iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012673

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase isozyme L3; Ubiquitin thioesterase L3

Genbank Nucleotide ID

BC110247

Gene Name

UCHL3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000008024.5	ENSBTAT00000035577.4	ENSBTAP00000035448.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	6.70e-73	246.1	3	230

Active Site

Position(s)	Description	Evidence
95	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10091}
169	Proton donor	ECO:0000255\|PROSITE-ProRule:PRU10091}

Domain Profile

DUB/UCH

   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakq 93
           +++wl+Le++P++ +++++++g++ ++q+ ++y++dpe l+++++pv+++lllF+i+ek+e +r+++   ++++++++d++++++f+kq
   Q: 3    GQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEE--EEKIKSQGQDVTSSVYFMKQ 89
           589*************************************************************766..5589**************** PP
   S: 94   vigNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfv 181
           +i+N+C+t++l+++++n++dk+ ++ G+tl++++e++ ++spe++a+ l+n ++++++h++ a+++++++p+ +       +k  +hf+
   Q: 90   TISNACGTIGLIHAIANNKDKMhFESGSTLKKFLEESASMSPEERARYLENYDAIRVTHETSAHEGQTEAPNID-------EKVDLHFI 171
           ***********************************************************************877.......7899**** PP
   S: 182  syvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
           ++v+++g+lyeldg+kpfP+++g++++++ l+d+++v+++f+er    + de+rfn++a++a+
   Q: 172  ALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMER----DPDELRFNAIALSAA 230
           ********************************************....***********9875 PP

Organism

Bos taurus

Functional Description
(View)

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3". Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome (By similarity).

Protein Sequence
(Fasta)

MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMDPE LLSMVPRPVC AVLLLFPITE 60
KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGL IHAIANNKDK MHFESGSTLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGGAGAGC GGCCGGGCGG AGCGGCCATG GAGGGTCAAC GCTGGCTGCC GCTGGAGGCC 60
AATCCCGAGG TGAGCGCGCC TCCAGTCTCG GCCTAAGGCC GCGGGCAGGG GCGGGGGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:520170

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000360	Aegilops tauschii	44.49	5.00e-54	204.00
IUUC-Aml-001344	Ailuropoda melanoleuca	99.13	2.00e-136	478.00
IUUC-Atr-002931	Amborella trichopoda	47.95	5.00e-49	187.00
IUUC-Apl-003949	Anas platyrhynchos	86.85	4.00e-104	370.00
IUUC-Aca-004924	Anolis carolinensis	81.82	2.00e-114	404.00
IUUC-Aly-005721	Arabidopsis lyrata	50.66	1.00e-60	226.00
IUUC-Ath-006827	Arabidopsis thaliana	51.33	5.00e-61	227.00
IUUC-Ago-007950	Ashbya gossypii	35.14	1.00e-27	116.00
IUUC-Acl-008305	Aspergillus clavatus	39.56	1.00e-40	159.00
IUUC-Afl-008611	Aspergillus flavus	40.25	7.00e-44	170.00
IUUC-Afu-008945	Aspergillus fumigatus	40.68	1.00e-43	169.00
IUUC-Ani-009339	Aspergillus nidulans	40.51	3.00e-44	171.00
IUUC-Ang-009691	Aspergillus niger	38.72	4.00e-43	167.00
IUUC-Aor-009961	Aspergillus oryzae	40.25	7.00e-44	170.00
IUUC-Ate-010316	Aspergillus terreus	40.85	1.00e-44	173.00
IUUC-Ame-011157	Astyanax mexicanus	72.61	1.00e-101	362.00
IUUC-Bgr-012125	Blumeria graminis	36.29	8.00e-39	153.00
IUUC-Bci-013734	Botrytis cinerea	38.03	1.00e-42	166.00
IUUC-Bdi-014330	Brachypodium distachyon	47.14	3.00e-57	214.00
IUUC-Bol-015214	Brassica oleracea	52.86	1.00e-63	236.00
IUUC-Bra-017491	Brassica rapa	53.74	2.00e-63	235.00
IUUC-Cel-018302	Caenorhabditis elegans	39.64	2.00e-35	141.00
IUUC-Cfa-020371	Canis familiaris	96.32	1.00e-106	378.00
IUUC-Cpo-022036	Cavia porcellus	96.52	1.00e-131	461.00
IUUC-Cre-022599	Chlamydomonas reinhardtii	44.19	2.00e-38	152.00
IUUC-Csa-023854	Chlorocebus sabaeus	99.13	1.00e-135	475.00
IUUC-Cin-025545	Ciona intestinalis	49.78	5.00e-67	247.00
IUUC-Cgl-026409	Colletotrichum gloeosporioides	34.47	2.00e-32	132.00
IUUC-Cne-026914	Cryptococcus neoformans	35.19	5.00e-30	124.00
IUUC-Cme-027216	Cyanidioschyzon merolae	37.39	3.00e-28	118.00
IUUC-Dre-028356	Danio rerio	74.78	8.00e-104	369.00
IUUC-Dse-031461	Dothistroma septosporum	40.08	1.00e-38	152.00
IUUC-Dme-032146	Drosophila melanogaster	51.56	3.00e-63	234.00
IUUC-Eca-033220	Equus caballus	98.70	2.00e-135	474.00
IUUC-Fca-036421	Felis catus	99.13	2.00e-136	478.00
IUUC-Fal-036773	Ficedula albicollis	86.64	8.00e-106	375.00
IUUC-Fox-037830	Fusarium oxysporum	36.80	2.00e-40	158.00
IUUC-Fso-038259	Fusarium solani	36.68	1.00e-38	155.00
IUUC-Gmo-039468	Gadus morhua	68.26	4.00e-84	303.00
IUUC-Ggr-039832	Gaeumannomyces graminis	37.12	4.00e-37	147.00
IUUC-Gga-041205	Gallus gallus	85.22	4.00e-111	393.00
IUUC-Gac-041629	Gasterosteus aculeatus	67.98	6.00e-88	316.00
IUUC-Gma-043057	Glycine max	50.22	3.00e-54	204.00
IUUC-Ggo-044533	Gorilla gorilla	98.70	4.00e-135	473.00
IUUC-Hsa-046754	Homo sapiens	99.13	2.00e-136	478.00
IUUC-Hvu-047176	Hordeum vulgare	41.48	2.00e-44	172.00
IUUC-Itr-047992	Ictidomys tridecemlineatus	96.84	2.00e-90	323.00
IUUC-Kpa-049123	Komagataella pastoris	36.62	6.00e-32	130.00
IUUC-Lch-049685	Latimeria chalumnae	78.07	6.00e-110	389.00
IUUC-Lpe-051377	Leersia perrieri	46.31	9.00e-48	182.00
IUUC-Loc-051988	Lepisosteus oculatus	76.09	8.00e-106	375.00
IUUC-Lma-053316	Leptosphaeria maculans	40.26	8.00e-42	163.00
IUUC-Laf-053985	Loxodonta africana	97.40	1.00e-133	468.00
IUUC-Mcc-055888	Macaca mulatta	97.83	1.00e-132	464.00
IUUC-Mor-057271	Magnaporthe oryzae	37.12	2.00e-41	161.00
IUUC-Mpo-057343	Magnaporthe poae	32.19	3.00e-22	97.80
IUUC-Mtr-057713	Medicago truncatula	49.12	3.00e-54	204.00
IUUC-Mla-058942	Melampsora laricipopulina	45.37	1.00e-47	182.00
IUUC-Mga-059702	Meleagris gallopavo	86.38	1.00e-103	368.00
IUUC-Mvi-060249	Microbotryum violaceum	44.30	2.00e-42	165.00
IUUC-Mmr-061284	Microcebus murinus	99.37	8.00e-92	329.00
IUUC-Mdo-062639	Monodelphis domestica	79.48	4.00e-122	430.00
IUUC-Mmu-063299	Mus musculus	97.39	9.00e-135	471.00
IUUC-Mac-065075	Musa acuminata	45.85	4.00e-54	204.00
IUUC-Mpu-066769	Mustela putorius furo	99.13	2.00e-136	478.00
IUUC-Mlu-066937	Myotis lucifugus	96.96	1.00e-132	465.00
IUUC-Nfi-068320	Neosartorya fischeri	40.76	1.00e-44	172.00
IUUC-Ncr-068673	Neurospora crassa	38.96	3.00e-45	174.00
IUUC-Nle-069175	Nomascus leucogenys	99.06	9.00e-124	435.00
IUUC-Opr-070652	Ochotona princeps	99.13	1.00e-63	236.00
IUUC-Ont-072170	Oreochromis niloticus	70.18	2.00e-89	321.00
IUUC-Oan-073247	Ornithorhynchus anatinus	93.81	2.00e-59	220.00
IUUC-Ocu-074422	Oryctolagus cuniculus	98.26	5.00e-136	476.00
IUUC-Oba-075098	Oryza barthii	42.48	8.00e-51	192.00
IUUC-Obr-076041	Oryza brachyantha	45.61	2.00e-55	208.00
IUUC-Ogl-076980	Oryza glaberrima	45.18	3.00e-54	204.00
IUUC-Ogu-078978	Oryza glumaepatula	38.74	3.00e-48	185.00
IUUC-Oin-079285	Oryza indica	42.04	5.00e-50	190.00
IUUC-Olo-080671	Oryza longistaminata	42.48	3.00e-50	191.00
IUUC-Ome-081428	Oryza meridionalis	41.59	7.00e-49	186.00
IUUC-Oni-082406	Oryza nivara	42.48	8.00e-51	192.00
IUUC-Opu-083305	Oryza punctata	42.48	3.00e-49	188.00
IUUC-Oru-084969	Oryza rufipogon	42.48	8.00e-51	192.00
IUUC-Osa-085830	Oryza sativa	45.18	3.00e-54	204.00
IUUC-Ola-086893	Oryzias latipes	67.98	9.00e-86	309.00
IUUC-Olu-087858	Ostreococcus lucimarinus	44.93	7.00e-53	199.00
IUUC-Oga-088055	Otolemur garnettii	98.70	4.00e-135	473.00
IUUC-Oar-090319	Ovis aries	99.57	4.00e-137	479.00
IUUC-Pan-092714	Papio anubis	98.70	6.00e-135	472.00
IUUC-Psi-094036	Pelodiscus sinensis	86.18	2.00e-105	375.00
IUUC-Pma-094412	Petromyzon marinus	65.58	1.00e-55	208.00
IUUC-Pno-094997	Phaeosphaeria nodorum	36.22	2.00e-34	139.00
IUUC-Ppa-095519	Physcomitrella patens	51.11	7.00e-65	239.00
IUUC-Pfo-096182	Poecilia formosa	67.83	1.00e-88	318.00
IUUC-Pab-098216	Pongo abelii	98.61	4.00e-82	296.00
IUUC-Pop-099282	Populus trichocarpa	49.12	6.00e-54	203.00
IUUC-Ppe-101332	Prunus persica	48.67	2.00e-56	212.00
IUUC-Pgr-103430	Puccinia graminis	47.06	1.00e-50	192.00
IUUC-Ptt-103955	Puccinia triticina	48.71	3.00e-51	194.00
IUUC-Pte-104414	Pyrenophora teres	38.89	4.00e-39	154.00
IUUC-Pyt-104753	Pyrenophora triticirepentis	34.03	3.00e-34	138.00
IUUC-Rno-105096	Rattus norvegicus	96.52	1.00e-133	468.00
IUUC-Sce-106412	Saccharomyces cerevisiae	36.08	3.00e-28	118.00
IUUC-Sha-106677	Sarcophilus harrisii	93.55	5.00e-121	426.00
IUUC-Sja-107753	Schizosaccharomyces japonicus	30.95	2.00e-26	112.00
IUUC-Spo-108322	Schizosaccharomyces pombe	31.00	2.00e-26	112.00
IUUC-Ssl-108641	Sclerotinia sclerotiorum	37.61	2.00e-38	152.00
IUUC-Smo-108914	Selaginella moellendorffii	49.14	2.00e-54	205.00
IUUC-Sit-110163	Setaria italica	48.28	8.00e-57	213.00
IUUC-Sly-111613	Solanum lycopersicum	50.22	8.00e-63	233.00
IUUC-Stu-112526	Solanum tuberosum	50.88	3.00e-58	218.00
IUUC-Sbi-114545	Sorghum bicolor	47.60	1.00e-54	206.00
IUUC-Sre-114961	Sporisorium reilianum	42.49	5.00e-41	160.00
IUUC-Ssc-115255	Sus scrofa	98.58	6.00e-124	436.00
IUUC-Tgu-117003	Taeniopygia guttata	85.65	2.00e-110	391.00
IUUC-Tru-118330	Takifugu rubripes	62.84	1.00e-68	254.00
IUUC-Tsy-119488	Tarsius syrichta	97.37	7.00e-63	233.00
IUUC-Tni-120042	Tetraodon nigroviridis	63.59	9.00e-71	261.00
IUUC-Tca-120976	Theobroma cacao	48.23	1.00e-56	212.00
IUUC-Tre-122149	Trichoderma reesei	38.70	3.00e-43	168.00
IUUC-Tvi-122450	Trichoderma virens	38.70	1.00e-43	169.00
IUUC-Tae-122693	Triticum aestivum	45.65	2.00e-54	206.00
IUUC-Tur-126250	Triticum urartu	44.49	1.00e-53	202.00
IUUC-Tme-126961	Tuber melanosporum	37.02	5.00e-36	144.00
IUUC-Uma-129382	Ustilago maydis	41.81	1.00e-43	169.00
IUUC-Vda-129678	Verticillium dahliae	32.07	2.00e-31	128.00
IUUC-Vpa-130783	Vicugna pacos	100.00	4.00e-64	237.00
IUUC-Vvi-131661	Vitis vinifera	48.47	1.00e-57	216.00
IUUC-Xtr-132428	Xenopus tropicalis	73.48	5.00e-106	376.00
IUUC-Xma-134245	Xiphophorus maculatus	67.11	2.00e-88	318.00
IUUC-Yli-134570	Yarrowia lipolytica	35.90	2.00e-36	145.00
IUUC-Zma-134740	Zea mays	46.72	3.00e-56	211.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence