iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007639

UUCD1 version

UUC-ArT-01598

Ensembl Protein ID

AT1G78870.2

UniProt Accession

Q94A97; Q2V4C1; Q9ZVA6; UBC35_ARATH

Genbank Protein ID

AAY44874.1; AAC83026.1; AEE36164.1; AEE36165.1; AEE36166.1; AAK83603.1; AAN18113.1; AAM63067.1

Protein Name

Ubiquitin-conjugating enzyme E2 35; E2 ubiquitin-conjugating enzyme 35; Ubiquitin carrier protein 35

Genbank Nucleotide ID

DQ027048; AC005679; CP002684; CP002684; CP002684; AY049261; BT000544; AY085854

Gene Name

UBC35; UBC13A; UBG13A; At1g78870; F9K20.8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G78870	AT1G78870.1	AT1G78870.1
AT1G78870	AT1G78870.2	AT1G78870.2
AT1G78870	AT1G78870.3	AT1G78870.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20435904; 16339806

Classification

Family	E-value	Score	Start	End
E2/UBC	1.80e-48	164.7	9	141

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           R+ ke+++l ++p +gisa+p+++ ++  ++v+ilGp+++pYeggvFkle+ +pe+YP+ +Pkv+fltki+hPn+++ G++Cl+ilk  +kWspal++
   Q: 9    RIIKETQRLLSEPAPGISASPSED-NMRYFNVMILGPTQSPYEGGVFKLELFLPEEYPMAAPKVRFLTKIYHPNIDKLGRICLDILK--DKWSPALQI 103
           899*********************.9************************************************************9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkk 136
           ++vllsiq+ll+ pnp++pl e++a+++k+n++e   +
   Q: 104  RTVLLSIQALLSAPNPDDPLSENIAKHWKSNEAEAVDT 141
           *******************************9876555 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Required for postreplication repair of UV-damaged DNA and for adapting root developmental programs to suboptimal availability of iron.

Protein Sequence
(Fasta)

MANSNLPRRI IKETQRLLSE PAPGISASPS EDNMRYFNVM ILGPTQSPYE GGVFKLELFL 60
PEEYPMAAPK VRFLTKIYHP NIDKLGRICL DILKDKWSPA LQIRTVLLSI QALLSAPNPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGCAATAAA CAAAGGTTGC GGGAAAATAC GTAAAATAAA AGCTAATATA TTATTTGATT 60
CGTCCAGAGT TGAATTTTAA AGATAGAGAA AGGAAATCGA ATTAAAATCT TCGTCAGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
GO:0046686--P:response to cadmium ion
GO:0010039--P:response to iron ion
GO:0010053--P:root epidermal cell differentiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT1G78870

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000100	Aegilops tauschii	92.81	6.00e-83	298.00
IUUC-Aml-001889	Ailuropoda melanoleuca	78.01	3.00e-66	243.00
IUUC-Atr-002818	Amborella trichopoda	96.71	1.00e-85	306.00
IUUC-Apl-003469	Anas platyrhynchos	78.17	1.00e-67	247.00
IUUC-Aca-005051	Anolis carolinensis	79.59	4.00e-70	255.00
IUUC-Aly-006258	Arabidopsis lyrata	99.35	2.00e-87	313.00
IUUC-Ago-007837	Ashbya gossypii	72.97	1.00e-54	204.00
IUUC-Acl-008263	Aspergillus clavatus	72.41	7.00e-65	238.00
IUUC-Afl-008733	Aspergillus flavus	71.72	2.00e-64	236.00
IUUC-Afu-008946	Aspergillus fumigatus	72.41	7.00e-65	238.00
IUUC-Ani-009482	Aspergillus nidulans	71.43	5.00e-64	235.00
IUUC-Ang-009678	Aspergillus niger	73.10	8.00e-65	238.00
IUUC-Aor-010025	Aspergillus oryzae	71.72	2.00e-64	236.00
IUUC-Ate-010254	Aspergillus terreus	71.23	2.00e-64	237.00
IUUC-Ame-010742	Astyanax mexicanus	79.05	5.00e-70	255.00
IUUC-Bgr-012156	Blumeria graminis	68.92	2.00e-57	213.00
IUUC-Bta-012636	Bos taurus	79.59	4.00e-70	255.00
IUUC-Bci-013761	Botrytis cinerea	73.10	5.00e-64	235.00
IUUC-Bdi-014796	Brachypodium distachyon	96.73	3.00e-86	309.00
IUUC-Bol-016613	Brassica oleracea	98.69	5.00e-87	311.00
IUUC-Bra-016938	Brassica rapa	98.69	5.00e-87	311.00
IUUC-Cel-018119	Caenorhabditis elegans	79.19	2.00e-69	253.00
IUUC-Cja-019108	Callithrix jacchus	79.59	4.00e-70	255.00
IUUC-Cfa-021195	Canis familiaris	79.59	2.00e-69	253.00
IUUC-Cpo-022280	Cavia porcellus	76.19	6.00e-67	245.00
IUUC-Cre-022978	Chlamydomonas reinhardtii	85.91	5.00e-76	275.00
IUUC-Csa-023860	Chlorocebus sabaeus	72.79	4.00e-63	232.00
IUUC-Cho-024459	Choloepus hoffmanni	79.59	4.00e-70	255.00
IUUC-Cin-025278	Ciona intestinalis	79.45	3.00e-69	253.00
IUUC-Csv-025952	Ciona savignyi	70.95	2.00e-58	216.00
IUUC-Cgl-026752	Colletotrichum gloeosporioides	73.79	7.00e-65	238.00
IUUC-Cme-027100	Cyanidioschyzon merolae	64.86	3.00e-56	209.00
IUUC-Dre-027931	Danio rerio	79.73	2.00e-70	256.00
IUUC-Dno-030059	Dasypus novemcinctus	78.23	1.00e-68	251.00
IUUC-Dor-030269	Dipodomys ordii	79.84	3.00e-61	226.00
IUUC-Dse-031505	Dothistroma septosporum	69.18	1.00e-61	228.00
IUUC-Dme-032097	Drosophila melanogaster	76.19	3.00e-67	246.00
IUUC-Ete-032369	Echinops telfairi	79.59	4.00e-70	255.00
IUUC-Eca-033230	Equus caballus	79.59	4.00e-70	255.00
IUUC-Fca-036161	Felis catus	77.55	1.00e-67	247.00
IUUC-Fal-036781	Ficedula albicollis	76.87	9.00e-68	248.00
IUUC-Fox-037840	Fusarium oxysporum	73.79	2.00e-64	237.00
IUUC-Fso-038118	Fusarium solani	73.29	1.00e-64	237.00
IUUC-Gmo-039561	Gadus morhua	78.23	5.00e-69	252.00
IUUC-Ggr-039807	Gaeumannomyces graminis	73.79	3.00e-65	239.00
IUUC-Gga-041024	Gallus gallus	79.59	4.00e-70	255.00
IUUC-Gac-042450	Gasterosteus aculeatus	78.38	2.00e-68	250.00
IUUC-Gma-043982	Glycine max	99.35	2.00e-87	313.00
IUUC-Ggo-044660	Gorilla gorilla	78.91	2.00e-69	253.00
IUUC-Hsa-045881	Homo sapiens	79.59	4.00e-70	255.00
IUUC-Hvu-047346	Hordeum vulgare	98.04	2.00e-86	310.00
IUUC-Itr-048096	Ictidomys tridecemlineatus	72.79	4.00e-62	229.00
IUUC-Kpa-049285	Komagataella pastoris	72.97	1.00e-65	241.00
IUUC-Lch-050548	Latimeria chalumnae	79.14	3.00e-66	243.00
IUUC-Lpe-051394	Leersia perrieri	96.73	1.00e-85	307.00
IUUC-Loc-052205	Lepisosteus oculatus	79.05	4.00e-70	256.00
IUUC-Lma-053056	Leptosphaeria maculans	72.60	1.00e-64	237.00
IUUC-Laf-053540	Loxodonta africana	79.71	6.00e-66	241.00
IUUC-Mcc-054863	Macaca mulatta	79.59	4.00e-70	255.00
IUUC-Meu-056482	Macropus eugenii	79.71	6.00e-66	241.00
IUUC-Mor-057014	Magnaporthe oryzae	71.23	9.00e-64	234.00
IUUC-Mpo-057586	Magnaporthe poae	73.79	4.00e-65	239.00
IUUC-Mtr-058552	Medicago truncatula	89.82	2.00e-83	300.00
IUUC-Mla-058920	Melampsora laricipopulina	69.80	6.00e-63	231.00
IUUC-Mga-059649	Meleagris gallopavo	76.71	7.00e-67	244.00
IUUC-Mvi-060483	Microbotryum violaceum	74.34	1.00e-67	248.00
IUUC-Mmr-061167	Microcebus murinus	79.59	4.00e-70	255.00
IUUC-Mdo-062701	Monodelphis domestica	79.59	4.00e-70	255.00
IUUC-Mmu-064070	Mus musculus	79.59	4.00e-70	255.00
IUUC-Mac-064742	Musa acuminata	97.39	2.00e-86	309.00
IUUC-Mpu-066401	Mustela putorius furo	79.59	4.00e-70	255.00
IUUC-Mlu-067229	Myotis lucifugus	79.02	3.00e-67	246.00
IUUC-Nfi-068526	Neosartorya fischeri	72.41	8.00e-65	238.00
IUUC-Ncr-068643	Neurospora crassa	74.48	6.00e-65	238.00
IUUC-Nle-070146	Nomascus leucogenys	79.59	4.00e-70	255.00
IUUC-Ont-072369	Oreochromis niloticus	79.05	1.00e-69	254.00
IUUC-Oan-073174	Ornithorhynchus anatinus	78.47	2.00e-67	246.00
IUUC-Ocu-074712	Oryctolagus cuniculus	79.59	4.00e-70	255.00
IUUC-Oba-075408	Oryza barthii	96.73	1.00e-85	307.00
IUUC-Obr-076881	Oryza brachyantha	96.73	1.00e-85	307.00
IUUC-Ogl-077242	Oryza glaberrima	96.73	1.00e-85	307.00
IUUC-Ogu-078465	Oryza glumaepatula	96.73	1.00e-85	307.00
IUUC-Oin-080035	Oryza indica	96.45	1.00e-78	283.00
IUUC-Olo-080555	Oryza longistaminata	96.73	1.00e-85	307.00
IUUC-Ome-081653	Oryza meridionalis	96.73	1.00e-85	307.00
IUUC-Oni-082400	Oryza nivara	96.73	1.00e-85	307.00
IUUC-Opu-083130	Oryza punctata	95.77	7.00e-78	282.00
IUUC-Oru-084649	Oryza rufipogon	96.73	1.00e-85	307.00
IUUC-Osa-085629	Oryza sativa	96.73	1.00e-85	307.00
IUUC-Ola-087083	Oryzias latipes	81.08	9.00e-71	258.00
IUUC-Olu-087886	Ostreococcus lucimarinus	68.71	2.00e-59	220.00
IUUC-Oga-088983	Otolemur garnettii	75.51	1.00e-66	244.00
IUUC-Oar-090440	Ovis aries	78.91	2.00e-69	253.00
IUUC-Ptr-090572	Pan troglodytes	79.59	4.00e-70	255.00
IUUC-Pan-092503	Papio anubis	77.55	2.00e-68	249.00
IUUC-Psi-093419	Pelodiscus sinensis	78.79	2.00e-62	230.00
IUUC-Pno-094838	Phaeosphaeria nodorum	71.81	1.00e-64	238.00
IUUC-Ppa-096014	Physcomitrella patens	94.08	6.00e-84	301.00
IUUC-Pfo-096074	Poecilia formosa	81.08	9.00e-71	258.00
IUUC-Pab-097778	Pongo abelii	79.59	4.00e-70	255.00
IUUC-Pop-099707	Populus trichocarpa	98.04	1.00e-86	310.00
IUUC-Pca-100334	Procavia capensis	66.67	7.00e-58	215.00
IUUC-Ppe-101149	Prunus persica	98.69	5.00e-87	311.00
IUUC-Pva-102979	Pteropus vampyrus	79.59	4.00e-70	255.00
IUUC-Pgr-103654	Puccinia graminis	72.11	9.00e-63	231.00
IUUC-Ptt-103752	Puccinia triticina	70.14	7.00e-60	221.00
IUUC-Pte-104137	Pyrenophora teres	73.29	2.00e-64	237.00
IUUC-Pyt-104513	Pyrenophora triticirepentis	73.29	2.00e-64	237.00
IUUC-Rno-105927	Rattus norvegicus	80.27	2.00e-70	256.00
IUUC-Sce-106178	Saccharomyces cerevisiae	68.71	9.00e-61	224.00
IUUC-Sha-107493	Sarcophilus harrisii	79.59	4.00e-70	255.00
IUUC-Sja-107878	Schizosaccharomyces japonicus	67.57	2.00e-58	217.00
IUUC-Spo-108062	Schizosaccharomyces pombe	68.28	7.00e-58	214.00
IUUC-Ssl-108395	Sclerotinia sclerotiorum	74.48	4.00e-64	236.00
IUUC-Smo-109587	Selaginella moellendorffii	84.77	9.00e-75	271.00
IUUC-Sit-110151	Setaria italica	97.39	1.00e-85	308.00
IUUC-Sly-110863	Solanum lycopersicum	98.69	5.00e-87	311.00
IUUC-Stu-112722	Solanum tuberosum	98.04	2.00e-86	310.00
IUUC-Sar-113464	Sorex araneus	79.71	6.00e-66	241.00
IUUC-Sbi-114278	Sorghum bicolor	96.08	4.00e-85	305.00
IUUC-Sre-114927	Sporisorium reilianum	76.71	2.00e-68	249.00
IUUC-Ssc-116096	Sus scrofa	79.59	4.00e-70	255.00
IUUC-Tgu-117266	Taeniopygia guttata	79.71	6.00e-66	241.00
IUUC-Tru-117903	Takifugu rubripes	77.70	2.00e-69	253.00
IUUC-Tsy-118952	Tarsius syrichta	79.71	6.00e-66	241.00
IUUC-Tni-120038	Tetraodon nigroviridis	77.70	2.00e-69	253.00
IUUC-Tca-121752	Theobroma cacao	96.53	1.00e-79	288.00
IUUC-Tre-121979	Trichoderma reesei	73.10	3.00e-64	236.00
IUUC-Tvi-122515	Trichoderma virens	71.43	1.00e-63	234.00
IUUC-Tae-125309	Triticum aestivum	98.04	2.00e-86	310.00
IUUC-Tur-126687	Triticum urartu	93.75	5.00e-78	281.00
IUUC-Tme-127129	Tuber melanosporum	73.10	1.00e-64	237.00
IUUC-Tbe-127846	Tupaia belangeri	79.71	6.00e-66	241.00
IUUC-Ttr-128808	Tursiops truncatus	78.77	1.00e-67	248.00
IUUC-Uma-129548	Ustilago maydis	76.03	4.00e-68	249.00
IUUC-Vda-129810	Verticillium dahliae	71.62	6.00e-65	238.00
IUUC-Vpa-130221	Vicugna pacos	71.01	2.00e-55	206.00
IUUC-Vvi-131416	Vitis vinifera	82.07	3.00e-82	296.00
IUUC-Xtr-132366	Xenopus tropicalis	77.85	3.00e-68	249.00
IUUC-Xma-132986	Xiphophorus maculatus	80.41	3.00e-70	256.00
IUUC-Yli-134605	Yarrowia lipolytica	71.43	2.00e-63	233.00
IUUC-Zma-135587	Zea mays	93.08	2.00e-83	300.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence