iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027517

Ensembl Protein ID

ENSDARP00000120039.2

UniProt Accession

Q5TYU7; Q5TYU7_DANRE

Genbank Protein ID

ENSDARP00000008826

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

BX842684

Gene Name

blk; bltk

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000007783.10	ENSDART00000138028.3	ENSDARP00000120039.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.50e-15	57.8	40	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++v+++yd++++++++L++kkGd +++i   +++++W+ +++  +g++G++P+ +v++++
   Q: 40   EDVVIAQYDFQPASENDLQFKKGDRLRII---KENGEWWLAKSLVTGYEGFIPSTYVARAQ 97
           6789*************************...999**********************9986 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MGCACSDQNH PKGHEHYNST NSKTSHASRD HKKQNNNQDE DVVIAQYDFQ PASENDLQFK 60
KGDRLRIIKE NGEWWLAKSL VTGYEGFIPS TYVARAQTLQ VERWFFKDMN RRDTERLLLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGCTGTC TAGGCGCCAG AGAATGGAGA ACGCTGGACG TCCATCGTGA CAGAACCTGC 60
AGGTGTGATA TAATTGCTGC CCTTCACAGT ATGTACCTTC ACAAAATGTC TCCCTCCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

dre:567764

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	71.56	0.00e+00	696.00
IUUC-Apl-003307	Anas platyrhynchos	72.75	0.00e+00	712.00
IUUC-Aca-004357	Anolis carolinensis	71.33	0.00e+00	673.00
IUUC-Ame-010642	Astyanax mexicanus	81.52	0.00e+00	842.00
IUUC-Bta-012400	Bos taurus	72.61	0.00e+00	705.00
IUUC-Bdi-014122	Brachypodium distachyon	31.52	2.00e-21	98.60
IUUC-Cfa-021056	Canis familiaris	71.11	0.00e+00	692.00
IUUC-Cpo-021779	Cavia porcellus	70.89	0.00e+00	706.00
IUUC-Csa-023557	Chlorocebus sabaeus	69.26	0.00e+00	694.00
IUUC-Eca-034218	Equus caballus	71.33	0.00e+00	691.00
IUUC-Fca-036015	Felis catus	69.26	0.00e+00	689.00
IUUC-Fal-036946	Ficedula albicollis	72.01	0.00e+00	703.00
IUUC-Gmo-038861	Gadus morhua	77.53	0.00e+00	736.00
IUUC-Gga-040822	Gallus gallus	70.96	0.00e+00	715.00
IUUC-Gac-041860	Gasterosteus aculeatus	73.36	0.00e+00	755.00
IUUC-Hsa-046719	Homo sapiens	68.83	0.00e+00	689.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	70.72	0.00e+00	684.00
IUUC-Lch-050114	Latimeria chalumnae	71.14	0.00e+00	704.00
IUUC-Loc-052326	Lepisosteus oculatus	75.56	0.00e+00	799.00
IUUC-Laf-053387	Loxodonta africana	69.26	0.00e+00	691.00
IUUC-Mcc-055026	Macaca mulatta	69.70	0.00e+00	698.00
IUUC-Mga-059427	Meleagris gallopavo	71.21	0.00e+00	698.00
IUUC-Mmr-061660	Microcebus murinus	71.85	0.00e+00	696.00
IUUC-Mdo-062318	Monodelphis domestica	69.49	0.00e+00	690.00
IUUC-Mmu-063325	Mus musculus	69.48	0.00e+00	699.00
IUUC-Mpu-066582	Mustela putorius furo	71.33	0.00e+00	696.00
IUUC-Nle-069624	Nomascus leucogenys	71.62	0.00e+00	692.00
IUUC-Ont-072266	Oreochromis niloticus	75.66	0.00e+00	798.00
IUUC-Ocu-073907	Oryctolagus cuniculus	71.71	0.00e+00	700.00
IUUC-Ola-086668	Oryzias latipes	80.72	0.00e+00	773.00
IUUC-Oga-088057	Otolemur garnettii	71.62	0.00e+00	688.00
IUUC-Ptr-091551	Pan troglodytes	68.62	0.00e+00	662.00
IUUC-Pan-092173	Papio anubis	71.40	0.00e+00	693.00
IUUC-Psi-093895	Pelodiscus sinensis	73.38	0.00e+00	721.00
IUUC-Pfo-096608	Poecilia formosa	77.30	0.00e+00	805.00
IUUC-Pab-097598	Pongo abelii	71.62	0.00e+00	694.00
IUUC-Pva-102135	Pteropus vampyrus	71.78	0.00e+00	699.00
IUUC-Rno-104891	Rattus norvegicus	70.64	0.00e+00	701.00
IUUC-Sha-107192	Sarcophilus harrisii	68.55	0.00e+00	693.00
IUUC-Ssc-115696	Sus scrofa	72.00	0.00e+00	699.00
IUUC-Tgu-117056	Taeniopygia guttata	71.11	0.00e+00	699.00
IUUC-Tru-117621	Takifugu rubripes	73.72	0.00e+00	769.00
IUUC-Ttr-128457	Tursiops truncatus	71.52	0.00e+00	696.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence