iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091213

Ensembl Protein ID

ENSPTRP00000023944.2

UniProt Accession

H2QL12; H2QL12_PANTR

Genbank Protein ID

ENSPTRP00000023944

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AL954225

Gene Name

BRWD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000013912.4	ENSPTRT00000025950.2	ENSPTRP00000023944.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.50e-35	119.0	184	221
UBD/Beta-Prp	8.50e-55	186.0	286	543

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH + v+c+af  + +++ +GsdD+ +k+W+++ g+ll
   Q: 184  GHLSAVYCVAFdRTgHRIFTGSDDCLVKIWSTHNGRLL 221
           8**********955599***************999987 PP

UBD/Beta-Prp

   S: 22   ksllatgsrdgtikvwdvttgkl......lrslsgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlsl 100
           +++++++++dgt+  w+++ ++l      l+  ++  ++v+ ++  fs  g +l+tgs+D++i+ +   +++++ +  l+ h+d+v s+
   Q: 286  QRYMVSTGADGTVCFWQWDLESLkfsprpLKFTEKPRPGVQMLCssFSVGGMFLATGSTDHVIRMYflGFEAPEKIAELESHTDKVDSI 374
           689*****************99999988777778888888755522888888**************99999****************** PP
   S: 101  sfspsgdklvsGshdrtirvwdletgqclee...............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrt 174
           +f+ +gd+++sGs+d t+r+w  e+ ++ +                 ++  +  v++++++++++++v++ +D ++++W++ tg+ll+ 
   Q: 375  QFCNNGDRFLSGSRDGTARIWRFEQLEWRSIlldmatrisgdlsseEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHN 463
           **************************99998999********998877777888*********************************** PP
   S: 175  ltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l g h d v  l+   fds  + ++s+++dg++ +wd+ +g+ ++ + +         v + +fs+++++++++ s+g + i+
   Q: 464  LMG-HADEVFVLEthpFDS--RIMLSAGHDGSIFIWDITKGTKMKHYFNMIegqghGAVFDCKFSQDGQHFACTDSHGHLLIF 543
           **9.*********555555..99****************999977766544444456677789999*****999999998886 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHN 60
RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV TSLLGAGRQS LLRTAKDCRH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGCGCGCA CGGTATGGCG GCGGCGGCGG CGGCGGCGGC GCGCGCCTGA GAAAAGGGGA 60
CGCCAGCCCG GTCAGGCCTC GGCGCGGCCT ACACGCTCCG CTCGCTCGCT CCCGCCTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	30.68	9.00e-63	236.00
IUUC-Aml-002332	Ailuropoda melanoleuca	84.65	0.00e+00	3315.00
IUUC-Atr-002600	Amborella trichopoda	29.68	5.00e-68	253.00
IUUC-Apl-004083	Anas platyrhynchos	69.58	0.00e+00	1970.00
IUUC-Aca-004348	Anolis carolinensis	72.75	0.00e+00	1958.00
IUUC-Aly-006517	Arabidopsis lyrata	30.58	2.00e-73	271.00
IUUC-Ath-006577	Arabidopsis thaliana	30.28	1.00e-72	268.00
IUUC-Ame-010718	Astyanax mexicanus	71.21	0.00e+00	1176.00
IUUC-Bta-013217	Bos taurus	88.76	0.00e+00	3697.00
IUUC-Bdi-014797	Brachypodium distachyon	29.25	3.00e-59	224.00
IUUC-Bol-015737	Brassica oleracea	30.00	5.00e-74	273.00
IUUC-Bra-017961	Brassica rapa	29.54	3.00e-73	270.00
IUUC-Cja-019966	Callithrix jacchus	95.17	0.00e+00	3998.00
IUUC-Cfa-021037	Canis familiaris	88.85	0.00e+00	3623.00
IUUC-Cpo-021934	Cavia porcellus	92.21	0.00e+00	2783.00
IUUC-Cre-023003	Chlamydomonas reinhardtii	34.15	8.00e-35	142.00
IUUC-Csa-023352	Chlorocebus sabaeus	97.62	0.00e+00	3846.00
IUUC-Cho-024690	Choloepus hoffmanni	80.16	0.00e+00	1372.00
IUUC-Csv-025813	Ciona savignyi	43.10	2.00e-179	622.00
IUUC-Dno-028938	Dasypus novemcinctus	85.06	0.00e+00	3558.00
IUUC-Dme-031752	Drosophila melanogaster	49.84	0.00e+00	671.00
IUUC-Eca-034349	Equus caballus	89.66	0.00e+00	3544.00
IUUC-Fca-035485	Felis catus	82.76	0.00e+00	3097.00
IUUC-Fal-037307	Ficedula albicollis	77.73	0.00e+00	2301.00
IUUC-Gma-043340	Glycine max	30.36	4.00e-71	263.00
IUUC-Ggo-045500	Gorilla gorilla	99.13	0.00e+00	4147.00
IUUC-Hsa-046350	Homo sapiens	99.35	0.00e+00	4174.00
IUUC-Itr-047962	Ictidomys tridecemlineatus	95.23	0.00e+00	1165.00
IUUC-Lch-049662	Latimeria chalumnae	57.77	0.00e+00	2113.00
IUUC-Lpe-051619	Leersia perrieri	31.23	1.00e-70	262.00
IUUC-Laf-053848	Loxodonta africana	87.50	0.00e+00	3559.00
IUUC-Mcc-054638	Macaca mulatta	97.89	0.00e+00	4120.00
IUUC-Meu-056739	Macropus eugenii	79.91	0.00e+00	1117.00
IUUC-Mtr-058094	Medicago truncatula	30.67	1.00e-72	268.00
IUUC-Mga-060165	Meleagris gallopavo	77.95	0.00e+00	2313.00
IUUC-Mmr-061227	Microcebus murinus	92.38	0.00e+00	3845.00
IUUC-Mdo-062074	Monodelphis domestica	83.31	0.00e+00	2471.00
IUUC-Mmu-064075	Mus musculus	83.03	0.00e+00	3019.00
IUUC-Mac-065343	Musa acuminata	31.02	1.00e-75	278.00
IUUC-Mpu-066643	Mustela putorius furo	90.36	0.00e+00	3010.00
IUUC-Mlu-067735	Myotis lucifugus	86.57	0.00e+00	3497.00
IUUC-Nle-069402	Nomascus leucogenys	96.37	0.00e+00	3156.00
IUUC-Oan-072954	Ornithorhynchus anatinus	85.15	0.00e+00	2539.00
IUUC-Ocu-074456	Oryctolagus cuniculus	88.43	0.00e+00	3700.00
IUUC-Oba-075709	Oryza barthii	30.17	8.00e-61	229.00
IUUC-Obr-076619	Oryza brachyantha	30.90	5.00e-71	263.00
IUUC-Ogl-077493	Oryza glaberrima	38.04	2.00e-28	122.00
IUUC-Opu-083233	Oryza punctata	30.47	2.00e-65	244.00
IUUC-Oru-085195	Oryza rufipogon	30.17	7.00e-61	229.00
IUUC-Ola-086648	Oryzias latipes	58.78	0.00e+00	1648.00
IUUC-Olu-087745	Ostreococcus lucimarinus	28.57	2.00e-56	215.00
IUUC-Oga-087938	Otolemur garnettii	83.10	0.00e+00	3275.00
IUUC-Oar-090214	Ovis aries	87.78	0.00e+00	3551.00
IUUC-Pan-092444	Papio anubis	97.16	0.00e+00	4086.00
IUUC-Psi-093271	Pelodiscus sinensis	60.33	0.00e+00	2217.00
IUUC-Pma-094427	Petromyzon marinus	66.98	3.00e-133	467.00
IUUC-Ppa-095793	Physcomitrella patens	29.84	2.00e-74	275.00
IUUC-Pfo-097318	Poecilia formosa	62.84	0.00e+00	1793.00
IUUC-Pab-097573	Pongo abelii	97.66	0.00e+00	4016.00
IUUC-Pop-099672	Populus trichocarpa	31.03	7.00e-73	269.00
IUUC-Pca-100759	Procavia capensis	70.97	0.00e+00	1162.00
IUUC-Ppe-101849	Prunus persica	29.72	4.00e-75	277.00
IUUC-Pva-102782	Pteropus vampyrus	88.13	0.00e+00	3581.00
IUUC-Rno-105687	Rattus norvegicus	79.10	0.00e+00	3298.00
IUUC-Sly-111348	Solanum lycopersicum	30.56	6.00e-76	280.00
IUUC-Sar-113519	Sorex araneus	80.46	0.00e+00	1783.00
IUUC-Sbi-114195	Sorghum bicolor	29.24	2.00e-58	220.00
IUUC-Tgu-116513	Taeniopygia guttata	77.62	0.00e+00	2315.00
IUUC-Tru-117625	Takifugu rubripes	59.14	0.00e+00	1669.00
IUUC-Tsy-118921	Tarsius syrichta	90.27	0.00e+00	2041.00
IUUC-Tni-120716	Tetraodon nigroviridis	58.79	0.00e+00	1671.00
IUUC-Tca-121098	Theobroma cacao	31.11	2.00e-79	291.00
IUUC-Tae-125478	Triticum aestivum	30.34	7.00e-72	266.00
IUUC-Tur-126809	Triticum urartu	30.40	2.00e-69	258.00
IUUC-Tbe-127663	Tupaia belangeri	80.76	0.00e+00	1359.00
IUUC-Ttr-128561	Tursiops truncatus	86.95	0.00e+00	3456.00
IUUC-Vpa-130444	Vicugna pacos	85.87	0.00e+00	3342.00
IUUC-Vvi-131362	Vitis vinifera	30.99	4.00e-74	273.00
IUUC-Xma-133633	Xiphophorus maculatus	64.02	0.00e+00	1123.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence