iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bdi-014592

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

CM000880

Gene Name

LOC100827652; BRADI_1g03800

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
BRADI1G03800	BRADI1G03800.1	BRADI1G03800.1
BRADI1G03800	BRADI1G03800.2	BRADI1G03800.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.80e-107	360.7	15	521

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahee 95
           YDRQ+r+wG+++q++l++a+++l++ g++G+E lKnLvl+G+gs+tvvD+++ve s+l+++FL+++e  g+s+A++++ +l+eln+ v+v+ +ee
   Q: 15   YDRQLRIWGDQGQAALEKASICLLNSGPTGTEALKNLVLGGIGSVTVVDGSKVEPSDLGNNFLLNKECLGQSRAQSVCSFLQELNDAVKVKYVEE 109
           *********************************************************************************************** PP
   S: 96   siteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn..... 181
           s+ +  ++++ Ff++f+vV++++ ++++ +k++ +c++a++ l+ ++++Gl G vrv++k++ +++s++d   d++++ +P+ +lk++       
   Q: 110  SPGTMIDTNPsFFSQFTVVIATQLPESSLLKLDGICRAADIVLVAARSYGLTGLVRVSVKEHCVIESKPDhflDDLRLHNPWTELKQFAKsidic 204
           ****************************************************************************************9999999 PP
   S: 182  ....aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtksksp 271
               +++++++++v++  l+e++a +++++ +++++ek+e+kd++++ + + deen++ea+e + k   +  i+  i+q++++ +  +v+ s+s+
   Q: 205  dkdpVVHKHTPYIVILVRLAEKWADAHDGKLPSTRQEKREFKDLIRAHMLNVDEENYKEAVESSYKVSVTPGISTeIRQIIDD-SSSEVNLSSSD 298
           9999*******************************************************************************.55599****** PP
   S: 272  fwv...........................................................................sfcsnaealq....... 284
           fwv                                                                           +fc+na++l+       
   Q: 299  FWVlvaalkefianegngdlplegtipdmtsqteyyvslqkiyqakaetdclamehrvknilkrigrhpdsisrayikTFCKNARKLRvcryrsm 393
           ****************************************************************************************6666666 PP
   S: 285  ....vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagniipai 369
                 + + + +++++++++     +y+llra++r++++++r pg ++ e d+d +++l+ aa +   +++g+++  l++dl++e+++++ ++i
   Q: 394  eeefNAPVISEVQKYFADEDScfamnFYILLRAVDRLAANYSRLPGIFDSEIDED-VPRLKVAAVSVL-SDMGLNGtSLSEDLVTEVCRFAGAEI 486
           55543355566666666666678888********************999999999.****99999887.************************** PP
   S: 370  attnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           ++++a++gG+a+qEviK+v+++f+pl  +f+f+++
   Q: 487  HPVAAFIGGVASQEVIKLVTKQFVPLMGTFIFNGI 521
           ********************************986 PP

Organism

Brachypodium distachyon

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAAAAVAVAE PKTKYDRQLR IWGDQGQAAL EKASICLLNS GPTGTEALKN LVLGGIGSVT 60
VVDGSKVEPS DLGNNFLLNK ECLGQSRAQS VCSFLQELND AVKVKYVEES PGTMIDTNPS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTCCAGTC CTTCACTTCG GCTTCCGCTT TATTCTTCGC CGGAGAGGAA CACGAAACCC 60
CATGGCCGCC GCCGCAGTCG CCGTAGCCGA GCCTAAGACC AAGTACGATC GCCAGCTCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

bdi:100827652

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	90.87	0.00e+00	959.00
IUUC-Aml-002333	Ailuropoda melanoleuca	43.54	1.00e-129	456.00
IUUC-Atr-002644	Amborella trichopoda	68.71	0.00e+00	729.00
IUUC-Apl-003446	Anas platyrhynchos	43.30	9.00e-120	422.00
IUUC-Aca-004450	Anolis carolinensis	42.21	8.00e-126	443.00
IUUC-Aly-005466	Arabidopsis lyrata	65.33	0.00e+00	738.00
IUUC-Ath-006692	Arabidopsis thaliana	66.09	0.00e+00	739.00
IUUC-Ago-007900	Ashbya gossypii	26.96	4.00e-40	158.00
IUUC-Acl-008333	Aspergillus clavatus	33.64	2.00e-70	259.00
IUUC-Afl-008529	Aspergillus flavus	33.58	9.00e-76	276.00
IUUC-Afu-009071	Aspergillus fumigatus	33.70	7.00e-71	260.00
IUUC-Ani-009443	Aspergillus nidulans	32.60	4.00e-63	234.00
IUUC-Ang-009669	Aspergillus niger	32.79	9.00e-73	266.00
IUUC-Aor-009914	Aspergillus oryzae	33.27	1.00e-73	270.00
IUUC-Ate-010450	Aspergillus terreus	32.37	1.00e-71	263.00
IUUC-Ame-011183	Astyanax mexicanus	41.51	1.00e-124	439.00
IUUC-Bgr-012111	Blumeria graminis	33.89	4.00e-64	238.00
IUUC-Bta-012583	Bos taurus	43.70	9.00e-131	459.00
IUUC-Bci-013892	Botrytis cinerea	32.78	4.00e-61	228.00
IUUC-Bol-016399	Brassica oleracea	65.83	0.00e+00	743.00
IUUC-Bra-017506	Brassica rapa	65.20	0.00e+00	726.00
IUUC-Cel-018456	Caenorhabditis elegans	30.90	7.00e-70	257.00
IUUC-Cja-020007	Callithrix jacchus	43.64	2.00e-129	454.00
IUUC-Cfa-020324	Canis familiaris	43.70	2.00e-131	462.00
IUUC-Cpo-022248	Cavia porcellus	39.31	4.00e-69	254.00
IUUC-Csa-023149	Chlorocebus sabaeus	40.52	7.00e-102	363.00
IUUC-Cho-024537	Choloepus hoffmanni	35.93	6.00e-87	313.00
IUUC-Cin-025763	Ciona intestinalis	40.94	2.00e-110	391.00
IUUC-Csv-026113	Ciona savignyi	39.78	3.00e-104	371.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.91	4.00e-59	221.00
IUUC-Cne-026884	Cryptococcus neoformans	32.70	3.00e-67	248.00
IUUC-Cme-027210	Cyanidioschyzon merolae	25.65	7.00e-16	78.20
IUUC-Dre-028140	Danio rerio	41.95	6.00e-128	450.00
IUUC-Dno-030033	Dasypus novemcinctus	43.48	1.00e-113	402.00
IUUC-Dor-030513	Dipodomys ordii	37.60	1.00e-39	156.00
IUUC-Dse-031536	Dothistroma septosporum	31.53	8.00e-66	243.00
IUUC-Dme-031683	Drosophila melanogaster	37.52	1.00e-96	346.00
IUUC-Ete-032420	Echinops telfairi	38.49	1.00e-109	389.00
IUUC-Eca-033992	Equus caballus	40.77	6.00e-100	356.00
IUUC-Eeu-034713	Erinaceus europaeus	33.19	2.00e-36	146.00
IUUC-Fca-036548	Felis catus	43.32	1.00e-130	459.00
IUUC-Fal-037600	Ficedula albicollis	42.48	1.00e-117	416.00
IUUC-Fox-038037	Fusarium oxysporum	32.42	3.00e-68	252.00
IUUC-Fso-038387	Fusarium solani	32.78	8.00e-69	253.00
IUUC-Gmo-038562	Gadus morhua	41.48	6.00e-122	430.00
IUUC-Ggr-040005	Gaeumannomyces graminis	35.81	2.00e-54	206.00
IUUC-Gga-041129	Gallus gallus	43.16	1.00e-120	426.00
IUUC-Gac-042558	Gasterosteus aculeatus	41.51	5.00e-125	440.00
IUUC-Gma-043610	Glycine max	67.95	0.00e+00	735.00
IUUC-Ggo-045611	Gorilla gorilla	43.26	2.00e-128	452.00
IUUC-Hsa-046563	Homo sapiens	43.51	1.00e-129	455.00
IUUC-Hvu-047790	Hordeum vulgare	91.77	0.00e+00	716.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	43.32	3.00e-129	454.00
IUUC-Kpa-049309	Komagataella pastoris	35.38	2.00e-76	278.00
IUUC-Lch-050038	Latimeria chalumnae	42.88	4.00e-125	440.00
IUUC-Lpe-051535	Leersia perrieri	84.10	0.00e+00	826.00
IUUC-Loc-051917	Lepisosteus oculatus	38.97	1.00e-107	382.00
IUUC-Lma-053112	Leptosphaeria maculans	32.85	4.00e-70	258.00
IUUC-Laf-053690	Loxodonta africana	43.70	1.00e-131	462.00
IUUC-Mcc-055117	Macaca mulatta	43.18	1.00e-126	446.00
IUUC-Meu-056761	Macropus eugenii	36.93	4.00e-96	344.00
IUUC-Mor-057230	Magnaporthe oryzae	32.90	7.00e-67	247.00
IUUC-Mpo-057514	Magnaporthe poae	31.68	3.00e-61	228.00
IUUC-Mtr-058551	Medicago truncatula	65.36	0.00e+00	710.00
IUUC-Mla-059183	Melampsora laricipopulina	35.30	8.00e-86	310.00
IUUC-Mga-060144	Meleagris gallopavo	42.64	5.00e-117	414.00
IUUC-Mvi-060221	Microbotryum violaceum	33.02	7.00e-69	254.00
IUUC-Mmr-061325	Microcebus murinus	43.07	5.00e-127	447.00
IUUC-Mdo-062532	Monodelphis domestica	44.11	1.00e-129	456.00
IUUC-Mmu-063956	Mus musculus	43.13	2.00e-129	454.00
IUUC-Mac-064521	Musa acuminata	73.22	0.00e+00	803.00
IUUC-Mpu-066716	Mustela putorius furo	43.90	5.00e-122	431.00
IUUC-Mlu-067459	Myotis lucifugus	44.00	7.00e-132	463.00
IUUC-Nfi-068245	Neosartorya fischeri	33.27	2.00e-69	255.00
IUUC-Ncr-068910	Neurospora crassa	32.72	8.00e-66	243.00
IUUC-Nle-070034	Nomascus leucogenys	42.12	1.00e-122	432.00
IUUC-Opr-070552	Ochotona princeps	39.35	3.00e-99	354.00
IUUC-Ont-071426	Oreochromis niloticus	42.02	4.00e-127	447.00
IUUC-Oan-073389	Ornithorhynchus anatinus	39.01	5.00e-87	314.00
IUUC-Ocu-074911	Oryctolagus cuniculus	43.70	5.00e-131	460.00
IUUC-Oba-075437	Oryza barthii	88.68	0.00e+00	899.00
IUUC-Obr-076684	Oryza brachyantha	86.71	0.00e+00	837.00
IUUC-Ogl-077170	Oryza glaberrima	88.68	0.00e+00	899.00
IUUC-Ogu-078844	Oryza glumaepatula	87.73	0.00e+00	847.00
IUUC-Oin-079105	Oryza indica	88.68	0.00e+00	898.00
IUUC-Olo-080943	Oryza longistaminata	85.83	0.00e+00	820.00
IUUC-Oni-082891	Oryza nivara	86.18	0.00e+00	870.00
IUUC-Opu-083457	Oryza punctata	88.29	0.00e+00	892.00
IUUC-Oru-084960	Oryza rufipogon	85.83	0.00e+00	822.00
IUUC-Osa-085358	Oryza sativa	88.29	0.00e+00	892.00
IUUC-Ola-086420	Oryzias latipes	39.10	1.00e-78	285.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.47	2.00e-61	229.00
IUUC-Oga-088810	Otolemur garnettii	43.32	8.00e-130	456.00
IUUC-Oar-089196	Ovis aries	43.26	6.00e-129	453.00
IUUC-Ptr-090617	Pan troglodytes	43.51	9.00e-130	456.00
IUUC-Pan-092761	Papio anubis	43.70	7.00e-131	459.00
IUUC-Psi-093191	Pelodiscus sinensis	40.73	1.00e-121	429.00
IUUC-Pma-094380	Petromyzon marinus	41.85	8.00e-111	393.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.28	1.00e-61	231.00
IUUC-Ppa-095798	Physcomitrella patens	55.81	2.00e-172	598.00
IUUC-Pfo-096467	Poecilia formosa	42.21	8.00e-124	436.00
IUUC-Pab-098255	Pongo abelii	45.03	2.00e-109	388.00
IUUC-Pop-099722	Populus trichocarpa	68.91	0.00e+00	770.00
IUUC-Pca-100807	Procavia capensis	53.23	9.00e-55	206.00
IUUC-Ppe-101280	Prunus persica	67.95	0.00e+00	758.00
IUUC-Pva-102333	Pteropus vampyrus	42.31	7.00e-124	436.00
IUUC-Pgr-103401	Puccinia graminis	29.96	2.00e-67	249.00
IUUC-Ptt-103889	Puccinia triticina	27.96	2.00e-59	222.00
IUUC-Pte-104355	Pyrenophora teres	33.63	8.00e-69	253.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	33.99	4.00e-69	254.00
IUUC-Rno-105810	Rattus norvegicus	42.75	2.00e-127	448.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.55	4.00e-32	131.00
IUUC-Sha-106770	Sarcophilus harrisii	50.00	1.00e-72	265.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	33.52	1.00e-78	286.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.10	6.00e-82	297.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	33.33	1.00e-61	229.00
IUUC-Smo-109296	Selaginella moellendorffii	53.08	2.00e-162	564.00
IUUC-Sit-110157	Setaria italica	87.33	0.00e+00	944.00
IUUC-Sly-111105	Solanum lycopersicum	66.36	0.00e+00	742.00
IUUC-Stu-112469	Solanum tuberosum	66.73	0.00e+00	749.00
IUUC-Sar-113083	Sorex araneus	34.04	3.00e-87	315.00
IUUC-Sbi-113813	Sorghum bicolor	88.29	0.00e+00	952.00
IUUC-Sre-115058	Sporisorium reilianum	31.19	1.00e-70	259.00
IUUC-Tgu-116772	Taeniopygia guttata	42.69	4.00e-117	414.00
IUUC-Tru-118686	Takifugu rubripes	40.75	3.00e-125	441.00
IUUC-Tsy-119111	Tarsius syrichta	45.63	1.00e-63	236.00
IUUC-Tni-120231	Tetraodon nigroviridis	39.77	6.00e-111	393.00
IUUC-Tca-121491	Theobroma cacao	68.33	0.00e+00	723.00
IUUC-Tre-122103	Trichoderma reesei	32.59	4.00e-72	264.00
IUUC-Tvi-122672	Trichoderma virens	33.08	7.00e-69	253.00
IUUC-Tae-125950	Triticum aestivum	91.94	0.00e+00	969.00
IUUC-Tur-126487	Triticum urartu	90.52	0.00e+00	936.00
IUUC-Tme-127097	Tuber melanosporum	34.38	2.00e-78	285.00
IUUC-Ttr-128465	Tursiops truncatus	40.23	1.00e-114	405.00
IUUC-Uma-129645	Ustilago maydis	32.58	3.00e-61	228.00
IUUC-Vda-129989	Verticillium dahliae	29.57	7.00e-50	190.00
IUUC-Vpa-130529	Vicugna pacos	41.18	2.00e-119	421.00
IUUC-Vvi-131059	Vitis vinifera	69.87	0.00e+00	773.00
IUUC-Xtr-132002	Xenopus tropicalis	43.32	6.00e-128	450.00
IUUC-Xma-133930	Xiphophorus maculatus	41.90	8.00e-127	446.00
IUUC-Yli-134505	Yarrowia lipolytica	34.49	2.00e-80	291.00
IUUC-Zma-135895	Zea mays	87.14	0.00e+00	940.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence