iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.00e-72	244.9	3	230

Active Site

Position(s)	Description	Evidence
95	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10091}
169	Proton donor	ECO:0000255\|PROSITE-ProRule:PRU10091}

Domain Profile

DUB/UCH

   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakq 93
           +++wl+Le++P++ +++++++g++ ++q+ ++y+++pe l+++++pv+++lllF+i+ek+e +r+++   ++++++++d++++++f+kq
   Q: 3    GQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMEPELLSMVPRPVCAVLLLFPITEKYEVFRTEE--EEKIKSQGQDVTSSVYFMKQ 89
           589*************************************************************766..5589**************** PP
   S: 94   vigNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfv 181
           +i+N+C+t++l+++++n++dk+ ++ G+tl++++e++ ++spe++a+ l+n ++++++h++ a+++++++p+ +       +k  +hf+
   Q: 90   TISNACGTIGLIHAIANNKDKMhFESGSTLKKFLEESVSMSPEERAKFLENYDAIRVTHETSAHEGQTEAPSID-------EKVDLHFI 171
           ***********************************************************************888.......8899**** PP
   S: 182  syvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
           ++v+++g+lyeldg+kpfP+++gk+++++ l+d+++v+++f+er    + de+rfn++a++a+
   Q: 172  ALVHVDGHLYELDGRKPFPINHGKTSDETLLEDAIEVCKKFMER----DPDELRFNAIALSAA 230
           ********************************************....***********9875 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.

Protein Sequence
(Fasta)

MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMEPE LLSMVPRPVC AVLLLFPITE 60
KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGL IHAIANNKDK MHFESGSTLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGCCGGCC GGAGCGCGCG GGGGCGGAAG CGGCGGCGGC GGCGGCTGCG GCGGTGGTGG 60
CGGCTGTCAG AGCTGGAGAG CGGCCGGCGG AGCAGTCATG GAGGGTCAAC GCTGGCTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0008233--F:peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0101005--F:ubiquitinyl hydrolase activity
GO:0007628--P:adult walking behavior
GO:0032869--P:cellular response to insulin stimulus
GO:0042755--P:eating behavior
GO:0045600--P:positive regulation of fat cell differentiation
GO:0030163--P:protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0060041--P:retina development in camera-type eye
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:50933

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000360	Aegilops tauschii	44.07	2.00e-53	202.00
IUUC-Aml-001344	Ailuropoda melanoleuca	98.26	1.00e-135	474.00
IUUC-Atr-002931	Amborella trichopoda	47.49	3.00e-48	184.00
IUUC-Apl-003949	Anas platyrhynchos	87.32	2.00e-104	371.00
IUUC-Aca-004924	Anolis carolinensis	83.12	2.00e-115	407.00
IUUC-Aly-005721	Arabidopsis lyrata	49.78	1.00e-59	222.00
IUUC-Ath-006827	Arabidopsis thaliana	51.33	1.00e-60	226.00
IUUC-Ago-007950	Ashbya gossypii	34.55	2.00e-26	112.00
IUUC-Acl-008305	Aspergillus clavatus	39.56	2.00e-40	159.00
IUUC-Afl-008611	Aspergillus flavus	40.68	4.00e-44	171.00
IUUC-Afu-008945	Aspergillus fumigatus	40.68	6.00e-44	170.00
IUUC-Ani-009339	Aspergillus nidulans	40.85	2.00e-44	172.00
IUUC-Ang-009691	Aspergillus niger	37.87	1.00e-42	166.00
IUUC-Aor-009961	Aspergillus oryzae	40.68	4.00e-44	171.00
IUUC-Ate-010316	Aspergillus terreus	40.85	8.00e-45	173.00
IUUC-Ame-011157	Astyanax mexicanus	73.48	9.00e-102	362.00
IUUC-Bgr-012125	Blumeria graminis	36.71	9.00e-40	156.00
IUUC-Bta-012673	Bos taurus	97.39	1.00e-134	471.00
IUUC-Bci-013734	Botrytis cinerea	37.93	2.00e-42	166.00
IUUC-Bdi-014330	Brachypodium distachyon	45.81	2.00e-56	212.00
IUUC-Bol-015214	Brassica oleracea	52.42	6.00e-63	233.00
IUUC-Bra-017491	Brassica rapa	52.86	1.00e-62	232.00
IUUC-Cel-018302	Caenorhabditis elegans	40.09	2.00e-35	142.00
IUUC-Cfa-020371	Canis familiaris	95.26	1.00e-105	375.00
IUUC-Cpo-022036	Cavia porcellus	95.65	1.00e-130	458.00
IUUC-Cre-022599	Chlamydomonas reinhardtii	42.79	8.00e-37	146.00
IUUC-Csa-023854	Chlorocebus sabaeus	97.39	7.00e-134	469.00
IUUC-Cin-025545	Ciona intestinalis	49.78	2.00e-66	244.00
IUUC-Cgl-026409	Colletotrichum gloeosporioides	34.04	9.00e-32	130.00
IUUC-Cne-026914	Cryptococcus neoformans	35.19	3.00e-30	125.00
IUUC-Cme-027216	Cyanidioschyzon merolae	37.39	2.00e-28	118.00
IUUC-Dre-028356	Danio rerio	75.65	2.00e-104	371.00
IUUC-Dse-031461	Dothistroma septosporum	39.66	3.00e-38	151.00
IUUC-Dme-032146	Drosophila melanogaster	50.67	5.00e-62	230.00
IUUC-Eca-033220	Equus caballus	97.83	1.00e-134	471.00
IUUC-Fca-036421	Felis catus	98.26	1.00e-135	474.00
IUUC-Fal-036773	Ficedula albicollis	87.10	3.00e-106	377.00
IUUC-Fox-037830	Fusarium oxysporum	36.80	7.00e-41	160.00
IUUC-Fso-038259	Fusarium solani	35.90	3.00e-38	154.00
IUUC-Gmo-039468	Gadus morhua	69.13	1.00e-84	305.00
IUUC-Ggr-039832	Gaeumannomyces graminis	36.68	4.00e-37	148.00
IUUC-Gga-041205	Gallus gallus	85.65	1.00e-111	395.00
IUUC-Gac-041629	Gasterosteus aculeatus	68.86	3.00e-88	317.00
IUUC-Gma-043057	Glycine max	49.78	2.00e-53	202.00
IUUC-Ggo-044533	Gorilla gorilla	97.84	3.00e-134	470.00
IUUC-Hsa-046754	Homo sapiens	98.26	1.00e-135	474.00
IUUC-Hvu-047176	Hordeum vulgare	40.17	4.00e-43	167.00
IUUC-Itr-047992	Ictidomys tridecemlineatus	95.57	2.00e-89	320.00
IUUC-Kpa-049123	Komagataella pastoris	37.31	2.00e-32	132.00
IUUC-Lch-049685	Latimeria chalumnae	78.07	3.00e-109	387.00
IUUC-Lpe-051377	Leersia perrieri	45.32	3.00e-47	181.00
IUUC-Loc-051988	Lepisosteus oculatus	76.96	3.00e-106	377.00
IUUC-Lma-053316	Leptosphaeria maculans	39.39	5.00e-42	164.00
IUUC-Laf-053985	Loxodonta africana	97.40	9.00e-134	468.00
IUUC-Mcc-055888	Macaca mulatta	96.09	1.00e-130	458.00
IUUC-Mor-057271	Magnaporthe oryzae	37.12	2.00e-41	162.00
IUUC-Mpo-057343	Magnaporthe poae	32.19	5.00e-22	97.10
IUUC-Mtr-057713	Medicago truncatula	48.67	2.00e-53	202.00
IUUC-Mla-058942	Melampsora laricipopulina	45.37	2.00e-47	182.00
IUUC-Mga-059702	Meleagris gallopavo	86.85	5.00e-104	370.00
IUUC-Mvi-060249	Microbotryum violaceum	44.30	4.00e-42	164.00
IUUC-Mmr-061284	Microcebus murinus	98.10	6.00e-91	327.00
IUUC-Mdo-062639	Monodelphis domestica	79.85	7.00e-123	432.00
IUUC-Mac-065075	Musa acuminata	45.85	6.00e-54	203.00
IUUC-Mpu-066769	Mustela putorius furo	98.26	1.00e-135	474.00
IUUC-Mlu-066937	Myotis lucifugus	95.22	6.00e-131	459.00
IUUC-Nfi-068320	Neosartorya fischeri	41.10	7.00e-45	173.00
IUUC-Ncr-068673	Neurospora crassa	37.66	3.00e-44	171.00
IUUC-Nle-069175	Nomascus leucogenys	98.11	9.00e-123	432.00
IUUC-Opr-070652	Ochotona princeps	67.20	9.00e-84	303.00
IUUC-Ont-072170	Oreochromis niloticus	71.05	9.00e-90	322.00
IUUC-Oan-073247	Ornithorhynchus anatinus	92.92	7.00e-59	218.00
IUUC-Ocu-074422	Oryctolagus cuniculus	98.26	8.00e-136	475.00
IUUC-Oba-075098	Oryza barthii	42.04	3.00e-50	191.00
IUUC-Obr-076041	Oryza brachyantha	45.18	6.00e-55	207.00
IUUC-Ogl-076980	Oryza glaberrima	45.61	1.00e-54	206.00
IUUC-Ogu-078978	Oryza glumaepatula	38.74	1.00e-47	182.00
IUUC-Oin-079285	Oryza indica	41.59	2.00e-49	189.00
IUUC-Olo-080671	Oryza longistaminata	42.04	9.00e-50	189.00
IUUC-Ome-081428	Oryza meridionalis	41.15	2.00e-48	184.00
IUUC-Oni-082406	Oryza nivara	42.04	3.00e-50	191.00
IUUC-Opu-083305	Oryza punctata	41.59	2.00e-48	184.00
IUUC-Oru-084969	Oryza rufipogon	42.04	3.00e-50	191.00
IUUC-Osa-085830	Oryza sativa	45.61	1.00e-54	206.00
IUUC-Ola-086893	Oryzias latipes	68.42	8.00e-86	309.00
IUUC-Olu-087858	Ostreococcus lucimarinus	44.93	1.00e-52	199.00
IUUC-Oga-088055	Otolemur garnettii	97.84	3.00e-134	470.00
IUUC-Oar-090319	Ovis aries	96.96	3.00e-134	470.00
IUUC-Pan-092714	Papio anubis	96.97	6.00e-133	466.00
IUUC-Psi-094036	Pelodiscus sinensis	86.18	2.00e-105	375.00
IUUC-Pma-094412	Petromyzon marinus	64.29	1.00e-54	205.00
IUUC-Pno-094997	Phaeosphaeria nodorum	35.83	2.00e-34	139.00
IUUC-Ppa-095519	Physcomitrella patens	51.11	4.00e-64	237.00
IUUC-Pfo-096182	Poecilia formosa	68.26	1.00e-88	319.00
IUUC-Pab-098216	Pongo abelii	97.92	8.00e-82	295.00
IUUC-Pop-099282	Populus trichocarpa	48.67	4.00e-53	201.00
IUUC-Ppe-101332	Prunus persica	48.23	6.00e-56	210.00
IUUC-Pgr-103430	Puccinia graminis	47.06	2.00e-50	192.00
IUUC-Ptt-103955	Puccinia triticina	48.71	4.00e-51	194.00
IUUC-Pte-104414	Pyrenophora teres	38.03	5.00e-39	154.00
IUUC-Pyt-104753	Pyrenophora triticirepentis	34.87	5.00e-35	140.00
IUUC-Rno-105096	Rattus norvegicus	97.83	1.00e-134	471.00
IUUC-Sce-106412	Saccharomyces cerevisiae	34.02	1.00e-28	119.00
IUUC-Sha-106677	Sarcophilus harrisii	94.01	1.00e-121	428.00
IUUC-Sja-107753	Schizosaccharomyces japonicus	30.95	6.00e-26	110.00
IUUC-Spo-108322	Schizosaccharomyces pombe	31.44	2.00e-26	112.00
IUUC-Ssl-108641	Sclerotinia sclerotiorum	37.61	7.00e-39	154.00
IUUC-Smo-109283	Selaginella moellendorffii	48.07	2.00e-53	201.00
IUUC-Sit-110163	Setaria italica	47.41	1.00e-55	209.00
IUUC-Sly-111613	Solanum lycopersicum	49.78	3.00e-62	231.00
IUUC-Stu-112526	Solanum tuberosum	50.88	1.00e-57	216.00
IUUC-Sbi-114545	Sorghum bicolor	46.72	2.00e-53	202.00
IUUC-Sre-114961	Sporisorium reilianum	42.49	1.00e-40	159.00
IUUC-Ssc-115255	Sus scrofa	95.75	5.00e-121	426.00
IUUC-Tgu-117003	Taeniopygia guttata	86.09	5.00e-111	393.00
IUUC-Tru-118330	Takifugu rubripes	62.84	7.00e-69	254.00
IUUC-Tsy-119488	Tarsius syrichta	98.25	4.00e-63	234.00
IUUC-Tni-120042	Tetraodon nigroviridis	63.59	2.00e-70	260.00
IUUC-Tca-120976	Theobroma cacao	48.67	6.00e-57	213.00
IUUC-Tre-122149	Trichoderma reesei	39.13	6.00e-44	170.00
IUUC-Tvi-122450	Trichoderma virens	39.57	4.00e-44	171.00
IUUC-Tae-122693	Triticum aestivum	45.22	6.00e-54	204.00
IUUC-Tur-126250	Triticum urartu	44.07	5.00e-53	200.00
IUUC-Tme-126961	Tuber melanosporum	36.60	1.00e-35	143.00
IUUC-Uma-129382	Ustilago maydis	41.38	2.00e-43	168.00
IUUC-Vda-129678	Verticillium dahliae	31.65	7.00e-32	130.00
IUUC-Vpa-130783	Vicugna pacos	97.39	8.00e-63	233.00
IUUC-Vvi-131661	Vitis vinifera	47.16	2.00e-56	212.00
IUUC-Xtr-132428	Xenopus tropicalis	73.91	3.00e-106	377.00
IUUC-Xma-134245	Xiphophorus maculatus	67.54	2.00e-88	318.00
IUUC-Yli-134570	Yarrowia lipolytica	36.32	6.00e-37	147.00
IUUC-Zma-134740	Zea mays	45.85	4.00e-55	207.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence