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Tag Content
iUUCD ID IUUC-Aor-009972
Ensembl Protein ID BAE61910
UniProt Accession Q2U955; NACA_ASPOR
Genbank Protein ID BAE61910.1
Protein Name Nascent polypeptide-associated complex subunit alpha; Alpha-NAC
Genbank Nucleotide ID AP007164
Gene Name egd2; AO090701000167
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AO090701000167 BAE61910 BAE61910
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 51.39 6.00e-18 85.50 IUUC-Sce-106371
UBD/Alpha-Helix/UBA 46.43 2.00e-29 123.00 IUUC-Spo-108121
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Aspergillus oryzae
Functional Description
(View)

Functional Description



     Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. Egd2 may also be involved in transcription regulation (By similarity).
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. Egd2 may also be involved in transcription regulation (By similarity).
Protein Sequence
(Fasta)
MADPRVEEIV EEETPKQTVE DAGSDSESEA GEANIPAGAA VTIHSRNEKK ARKAIGKLGL 60
KHVPGITRVT LRRPKNILFV INQPDVYRSP SSNTWIIFGE AKIEDLNSQA QASAAQQLAA 120
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Protein Fasta Sequence



>IUUC-Aor-009972|UBD,UBA|Aspergillus oryzae
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Nucleotide Sequence
(Fasta)
ATGGCCGACC CCCGTGTTGA AGAAATCGTT GAGGAGGAGA CTCCCAAGCA GACCGTTGAG 60
GATGCTGGCA GCGACTCCGA GTCTGAGGCT GGCGAGGCCA ACATTCCCGC CGGTGCTGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Aor-009972|UBD,UBA|Aspergillus oryzae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR016641--EGD2/NACA
IPR002715--Nas_poly-pep-assoc_cplx_dom

PROSITE

PS51151--NAC_AB

Pfam

PF01849--NAC

SMART

SM01407--NAC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0015031--P:protein transport

KEGG aor:AOR_1_312114
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001167 Aegilops tauschii 48.65 3.00e-25 106.00
IUUC-Aml-002185 Ailuropoda melanoleuca 62.50 9.00e-22 97.80
IUUC-Atr-002586 Amborella trichopoda 40.85 1.00e-19 87.40
IUUC-Apl-003190 Anas platyrhynchos 62.12 1.00e-21 93.60
IUUC-Aca-005265 Anolis carolinensis 50.94 1.00e-31 127.00
IUUC-Aly-006488 Arabidopsis lyrata 49.32 2.00e-24 103.00
IUUC-Ath-007378 Arabidopsis thaliana 61.54 1.00e-16 77.80
IUUC-Ago-007936 Ashbya gossypii 47.90 3.00e-29 119.00
IUUC-Acl-008036 Aspergillus clavatus 89.52 2.00e-42 163.00
IUUC-Afl-008462 Aspergillus flavus 100.00 1.00e-77 280.00
IUUC-Afu-008832 Aspergillus fumigatus 86.67 8.00e-39 151.00
IUUC-Ani-009246 Aspergillus nidulans 82.27 7.00e-57 211.00
IUUC-Ang-009808 Aspergillus niger 88.57 1.00e-42 163.00
IUUC-Ame-011674 Astyanax mexicanus 70.31 2.00e-25 106.00
IUUC-Bgr-012162 Blumeria graminis 60.91 5.00e-32 129.00
IUUC-Bta-012508 Bos taurus 70.31 2.00e-25 106.00
IUUC-Bci-013643 Botrytis cinerea 62.28 7.00e-33 131.00
IUUC-Bdi-014874 Brachypodium distachyon 61.54 1.00e-17 81.30
IUUC-Bol-015132 Brassica oleracea 46.10 2.00e-26 110.00
IUUC-Bra-017540 Brassica rapa 48.68 2.00e-24 103.00
IUUC-Cel-018111 Caenorhabditis elegans 51.25 2.00e-33 133.00
IUUC-Cja-019846 Callithrix jacchus 41.84 5.00e-29 122.00
IUUC-Cfa-020429 Canis familiaris 70.31 2.00e-25 107.00
IUUC-Cpo-022542 Cavia porcellus 70.31 3.00e-25 106.00
IUUC-Cre-022679 Chlamydomonas reinhardtii 50.31 9.00e-33 130.00
IUUC-Csa-023260 Chlorocebus sabaeus 51.57 8.00e-29 121.00
IUUC-Cho-024869 Choloepus hoffmanni 72.97 9.00e-11 58.20
IUUC-Cin-025166 Ciona intestinalis 52.83 9.00e-33 130.00
IUUC-Csv-026284 Ciona savignyi 49.32 7.00e-26 107.00
IUUC-Cgl-026520 Colletotrichum gloeosporioides 62.16 3.00e-32 129.00
IUUC-Cne-026920 Cryptococcus neoformans 61.54 2.00e-25 106.00
IUUC-Cme-027301 Cyanidioschyzon merolae 58.33 1.00e-19 87.80
IUUC-Dre-028709 Danio rerio 70.31 7.00e-25 107.00
IUUC-Dno-029367 Dasypus novemcinctus 48.43 8.00e-29 121.00
IUUC-Dor-030962 Dipodomys ordii 70.31 3.00e-25 106.00
IUUC-Dme-032061 Drosophila melanogaster 67.19 9.00e-23 98.20
IUUC-Ete-032965 Echinops telfairi 53.29 2.00e-33 133.00
IUUC-Eca-034049 Equus caballus 68.75 1.00e-24 104.00
IUUC-Eeu-034673 Erinaceus europaeus 70.31 2.00e-25 107.00
IUUC-Fca-036369 Felis catus 70.31 2.00e-24 107.00
IUUC-Fal-037006 Ficedula albicollis 70.31 3.00e-25 106.00
IUUC-Fox-037704 Fusarium oxysporum 61.61 1.00e-32 130.00
IUUC-Fso-038247 Fusarium solani 54.42 4.00e-45 172.00
IUUC-Gmo-039002 Gadus morhua 70.73 4.00e-12 62.80
IUUC-Ggr-039888 Gaeumannomyces graminis 66.36 1.00e-34 137.00
IUUC-Gga-040237 Gallus gallus 70.31 3.00e-25 106.00
IUUC-Gac-041800 Gasterosteus aculeatus 70.31 8.00e-25 106.00
IUUC-Gma-043275 Glycine max 49.37 2.00e-28 117.00
IUUC-Ggo-045163 Gorilla gorilla 46.86 1.00e-34 137.00
IUUC-Hsa-045795 Homo sapiens 70.31 3.00e-24 107.00
IUUC-Hvu-047376 Hordeum vulgare 48.65 4.00e-25 105.00
IUUC-Itr-048152 Ictidomys tridecemlineatus 70.31 2.00e-25 107.00
IUUC-Kpa-049166 Komagataella pastoris 43.24 1.00e-25 107.00
IUUC-Lch-050076 Latimeria chalumnae 70.31 2.00e-25 107.00
IUUC-Lpe-051258 Leersia perrieri 50.00 1.00e-26 110.00
IUUC-Loc-052292 Lepisosteus oculatus 70.31 2.00e-24 103.00
IUUC-Lma-053293 Leptosphaeria maculans 72.73 8.00e-40 154.00
IUUC-Laf-054393 Loxodonta africana 49.06 7.00e-34 135.00
IUUC-Mcc-054632 Macaca mulatta 70.31 4.00e-24 106.00
IUUC-Meu-056242 Macropus eugenii 70.31 2.00e-25 107.00
IUUC-Mor-057099 Magnaporthe oryzae 66.36 1.00e-33 134.00
IUUC-Mpo-057543 Magnaporthe poae 61.00 6.00e-26 108.00
IUUC-Mtr-058769 Medicago truncatula 61.54 1.00e-16 77.80
IUUC-Mla-059166 Melampsora laricipopulina 40.00 4.00e-21 92.00
IUUC-Mga-059406 Meleagris gallopavo 70.31 1.00e-24 104.00
IUUC-Mvi-060390 Microbotryum violaceum 38.71 2.00e-22 96.70
IUUC-Mmr-061569 Microcebus murinus 70.31 2.00e-25 107.00
IUUC-Mdo-062077 Monodelphis domestica 70.31 1.00e-24 106.00
IUUC-Mmu-063984 Mus musculus 70.31 1.00e-24 107.00
IUUC-Mac-065175 Musa acuminata 46.62 1.00e-27 114.00
IUUC-Mpu-066751 Mustela putorius furo 45.92 2.00e-28 120.00
IUUC-Mlu-068234 Myotis lucifugus 70.31 2.00e-25 107.00
IUUC-Nfi-068541 Neosartorya fischeri 86.67 8.00e-39 151.00
IUUC-Ncr-068830 Neurospora crassa 69.37 2.00e-37 147.00
IUUC-Nle-069126 Nomascus leucogenys 70.31 3.00e-25 106.00
IUUC-Opr-070742 Ochotona princeps 70.31 2.00e-25 106.00
IUUC-Ont-071828 Oreochromis niloticus 70.31 7.00e-25 105.00
IUUC-Oan-073462 Ornithorhynchus anatinus 70.31 3.00e-24 106.00
IUUC-Ocu-074890 Oryctolagus cuniculus 49.69 7.00e-33 134.00
IUUC-Oba-075995 Oryza barthii 49.32 2.00e-27 113.00
IUUC-Obr-076073 Oryza brachyantha 49.32 8.00e-28 114.00
IUUC-Ogl-077445 Oryza glaberrima 49.32 2.00e-27 113.00
IUUC-Ogu-078606 Oryza glumaepatula 49.32 2.00e-27 113.00
IUUC-Oin-079287 Oryza indica 49.32 2.00e-27 113.00
IUUC-Olo-080686 Oryza longistaminata 43.71 1.00e-22 97.40
IUUC-Ome-081567 Oryza meridionalis 49.32 9.00e-27 110.00
IUUC-Oni-082873 Oryza nivara 49.32 2.00e-27 113.00
IUUC-Opu-083488 Oryza punctata 47.97 5.00e-26 108.00
IUUC-Oru-084592 Oryza rufipogon 49.32 2.00e-27 113.00
IUUC-Osa-086102 Oryza sativa 48.65 2.00e-27 113.00
IUUC-Ola-087531 Oryzias latipes 55.35 2.00e-34 136.00
IUUC-Olu-087895 Ostreococcus lucimarinus 42.47 5.00e-23 97.40
IUUC-Oga-088239 Otolemur garnettii 70.31 2.00e-25 107.00
IUUC-Oar-090371 Ovis aries 46.27 2.00e-29 123.00
IUUC-Ptr-090481 Pan troglodytes 50.94 3.00e-27 115.00
IUUC-Pan-092210 Papio anubis 51.57 2.00e-28 120.00
IUUC-Psi-093588 Pelodiscus sinensis 70.31 2.00e-25 107.00
IUUC-Pma-094702 Petromyzon marinus 70.31 4.00e-25 105.00
IUUC-Pno-094927 Phaeosphaeria nodorum 72.73 3.00e-39 152.00
IUUC-Ppa-095389 Physcomitrella patens 67.74 3.00e-22 95.90
IUUC-Pfo-096744 Poecilia formosa 70.31 3.00e-25 106.00
IUUC-Pab-098044 Pongo abelii 70.31 2.00e-25 107.00
IUUC-Pop-099938 Populus trichocarpa 47.30 2.00e-28 116.00
IUUC-Pca-100355 Procavia capensis 52.20 2.00e-28 120.00
IUUC-Ppe-101786 Prunus persica 47.30 3.00e-28 116.00
IUUC-Pva-102494 Pteropus vampyrus 70.31 2.00e-25 107.00
IUUC-Pgr-103303 Puccinia graminis 60.00 2.00e-19 87.00
IUUC-Ptt-103748 Puccinia triticina 59.09 3.00e-11 59.70
IUUC-Pte-104368 Pyrenophora teres 70.91 6.00e-38 148.00
IUUC-Pyt-104542 Pyrenophora triticirepentis 69.09 2.00e-37 146.00
IUUC-Rno-105387 Rattus norvegicus 70.31 1.00e-24 107.00
IUUC-Sce-106371 Saccharomyces cerevisiae 39.77 6.00e-25 104.00
IUUC-Sha-107189 Sarcophilus harrisii 70.31 2.00e-25 107.00
IUUC-Sja-107942 Schizosaccharomyces japonicus 46.91 6.00e-17 78.20
IUUC-Spo-108121 Schizosaccharomyces pombe 48.21 1.00e-30 123.00
IUUC-Ssl-108595 Sclerotinia sclerotiorum 62.28 1.00e-34 137.00
IUUC-Smo-108783 Selaginella moellendorffii 52.03 2.00e-28 116.00
IUUC-Sit-109728 Setaria italica 50.68 2.00e-27 113.00
IUUC-Sly-110957 Solanum lycopersicum 63.46 3.00e-18 83.20
IUUC-Stu-112873 Solanum tuberosum 61.54 1.00e-17 80.90
IUUC-Sar-113668 Sorex araneus 72.97 1.00e-10 58.20
IUUC-Sbi-114223 Sorghum bicolor 52.03 3.00e-27 112.00
IUUC-Sre-115220 Sporisorium reilianum 51.90 1.00e-19 87.40
IUUC-Ssc-116119 Sus scrofa 70.31 2.00e-25 107.00
IUUC-Tgu-116528 Taeniopygia guttata 70.31 2.00e-25 106.00
IUUC-Tru-117538 Takifugu rubripes 70.31 2.00e-25 106.00
IUUC-Tsy-118855 Tarsius syrichta 72.97 1.00e-10 57.40
IUUC-Tni-120134 Tetraodon nigroviridis 55.35 1.00e-34 137.00
IUUC-Tca-121524 Theobroma cacao 46.62 5.00e-28 115.00
IUUC-Tre-121915 Trichoderma reesei 60.53 7.00e-31 125.00
IUUC-Tvi-122411 Trichoderma virens 59.63 3.00e-27 113.00
IUUC-Tae-124851 Triticum aestivum 48.65 3.00e-25 106.00
IUUC-Tur-126821 Triticum urartu 48.65 3.00e-25 105.00
IUUC-Tme-126875 Tuber melanosporum 72.73 7.00e-36 140.00
IUUC-Tbe-127759 Tupaia belangeri 49.32 6.00e-24 102.00
IUUC-Ttr-129124 Tursiops truncatus 55.48 1.00e-32 133.00
IUUC-Uma-129551 Ustilago maydis 49.38 8.00e-20 87.80
IUUC-Vda-129992 Verticillium dahliae 62.75 3.00e-44 169.00
IUUC-Vpa-130096 Vicugna pacos 67.19 3.00e-22 96.70
IUUC-Vvi-130940 Vitis vinifera 47.30 2.00e-22 97.10
IUUC-Xtr-132454 Xenopus tropicalis 70.31 7.00e-25 105.00
IUUC-Xma-133842 Xiphophorus maculatus 70.31 4.00e-25 105.00
IUUC-Yli-134485 Yarrowia lipolytica 36.19 9.00e-16 74.70
IUUC-Zma-135748 Zea mays 52.03 9.00e-28 114.00
Created Date 25-Jun-2017

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