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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045718
UUCD1 version UUC-HoS-00468
Ensembl Protein ID ENSP00000369217.4
UniProt Accession Q9Y4X5; B2R6U3; O76026; Q9H3T6; Q9UEN0; Q9UP39; ARI1_HUMAN
Genbank Protein ID CAB45870.1; AAD28088.1; BAG35590.1; EAW77907.1; AAH51877.1; CAA10274.1; CAA08817.1; BAB19786.1
Protein Name E3 ubiquitin-protein ligase ARIH1; H7-AP2; HHARI; Monocyte protein 6; Protein ariadne-1 homolog; UbcH7-binding protein; UbcM4-interacting protein; Ubiquitin-conjugating enzyme E2-binding protein 1
Genbank Nucleotide ID AJ243190; AF072832; AK312715; AC079322; BC051877; AJ130976; AJ009771; AB014774
Gene Name ARIH1; ARI; MOP6; UBCH7BP; HUSSY-27
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000166233.13 ENST00000379887.8 ENSP00000369217.4
ENSG00000166233.13 ENST00000570085.5 ENSP00000456746.1
ENSG00000166233.13 ENST00000564062.1 ENSP00000454774.1
ENSG00000166233.13 ENST00000561770.1 ENSP00000457767.1
ENSG00000166233.13 ENST00000562891.2 ENSP00000477687.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetTRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RBR RBR 17289916; 20212144; 15963499
Classification
Family E-value Score Start End
E3 activity/RBR 1.70e-54 185.3 186 375
Active Site
Position(s) Description Evidence
357 N/A {ECO:0000269|PubMed:21532592,
ECO:0000269|PubMed:23707686}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelki.kegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalk 89
           C++C+l+++++ +t  leC h+fC++C+++yl++ki +eg+ ++iscpa+ c   ++++++++l+++++++ +y++l ++++ve+++ lk
   Q: 186  CQICYLNYPNSYFTG-LECGHKFCMQCWSEYLTTKImEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLK 274
           **********99985.5**************87775277899************************************************ PP
   S: 90   wcpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnh 179
           wcpapdC++vv ++   +++ v+c kcg++fC++C e+wH++++Ck+lk++ +k++   +++e++++++an+k+CpkC+v+iek++gCnh
   Q: 275  WCPAPDCHHVVKVQYP-DAKPVRC-KCGRQFCFNCGENWHDPVKCKWLKKWIKKCD---DDSETSNWIAANTKECPKCHVTIEKDGGCNH 359
           ***************7.9999999.9******************************...99***************************** PP
   S: 180  mtC..akCkaefCwlC 193
           m C  ++CkaefCw+C
   Q: 360  MVCrnQNCKAEFCWVC 375
           ***9999********* PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916).
 E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916).
Protein Sequence
(Fasta)
MDSDEGYNYE FDEDEECSEE DSGAEEEEDE DDDEPDDDTL DLGEVELVEP GLGVGGERDG 60
LLCGETGGGG GSALGPGGGG GGGGGGGGGG PGHEQEEDYR YEVLTAEQIL QHMVECIREV 120
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Protein Fasta Sequence


>IUUC-Hsa-045718|E3,RBR|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCTCAGTAGC GATAGCAGCG GCCGTGGAGG TGGCGTTGGG GACTGTTTTC TCTCGGAGGC 60
CGGAGCGGAG CCGCGTCTGA CTGAGGCGGG CAGCAAGCGG CCCCCTCGCT CCCTCCCTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045718|E3,RBR|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF01485--IBR
SMART

SM00647--IBR
SM00184--RING
Gene Ontology

GO:0015030--C:Cajal body
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0097413--C:Lewy body
GO:0016604--C:nuclear body
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0019787--F:ubiquitin-like protein transferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:25820
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000970 Aegilops tauschii 29.78 2.00e-55 209.00
IUUC-Aml-001385 Ailuropoda melanoleuca 100.00 0.00e+00 927.00
IUUC-Atr-002480 Amborella trichopoda 31.85 7.00e-65 241.00
IUUC-Apl-004184 Anas platyrhynchos 98.42 0.00e+00 876.00
IUUC-Aca-004976 Anolis carolinensis 99.54 0.00e+00 877.00
IUUC-Aly-005807 Arabidopsis lyrata 32.37 2.00e-64 240.00
IUUC-Ath-007166 Arabidopsis thaliana 32.81 1.00e-64 241.00
IUUC-Ago-007926 Ashbya gossypii 29.37 2.00e-55 210.00
IUUC-Acl-008252 Aspergillus clavatus 42.49 2.00e-104 373.00
IUUC-Afl-008468 Aspergillus flavus 42.95 9.00e-106 377.00
IUUC-Afu-009062 Aspergillus fumigatus 44.69 2.00e-106 379.00
IUUC-Ani-009219 Aspergillus nidulans 42.73 1.00e-106 380.00
IUUC-Ang-009538 Aspergillus niger 43.29 9.00e-99 353.00
IUUC-Aor-010009 Aspergillus oryzae 42.95 4.00e-105 375.00
IUUC-Ate-010497 Aspergillus terreus 44.25 8.00e-99 354.00
IUUC-Ame-011264 Astyanax mexicanus 89.79 0.00e+00 963.00
IUUC-Bgr-012016 Blumeria graminis 41.19 3.00e-102 365.00
IUUC-Bta-013518 Bos taurus 100.00 0.00e+00 939.00
IUUC-Bci-013819 Botrytis cinerea 42.46 8.00e-107 380.00
IUUC-Bdi-014685 Brachypodium distachyon 32.59 3.00e-67 249.00
IUUC-Bol-016087 Brassica oleracea 31.94 1.00e-60 227.00
IUUC-Bra-017944 Brassica rapa 33.10 1.00e-55 211.00
IUUC-Cel-018521 Caenorhabditis elegans 55.04 4.00e-138 484.00
IUUC-Cja-019869 Callithrix jacchus 92.52 0.00e+00 845.00
IUUC-Cfa-020812 Canis familiaris 99.78 0.00e+00 932.00
IUUC-Cpo-021627 Cavia porcellus 100.00 0.00e+00 939.00
IUUC-Csa-023034 Chlorocebus sabaeus 100.00 0.00e+00 873.00
IUUC-Cho-024444 Choloepus hoffmanni 97.20 0.00e+00 906.00
IUUC-Cin-025135 Ciona intestinalis 69.11 0.00e+00 685.00
IUUC-Csv-026243 Ciona savignyi 68.39 0.00e+00 663.00
IUUC-Cgl-026434 Colletotrichum gloeosporioides 42.40 2.00e-107 382.00
IUUC-Cne-026861 Cryptococcus neoformans 41.98 4.00e-102 365.00
IUUC-Dre-027785 Danio rerio 89.98 0.00e+00 964.00
IUUC-Dno-029205 Dasypus novemcinctus 100.00 0.00e+00 939.00
IUUC-Dor-030769 Dipodomys ordii 82.18 0.00e+00 723.00
IUUC-Dse-031171 Dothistroma septosporum 42.46 3.00e-105 375.00
IUUC-Dme-031903 Drosophila melanogaster 70.35 0.00e+00 698.00
IUUC-Ete-032929 Echinops telfairi 84.30 1.00e-135 476.00
IUUC-Eca-033431 Equus caballus 99.78 0.00e+00 895.00
IUUC-Eeu-034838 Erinaceus europaeus 86.34 0.00e+00 753.00
IUUC-Fca-035882 Felis catus 95.88 0.00e+00 788.00
IUUC-Fal-037068 Ficedula albicollis 99.55 0.00e+00 895.00
IUUC-Fox-037790 Fusarium oxysporum 49.82 1.00e-77 282.00
IUUC-Fso-038125 Fusarium solani 42.25 2.00e-105 376.00
IUUC-Gmo-038703 Gadus morhua 90.19 0.00e+00 959.00
IUUC-Ggr-039722 Gaeumannomyces graminis 41.54 2.00e-105 375.00
IUUC-Gga-040319 Gallus gallus 100.00 0.00e+00 697.00
IUUC-Gac-041708 Gasterosteus aculeatus 96.73 0.00e+00 944.00
IUUC-Gma-043188 Glycine max 32.35 6.00e-60 225.00
IUUC-Ggo-045178 Gorilla gorilla 100.00 0.00e+00 939.00
IUUC-Hvu-047322 Hordeum vulgare 31.87 8.00e-59 221.00
IUUC-Itr-048934 Ictidomys tridecemlineatus 100.00 8.00e-178 615.00
IUUC-Kpa-049350 Komagataella pastoris 31.68 9.00e-65 241.00
IUUC-Lpe-051110 Leersia perrieri 33.18 5.00e-68 252.00
IUUC-Loc-052442 Lepisosteus oculatus 91.33 0.00e+00 973.00
IUUC-Lma-053253 Leptosphaeria maculans 42.83 1.00e-111 396.00
IUUC-Laf-054351 Loxodonta africana 100.00 0.00e+00 874.00
IUUC-Mcc-054670 Macaca mulatta 96.56 0.00e+00 928.00
IUUC-Meu-056335 Macropus eugenii 92.11 2.00e-142 499.00
IUUC-Mor-057179 Magnaporthe oryzae 42.00 1.00e-105 376.00
IUUC-Mpo-057553 Magnaporthe poae 41.33 3.00e-104 372.00
IUUC-Mtr-058263 Medicago truncatula 31.88 6.00e-58 218.00
IUUC-Mla-058889 Melampsora laricipopulina 36.76 4.00e-78 285.00
IUUC-Mga-059385 Meleagris gallopavo 98.21 0.00e+00 882.00
IUUC-Mvi-060517 Microbotryum violaceum 40.74 4.00e-105 375.00
IUUC-Mmr-061439 Microcebus murinus 93.38 0.00e+00 855.00
IUUC-Mdo-062890 Monodelphis domestica 99.78 0.00e+00 937.00
IUUC-Mmu-063433 Mus musculus 100.00 0.00e+00 939.00
IUUC-Mac-065341 Musa acuminata 33.79 2.00e-64 240.00
IUUC-Mpu-066288 Mustela putorius furo 100.00 0.00e+00 939.00
IUUC-Mlu-067187 Myotis lucifugus 99.78 0.00e+00 932.00
IUUC-Nfi-068339 Neosartorya fischeri 44.47 1.00e-105 377.00
IUUC-Ncr-068947 Neurospora crassa 43.53 3.00e-103 369.00
IUUC-Nle-069263 Nomascus leucogenys 100.00 0.00e+00 939.00
IUUC-Opr-071000 Ochotona princeps 100.00 1.00e-97 350.00
IUUC-Ont-072309 Oreochromis niloticus 96.53 0.00e+00 940.00
IUUC-Oan-073731 Ornithorhynchus anatinus 100.00 0.00e+00 831.00
IUUC-Ocu-074000 Oryctolagus cuniculus 98.19 0.00e+00 876.00
IUUC-Oba-075628 Oryza barthii 31.84 8.00e-62 231.00
IUUC-Obr-076492 Oryza brachyantha 32.74 2.00e-68 253.00
IUUC-Ogl-077447 Oryza glaberrima 33.18 6.00e-69 255.00
IUUC-Ogu-078881 Oryza glumaepatula 32.97 7.00e-69 254.00
IUUC-Oin-079573 Oryza indica 33.18 7.00e-67 248.00
IUUC-Olo-080774 Oryza longistaminata 33.19 2.00e-69 256.00
IUUC-Ome-081275 Oryza meridionalis 31.83 3.00e-61 229.00
IUUC-Oni-082267 Oryza nivara 31.83 3.00e-61 229.00
IUUC-Opu-084135 Oryza punctata 33.18 5.00e-69 255.00
IUUC-Oru-084849 Oryza rufipogon 32.97 1.00e-68 254.00
IUUC-Osa-085435 Oryza sativa 33.18 1.00e-68 254.00
IUUC-Ola-086792 Oryzias latipes 96.53 0.00e+00 939.00
IUUC-Olu-087826 Ostreococcus lucimarinus 32.90 3.00e-50 192.00
IUUC-Oga-088706 Otolemur garnettii 100.00 0.00e+00 939.00
IUUC-Oar-089354 Ovis aries 99.78 0.00e+00 938.00
IUUC-Ptr-091287 Pan troglodytes 100.00 0.00e+00 939.00
IUUC-Pan-091701 Papio anubis 100.00 0.00e+00 873.00
IUUC-Psi-093814 Pelodiscus sinensis 100.00 0.00e+00 873.00
IUUC-Pno-095124 Phaeosphaeria nodorum 35.71 6.00e-79 288.00
IUUC-Ppa-095545 Physcomitrella patens 32.44 2.00e-61 230.00
IUUC-Pfo-096449 Poecilia formosa 89.81 0.00e+00 941.00
IUUC-Pab-098132 Pongo abelii 100.00 0.00e+00 939.00
IUUC-Pop-099139 Populus trichocarpa 32.27 1.00e-63 238.00
IUUC-Pca-100303 Procavia capensis 99.70 0.00e+00 652.00
IUUC-Ppe-101740 Prunus persica 31.79 2.00e-59 223.00
IUUC-Pva-102457 Pteropus vampyrus 100.00 0.00e+00 939.00
IUUC-Pgr-103443 Puccinia graminis 42.53 7.00e-104 371.00
IUUC-Ptt-103795 Puccinia triticina 39.88 5.00e-93 335.00
IUUC-Pte-104022 Pyrenophora teres 40.77 4.00e-102 365.00
IUUC-Pyt-104643 Pyrenophora triticirepentis 42.37 9.00e-110 390.00
IUUC-Rno-106083 Rattus norvegicus 100.00 0.00e+00 939.00
IUUC-Sce-106154 Saccharomyces cerevisiae 30.63 3.00e-64 239.00
IUUC-Sha-106765 Sarcophilus harrisii 97.75 0.00e+00 882.00
IUUC-Sja-107977 Schizosaccharomyces japonicus 43.59 1.00e-98 353.00
IUUC-Spo-108222 Schizosaccharomyces pombe 44.73 5.00e-111 394.00
IUUC-Smo-109078 Selaginella moellendorffii 32.71 5.00e-59 222.00
IUUC-Sit-110348 Setaria italica 32.14 9.00e-65 241.00
IUUC-Sly-111454 Solanum lycopersicum 32.79 2.00e-61 229.00
IUUC-Stu-112599 Solanum tuberosum 32.95 2.00e-58 220.00
IUUC-Sar-113023 Sorex araneus 99.77 0.00e+00 867.00
IUUC-Sbi-114262 Sorghum bicolor 32.81 2.00e-66 246.00
IUUC-Sre-115120 Sporisorium reilianum 44.80 3.00e-110 392.00
IUUC-Ssc-115667 Sus scrofa 89.47 0.00e+00 629.00
IUUC-Tgu-117273 Taeniopygia guttata 99.54 0.00e+00 873.00
IUUC-Tru-118338 Takifugu rubripes 86.63 0.00e+00 939.00
IUUC-Tsy-119096 Tarsius syrichta 91.67 0.00e+00 778.00
IUUC-Tni-120238 Tetraodon nigroviridis 86.56 0.00e+00 936.00
IUUC-Tca-121037 Theobroma cacao 33.33 2.00e-66 246.00
IUUC-Tre-121902 Trichoderma reesei 41.89 2.00e-103 370.00
IUUC-Tvi-122474 Trichoderma virens 41.19 5.00e-104 371.00
IUUC-Tae-124132 Triticum aestivum 33.11 1.00e-67 251.00
IUUC-Tur-126320 Triticum urartu 30.75 4.00e-55 209.00
IUUC-Tme-127089 Tuber melanosporum 42.92 2.00e-104 372.00
IUUC-Tbe-127409 Tupaia belangeri 93.09 1.00e-121 430.00
IUUC-Ttr-128909 Tursiops truncatus 90.85 0.00e+00 815.00
IUUC-Uma-129487 Ustilago maydis 42.49 4.00e-111 395.00
IUUC-Vda-129939 Verticillium dahliae 42.18 9.00e-106 377.00
IUUC-Vpa-130259 Vicugna pacos 96.77 0.00e+00 896.00
IUUC-Vvi-131463 Vitis vinifera 32.52 1.00e-58 221.00
IUUC-Xtr-132219 Xenopus tropicalis 99.13 0.00e+00 922.00
IUUC-Xma-133423 Xiphophorus maculatus 89.81 0.00e+00 941.00
IUUC-Yli-134622 Yarrowia lipolytica 35.65 2.00e-73 270.00
IUUC-Zma-135131 Zea mays 33.11 1.00e-66 248.00
Created Date 25-Jun-2017

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