iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bci-013972

Ensembl Protein ID

Bcin08g04530.1

UniProt Accession

A6S8P6; ATG3_BOTFB

Genbank Protein ID

EDN29569.1

Protein Name

Autophagy-related protein 3; Autophagy-related E2-like conjugation enzyme atg3

Genbank Nucleotide ID

CH476898

Gene Name

atg3; BC1G_08793

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bcin08g04530	Bcin08g04530.1	Bcin08g04530.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E2/Autophagy_C	54.05	7.00e-17	85.90	IUUC-Hsa-046449
E2/Autophagy_C	36.97	3.00e-23	103.00	IUUC-Sce-106172

Active Site

Position(s)	Description	Evidence
231	Glycyl thioester intermediate	{ECO:0000250}

Organism

Botrytis cinerea

Functional Description
(View)

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8. The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8 from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8. The formation of the atg8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).

Protein Sequence
(Fasta)

MNFLHSTLDR LREFTPVSNT STFRTNGQIT PEEFVAAGDY LVFKFPTWSW ADASPTSKRA 60
NYLPAGKQFL VTRGVPCHRR LDDDFAGDAG HDETVVRDGE DFRGDGPHSP GDDEDGWLRT 120

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Nucleotide Sequence
(Fasta)

ATGAACTTCC TCCACAGTAC TCTCGATAGA CTTCGAGAGT TTACACCCGT ATCTAATACC 60
TCTACCTTTC GTACCAATGG ACAAATCACG CCAGAAGAAT TCGTTGCAGC AGGAGATTAT 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007135--Autophagy-rel_prot_3
IPR019461--Autophagy-rel_prot_3_C
IPR007134--Autophagy-rel_prot_3_N

Pfam

PF03987--Autophagy_act_C
PF10381--Autophagy_C
PF03986--Autophagy_N

Gene Ontology

GO:0005737--C:cytoplasm
GO:0006914--P:autophagy
GO:0015031--P:protein transport

KEGG

bfu:BC1G_08793

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001111	Aegilops tauschii	34.47	5.00e-32	129.00
IUUC-Aml-002081	Ailuropoda melanoleuca	54.05	1.00e-18	85.50
IUUC-Atr-002712	Amborella trichopoda	32.96	6.00e-32	129.00
IUUC-Apl-003956	Anas platyrhynchos	38.10	9.00e-13	65.90
IUUC-Aca-004578	Anolis carolinensis	54.05	2.00e-18	84.70
IUUC-Aly-005823	Arabidopsis lyrata	36.11	8.00e-36	142.00
IUUC-Ath-006802	Arabidopsis thaliana	36.51	7.00e-36	142.00
IUUC-Ago-007855	Ashbya gossypii	34.44	9.00e-50	188.00
IUUC-Acl-008147	Aspergillus clavatus	60.90	3.00e-108	383.00
IUUC-Afl-008483	Aspergillus flavus	67.12	3.00e-114	403.00
IUUC-Afu-008818	Aspergillus fumigatus	66.85	2.00e-121	427.00
IUUC-Ani-009481	Aspergillus nidulans	64.25	2.00e-108	384.00
IUUC-Ang-009800	Aspergillus niger	58.15	5.00e-108	382.00
IUUC-Aor-010150	Aspergillus oryzae	67.12	3.00e-114	403.00
IUUC-Ate-010545	Aspergillus terreus	67.32	9.00e-70	254.00
IUUC-Ame-011793	Astyanax mexicanus	57.35	8.00e-18	82.80
IUUC-Bgr-012167	Blumeria graminis	75.14	9.00e-135	471.00
IUUC-Bta-012695	Bos taurus	54.05	5.00e-19	86.70
IUUC-Bdi-014756	Brachypodium distachyon	51.69	1.00e-20	92.00
IUUC-Bol-015091	Brassica oleracea	36.88	9.00e-32	129.00
IUUC-Bra-016662	Brassica rapa	47.19	5.00e-18	83.20
IUUC-Cel-018143	Caenorhabditis elegans	35.91	2.00e-34	137.00
IUUC-Cja-018991	Callithrix jacchus	35.42	2.00e-35	141.00
IUUC-Cfa-020070	Canis familiaris	54.05	7.00e-19	85.90
IUUC-Cpo-021860	Cavia porcellus	54.05	4.00e-19	86.70
IUUC-Cre-022948	Chlamydomonas reinhardtii	33.93	4.00e-32	130.00
IUUC-Csa-023881	Chlorocebus sabaeus	55.41	2.00e-19	87.80
IUUC-Cho-024852	Choloepus hoffmanni	54.05	1.00e-18	85.10
IUUC-Cin-025787	Ciona intestinalis	53.73	1.00e-17	82.40
IUUC-Csv-026369	Ciona savignyi	52.94	4.00e-18	83.60
IUUC-Cgl-026680	Colletotrichum gloeosporioides	64.84	8.00e-107	378.00
IUUC-Cne-026905	Cryptococcus neoformans	46.43	3.00e-18	84.30
IUUC-Dre-028811	Danio rerio	51.22	2.00e-17	81.60
IUUC-Dno-030081	Dasypus novemcinctus	54.67	8.00e-18	82.40
IUUC-Dor-030183	Dipodomys ordii	54.79	7.00e-19	86.30
IUUC-Dse-031539	Dothistroma septosporum	49.28	4.00e-24	103.00
IUUC-Dme-031805	Drosophila melanogaster	53.95	1.00e-18	85.50
IUUC-Ete-033171	Echinops telfairi	48.84	8.00e-19	85.90
IUUC-Eca-034083	Equus caballus	54.05	7.00e-19	85.90
IUUC-Eeu-034804	Erinaceus europaeus	49.37	2.00e-17	81.60
IUUC-Fca-036289	Felis catus	54.05	7.00e-19	85.90
IUUC-Fal-037060	Ficedula albicollis	40.00	3.00e-18	84.00
IUUC-Fox-038051	Fusarium oxysporum	63.84	6.00e-116	408.00
IUUC-Fso-038124	Fusarium solani	66.76	1.00e-102	364.00
IUUC-Gmo-039538	Gadus morhua	37.41	6.00e-35	139.00
IUUC-Ggr-039880	Gaeumannomyces graminis	60.96	7.00e-113	398.00
IUUC-Gga-041108	Gallus gallus	34.64	3.00e-33	134.00
IUUC-Gac-041558	Gasterosteus aculeatus	36.63	4.00e-35	139.00
IUUC-Gma-043969	Glycine max	36.40	1.00e-33	135.00
IUUC-Ggo-045071	Gorilla gorilla	54.05	8.00e-19	85.90
IUUC-Hsa-046449	Homo sapiens	54.05	8.00e-19	85.90
IUUC-Hvu-047451	Hordeum vulgare	35.23	8.00e-33	132.00
IUUC-Itr-048360	Ictidomys tridecemlineatus	54.05	8.00e-19	85.90
IUUC-Kpa-049096	Komagataella pastoris	40.00	2.00e-33	134.00
IUUC-Lch-049726	Latimeria chalumnae	35.94	4.00e-35	140.00
IUUC-Lpe-050734	Leersia perrieri	38.15	7.00e-39	152.00
IUUC-Loc-051983	Lepisosteus oculatus	36.21	1.00e-34	138.00
IUUC-Lma-053038	Leptosphaeria maculans	63.09	2.00e-110	390.00
IUUC-Laf-054510	Loxodonta africana	36.60	1.00e-33	135.00
IUUC-Mcc-054792	Macaca mulatta	55.41	2.00e-19	87.80
IUUC-Meu-055965	Macropus eugenii	45.98	6.00e-18	82.80
IUUC-Mor-057292	Magnaporthe oryzae	66.30	2.00e-114	403.00
IUUC-Mtr-058282	Medicago truncatula	36.40	3.00e-36	143.00
IUUC-Mla-059144	Melampsora laricipopulina	40.22	2.00e-26	112.00
IUUC-Mga-059509	Meleagris gallopavo	40.80	1.00e-18	85.50
IUUC-Mvi-060281	Microbotryum violaceum	46.74	3.00e-20	91.30
IUUC-Mmr-061788	Microcebus murinus	54.05	5.00e-19	86.70
IUUC-Mdo-062922	Monodelphis domestica	54.05	1.00e-18	85.10
IUUC-Mmu-064249	Mus musculus	52.70	6.00e-18	83.20
IUUC-Mac-064474	Musa acuminata	33.70	4.00e-32	130.00
IUUC-Mpu-065717	Mustela putorius furo	54.05	8.00e-19	85.90
IUUC-Mlu-067151	Myotis lucifugus	60.66	5.00e-17	79.70
IUUC-Nfi-068551	Neosartorya fischeri	66.58	4.00e-123	432.00
IUUC-Ncr-068846	Neurospora crassa	63.74	2.00e-107	380.00
IUUC-Nle-069790	Nomascus leucogenys	54.05	8.00e-19	85.90
IUUC-Ont-072517	Oreochromis niloticus	46.07	1.00e-18	85.10
IUUC-Oan-073285	Ornithorhynchus anatinus	46.51	9.00e-18	82.00
IUUC-Ocu-074695	Oryctolagus cuniculus	54.05	7.00e-19	85.90
IUUC-Oba-075515	Oryza barthii	38.15	5.00e-39	153.00
IUUC-Obr-076787	Oryza brachyantha	38.66	1.00e-38	151.00
IUUC-Ogl-077440	Oryza glaberrima	38.30	1.00e-38	151.00
IUUC-Ogu-078294	Oryza glumaepatula	38.15	6.00e-39	152.00
IUUC-Oin-079452	Oryza indica	38.66	5.00e-39	152.00
IUUC-Olo-080450	Oryza longistaminata	38.13	3.00e-37	147.00
IUUC-Ome-081514	Oryza meridionalis	38.15	1.00e-38	152.00
IUUC-Oni-082677	Oryza nivara	38.66	5.00e-39	152.00
IUUC-Opu-083925	Oryza punctata	37.78	4.00e-38	149.00
IUUC-Oru-084828	Oryza rufipogon	39.06	6.00e-37	146.00
IUUC-Osa-085937	Oryza sativa	38.66	5.00e-39	153.00
IUUC-Ola-086559	Oryzias latipes	51.22	2.00e-17	80.90
IUUC-Olu-087766	Ostreococcus lucimarinus	37.36	2.00e-32	131.00
IUUC-Oga-087983	Otolemur garnettii	46.51	8.00e-18	82.80
IUUC-Oar-089281	Ovis aries	54.05	5.00e-19	86.70
IUUC-Ptr-090983	Pan troglodytes	54.05	8.00e-19	85.90
IUUC-Pan-092457	Papio anubis	55.41	2.00e-19	87.80
IUUC-Psi-094046	Pelodiscus sinensis	47.31	3.00e-18	84.00
IUUC-Pno-094925	Phaeosphaeria nodorum	62.53	1.00e-111	394.00
IUUC-Ppa-095487	Physcomitrella patens	35.69	3.00e-35	140.00
IUUC-Pfo-096968	Poecilia formosa	46.07	2.00e-18	84.70
IUUC-Pab-098621	Pongo abelii	34.77	3.00e-32	130.00
IUUC-Pop-100007	Populus trichocarpa	35.58	3.00e-35	140.00
IUUC-Pca-100590	Procavia capensis	46.51	1.00e-17	82.00
IUUC-Ppe-101657	Prunus persica	35.11	8.00e-33	132.00
IUUC-Pva-102446	Pteropus vampyrus	54.05	7.00e-19	85.90
IUUC-Pgr-103604	Puccinia graminis	48.86	3.00e-21	94.70
IUUC-Ptt-103941	Puccinia triticina	38.62	1.00e-26	112.00
IUUC-Pte-104252	Pyrenophora teres	63.36	6.00e-113	398.00
IUUC-Pyt-104556	Pyrenophora triticirepentis	63.09	5.00e-112	395.00
IUUC-Rno-106025	Rattus norvegicus	54.05	8.00e-19	85.90
IUUC-Sce-106172	Saccharomyces cerevisiae	34.62	3.00e-49	186.00
IUUC-Sha-106858	Sarcophilus harrisii	54.05	6.00e-19	86.30
IUUC-Sja-107905	Schizosaccharomyces japonicus	51.81	1.00e-19	88.20
IUUC-Spo-108185	Schizosaccharomyces pombe	52.05	1.00e-15	74.70
IUUC-Smo-108883	Selaginella moellendorffii	35.71	2.00e-29	121.00
IUUC-Sit-110512	Setaria italica	49.44	3.00e-19	87.00
IUUC-Sly-111238	Solanum lycopersicum	34.55	1.00e-36	144.00
IUUC-Stu-112441	Solanum tuberosum	33.92	3.00e-36	144.00
IUUC-Sar-113039	Sorex araneus	46.51	1.00e-17	82.00
IUUC-Sbi-113776	Sorghum bicolor	35.11	8.00e-31	125.00
IUUC-Sre-115074	Sporisorium reilianum	51.22	5.00e-19	87.40
IUUC-Ssc-115262	Sus scrofa	35.00	5.00e-34	136.00
IUUC-Tgu-116790	Taeniopygia guttata	40.00	2.00e-18	84.30
IUUC-Tru-118160	Takifugu rubripes	51.22	4.00e-18	84.00
IUUC-Tsy-119145	Tarsius syrichta	54.76	6.00e-08	49.70
IUUC-Tni-119937	Tetraodon nigroviridis	32.60	2.00e-27	114.00
IUUC-Tca-121323	Theobroma cacao	34.60	6.00e-35	139.00
IUUC-Tre-121993	Trichoderma reesei	53.15	1.00e-94	338.00
IUUC-Tvi-122332	Trichoderma virens	57.81	6.00e-98	348.00
IUUC-Tae-123478	Triticum aestivum	34.85	3.00e-32	130.00
IUUC-Tur-126679	Triticum urartu	34.47	7.00e-32	129.00
IUUC-Tme-127159	Tuber melanosporum	51.72	3.00e-19	87.00
IUUC-Ttr-128261	Tursiops truncatus	46.51	8.00e-18	82.40
IUUC-Uma-129572	Ustilago maydis	33.65	2.00e-25	108.00
IUUC-Vda-129966	Verticillium dahliae	64.93	8.00e-119	418.00
IUUC-Vpa-130698	Vicugna pacos	46.51	1.00e-17	82.40
IUUC-Xtr-132878	Xenopus tropicalis	36.36	1.00e-34	138.00
IUUC-Xma-134017	Xiphophorus maculatus	44.94	5.00e-18	83.20
IUUC-Yli-134373	Yarrowia lipolytica	40.77	2.00e-56	210.00
IUUC-Zma-135222	Zea mays	40.00	4.00e-16	77.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence