iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106283

UUCD1 version

UUC-SaC-00250

Ensembl Protein ID

YGL058W

UniProt Accession

P06104; D6VU83; UBC2_YEAST

Genbank Protein ID

AAA34952.1; CAA96761.1; DAA08044.1

Protein Name

Ubiquitin-conjugating enzyme E2 2; E2 ubiquitin-conjugating enzyme 2; Radiation sensitivity protein 6; Ubiquitin carrier protein UBC2; Ubiquitin-protein ligase UBC2

Genbank Nucleotide ID

K02962; Z72580; BK006941

Gene Name

RAD6; UBC2; YGL058W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YGL058W	YGL058W	YGL058W

Annotation

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20566477; 20463880; 17130289

Classification

Family	E-value	Score	Start	End
E2/UBC	1.80e-52	175.3	8	143

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesvl 102
           Rl++++k++++d p+g+sa+p  + +++ w+++i+Gp+dtpYe+g+F+l +ef+e+YP kPP+vkfl+++fhPnvy+nG++Cl+il+  ++W+p+++v+s+l
   Q: 8    RLMRDFKRMKEDAPPGVSASPLPD-NVMVWNAMIIGPADTPYEDGTFRLLLEFDEEYPNKPPHVKFLSEMFHPNVYANGEICLDILQ--NRWTPTYDVASIL 106
           9***********************.9************************************************************9..************* PP
   S: 103  lsiqsllaepnpesplneeaaellkknreeykkkvre 139
           +siqsl+++pnp+sp+n+eaa+l+k+++++y k+v+e
   Q: 107  TSIQSLFNDPNPASPANVEAATLFKDHKSQYVKRVKE 143
           **********************************985 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. In association with the E3 enzyme BRE1 and LGE1, it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In association with the E3 enzyme RAD18, it catalyzes the monoubiquitination of POL30 'Lys-164', involved in postreplication repair of UV-damaged DNA. The RAD6/UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine. In association with the E3 enzyme UBR1, is involved in N-end rule-dependent protein degradation. Also involved in sporulation.

Protein Sequence
(Fasta)

MSTPARRRLM RDFKRMKEDA PPGVSASPLP DNVMVWNAMI IGPADTPYED GTFRLLLEFD 60
EEYPNKPPHV KFLSEMFHPN VYANGEICLD ILQNRWTPTY DVASILTSIQ SLFNDPNPAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCACAC CAGCTAGAAG AAGGTTGATG AGAGATTTTA AACGTATGAA GGAAGATGCC 60
CCACCGGGTG TATCTGCTTC ACCATTACCT GATAACGTCA TGGTATGGAA CGCCATGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0749--Sporulation
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:1990304--C:MUB1-RAD6-UBR2 ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0097505--C:Rad6-Rad18 complex
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006348--P:chromatin silencing at telomere
GO:0006353--P:DNA-templated transcription, termination
GO:0000724--P:double-strand break repair via homologous recombination
GO:0042275--P:error-free postreplication DNA repair
GO:0070987--P:error-free translesion synthesis
GO:0042276--P:error-prone translesion synthesis
GO:0010390--P:histone monoubiquitination
GO:0042138--P:meiotic DNA double-strand break formation
GO:0031571--P:mitotic G1 DNA damage checkpoint
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090089--P:regulation of dipeptide transport
GO:0030435--P:sporulation resulting in formation of a cellular spore
GO:0000722--P:telomere maintenance via recombination
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway

KEGG

sce:YGL058W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001001	Aegilops tauschii	63.76	8.00e-60	220.00
IUUC-Aml-002120	Ailuropoda melanoleuca	69.80	2.00e-63	232.00
IUUC-Atr-002623	Amborella trichopoda	65.10	1.00e-60	223.00
IUUC-Apl-004063	Anas platyrhynchos	61.64	5.00e-52	194.00
IUUC-Aca-005001	Anolis carolinensis	69.80	2.00e-63	232.00
IUUC-Aly-006336	Arabidopsis lyrata	65.10	2.00e-55	205.00
IUUC-Ath-007547	Arabidopsis thaliana	65.10	2.00e-55	205.00
IUUC-Ago-007745	Ashbya gossypii	100.00	3.00e-88	315.00
IUUC-Acl-008139	Aspergillus clavatus	76.00	1.00e-70	256.00
IUUC-Afl-008551	Aspergillus flavus	76.67	4.00e-71	257.00
IUUC-Afu-008980	Aspergillus fumigatus	76.67	4.00e-71	257.00
IUUC-Ang-009554	Aspergillus niger	76.67	4.00e-71	257.00
IUUC-Aor-010242	Aspergillus oryzae	76.67	4.00e-71	257.00
IUUC-Ate-010390	Aspergillus terreus	76.67	4.00e-71	257.00
IUUC-Ame-010743	Astyanax mexicanus	69.13	1.00e-63	233.00
IUUC-Bgr-012039	Blumeria graminis	74.07	1.00e-62	229.00
IUUC-Bta-012840	Bos taurus	69.80	2.00e-63	232.00
IUUC-Bci-013919	Botrytis cinerea	76.67	5.00e-71	257.00
IUUC-Bdi-014308	Brachypodium distachyon	65.10	5.00e-60	220.00
IUUC-Bol-015726	Brassica oleracea	63.76	3.00e-59	221.00
IUUC-Bra-016803	Brassica rapa	65.10	2.00e-55	205.00
IUUC-Cel-018244	Caenorhabditis elegans	67.11	2.00e-62	229.00
IUUC-Cja-019737	Callithrix jacchus	69.80	2.00e-63	232.00
IUUC-Cfa-020646	Canis familiaris	69.80	2.00e-63	233.00
IUUC-Cpo-022192	Cavia porcellus	69.80	2.00e-63	232.00
IUUC-Cre-022822	Chlamydomonas reinhardtii	68.99	9.00e-53	196.00
IUUC-Csa-023430	Chlorocebus sabaeus	69.80	2.00e-63	232.00
IUUC-Cho-024773	Choloepus hoffmanni	53.69	3.00e-43	165.00
IUUC-Cin-025537	Ciona intestinalis	68.46	2.00e-52	195.00
IUUC-Csv-025846	Ciona savignyi	68.46	1.00e-55	206.00
IUUC-Cgl-026381	Colletotrichum gloeosporioides	77.33	4.00e-72	261.00
IUUC-Cne-026864	Cryptococcus neoformans	71.14	3.00e-65	238.00
IUUC-Cme-027284	Cyanidioschyzon merolae	58.00	2.00e-45	173.00
IUUC-Dre-028774	Danio rerio	69.80	2.00e-63	232.00
IUUC-Dno-029661	Dasypus novemcinctus	69.80	2.00e-63	232.00
IUUC-Dor-030452	Dipodomys ordii	66.42	6.00e-54	200.00
IUUC-Dse-031487	Dothistroma septosporum	76.00	1.00e-70	255.00
IUUC-Dme-031863	Drosophila melanogaster	69.13	8.00e-63	230.00
IUUC-Ete-032595	Echinops telfairi	68.46	3.00e-62	228.00
IUUC-Eca-033377	Equus caballus	69.80	2.00e-63	232.00
IUUC-Eeu-035191	Erinaceus europaeus	54.30	4.00e-43	164.00
IUUC-Fca-036336	Felis catus	69.80	2.00e-63	232.00
IUUC-Fal-037474	Ficedula albicollis	69.83	9.00e-49	182.00
IUUC-Fox-037808	Fusarium oxysporum	77.33	3.00e-72	261.00
IUUC-Fso-038232	Fusarium solani	78.00	1.00e-72	262.00
IUUC-Gmo-038517	Gadus morhua	69.80	2.00e-63	232.00
IUUC-Ggr-039875	Gaeumannomyces graminis	77.33	1.00e-71	259.00
IUUC-Gga-040494	Gallus gallus	69.80	2.00e-63	232.00
IUUC-Gac-041504	Gasterosteus aculeatus	69.80	4.00e-63	231.00
IUUC-Gma-043865	Glycine max	65.10	8.00e-61	223.00
IUUC-Ggo-044896	Gorilla gorilla	69.80	2.00e-63	232.00
IUUC-Hsa-046239	Homo sapiens	69.80	2.00e-63	232.00
IUUC-Hvu-047054	Hordeum vulgare	63.76	8.00e-60	220.00
IUUC-Itr-048960	Ictidomys tridecemlineatus	69.80	2.00e-63	232.00
IUUC-Kpa-049225	Komagataella pastoris	80.00	3.00e-75	271.00
IUUC-Lch-049964	Latimeria chalumnae	69.80	2.00e-63	232.00
IUUC-Lpe-051301	Leersia perrieri	65.10	4.00e-60	221.00
IUUC-Loc-051731	Lepisosteus oculatus	69.80	2.00e-63	232.00
IUUC-Laf-053380	Loxodonta africana	69.80	2.00e-63	232.00
IUUC-Mcc-054819	Macaca mulatta	69.80	1.00e-63	233.00
IUUC-Meu-056231	Macropus eugenii	69.80	2.00e-63	232.00
IUUC-Mor-057087	Magnaporthe oryzae	75.56	4.00e-63	231.00
IUUC-Mpo-057498	Magnaporthe poae	77.33	1.00e-71	259.00
IUUC-Mtr-058305	Medicago truncatula	65.10	2.00e-60	222.00
IUUC-Mla-058876	Melampsora laricipopulina	71.81	6.00e-60	220.00
IUUC-Mga-059863	Meleagris gallopavo	65.69	9.00e-55	203.00
IUUC-Mvi-060330	Microbotryum violaceum	73.15	6.00e-58	214.00
IUUC-Mmr-060630	Microcebus murinus	69.80	2.00e-63	232.00
IUUC-Mdo-062676	Monodelphis domestica	69.80	2.00e-63	232.00
IUUC-Mmu-063491	Mus musculus	69.80	2.00e-63	232.00
IUUC-Mac-064774	Musa acuminata	65.10	3.00e-60	221.00
IUUC-Mpu-065803	Mustela putorius furo	69.80	2.00e-63	232.00
IUUC-Mlu-067147	Myotis lucifugus	69.80	2.00e-63	232.00
IUUC-Nfi-068580	Neosartorya fischeri	76.67	4.00e-71	257.00
IUUC-Ncr-068913	Neurospora crassa	78.00	1.00e-71	259.00
IUUC-Nle-070105	Nomascus leucogenys	69.80	2.00e-63	232.00
IUUC-Opr-070935	Ochotona princeps	69.80	2.00e-63	232.00
IUUC-Ont-071716	Oreochromis niloticus	69.80	1.00e-63	233.00
IUUC-Oan-072706	Ornithorhynchus anatinus	63.70	7.00e-56	207.00
IUUC-Ocu-074130	Oryctolagus cuniculus	69.80	2.00e-63	232.00
IUUC-Oba-075896	Oryza barthii	65.10	5.00e-60	220.00
IUUC-Obr-076713	Oryza brachyantha	65.10	4.00e-60	221.00
IUUC-Ogl-077116	Oryza glaberrima	65.10	4.00e-60	221.00
IUUC-Ogu-078696	Oryza glumaepatula	65.10	4.00e-60	221.00
IUUC-Oin-079099	Oryza indica	65.10	4.00e-60	221.00
IUUC-Olo-081018	Oryza longistaminata	55.15	2.00e-50	189.00
IUUC-Ome-081285	Oryza meridionalis	65.10	4.00e-60	221.00
IUUC-Oni-082088	Oryza nivara	65.10	4.00e-60	221.00
IUUC-Opu-083310	Oryza punctata	65.10	4.00e-60	221.00
IUUC-Oru-084449	Oryza rufipogon	65.10	4.00e-60	221.00
IUUC-Osa-085923	Oryza sativa	65.10	4.00e-60	221.00
IUUC-Ola-087160	Oryzias latipes	69.80	9.00e-64	233.00
IUUC-Olu-087830	Ostreococcus lucimarinus	62.42	3.00e-49	185.00
IUUC-Oga-088836	Otolemur garnettii	69.80	2.00e-63	232.00
IUUC-Oar-090141	Ovis aries	69.80	2.00e-63	232.00
IUUC-Ptr-091453	Pan troglodytes	69.80	2.00e-63	232.00
IUUC-Pan-092511	Papio anubis	69.80	2.00e-63	232.00
IUUC-Psi-094094	Pelodiscus sinensis	69.80	2.00e-63	232.00
IUUC-Pma-094376	Petromyzon marinus	69.80	8.00e-63	230.00
IUUC-Pno-094935	Phaeosphaeria nodorum	74.67	3.00e-69	251.00
IUUC-Ppa-095689	Physcomitrella patens	63.09	1.00e-52	196.00
IUUC-Pfo-096784	Poecilia formosa	69.80	7.00e-64	233.00
IUUC-Pab-098121	Pongo abelii	69.80	2.00e-63	232.00
IUUC-Pop-099517	Populus trichocarpa	65.10	2.00e-60	222.00
IUUC-Pca-100906	Procavia capensis	65.10	2.00e-57	212.00
IUUC-Ppe-101594	Prunus persica	65.10	2.00e-60	222.00
IUUC-Pva-102380	Pteropus vampyrus	69.13	2.00e-61	225.00
IUUC-Pgr-103611	Puccinia graminis	71.81	3.00e-60	221.00
IUUC-Ptt-103971	Puccinia triticina	76.72	8.00e-47	176.00
IUUC-Pte-104378	Pyrenophora teres	75.33	9.00e-70	253.00
IUUC-Pyt-104757	Pyrenophora triticirepentis	75.33	9.00e-70	253.00
IUUC-Rno-105772	Rattus norvegicus	69.80	1.00e-63	233.00
IUUC-Sha-107650	Sarcophilus harrisii	69.13	4.00e-62	228.00
IUUC-Sja-107790	Schizosaccharomyces japonicus	76.67	7.00e-62	226.00
IUUC-Spo-108073	Schizosaccharomyces pombe	77.33	5.00e-62	227.00
IUUC-Ssl-108432	Sclerotinia sclerotiorum	76.67	5.00e-71	257.00
IUUC-Smo-109512	Selaginella moellendorffii	63.09	3.00e-59	218.00
IUUC-Sit-110731	Setaria italica	65.10	4.00e-60	221.00
IUUC-Sly-111506	Solanum lycopersicum	65.10	1.00e-60	223.00
IUUC-Stu-112080	Solanum tuberosum	65.10	1.00e-60	223.00
IUUC-Sar-113429	Sorex araneus	69.80	2.00e-63	232.00
IUUC-Sbi-114788	Sorghum bicolor	65.10	2.00e-60	222.00
IUUC-Sre-115106	Sporisorium reilianum	71.14	9.00e-59	217.00
IUUC-Ssc-116265	Sus scrofa	69.80	2.00e-63	232.00
IUUC-Tgu-117383	Taeniopygia guttata	69.80	2.00e-63	232.00
IUUC-Tru-118576	Takifugu rubripes	69.80	8.00e-64	233.00
IUUC-Tsy-119000	Tarsius syrichta	69.80	2.00e-63	232.00
IUUC-Tni-119745	Tetraodon nigroviridis	69.80	8.00e-64	233.00
IUUC-Tca-121827	Theobroma cacao	65.10	1.00e-60	223.00
IUUC-Tre-122002	Trichoderma reesei	76.67	5.00e-72	260.00
IUUC-Tvi-122331	Trichoderma virens	76.67	5.00e-72	260.00
IUUC-Tae-125400	Triticum aestivum	65.10	5.00e-60	221.00
IUUC-Tur-126866	Triticum urartu	63.76	3.00e-59	218.00
IUUC-Tme-127148	Tuber melanosporum	78.00	1.00e-71	259.00
IUUC-Tbe-127921	Tupaia belangeri	68.46	7.00e-60	220.00
IUUC-Ttr-129121	Tursiops truncatus	69.80	2.00e-63	232.00
IUUC-Uma-129561	Ustilago maydis	71.14	5.00e-59	218.00
IUUC-Vda-129711	Verticillium dahliae	77.33	4.00e-72	261.00
IUUC-Vpa-130570	Vicugna pacos	61.94	9.00e-49	183.00
IUUC-Vvi-131108	Vitis vinifera	65.77	5.00e-61	224.00
IUUC-Xtr-131824	Xenopus tropicalis	69.80	9.00e-64	233.00
IUUC-Xma-133667	Xiphophorus maculatus	69.80	9.00e-64	233.00
IUUC-Yli-134660	Yarrowia lipolytica	75.17	2.00e-70	255.00
IUUC-Zma-135584	Zea mays	65.10	3.00e-60	221.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence