iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000019464.2	ENSCJAT00000038169.1	ENSCJAP00000036143.1
ENSCJAG00000019464.2	ENSCJAT00000038171.1	ENSCJAP00000036145.1
ENSCJAG00000019464.2	ENSCJAT00000038173.2	ENSCJAP00000036147.2
ENSCJAG00000019464.2	ENSCJAT00000038164.2	ENSCJAP00000036138.2
ENSCJAG00000019464.2	ENSCJAT00000038165.2	ENSCJAP00000036139.2
ENSCJAG00000019464.2	ENSCJAT00000038161.2	ENSCJAP00000036135.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.70e-46	156.5	8	146
UBD/UBC-like/UBD_UBC	1.10e-72	243.6	8	149
UBD/Alpha-Helix/UBA	9.00e-11	42.5	161	199

Active Site

Position(s)	Description	Evidence
92	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkel...ekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsi 85
           R+k+e+ke+   e++++++i++++vde ++te++ +i Gp+dtpYegg ++lei++pe+YPf+PPkv+f+tki+hPn+++  G++Cl+i
   Q: 8    RIKREFKEVlksEETSKNQIKVDLVDE-NFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVtGAICLDI 95
           7888888873335556699********.9***************************************************99******* PP
   S: 86   lkeeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           lk  ++W +a+++++vlls+q+lla ++p++p+++ +a+++k+n+e++k+++r
   Q: 96   LK--DQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTAR 146
           *9..**********************************************986 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeea...qisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpnins.ngsicldil 85
           rik+e+k++l++ee+   qi++dlvd++++elr++iagppd+pyegg+++l+ik+p++ypf+ppkv+fitki+hpni+s +g+icldil
   Q: 8    RIKREFKEVLKSEETsknQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSvTGAICLDIL 96
           8*************9999*********************************************************************** PP
   S: 86   rsqwsaaltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           ++qw+aa+tl++vllsl++lla+aepddp++a++a++yk+++e++k++ar+w+
   Q: 97   KDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWA 149
           ****************************************************7 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           e++ k+e+l++MGFdr++++ aL + ++++e A+e+Ll+
   Q: 161  EYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLS 199
           6789*********************************97 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI 60
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGCGCGCTC GTGGCTCGGG CGAATGGGGG CTACAACGGG AGCGGCTGCG CCGCCCGGCC 60
GGGTCAGCAT CATGCGCATG CGCGGACCCG GCGCCATTTT GGTGGCCGGG CGCGGAGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00627--UBA
PF00179--UQ_con

SMART

SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0032433--C:filopodium tip
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0035458--P:cellular response to interferon-beta
GO:0010994--P:free ubiquitin chain polymerization
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0070936--P:protein K48-linked ubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process

KEGG

cjc:100412448

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000621	Aegilops tauschii	51.55	3.00e-28	118.00
IUUC-Aml-001286	Ailuropoda melanoleuca	99.50	4.00e-109	386.00
IUUC-Atr-003063	Amborella trichopoda	47.94	1.00e-39	155.00
IUUC-Apl-004122	Anas platyrhynchos	91.00	6.00e-96	342.00
IUUC-Aca-004565	Anolis carolinensis	94.21	2.00e-98	350.00
IUUC-Aly-006390	Arabidopsis lyrata	47.72	6.00e-44	169.00
IUUC-Ath-006637	Arabidopsis thaliana	46.86	3.00e-41	161.00
IUUC-Ago-007714	Ashbya gossypii	44.62	5.00e-38	150.00
IUUC-Acl-008189	Aspergillus clavatus	49.68	7.00e-28	117.00
IUUC-Afl-008489	Aspergillus flavus	41.40	2.00e-28	119.00
IUUC-Afu-008850	Aspergillus fumigatus	40.65	9.00e-29	120.00
IUUC-Ani-009361	Aspergillus nidulans	50.68	1.00e-26	113.00
IUUC-Ang-009548	Aspergillus niger	48.39	2.00e-26	112.00
IUUC-Aor-010105	Aspergillus oryzae	41.40	2.00e-28	119.00
IUUC-Ate-010389	Aspergillus terreus	40.55	7.00e-28	117.00
IUUC-Ame-011454	Astyanax mexicanus	96.50	1.00e-106	378.00
IUUC-Bgr-012255	Blumeria graminis	48.41	7.00e-34	137.00
IUUC-Bta-012992	Bos taurus	99.50	4.00e-109	386.00
IUUC-Bci-013806	Botrytis cinerea	40.09	3.00e-36	145.00
IUUC-Bdi-015024	Brachypodium distachyon	48.22	1.00e-40	159.00
IUUC-Bol-015985	Brassica oleracea	48.22	2.00e-44	172.00
IUUC-Bra-016805	Brassica rapa	48.22	8.00e-45	172.00
IUUC-Cel-018353	Caenorhabditis elegans	52.26	8.00e-57	213.00
IUUC-Cfa-020016	Canis familiaris	99.50	4.00e-109	386.00
IUUC-Cpo-022026	Cavia porcellus	99.50	4.00e-109	386.00
IUUC-Cre-022987	Chlamydomonas reinhardtii	48.98	6.00e-42	163.00
IUUC-Csa-023059	Chlorocebus sabaeus	99.50	4.00e-109	386.00
IUUC-Cho-024276	Choloepus hoffmanni	95.92	8.00e-73	265.00
IUUC-Cin-025598	Ciona intestinalis	60.71	4.00e-56	210.00
IUUC-Csv-025831	Ciona savignyi	62.24	2.00e-54	204.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	44.51	2.00e-34	138.00
IUUC-Cne-027068	Cryptococcus neoformans	41.38	3.00e-41	161.00
IUUC-Dre-028139	Danio rerio	96.50	2.00e-106	378.00
IUUC-Dno-029169	Dasypus novemcinctus	93.00	3.00e-101	360.00
IUUC-Dor-030382	Dipodomys ordii	85.50	2.00e-87	314.00
IUUC-Dse-031335	Dothistroma septosporum	50.96	5.00e-37	147.00
IUUC-Dme-032003	Drosophila melanogaster	68.84	4.00e-72	263.00
IUUC-Ete-032868	Echinops telfairi	90.50	1.00e-87	315.00
IUUC-Eca-033428	Equus caballus	99.50	4.00e-109	386.00
IUUC-Eeu-035103	Erinaceus europaeus	72.66	2.00e-48	184.00
IUUC-Fca-035366	Felis catus	99.50	4.00e-109	386.00
IUUC-Fal-037016	Ficedula albicollis	99.50	4.00e-109	386.00
IUUC-Fox-037969	Fusarium oxysporum	42.62	3.00e-34	137.00
IUUC-Fso-038296	Fusarium solani	44.26	4.00e-36	144.00
IUUC-Gmo-039135	Gadus morhua	95.50	4.00e-105	373.00
IUUC-Ggr-039768	Gaeumannomyces graminis	46.25	7.00e-26	110.00
IUUC-Gga-041018	Gallus gallus	99.00	8.00e-109	385.00
IUUC-Gac-041503	Gasterosteus aculeatus	96.00	5.00e-106	376.00
IUUC-Gma-042779	Glycine max	50.26	4.00e-43	167.00
IUUC-Ggo-045032	Gorilla gorilla	99.50	4.00e-109	386.00
IUUC-Hsa-046490	Homo sapiens	99.50	4.00e-109	386.00
IUUC-Itr-048373	Ictidomys tridecemlineatus	99.50	4.00e-109	386.00
IUUC-Kpa-049297	Komagataella pastoris	49.02	1.00e-33	136.00
IUUC-Lch-050588	Latimeria chalumnae	67.77	3.00e-75	274.00
IUUC-Lpe-051070	Leersia perrieri	48.22	1.00e-32	132.00
IUUC-Loc-052549	Lepisosteus oculatus	97.00	6.00e-107	379.00
IUUC-Lma-052949	Leptosphaeria maculans	49.36	6.00e-37	147.00
IUUC-Laf-053688	Loxodonta africana	91.67	3.00e-99	353.00
IUUC-Mcc-055606	Macaca mulatta	99.50	4.00e-109	386.00
IUUC-Mor-056946	Magnaporthe oryzae	37.44	6.00e-23	100.00
IUUC-Mpo-057441	Magnaporthe poae	49.04	7.00e-26	110.00
IUUC-Mtr-058002	Medicago truncatula	49.74	8.00e-43	166.00
IUUC-Mla-059007	Melampsora laricipopulina	43.52	1.00e-37	149.00
IUUC-Mga-059254	Meleagris gallopavo	98.33	1.00e-96	345.00
IUUC-Mvi-060346	Microbotryum violaceum	41.50	1.00e-33	135.00
IUUC-Mmr-061211	Microcebus murinus	99.50	4.00e-109	386.00
IUUC-Mdo-062458	Monodelphis domestica	98.50	1.00e-106	378.00
IUUC-Mmu-063648	Mus musculus	99.50	4.00e-109	386.00
IUUC-Mac-065447	Musa acuminata	48.22	4.00e-41	160.00
IUUC-Mpu-066407	Mustela putorius furo	99.50	2.00e-108	385.00
IUUC-Mlu-067682	Myotis lucifugus	92.42	3.00e-99	353.00
IUUC-Nfi-068517	Neosartorya fischeri	40.65	7.00e-29	120.00
IUUC-Ncr-068749	Neurospora crassa	48.08	2.00e-38	152.00
IUUC-Nle-069712	Nomascus leucogenys	98.33	8.00e-97	345.00
IUUC-Opr-070651	Ochotona princeps	99.50	4.00e-109	386.00
IUUC-Ont-071595	Oreochromis niloticus	96.00	5.00e-106	376.00
IUUC-Oan-073058	Ornithorhynchus anatinus	99.32	5.00e-78	282.00
IUUC-Ocu-074939	Oryctolagus cuniculus	99.50	4.00e-109	386.00
IUUC-Oba-075530	Oryza barthii	48.99	7.00e-32	130.00
IUUC-Obr-076838	Oryza brachyantha	48.48	3.00e-31	128.00
IUUC-Ogl-077606	Oryza glaberrima	48.99	7.00e-32	130.00
IUUC-Ogu-078238	Oryza glumaepatula	48.99	7.00e-32	130.00
IUUC-Oin-079643	Oryza indica	48.99	2.00e-31	128.00
IUUC-Ome-081274	Oryza meridionalis	48.99	7.00e-32	130.00
IUUC-Oni-082651	Oryza nivara	48.99	7.00e-32	130.00
IUUC-Opu-083933	Oryza punctata	48.99	1.00e-31	129.00
IUUC-Oru-085054	Oryza rufipogon	48.99	1.00e-31	129.00
IUUC-Osa-085716	Oryza sativa	48.99	2.00e-31	128.00
IUUC-Ola-087043	Oryzias latipes	96.00	5.00e-106	376.00
IUUC-Olu-087846	Ostreococcus lucimarinus	46.63	4.00e-42	164.00
IUUC-Oga-088897	Otolemur garnettii	93.43	2.00e-99	354.00
IUUC-Oar-089673	Ovis aries	92.42	8.00e-100	355.00
IUUC-Ptr-091295	Pan troglodytes	99.50	4.00e-109	386.00
IUUC-Pan-092034	Papio anubis	99.44	7.00e-97	345.00
IUUC-Psi-093498	Pelodiscus sinensis	99.50	4.00e-109	386.00
IUUC-Pma-094115	Petromyzon marinus	82.41	6.00e-89	319.00
IUUC-Pno-095102	Phaeosphaeria nodorum	40.76	6.00e-38	150.00
IUUC-Ppa-095326	Physcomitrella patens	46.19	8.00e-40	156.00
IUUC-Pfo-096940	Poecilia formosa	96.00	4.00e-106	376.00
IUUC-Pab-098279	Pongo abelii	99.50	4.00e-109	386.00
IUUC-Pop-099543	Populus trichocarpa	49.24	3.00e-44	171.00
IUUC-Pca-100782	Procavia capensis	99.00	4.00e-107	379.00
IUUC-Ppe-101789	Prunus persica	47.94	4.00e-37	147.00
IUUC-Pva-102147	Pteropus vampyrus	70.45	3.00e-57	213.00
IUUC-Pgr-103643	Puccinia graminis	45.06	1.00e-37	150.00
IUUC-Ptt-103772	Puccinia triticina	47.95	3.00e-36	145.00
IUUC-Pte-104370	Pyrenophora teres	49.36	9.00e-37	146.00
IUUC-Pyt-104592	Pyrenophora triticirepentis	40.74	1.00e-36	146.00
IUUC-Rno-104984	Rattus norvegicus	99.50	4.00e-109	386.00
IUUC-Sce-106394	Saccharomyces cerevisiae	43.01	3.00e-35	141.00
IUUC-Sha-106624	Sarcophilus harrisii	93.00	5.00e-103	366.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	42.86	8.00e-41	160.00
IUUC-Smo-109656	Selaginella moellendorffii	48.47	3.00e-40	157.00
IUUC-Sit-110639	Setaria italica	47.98	2.00e-39	155.00
IUUC-Sly-110978	Solanum lycopersicum	48.22	5.00e-44	170.00
IUUC-Stu-112088	Solanum tuberosum	48.22	2.00e-44	171.00
IUUC-Sar-113285	Sorex araneus	83.80	3.00e-75	273.00
IUUC-Sbi-113986	Sorghum bicolor	47.98	2.00e-39	154.00
IUUC-Sre-115046	Sporisorium reilianum	46.71	9.00e-37	146.00
IUUC-Ssc-116314	Sus scrofa	99.50	4.00e-109	386.00
IUUC-Tgu-117427	Taeniopygia guttata	98.89	5.00e-97	346.00
IUUC-Tru-118618	Takifugu rubripes	91.00	4.00e-101	360.00
IUUC-Tsy-119208	Tarsius syrichta	97.47	9.00e-106	375.00
IUUC-Tni-119667	Tetraodon nigroviridis	96.50	2.00e-106	377.00
IUUC-Tca-121446	Theobroma cacao	49.75	3.00e-45	174.00
IUUC-Tre-122053	Trichoderma reesei	38.12	9.00e-32	129.00
IUUC-Tvi-122533	Trichoderma virens	36.00	4.00e-31	127.00
IUUC-Tae-124726	Triticum aestivum	48.73	2.00e-33	135.00
IUUC-Tme-127024	Tuber melanosporum	48.77	3.00e-38	151.00
IUUC-Tbe-127752	Tupaia belangeri	96.00	4.00e-104	369.00
IUUC-Ttr-128287	Tursiops truncatus	99.44	7.00e-97	345.00
IUUC-Uma-129512	Ustilago maydis	39.22	3.00e-36	144.00
IUUC-Vda-129947	Verticillium dahliae	37.20	2.00e-31	129.00
IUUC-Vpa-130481	Vicugna pacos	99.49	4.00e-107	379.00
IUUC-Vvi-131429	Vitis vinifera	46.19	3.00e-41	160.00
IUUC-Xtr-132710	Xenopus tropicalis	82.67	2.00e-94	338.00
IUUC-Xma-134165	Xiphophorus maculatus	95.50	1.00e-105	375.00
IUUC-Yli-134523	Yarrowia lipolytica	44.00	4.00e-34	137.00
IUUC-Zma-135733	Zea mays	47.14	9.00e-38	149.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence