iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-21	76.8	461	498
UBD/Beta-Prp	2.30e-45	155.9	394	629

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvs.GsdDgtikvWDlrtgvl 35
           H ++v+++af  ++  l v+ ++dD+tikvWD  tgv+
   Q: 461  HVGGVNDIAFstPNkQLCVTtCGDDKTIKVWDAATGVK 498
           99********99775665557***********999986 PP

UBD/Beta-Prp

   S: 74   rtikvwdlstgkcvhtlkghedsvls...lsfspsgdklvsGshdrtirvwdletgqclee...tlsghdgvvncvvvhpdgnllv.sGslDrtvrlW 164
           +t kvwdls++++       ++ v+s   + +sp+g+ + ++ +  +++++  + g+ +++   +++   gv+ ++ + p+++l+v ++++D+t+++W
   Q: 394  KTFKVWDLSKCSMPLQAALVKEPVVSvnrVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRQhleIDAHVGGVNDIAFSTPNKQLCVtTCGDDKTIKVW 491
           688******999988888888888885557799********************9999999988677777777777777777766662799******** PP
   S: 165  dlktgkllrtltgghtdsvysls..fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgs..sDgsiri..Wdlrsgdl 256
           d +tg   +t++g h+ +vys+   +++n +++ s +ldg++k w + +    + +++  ++ + ++ s +++rl s++  +Dg  +i  W+   g +
   Q: 492  DAATGVKRYTFEG-HEAPVYSICphYKENIQFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFSCGtsKDGESFIveWNESEGAV 588
           ************9.********98899999******************9999*************************9888999999899******** PP
   S: 257  lktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkn 297
            +t+q+ ++++  v  ++ ++n ++++++d ++++w+++++
   Q: 589  KRTYQGFHKRSLGVVQFDTTKNRYLAAGDDFSIKFWDMDTI 629
           ********999888888********************9876 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Transcriptional corepressor. Activates TIR-NB-LRR R protein-mediated immune responses through repression of negative regulators such as CNGC2/DND1 (PubMed:20647385). Negative regulator of jasmonate responses (By similarity).

Protein Sequence
(Fasta)

MSSLSRELVF LILQFLDEEK FKETVHKLEQ ESGFFFNMKY FEDEVHNGNW DEVEKYLSGF 60
TKVDDNRYSM KIFFEIRKQK YLEALDRHDR PKAVDILVKD LKVFSTFNEE LFKEITQLLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCTCCATTT CTGCAAGATT TTAATGTTCG TATAAATAAG CCTGAAGAGA GAGAGAGAGA 60
GAGAGAGAAA ACTTGTTTTT TTTTTTTCCA TTAGTTTTTT TCTTACTTTC TGGTCGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR006595--CTLH_C
IPR006594--LisH
IPR027295--Quinoprotein_ADH-like_fam
IPR011047--Quinoprotein_ADH-like_supfam
IPR027728--Topless_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50897--CTLH
PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00668--CTLH
SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0010072--P:primary shoot apical meristem specification
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

ath:AT1G80490

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000565	Aegilops tauschii	76.59	0.00e+00	1777.00
IUUC-Aly-005472	Arabidopsis lyrata	98.39	0.00e+00	2158.00
IUUC-Bdi-014914	Brachypodium distachyon	76.29	0.00e+00	1751.00
IUUC-Bol-016225	Brassica oleracea	95.11	0.00e+00	2160.00
IUUC-Bra-017496	Brassica rapa	96.05	0.00e+00	2132.00
IUUC-Gma-043911	Glycine max	83.91	0.00e+00	1905.00
IUUC-Hvu-047688	Hordeum vulgare	77.25	0.00e+00	1686.00
IUUC-Lpe-051514	Leersia perrieri	74.65	0.00e+00	1670.00
IUUC-Mtr-058037	Medicago truncatula	82.27	0.00e+00	1884.00
IUUC-Oba-075912	Oryza barthii	77.26	0.00e+00	1751.00
IUUC-Obr-076921	Oryza brachyantha	76.97	0.00e+00	1756.00
IUUC-Ogl-077334	Oryza glaberrima	77.17	0.00e+00	1765.00
IUUC-Ogu-078494	Oryza glumaepatula	77.17	0.00e+00	1765.00
IUUC-Oin-079720	Oryza indica	75.97	0.00e+00	1756.00
IUUC-Olo-081034	Oryza longistaminata	76.75	0.00e+00	1751.00
IUUC-Ome-081778	Oryza meridionalis	77.08	0.00e+00	1767.00
IUUC-Oni-082412	Oryza nivara	77.26	0.00e+00	1752.00
IUUC-Opu-083406	Oryza punctata	75.55	0.00e+00	1702.00
IUUC-Oru-084328	Oryza rufipogon	77.15	0.00e+00	1754.00
IUUC-Osa-085765	Oryza sativa	77.17	0.00e+00	1765.00
IUUC-Pop-098876	Populus trichocarpa	82.86	0.00e+00	1902.00
IUUC-Smo-109617	Selaginella moellendorffii	68.76	0.00e+00	1504.00
IUUC-Sit-110288	Setaria italica	76.45	0.00e+00	1745.00
IUUC-Sbi-114078	Sorghum bicolor	77.44	0.00e+00	1753.00
IUUC-Tca-121628	Theobroma cacao	83.93	0.00e+00	1926.00
IUUC-Tae-125600	Triticum aestivum	76.99	0.00e+00	1779.00
IUUC-Tur-126412	Triticum urartu	77.92	0.00e+00	1782.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence