iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000012228.3	ENSMMUT00000045097.2	ENSMMUP00000038114.2
ENSMMUG00000012228.3	ENSMMUT00000017124.3	ENSMMUP00000016037.2
ENSMMUG00000012228.3	ENSMMUT00000017135.3	ENSMMUP00000016048.2
ENSMMUG00000012228.3	ENSMMUT00000057128.1	ENSMMUP00000058871.1
ENSMMUG00000012228.3	ENSMMUT00000077874.1	ENSMMUP00000044703.1
ENSMMUG00000012228.3	ENSMMUT00000072551.1	ENSMMUP00000044863.1
ENSMMUG00000012228.3	ENSMMUT00000063634.1	ENSMMUP00000057650.1
ENSMMUG00000012228.3	ENSMMUT00000072730.1	ENSMMUP00000052679.1
ENSMMUG00000012228.3	ENSMMUT00000071634.1	ENSMMUP00000055930.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.60e-18	67.9	256	361
E2/UEV	5.00e-66	222.1	230	368

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UBC

   S: 17   isakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.Gkv...ClsilkeeekWspalsve 99
           +s +++d++d  lt+w  +i+Gp++t+Ye+++++l+ie+ ++YP  PP v+f+tki    v+++ G v    +s+l    kW+  +s++
   Q: 256  VSWGLEDDEDmtLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSnGVVdprAISVL---AKWQNSYSIK 341
           55666777776689*****************************************999999988798866668888...5********* PP
   S: 100  svllsiqsll.aepnpespl 118
            vl ++ +l+ ++ n++ p+
   Q: 342  VVLQELRRLMmSKENMKLPQ 361
           ********996667777665 PP

E2/UEV

   S: 7    lkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevnd 95
           + v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp+rt ye+rIy+lk+++g+kYPe+PP+vrf++kinm++vn+
   Q: 230  TGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNS 318
           579************************************************************************************** PP
   S: 96   snGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           snGvvdpra++vLa+W+++ysi+vvl++l++ ++sken+kl+qPpeG+++
   Q: 319  SNGVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCY 368
           ************************************************98 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAGAEDGPGQ QLELDEDEAS CCRWGAQHAG ARELAALYSP GKRLQEWCSV ILCFSLIAHN 60
LVHLLLLARW EHTPLVIVGV VAGALIADFL SGLVHWGADT WGSVELPIVG KAFIRPFREH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCGAGTGG CCATGGCGGG CGCCGAGGAT GGGCCGGGCC AGCAGCTGGA GCTGGACGAG 60
GACGAGGCGT CCTGTTGCCG CTGGGGCGCG CAGCACGCTG GGGCCCGCGA GCTGGCTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR019547--TMEM189_B_dmain
IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF10520--TMEM189_B_dmain
PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000910	Aegilops tauschii	55.15	2.00e-38	150.00
IUUC-Aml-001242	Ailuropoda melanoleuca	97.02	0.00e+00	690.00
IUUC-Atr-003059	Amborella trichopoda	52.63	1.00e-37	149.00
IUUC-Apl-003600	Anas platyrhynchos	100.00	6.00e-74	268.00
IUUC-Aca-005104	Anolis carolinensis	95.83	2.00e-79	286.00
IUUC-Aly-005402	Arabidopsis lyrata	53.57	4.00e-38	150.00
IUUC-Ath-006915	Arabidopsis thaliana	54.07	8.00e-38	149.00
IUUC-Ago-007810	Ashbya gossypii	52.21	8.00e-34	135.00
IUUC-Ame-010710	Astyanax mexicanus	89.36	8.00e-74	268.00
IUUC-Bgr-012010	Blumeria graminis	51.45	8.00e-33	132.00
IUUC-Bta-013403	Bos taurus	99.29	2.00e-74	270.00
IUUC-Bci-013649	Botrytis cinerea	51.45	2.00e-32	130.00
IUUC-Bdi-014636	Brachypodium distachyon	53.73	3.00e-37	147.00
IUUC-Bol-015323	Brassica oleracea	53.24	5.00e-39	153.00
IUUC-Bra-018041	Brassica rapa	53.24	5.00e-39	153.00
IUUC-Cel-018398	Caenorhabditis elegans	66.67	4.00e-48	183.00
IUUC-Cja-019316	Callithrix jacchus	99.29	2.00e-74	270.00
IUUC-Cfa-021118	Canis familiaris	100.00	8.00e-74	268.00
IUUC-Cre-022629	Chlamydomonas reinhardtii	49.64	2.00e-37	147.00
IUUC-Csa-024275	Chlorocebus sabaeus	99.73	0.00e+00	687.00
IUUC-Cgl-026596	Colletotrichum gloeosporioides	53.62	2.00e-36	144.00
IUUC-Cne-026817	Cryptococcus neoformans	50.00	6.00e-37	146.00
IUUC-Cme-027257	Cyanidioschyzon merolae	56.30	4.00e-28	117.00
IUUC-Dno-029762	Dasypus novemcinctus	99.29	4.00e-74	269.00
IUUC-Dor-030185	Dipodomys ordii	94.47	7.00e-107	379.00
IUUC-Dme-031635	Drosophila melanogaster	67.86	3.00e-58	216.00
IUUC-Ete-033017	Echinops telfairi	72.59	5.00e-98	350.00
IUUC-Eca-034422	Equus caballus	100.00	2.00e-73	266.00
IUUC-Eeu-035327	Erinaceus europaeus	85.71	9.00e-180	622.00
IUUC-Fal-037350	Ficedula albicollis	99.29	3.00e-74	270.00
IUUC-Fso-038147	Fusarium solani	53.96	2.00e-37	147.00
IUUC-Gmo-039237	Gadus morhua	83.45	5.00e-69	252.00
IUUC-Gga-040746	Gallus gallus	97.22	2.00e-74	270.00
IUUC-Gac-042619	Gasterosteus aculeatus	74.21	1.00e-100	358.00
IUUC-Gma-042869	Glycine max	55.97	6.00e-38	149.00
IUUC-Ggo-045491	Gorilla gorilla	98.65	0.00e+00	703.00
IUUC-Hsa-046426	Homo sapiens	98.92	0.00e+00	709.00
IUUC-Hvu-047368	Hordeum vulgare	54.48	2.00e-37	147.00
IUUC-Itr-048139	Ictidomys tridecemlineatus	100.00	9.00e-74	268.00
IUUC-Kpa-049337	Komagataella pastoris	51.11	1.00e-31	128.00
IUUC-Lch-050494	Latimeria chalumnae	87.86	4.00e-73	266.00
IUUC-Loc-052024	Lepisosteus oculatus	82.81	1.00e-176	612.00
IUUC-Laf-054176	Loxodonta africana	99.29	2.00e-74	270.00
IUUC-Meu-056842	Macropus eugenii	74.42	2.00e-142	498.00
IUUC-Mor-056915	Magnaporthe oryzae	38.41	2.00e-20	91.70
IUUC-Mga-059951	Meleagris gallopavo	97.20	8.00e-74	268.00
IUUC-Mvi-060260	Microbotryum violaceum	54.01	4.00e-36	143.00
IUUC-Mmr-060769	Microcebus murinus	92.18	0.00e+00	674.00
IUUC-Mmu-063234	Mus musculus	92.72	0.00e+00	640.00
IUUC-Mac-065351	Musa acuminata	54.41	2.00e-38	151.00
IUUC-Mpu-065775	Mustela putorius furo	99.29	2.00e-74	270.00
IUUC-Mlu-067269	Myotis lucifugus	91.56	5.00e-73	266.00
IUUC-Nle-069245	Nomascus leucogenys	99.29	2.00e-74	270.00
IUUC-Opr-070859	Ochotona princeps	91.11	0.00e+00	657.00
IUUC-Ocu-074447	Oryctolagus cuniculus	97.86	6.00e-73	265.00
IUUC-Obr-076191	Oryza brachyantha	53.24	2.00e-38	150.00
IUUC-Ola-086519	Oryzias latipes	75.07	6.00e-167	580.00
IUUC-Oga-087972	Otolemur garnettii	97.24	5.00e-74	269.00
IUUC-Oar-090166	Ovis aries	95.17	0.00e+00	644.00
IUUC-Ptr-090866	Pan troglodytes	99.29	2.00e-74	270.00
IUUC-Pma-094142	Petromyzon marinus	91.11	4.00e-21	92.00
IUUC-Pab-098403	Pongo abelii	99.39	0.00e+00	630.00
IUUC-Pop-099786	Populus trichocarpa	51.72	3.00e-38	150.00
IUUC-Pca-100723	Procavia capensis	94.61	0.00e+00	707.00
IUUC-Ppe-101725	Prunus persica	55.88	6.00e-39	153.00
IUUC-Pva-102393	Pteropus vampyrus	91.37	0.00e+00	667.00
IUUC-Sha-107363	Sarcophilus harrisii	97.90	2.00e-74	270.00
IUUC-Sja-107722	Schizosaccharomyces japonicus	54.01	4.00e-34	136.00
IUUC-Spo-108027	Schizosaccharomyces pombe	51.09	1.00e-32	131.00
IUUC-Ssl-108493	Sclerotinia sclerotiorum	53.96	5.00e-34	136.00
IUUC-Smo-109006	Selaginella moellendorffii	47.41	5.00e-29	119.00
IUUC-Sit-110302	Setaria italica	55.40	8.00e-40	155.00
IUUC-Sly-111205	Solanum lycopersicum	52.52	1.00e-38	151.00
IUUC-Stu-112459	Solanum tuberosum	51.80	3.00e-38	150.00
IUUC-Sbi-114210	Sorghum bicolor	54.68	4.00e-39	153.00
IUUC-Ssc-115939	Sus scrofa	99.29	2.00e-74	270.00
IUUC-Tgu-117289	Taeniopygia guttata	93.67	3.00e-116	410.00
IUUC-Tsy-119103	Tarsius syrichta	96.67	1.00e-65	242.00
IUUC-Tca-121025	Theobroma cacao	57.04	1.00e-39	156.00
IUUC-Tae-123220	Triticum aestivum	54.48	2.00e-37	147.00
IUUC-Tur-126236	Triticum urartu	54.81	6.00e-38	149.00
IUUC-Tme-127171	Tuber melanosporum	48.18	2.00e-29	120.00
IUUC-Tbe-128105	Tupaia belangeri	83.51	2.00e-175	608.00
IUUC-Ttr-128790	Tursiops truncatus	94.61	0.00e+00	701.00
IUUC-Vda-129776	Verticillium dahliae	52.86	4.00e-36	143.00
IUUC-Vpa-130575	Vicugna pacos	99.28	3.00e-71	261.00
IUUC-Vvi-130831	Vitis vinifera	55.88	1.00e-39	155.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence