IUUC-Cja-018804	Callithrix jacchus	94.41	0.00e+00	1197.00
IUUC-Cfa-020076	Canis familiaris	94.86	0.00e+00	1202.00
IUUC-Cpo-021721	Cavia porcellus	93.50	0.00e+00	1181.00
IUUC-Cre-022779	Chlamydomonas reinhardtii	30.73	9.00e-40	159.00
IUUC-Csa-023188	Chlorocebus sabaeus	94.86	0.00e+00	1202.00
IUUC-Cho-024932	Choloepus hoffmanni	93.66	0.00e+00	1203.00
IUUC-Cin-025591	Ciona intestinalis	56.66	0.00e+00	719.00
IUUC-Cgl-026540	Colletotrichum gloeosporioides	27.86	1.00e-20	95.10
IUUC-Cne-026819	Cryptococcus neoformans	35.09	2.00e-34	140.00
IUUC-Cme-027188	Cyanidioschyzon merolae	32.26	3.00e-72	265.00
IUUC-Dre-027926	Danio rerio	90.94	0.00e+00	1217.00
IUUC-Dno-029960	Dasypus novemcinctus	94.26	0.00e+00	1193.00
IUUC-Dor-030933	Dipodomys ordii	90.52	0.00e+00	684.00
IUUC-Dse-031532	Dothistroma septosporum	35.69	1.00e-45	178.00
IUUC-Dme-032168	Drosophila melanogaster	55.95	0.00e+00	671.00
IUUC-Ete-033107	Echinops telfairi	92.74	0.00e+00	1161.00
IUUC-Eca-034028	Equus caballus	95.02	0.00e+00	1204.00
IUUC-Eeu-034894	Erinaceus europaeus	92.55	0.00e+00	821.00
IUUC-Fca-035619	Felis catus	95.17	0.00e+00	890.00
IUUC-Fal-036869	Ficedula albicollis	95.02	0.00e+00	1230.00
IUUC-Fox-037907	Fusarium oxysporum	33.05	8.00e-41	162.00
IUUC-Fso-038101	Fusarium solani	33.33	3.00e-40	160.00
IUUC-Gmo-038627	Gadus morhua	92.45	0.00e+00	1232.00
IUUC-Ggr-039995	Gaeumannomyces graminis	31.76	1.00e-41	164.00
IUUC-Gga-040555	Gallus gallus	94.87	0.00e+00	1228.00
IUUC-Gac-042497	Gasterosteus aculeatus	91.84	0.00e+00	1204.00
IUUC-Gma-043089	Glycine max	34.75	4.00e-109	388.00
IUUC-Ggo-045561	Gorilla gorilla	94.86	0.00e+00	1202.00
IUUC-Hsa-045710	Homo sapiens	94.86	0.00e+00	1202.00
IUUC-Hvu-047730	Hordeum vulgare	35.93	4.00e-83	301.00
IUUC-Itr-049030	Ictidomys tridecemlineatus	93.25	0.00e+00	861.00
IUUC-Kpa-049237	Komagataella pastoris	30.77	5.00e-30	125.00
IUUC-Lch-049507	Latimeria chalumnae	93.66	0.00e+00	1200.00
IUUC-Lpe-051608	Leersia perrieri	34.90	1.00e-107	383.00
IUUC-Loc-052373	Lepisosteus oculatus	90.51	0.00e+00	1184.00
IUUC-Lma-053025	Leptosphaeria maculans	37.05	7.00e-49	188.00
IUUC-Laf-053706	Loxodonta africana	94.26	0.00e+00	1196.00
IUUC-Mcc-055046	Macaca mulatta	94.86	0.00e+00	1202.00
IUUC-Meu-056840	Macropus eugenii	78.01	1.00e-146	512.00
IUUC-Mor-057284	Magnaporthe oryzae	32.63	1.00e-42	167.00
IUUC-Mpo-057418	Magnaporthe poae	31.18	7.00e-40	159.00
IUUC-Mtr-058384	Medicago truncatula	34.96	2.00e-106	379.00
IUUC-Mla-059101	Melampsora laricipopulina	45.10	3.00e-46	180.00
IUUC-Mga-059297	Meleagris gallopavo	94.87	0.00e+00	1228.00
IUUC-Mvi-060419	Microbotryum violaceum	39.74	8.00e-39	155.00
IUUC-Mmr-061196	Microcebus murinus	88.17	0.00e+00	1106.00
IUUC-Mdo-062762	Monodelphis domestica	91.29	0.00e+00	1215.00
IUUC-Mmu-063915	Mus musculus	93.96	0.00e+00	1217.00
IUUC-Mac-065434	Musa acuminata	34.16	1.00e-105	377.00
IUUC-Mpu-065999	Mustela putorius furo	95.40	0.00e+00	790.00
IUUC-Mlu-068226	Myotis lucifugus	94.56	0.00e+00	1197.00
IUUC-Nfi-068416	Neosartorya fischeri	33.70	2.00e-46	181.00
IUUC-Ncr-068825	Neurospora crassa	32.17	1.00e-39	158.00
IUUC-Nle-069416	Nomascus leucogenys	94.86	0.00e+00	1202.00
IUUC-Opr-070515	Ochotona princeps	90.63	0.00e+00	1127.00
IUUC-Ont-072052	Oreochromis niloticus	89.34	0.00e+00	1140.00
IUUC-Ocu-074799	Oryctolagus cuniculus	94.71	0.00e+00	1200.00
IUUC-Oba-075146	Oryza barthii	35.30	2.00e-108	386.00
IUUC-Obr-076699	Oryza brachyantha	34.99	1.00e-108	387.00
IUUC-Ogl-077883	Oryza glaberrima	34.12	1.00e-66	246.00
IUUC-Ogu-078114	Oryza glumaepatula	34.85	1.00e-107	383.00
IUUC-Oin-079575	Oryza indica	35.33	2.00e-111	396.00
IUUC-Olo-080531	Oryza longistaminata	32.99	6.00e-98	351.00
IUUC-Ome-081368	Oryza meridionalis	40.85	2.00e-97	349.00
IUUC-Oni-082457	Oryza nivara	35.30	2.00e-108	386.00
IUUC-Opu-084050	Oryza punctata	35.17	2.00e-107	382.00
IUUC-Oru-084330	Oryza rufipogon	35.30	2.00e-108	386.00
IUUC-Osa-085408	Oryza sativa	35.33	2.00e-111	396.00
IUUC-Ola-087546	Oryzias latipes	91.03	0.00e+00	1199.00
IUUC-Olu-087710	Ostreococcus lucimarinus	31.70	5.00e-77	281.00
IUUC-Oga-087998	Otolemur garnettii	94.86	0.00e+00	1203.00
IUUC-Oar-090303	Ovis aries	94.71	0.00e+00	1201.00
IUUC-Ptr-090588	Pan troglodytes	94.86	0.00e+00	1202.00
IUUC-Pan-092722	Papio anubis	94.86	0.00e+00	1202.00
IUUC-Psi-093911	Pelodiscus sinensis	94.45	0.00e+00	1228.00
IUUC-Pma-094580	Petromyzon marinus	86.40	0.00e+00	1142.00
IUUC-Pno-095085	Phaeosphaeria nodorum	35.35	1.00e-43	171.00
IUUC-Ppa-095594	Physcomitrella patens	36.83	8.00e-114	404.00
IUUC-Pfo-096994	Poecilia formosa	91.30	0.00e+00	1194.00
IUUC-Pab-097586	Pongo abelii	94.71	0.00e+00	1201.00
IUUC-Pop-099740	Populus trichocarpa	34.89	2.00e-101	362.00
IUUC-Pca-100458	Procavia capensis	97.60	3.00e-106	378.00
IUUC-Ppe-102060	Prunus persica	33.91	1.00e-106	380.00
IUUC-Pva-102698	Pteropus vampyrus	90.48	0.00e+00	1185.00
IUUC-Pgr-103649	Puccinia graminis	38.70	5.00e-48	186.00
IUUC-Ptt-103910	Puccinia triticina	43.50	3.00e-53	203.00
IUUC-Pte-104181	Pyrenophora teres	36.75	8.00e-49	188.00
IUUC-Pyt-104439	Pyrenophora triticirepentis	36.45	2.00e-48	187.00
IUUC-Rno-104978	Rattus norvegicus	94.10	0.00e+00	1218.00
IUUC-Sha-107079	Sarcophilus harrisii	94.30	0.00e+00	1162.00
IUUC-Sja-107716	Schizosaccharomyces japonicus	30.28	5.00e-58	219.00
IUUC-Spo-108325	Schizosaccharomyces pombe	29.93	4.00e-52	199.00
IUUC-Ssl-108542	Sclerotinia sclerotiorum	29.19	7.00e-48	185.00
IUUC-Smo-109427	Selaginella moellendorffii	35.01	4.00e-108	384.00
IUUC-Sit-110755	Setaria italica	35.93	2.00e-111	396.00
IUUC-Sly-111099	Solanum lycopersicum	35.52	4.00e-98	352.00
IUUC-Sar-113408	Sorex araneus	95.48	0.00e+00	714.00
IUUC-Sbi-113789	Sorghum bicolor	35.09	2.00e-109	389.00
IUUC-Sre-114998	Sporisorium reilianum	40.26	1.00e-52	201.00
IUUC-Ssc-115434	Sus scrofa	94.86	0.00e+00	1202.00
IUUC-Tgu-116517	Taeniopygia guttata	95.17	0.00e+00	1233.00
IUUC-Tru-118174	Takifugu rubripes	91.73	0.00e+00	1203.00
IUUC-Tsy-118935	Tarsius syrichta	94.56	0.00e+00	1222.00
IUUC-Tni-119744	Tetraodon nigroviridis	92.15	0.00e+00	1176.00
IUUC-Tca-121360	Theobroma cacao	34.75	5.00e-111	394.00
IUUC-Tre-122198	Trichoderma reesei	32.85	1.00e-42	167.00
IUUC-Tvi-122389	Trichoderma virens	32.85	1.00e-42	167.00
IUUC-Tae-123915	Triticum aestivum	35.20	5.00e-110	391.00
IUUC-Tur-126699	Triticum urartu	34.55	4.00e-107	381.00
IUUC-Tme-126932	Tuber melanosporum	31.54	3.00e-54	206.00
IUUC-Tbe-127267	Tupaia belangeri	80.13	0.00e+00	707.00
IUUC-Ttr-129153	Tursiops truncatus	94.26	0.00e+00	1227.00
IUUC-Uma-129604	Ustilago maydis	37.58	3.00e-50	194.00
IUUC-Vda-129925	Verticillium dahliae	34.51	5.00e-45	176.00
IUUC-Vpa-130553	Vicugna pacos	94.32	0.00e+00	920.00
IUUC-Vvi-130995	Vitis vinifera	34.13	2.00e-106	379.00
IUUC-Xtr-132346	Xenopus tropicalis	92.31	0.00e+00	1180.00
IUUC-Xma-134266	Xiphophorus maculatus	88.68	0.00e+00	645.00
IUUC-Yli-134451	Yarrowia lipolytica	27.23	9.00e-39	154.00
IUUC-Zma-135647	Zea mays	35.03	8.00e-110	390.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence