iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-026963

Ensembl Protein ID

AAW44827

UniProt Accession

Q5KDC2; Q55Q45; Q5KDC2_CRYNJ

Genbank Protein ID

AAW44827.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 6, putative

Genbank Nucleotide ID

AE017347

Gene Name

CNG04540

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CNG04540	AAW44827	AAW44827

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-52	177.1	105	481

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs......gyeqqDaqEf 95
           tGl NlgNtCY+NS+LQ++ ++pe+ ++l+e ++++ + +  + p+ ++++sl++lf  + +++ +av p e+++ l+ +a++f        y+qqDa E 
   Q: 105  TGLINLGNTCYLNSTLQAIRAMPEVHQALKEFTPSSSSSS--SLPEFRVTNSLKNLFVTI-DNTPNAVPPLEVISNLRILAPQFAerdqrgHYAQQDADEA 202
           7******************************555555544..789************999.***********************99999999********* PP
   S: 96   laflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvs..sreepfldlslpvpgkeetkkeslqdcLesf 194
           +++l+++l+ +l                          k+  + s++++l+ ++l++++k  e +++   +++e+ l+l+++++g ++  ++ +qd L++ 
   Q: 203  WTQLVQALRAAL-------------------------PKNGDEGSVVDRLMSIELTKTLKNAETEEEPetTSTETVLKLECNISGTTNFLMSGIQDNLNQQ 278
           ************.........................4566778****************98877765337889999************999******887 PP
   S: 195  tkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..................... 274
           +++ + +           ++ + + + ++++lPe+L++h+ Rf ++++ +++ ki +kv+fpleLdls  +t+p +k+ +                     
   Q: 279  VEKTSAT---------LGRNATYSMQSRVSRLPEYLVVHMVRFYWRRDIQKKAKIMRKVKFPLELDLSDIVTEPLRKKIQplntatkqilkerdaranilk 370
           7766654.........455556677889*********************************************5555555566666666666666666666 PP
   S: 275  ...................................kkkYeLiavvvHsG.slssGHYvayvkn........ekgkWllfdDskVtevkeeevleetg.... 327
                                              +  YeL avv H+G s++sGHY+ + +         e+++W +fdD++Vt ++ +++l++ g    
   Q: 371  rkpgqgldeeekkrgeekamveelvkeggltsgegSGMYELAAVVTHKGaSADSGHYIGWSRVdngacvpaEQQRWAKFDDNNVTFTDANKILSMDGgged 471
           77777777777777888899999999999999999*************************999666666655666*******************999**** PP
   S: 328  staYvlfYkr 337
           s aY+l+Y+ 
   Q: 472  SVAYILLYRA 481
           ********85 PP

Organism

Cryptococcus neoformans

Protein Sequence
(Fasta)

MPKSQNMELS VKHSGKTYTV PVTQETTTQA FKDAISQLTR VPTERMKVMV KGKLVKDDTD 60
YVALANQKQS VMVIGAAEAL PPPPTQQIVF LEDVGDEGIK SDEPTGLINL GNTCYLNSTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCATACCGA TGCCCAAATC TCAAAATATG GAACGTGAGT ACCTGGATCA GGATGGTAGT 60
AAGGTAATGC TGACACGTAG ATGCGTAGTC AGCGTAAAAC ATTCTGGCAA GACGTACACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00240--ubiquitin
PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005838--C:proteasome regulatory particle
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cne:CNG04540

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	29.59	6.00e-26	110.00
IUUC-Aml-002053	Ailuropoda melanoleuca	34.18	1.00e-72	265.00
IUUC-Atr-002725	Amborella trichopoda	36.05	1.00e-69	255.00
IUUC-Apl-004031	Anas platyrhynchos	34.87	1.00e-73	268.00
IUUC-Aca-004361	Anolis carolinensis	34.73	2.00e-76	278.00
IUUC-Aly-006078	Arabidopsis lyrata	36.27	6.00e-76	276.00
IUUC-Ath-007623	Arabidopsis thaliana	36.48	2.00e-76	277.00
IUUC-Ago-007796	Ashbya gossypii	32.47	2.00e-68	251.00
IUUC-Acl-008258	Aspergillus clavatus	40.21	2.00e-64	238.00
IUUC-Afl-008732	Aspergillus flavus	35.78	1.00e-77	281.00
IUUC-Afu-008755	Aspergillus fumigatus	36.17	5.00e-77	280.00
IUUC-Ani-009148	Aspergillus nidulans	39.64	6.00e-68	249.00
IUUC-Ang-009878	Aspergillus niger	40.26	2.00e-66	244.00
IUUC-Aor-010239	Aspergillus oryzae	35.78	1.00e-77	281.00
IUUC-Ate-010243	Aspergillus terreus	35.33	4.00e-71	260.00
IUUC-Ame-011327	Astyanax mexicanus	43.24	4.00e-15	73.90
IUUC-Bgr-012231	Blumeria graminis	38.83	4.00e-65	240.00
IUUC-Bta-012553	Bos taurus	34.89	1.00e-72	265.00
IUUC-Bci-013606	Botrytis cinerea	38.50	7.00e-67	246.00
IUUC-Bdi-014567	Brachypodium distachyon	37.45	6.00e-78	282.00
IUUC-Bol-016127	Brassica oleracea	36.62	3.00e-75	273.00
IUUC-Bra-017501	Brassica rapa	36.62	1.00e-75	274.00
IUUC-Cel-018140	Caenorhabditis elegans	28.86	7.00e-52	196.00
IUUC-Cja-019516	Callithrix jacchus	33.83	1.00e-72	265.00
IUUC-Cfa-020808	Canis familiaris	34.18	3.00e-73	267.00
IUUC-Cpo-021688	Cavia porcellus	35.46	3.00e-73	266.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	31.74	1.00e-50	191.00
IUUC-Csa-023429	Chlorocebus sabaeus	34.68	1.00e-72	265.00
IUUC-Cho-024347	Choloepus hoffmanni	33.62	1.00e-72	265.00
IUUC-Cin-025198	Ciona intestinalis	31.25	5.00e-55	206.00
IUUC-Csv-026007	Ciona savignyi	33.06	2.00e-62	231.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	40.95	6.00e-64	236.00
IUUC-Cme-027240	Cyanidioschyzon merolae	29.32	5.00e-46	176.00
IUUC-Dre-027647	Danio rerio	34.77	7.00e-73	265.00
IUUC-Dno-029967	Dasypus novemcinctus	33.83	4.00e-72	263.00
IUUC-Dor-030886	Dipodomys ordii	30.89	8.00e-56	209.00
IUUC-Dse-031466	Dothistroma septosporum	37.63	9.00e-59	219.00
IUUC-Dme-032079	Drosophila melanogaster	31.89	2.00e-64	238.00
IUUC-Ete-032351	Echinops telfairi	32.02	2.00e-65	240.00
IUUC-Eca-033461	Equus caballus	33.62	2.00e-74	270.00
IUUC-Eeu-035220	Erinaceus europaeus	29.14	6.00e-37	146.00
IUUC-Fca-036210	Felis catus	33.83	4.00e-73	266.00
IUUC-Fal-037528	Ficedula albicollis	34.66	3.00e-73	267.00
IUUC-Fox-037805	Fusarium oxysporum	39.72	6.00e-68	249.00
IUUC-Fso-038177	Fusarium solani	41.48	7.00e-68	249.00
IUUC-Gmo-038953	Gadus morhua	32.99	6.00e-69	253.00
IUUC-Ggr-039972	Gaeumannomyces graminis	35.79	2.00e-60	224.00
IUUC-Gga-040462	Gallus gallus	33.89	8.00e-72	262.00
IUUC-Gac-041312	Gasterosteus aculeatus	34.44	2.00e-72	264.00
IUUC-Gma-043255	Glycine max	36.25	1.00e-75	275.00
IUUC-Ggo-045458	Gorilla gorilla	31.79	3.00e-55	207.00
IUUC-Hsa-045706	Homo sapiens	34.68	2.00e-72	264.00
IUUC-Hvu-047821	Hordeum vulgare	37.98	6.00e-31	125.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	34.47	3.00e-73	267.00
IUUC-Lch-050464	Latimeria chalumnae	35.47	3.00e-74	270.00
IUUC-Lpe-051419	Leersia perrieri	36.23	1.00e-72	265.00
IUUC-Loc-052732	Lepisosteus oculatus	33.76	5.00e-73	266.00
IUUC-Lma-053177	Leptosphaeria maculans	38.98	1.00e-64	239.00
IUUC-Laf-053822	Loxodonta africana	33.83	6.00e-73	266.00
IUUC-Mcc-055893	Macaca mulatta	34.68	2.00e-72	264.00
IUUC-Meu-056307	Macropus eugenii	32.91	7.00e-67	246.00
IUUC-Mor-057171	Magnaporthe oryzae	38.92	8.00e-67	246.00
IUUC-Mpo-057415	Magnaporthe poae	38.42	5.00e-64	236.00
IUUC-Mtr-057901	Medicago truncatula	36.73	7.00e-76	276.00
IUUC-Mla-058897	Melampsora laricipopulina	45.13	9.00e-77	279.00
IUUC-Mga-060016	Meleagris gallopavo	34.32	1.00e-72	265.00
IUUC-Mvi-060562	Microbotryum violaceum	44.94	1.00e-74	271.00
IUUC-Mmr-060624	Microcebus murinus	35.01	5.00e-75	273.00
IUUC-Mdo-061809	Monodelphis domestica	34.11	2.00e-72	264.00
IUUC-Mmu-063869	Mus musculus	34.47	4.00e-72	263.00
IUUC-Mac-064876	Musa acuminata	33.54	4.00e-64	236.00
IUUC-Mpu-066480	Mustela putorius furo	34.18	2.00e-73	268.00
IUUC-Mlu-067866	Myotis lucifugus	33.40	2.00e-72	264.00
IUUC-Nfi-068393	Neosartorya fischeri	34.75	1.00e-72	265.00
IUUC-Ncr-068815	Neurospora crassa	40.48	7.00e-71	259.00
IUUC-Nle-070121	Nomascus leucogenys	39.04	6.00e-36	142.00
IUUC-Opr-070712	Ochotona princeps	31.12	2.00e-41	161.00
IUUC-Ont-071544	Oreochromis niloticus	33.89	2.00e-66	244.00
IUUC-Oan-073635	Ornithorhynchus anatinus	33.79	2.00e-66	244.00
IUUC-Ocu-074926	Oryctolagus cuniculus	34.54	6.00e-72	263.00
IUUC-Oba-075633	Oryza barthii	36.40	2.00e-71	260.00
IUUC-Obr-076423	Oryza brachyantha	36.68	5.00e-74	269.00
IUUC-Ogl-077913	Oryza glaberrima	35.77	1.00e-75	275.00
IUUC-Ogu-078435	Oryza glumaepatula	36.40	2.00e-71	260.00
IUUC-Oin-080072	Oryza indica	36.40	2.00e-71	260.00
IUUC-Olo-080535	Oryza longistaminata	33.20	1.00e-58	218.00
IUUC-Ome-081309	Oryza meridionalis	36.40	2.00e-71	260.00
IUUC-Oni-083113	Oryza nivara	36.40	2.00e-71	260.00
IUUC-Opu-083168	Oryza punctata	35.66	9.00e-68	248.00
IUUC-Oru-084253	Oryza rufipogon	36.40	2.00e-71	260.00
IUUC-Osa-085554	Oryza sativa	35.77	1.00e-75	275.00
IUUC-Ola-086998	Oryzias latipes	32.92	3.00e-68	250.00
IUUC-Olu-087818	Ostreococcus lucimarinus	33.13	5.00e-62	229.00
IUUC-Oga-088571	Otolemur garnettii	35.39	3.00e-74	270.00
IUUC-Oar-089526	Ovis aries	33.83	1.00e-72	265.00
IUUC-Ptr-091433	Pan troglodytes	34.68	2.00e-72	264.00
IUUC-Pan-091966	Papio anubis	34.68	1.00e-72	265.00
IUUC-Psi-093458	Pelodiscus sinensis	34.68	4.00e-76	276.00
IUUC-Pma-094343	Petromyzon marinus	34.98	3.00e-36	143.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.52	4.00e-63	234.00
IUUC-Ppa-095756	Physcomitrella patens	36.55	2.00e-78	284.00
IUUC-Pfo-096514	Poecilia formosa	34.30	5.00e-67	246.00
IUUC-Pab-098477	Pongo abelii	32.42	3.00e-56	210.00
IUUC-Pop-099221	Populus trichocarpa	34.82	3.00e-69	253.00
IUUC-Pca-100791	Procavia capensis	28.18	5.00e-46	176.00
IUUC-Ppe-101812	Prunus persica	35.17	4.00e-69	253.00
IUUC-Pva-102462	Pteropus vampyrus	32.95	2.00e-66	244.00
IUUC-Pgr-103623	Puccinia graminis	46.53	8.00e-76	275.00
IUUC-Ptt-103767	Puccinia triticina	46.73	4.00e-75	273.00
IUUC-Pte-104109	Pyrenophora teres	39.15	6.00e-63	233.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	39.26	1.00e-62	232.00
IUUC-Rno-105351	Rattus norvegicus	34.04	3.00e-70	256.00
IUUC-Sce-106168	Saccharomyces cerevisiae	32.81	9.00e-67	245.00
IUUC-Sha-107491	Sarcophilus harrisii	34.32	4.00e-72	263.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	36.66	5.00e-76	276.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.42	1.00e-68	251.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	39.51	4.00e-66	243.00
IUUC-Smo-109276	Selaginella moellendorffii	36.85	1.00e-80	291.00
IUUC-Sit-110361	Setaria italica	36.08	5.00e-78	283.00
IUUC-Sly-110965	Solanum lycopersicum	34.96	6.00e-74	269.00
IUUC-Sar-113355	Sorex araneus	35.39	3.00e-52	197.00
IUUC-Sbi-114778	Sorghum bicolor	37.91	2.00e-79	287.00
IUUC-Sre-115011	Sporisorium reilianum	44.72	1.00e-77	282.00
IUUC-Ssc-116273	Sus scrofa	34.24	2.00e-71	261.00
IUUC-Tgu-117063	Taeniopygia guttata	34.45	4.00e-73	266.00
IUUC-Tru-118381	Takifugu rubripes	34.09	1.00e-68	251.00
IUUC-Tsy-119076	Tarsius syrichta	29.52	1.00e-26	112.00
IUUC-Tni-119941	Tetraodon nigroviridis	34.62	5.00e-68	249.00
IUUC-Tca-121246	Theobroma cacao	36.17	8.00e-75	272.00
IUUC-Tre-121969	Trichoderma reesei	38.26	6.00e-61	226.00
IUUC-Tvi-122543	Trichoderma virens	37.66	8.00e-67	246.00
IUUC-Tae-125484	Triticum aestivum	36.85	2.00e-76	277.00
IUUC-Tur-126128	Triticum urartu	29.69	8.00e-29	119.00
IUUC-Tbe-128030	Tupaia belangeri	29.16	1.00e-53	202.00
IUUC-Ttr-128701	Tursiops truncatus	33.26	2.00e-63	234.00
IUUC-Uma-129657	Ustilago maydis	38.20	5.00e-81	293.00
IUUC-Vda-129723	Verticillium dahliae	38.64	5.00e-64	236.00
IUUC-Vpa-130284	Vicugna pacos	23.82	4.00e-24	103.00
IUUC-Vvi-131037	Vitis vinifera	36.57	4.00e-78	283.00
IUUC-Xtr-132235	Xenopus tropicalis	35.79	8.00e-76	275.00
IUUC-Xma-133840	Xiphophorus maculatus	34.10	4.00e-71	259.00
IUUC-Yli-134453	Yarrowia lipolytica	39.07	8.00e-78	282.00
IUUC-Zma-135669	Zea mays	29.94	2.00e-56	211.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence