iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssl-108570

Ensembl Protein ID

EDO02541

UniProt Accession

A7EI75; ATG7_SCLS1

Genbank Protein ID

EDO02541.1

Protein Name

Ubiquitin-like modifier-activating enzyme atg7; ATG12-activating enzyme E1 atg7; Autophagy-related protein 7

Genbank Nucleotide ID

CH476626

Gene Name

atg7; SS1G_05017

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SS1G_05017	EDO02541	EDO02541

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	41.25	3.00e-133	470.00	IUUC-Sce-106413

Active Site

Position(s)	Description	Evidence
534	Glycyl thioester intermediate	{ECO:0000250}

Organism

Sclerotinia sclerotiorum

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).

Protein Sequence
(Fasta)

MALKFAPFAS EIELPFYTAL SQLKIDHDKL DDSARPVLGL YEPRATQSPD QSSRMRVLGN 60
ALSSTEVPLG HIRAEGIIKN VNTIEDFKNT DKQAMLQTSA KQIWDAINDG TIYSIPSLLS 120

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Nucleotide Sequence
(Fasta)

ATGGCTTTAA AATTTGCCCC GTTTGCTTCT GAAATAGAGC TACCATTTTA CACAGCTCTT 60
TCCCAGTTGA AAATCGATCA TGATAAGTTA GATGATTCTG CACGACCGGT TCTCGGGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0000407--C:pre-autophagosomal structure
GO:0008641--F:small protein activating enzyme activity
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

ssl:SS1G_05017

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	33.48	6.00e-91	327.00
IUUC-Aml-002316	Ailuropoda melanoleuca	43.41	2.00e-138	484.00
IUUC-Atr-002579	Amborella trichopoda	41.32	4.00e-146	509.00
IUUC-Apl-003805	Anas platyrhynchos	40.70	2.00e-145	507.00
IUUC-Aca-004618	Anolis carolinensis	42.88	2.00e-129	453.00
IUUC-Aly-005670	Arabidopsis lyrata	39.83	3.00e-123	433.00
IUUC-Ath-007499	Arabidopsis thaliana	40.20	2.00e-126	444.00
IUUC-Ago-007838	Ashbya gossypii	41.05	5.00e-131	459.00
IUUC-Acl-008093	Aspergillus clavatus	57.65	0.00e+00	779.00
IUUC-Afl-008663	Aspergillus flavus	58.39	0.00e+00	707.00
IUUC-Afu-008926	Aspergillus fumigatus	55.46	0.00e+00	741.00
IUUC-Ani-009156	Aspergillus nidulans	59.38	0.00e+00	799.00
IUUC-Ang-009853	Aspergillus niger	64.08	2.00e-85	306.00
IUUC-Aor-010055	Aspergillus oryzae	56.88	0.00e+00	810.00
IUUC-Ate-010281	Aspergillus terreus	52.76	0.00e+00	711.00
IUUC-Ame-010939	Astyanax mexicanus	40.00	2.00e-146	511.00
IUUC-Bgr-012006	Blumeria graminis	63.91	0.00e+00	897.00
IUUC-Bta-012336	Bos taurus	41.36	3.00e-136	476.00
IUUC-Bci-013598	Botrytis cinerea	93.70	0.00e+00	1279.00
IUUC-Bdi-014170	Brachypodium distachyon	33.53	2.00e-88	318.00
IUUC-Bol-015357	Brassica oleracea	41.06	1.00e-134	471.00
IUUC-Bra-016835	Brassica rapa	40.64	4.00e-134	469.00
IUUC-Cel-018172	Caenorhabditis elegans	33.73	5.00e-103	366.00
IUUC-Cja-019544	Callithrix jacchus	42.01	1.00e-144	504.00
IUUC-Cfa-021043	Canis familiaris	41.42	4.00e-143	499.00
IUUC-Cpo-022366	Cavia porcellus	41.44	1.00e-143	501.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	36.08	2.00e-81	294.00
IUUC-Csa-023373	Chlorocebus sabaeus	41.87	2.00e-144	504.00
IUUC-Cho-024965	Choloepus hoffmanni	52.63	1.00e-49	188.00
IUUC-Cin-025710	Ciona intestinalis	42.44	2.00e-142	497.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	62.26	0.00e+00	855.00
IUUC-Cne-027083	Cryptococcus neoformans	41.37	5.00e-141	492.00
IUUC-Dre-028740	Danio rerio	38.19	3.00e-126	443.00
IUUC-Dno-029637	Dasypus novemcinctus	43.29	9.00e-138	481.00
IUUC-Dor-030492	Dipodomys ordii	42.43	2.00e-145	507.00
IUUC-Dse-031267	Dothistroma septosporum	49.12	0.00e+00	744.00
IUUC-Dme-032084	Drosophila melanogaster	38.83	1.00e-129	454.00
IUUC-Ete-032616	Echinops telfairi	39.24	1.00e-125	441.00
IUUC-Eca-033991	Equus caballus	42.01	8.00e-144	501.00
IUUC-Eeu-035126	Erinaceus europaeus	51.05	4.00e-65	240.00
IUUC-Fca-035472	Felis catus	41.87	5.00e-144	502.00
IUUC-Fal-037178	Ficedula albicollis	41.75	3.00e-146	510.00
IUUC-Fox-037901	Fusarium oxysporum	64.22	0.00e+00	882.00
IUUC-Fso-038279	Fusarium solani	64.77	0.00e+00	897.00
IUUC-Gmo-039329	Gadus morhua	41.76	2.00e-141	494.00
IUUC-Ggr-040061	Gaeumannomyces graminis	63.50	0.00e+00	853.00
IUUC-Gga-040244	Gallus gallus	41.63	1.00e-148	518.00
IUUC-Gac-041880	Gasterosteus aculeatus	41.63	8.00e-139	485.00
IUUC-Gma-043235	Glycine max	40.20	3.00e-134	469.00
IUUC-Ggo-045428	Gorilla gorilla	41.16	3.00e-143	499.00
IUUC-Hsa-046183	Homo sapiens	41.73	2.00e-144	504.00
IUUC-Hvu-047509	Hordeum vulgare	33.38	4.00e-88	317.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	42.37	6.00e-138	482.00
IUUC-Kpa-049142	Komagataella pastoris	41.68	8.00e-142	494.00
IUUC-Lch-049601	Latimeria chalumnae	36.94	1.00e-99	355.00
IUUC-Lpe-051496	Leersia perrieri	32.13	3.00e-85	307.00
IUUC-Loc-051751	Lepisosteus oculatus	42.70	4.00e-153	532.00
IUUC-Lma-053203	Leptosphaeria maculans	60.11	0.00e+00	664.00
IUUC-Laf-053424	Loxodonta africana	41.70	8.00e-144	501.00
IUUC-Mcc-054633	Macaca mulatta	41.87	1.00e-144	504.00
IUUC-Meu-056523	Macropus eugenii	38.09	6.00e-122	429.00
IUUC-Mor-056983	Magnaporthe oryzae	63.20	0.00e+00	873.00
IUUC-Mpo-057615	Magnaporthe poae	63.85	0.00e+00	880.00
IUUC-Mtr-058366	Medicago truncatula	40.60	5.00e-129	452.00
IUUC-Mla-058826	Melampsora laricipopulina	43.82	2.00e-161	560.00
IUUC-Mga-059447	Meleagris gallopavo	42.05	4.00e-149	519.00
IUUC-Mvi-060537	Microbotryum violaceum	41.48	1.00e-146	511.00
IUUC-Mmr-060676	Microcebus murinus	41.44	2.00e-143	500.00
IUUC-Mdo-062967	Monodelphis domestica	41.30	3.00e-138	483.00
IUUC-Mmu-063217	Mus musculus	42.61	3.00e-146	509.00
IUUC-Mac-065527	Musa acuminata	41.09	8.00e-126	442.00
IUUC-Mpu-066417	Mustela putorius furo	41.28	5.00e-143	499.00
IUUC-Mlu-067195	Myotis lucifugus	41.05	4.00e-145	506.00
IUUC-Nfi-068576	Neosartorya fischeri	55.35	0.00e+00	773.00
IUUC-Ncr-068867	Neurospora crassa	63.86	0.00e+00	877.00
IUUC-Nle-069447	Nomascus leucogenys	49.45	5.00e-94	335.00
IUUC-Opr-070737	Ochotona princeps	49.54	2.00e-115	407.00
IUUC-Ont-071260	Oreochromis niloticus	40.93	4.00e-145	506.00
IUUC-Oan-073622	Ornithorhynchus anatinus	40.32	6.00e-95	338.00
IUUC-Ocu-074584	Oryctolagus cuniculus	42.09	1.00e-149	521.00
IUUC-Oba-075483	Oryza barthii	31.30	6.00e-80	290.00
IUUC-Obr-076786	Oryza brachyantha	32.42	1.00e-87	315.00
IUUC-Ogl-077388	Oryza glaberrima	31.16	1.00e-77	282.00
IUUC-Ogu-078618	Oryza glumaepatula	31.30	4.00e-84	304.00
IUUC-Oin-080007	Oryza indica	31.30	4.00e-80	290.00
IUUC-Olo-080994	Oryza longistaminata	31.77	7.00e-75	273.00
IUUC-Ome-081735	Oryza meridionalis	31.30	1.00e-79	289.00
IUUC-Oni-082153	Oryza nivara	31.15	3.00e-79	287.00
IUUC-Opu-083146	Oryza punctata	31.88	1.00e-78	286.00
IUUC-Oru-084919	Oryza rufipogon	31.15	4.00e-79	287.00
IUUC-Osa-086182	Oryza sativa	31.30	1.00e-79	289.00
IUUC-Ola-086441	Oryzias latipes	41.78	5.00e-152	529.00
IUUC-Olu-087664	Ostreococcus lucimarinus	39.55	6.00e-122	429.00
IUUC-Oga-089074	Otolemur garnettii	42.56	4.00e-137	479.00
IUUC-Oar-090159	Ovis aries	40.93	2.00e-134	471.00
IUUC-Ptr-091105	Pan troglodytes	43.16	3.00e-130	456.00
IUUC-Pan-092446	Papio anubis	41.87	2.00e-144	503.00
IUUC-Psi-093372	Pelodiscus sinensis	42.62	5.00e-142	495.00
IUUC-Pma-094661	Petromyzon marinus	41.67	9.00e-128	448.00
IUUC-Pno-094813	Phaeosphaeria nodorum	55.02	0.00e+00	650.00
IUUC-Ppa-095224	Physcomitrella patens	40.99	1.00e-133	468.00
IUUC-Pfo-096565	Poecilia formosa	42.22	4.00e-142	496.00
IUUC-Pop-099702	Populus trichocarpa	40.58	1.00e-143	501.00
IUUC-Pca-100324	Procavia capensis	35.15	4.00e-72	263.00
IUUC-Ppe-101416	Prunus persica	39.64	6.00e-132	462.00
IUUC-Pva-102589	Pteropus vampyrus	38.98	2.00e-128	450.00
IUUC-Pgr-103497	Puccinia graminis	40.03	2.00e-148	517.00
IUUC-Ptt-103718	Puccinia triticina	41.84	3.00e-149	520.00
IUUC-Pte-104206	Pyrenophora teres	60.36	0.00e+00	656.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	56.50	0.00e+00	726.00
IUUC-Rno-105911	Rattus norvegicus	42.47	1.00e-145	508.00
IUUC-Sce-106413	Saccharomyces cerevisiae	41.32	2.00e-136	477.00
IUUC-Sha-106679	Sarcophilus harrisii	41.81	9.00e-145	504.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	37.66	3.00e-132	462.00
IUUC-Spo-108107	Schizosaccharomyces pombe	40.03	4.00e-126	442.00
IUUC-Smo-109677	Selaginella moellendorffii	39.09	4.00e-117	413.00
IUUC-Sit-110319	Setaria italica	43.52	1.00e-75	275.00
IUUC-Sly-111215	Solanum lycopersicum	40.34	2.00e-136	477.00
IUUC-Stu-112442	Solanum tuberosum	40.91	7.00e-136	475.00
IUUC-Sar-113370	Sorex araneus	46.65	7.00e-101	359.00
IUUC-Sbi-114261	Sorghum bicolor	32.31	5.00e-82	297.00
IUUC-Sre-114997	Sporisorium reilianum	42.08	6.00e-153	532.00
IUUC-Ssc-115304	Sus scrofa	42.68	7.00e-141	491.00
IUUC-Tgu-117235	Taeniopygia guttata	42.19	5.00e-148	515.00
IUUC-Tru-118374	Takifugu rubripes	41.92	5.00e-146	509.00
IUUC-Tsy-118966	Tarsius syrichta	35.84	2.00e-108	384.00
IUUC-Tni-120269	Tetraodon nigroviridis	40.15	1.00e-127	447.00
IUUC-Tca-121245	Theobroma cacao	40.03	7.00e-143	498.00
IUUC-Tre-121966	Trichoderma reesei	61.14	0.00e+00	848.00
IUUC-Tvi-122360	Trichoderma virens	61.02	0.00e+00	837.00
IUUC-Tae-125251	Triticum aestivum	33.00	6.00e-89	320.00
IUUC-Tur-126294	Triticum urartu	33.14	4.00e-85	307.00
IUUC-Tme-127117	Tuber melanosporum	54.59	0.00e+00	670.00
IUUC-Tbe-127662	Tupaia belangeri	42.31	9.00e-40	155.00
IUUC-Ttr-129054	Tursiops truncatus	41.82	6.00e-142	495.00
IUUC-Uma-129526	Ustilago maydis	39.60	5.00e-153	532.00
IUUC-Vda-129878	Verticillium dahliae	60.23	0.00e+00	842.00
IUUC-Vpa-130264	Vicugna pacos	38.00	1.00e-74	272.00
IUUC-Vvi-131163	Vitis vinifera	40.06	5.00e-142	496.00
IUUC-Xtr-132328	Xenopus tropicalis	32.81	2.00e-89	321.00
IUUC-Xma-133015	Xiphophorus maculatus	40.00	2.00e-128	450.00
IUUC-Yli-134468	Yarrowia lipolytica	41.69	3.00e-139	486.00
IUUC-Zma-134871	Zea mays	32.60	9.00e-89	319.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence