iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.90e-74	249.4	542	846

Active Site

Position(s)	Description	Evidence
551	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092}
807	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           +Gl N+gN+C+ N v QcL+++p+l+ ++l+++++    ++ +++++++++ ++kl+ +  k++k+  sp+ ll++l+++   + + +++Da+Efl+f
   Q: 542  CGLINVGNSCFANVVFQCLMFTPPLTTYFLQQFHS----RACTKKEQCFTCGFEKLVVKA-KEEKSPLSPNGLLSQLQNIGIFLGNGKEEDAHEFLRF 634
           7******************************4444....4446789***********999.9*******************99999************ PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftk 196
           ++d++++ + k        +       ++ +  ++ k + ++li  +F+g l+s+ikc +c+ +s+ +e+++dl++++ g+ +    +l+d+L+ ft+
   Q: 635  VVDTMQSVCIK--------A-------SEYDMTKSSKLEDTTLIGLTFGGYLRSKIKCMKCQVKSELREKMMDLTVEIDGDIS----TLDDALRRFTR 713
           *********22........2.......22224567788999*****************************************6....7********** PP
   S: 197  eeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG...sls 291
           +e l+genky c +ck++ +a+kklk+++ P+vL++ LkRf+     ++  k+nk + fp++Ldl+p+++  +ek   ++ Y+L++v+vH      + 
   Q: 714  TEILDGENKYRCGSCKSYERAKKKLKITEPPNVLTIALKRFQA----GKFGKLNKLIRFPETLDLAPYVSGGSEK---SHDYKLYGVIVHLDvmnAAF 804
           *****************************************33....4457*******************95544...8***********87332556 PP
   S: 292  sGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           sGHYv+y++n ++kW++ dDs+V +++ e++l+   + aY+lfY r
   Q: 805  SGHYVCYIRN-QNKWYKADDSTVVTSDVERILT---KGAYMLFYAR 846
           9*********.889*******************...********87 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Involved in salt tolerance by modulating sodium transport activity and repressing cell death at least partially through modulating SHM1 stability and activity (PubMed:23232097). Involved in cadmium tolerance by interacting with HIPP27 and probably modulating its stability (PubMed:23857362).

Protein Sequence
(Fasta)

MLLVLDLGIS SLVLVVSLVL PLIGLFVRHK WRVAAQRREE IRRLLIHASE EAARAELEAS 60
VEFSSVAVSN VFHCPVCYCL ATTRCSRCKA VRYCSGKCQI IHWRQGHKDE CHPASIVYDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAAAAAAAA AAAAGGTTGT CTGGTCTGGT AAAATGAAAA AGCAAAGCGT CTTGGTATAG 60
AAAAGTAATA TACTGCCTCC TAATTTCTTC GTCCTTCTAC CGAAGAATCT CTCCACTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS00972--USP_1
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0046872--F:metal ion binding
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008283--P:cell proliferation
GO:0009908--P:flower development
GO:0048366--P:leaf development
GO:0016579--P:protein deubiquitination
GO:1901000--P:regulation of response to salt stress
GO:0009651--P:response to salt stress
GO:0048364--P:root development
GO:0048367--P:shoot system development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT4G24560

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005811	Arabidopsis lyrata	91.50	0.00e+00	1594.00
IUUC-Bdi-014317	Brachypodium distachyon	46.14	1.00e-126	447.00
IUUC-Bol-015264	Brassica oleracea	76.18	0.00e+00	1251.00
IUUC-Bra-018079	Brassica rapa	76.60	0.00e+00	1251.00
IUUC-Gma-044069	Glycine max	45.13	6.00e-149	521.00
IUUC-Hvu-047748	Hordeum vulgare	59.58	1.00e-119	423.00
IUUC-Lpe-051561	Leersia perrieri	49.89	3.00e-123	436.00
IUUC-Mtr-058629	Medicago truncatula	43.81	3.00e-150	525.00
IUUC-Mac-065141	Musa acuminata	53.63	1.00e-132	467.00
IUUC-Oba-075163	Oryza barthii	48.61	4.00e-123	435.00
IUUC-Ogl-077565	Oryza glaberrima	48.61	4.00e-123	435.00
IUUC-Ogu-078443	Oryza glumaepatula	48.41	9.00e-123	434.00
IUUC-Oni-082570	Oryza nivara	48.61	5.00e-123	434.00
IUUC-Opu-084076	Oryza punctata	56.51	9.00e-123	434.00
IUUC-Oru-084237	Oryza rufipogon	48.61	5.00e-123	435.00
IUUC-Osa-085297	Oryza sativa	48.61	5.00e-123	435.00
IUUC-Pop-098941	Populus trichocarpa	62.73	3.00e-157	548.00
IUUC-Ppe-101801	Prunus persica	48.60	1.00e-155	543.00
IUUC-Sly-111806	Solanum lycopersicum	56.90	1.00e-142	500.00
IUUC-Sbi-114259	Sorghum bicolor	59.89	1.00e-124	440.00
IUUC-Tca-121756	Theobroma cacao	51.30	8.00e-166	577.00
IUUC-Tae-125220	Triticum aestivum	50.21	8.00e-125	441.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence