iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092019

Ensembl Protein ID

ENSPANP00000000430.1

UniProt Accession

A0A096MLK1; A0A096MLK1_PAPAN

Genbank Protein ID

ENSPANP00000000430

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01100573

Gene Name

DDB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000000242.1	ENSPANT00000007097.1	ENSPANP00000000430.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DDB1	0	1809.6	1	1145

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DDB1

   S: 2    mldrYvvtarkpsavvklvvgnftshkelNLliaksnrieiflvtpeglrpvvevklegsiavlrlfrpknekkdllfilteryntl 88
           m+++Yvvta+kp+av+ +v+g+fts+++lNLliak++r+ei++vt+eglrpv+ev ++g+iav++lfrpk+e+kdllfilt++yn++
   Q: 1    MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNAC 87
           799************************************************************************************ PP
   S: 89   ilelrdidessevvtradgevlDdigrssdsGlinviepkirlialelyqglfklIvldndikelkafnirleelnvsdvkflillt 175
           ile+++++es++++tra+g+v+D+igr+s++G+i++i+p++r+i+l+ly+glfk+I+ld+d+kelkafnirleel+v+dvkfl++++
   Q: 88   ILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQ 174
           *************************************************************************************** PP
   S: 176  qptgrvlviyqdddgkhlktyelslkdKeFvkis.kqesiekeaellipvpsqlvgvlvlgeesivyksadnykdvdPylirqstai 261
           +pt  ++++yqd++g+h+ktye+sl++KeF+k++ kqe++e+ea+++i+vp++++g++++g+esi+y+++d+y +++P++i+qst++
   Q: 175  APT--ICFVYQDPQGRHVKTYEVSLREKEFNKGPwKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIV 259
           ***..********************************************************************************** PP
   S: 262  ryervdnngirylLgdfdGelkllllsaeeemsG.vevkslkielLgeisiaesisyldngllfvgsrfgdsQlvklisestgkgsy 347
           +++rvd ng+rylLgd++G+l++lll++ee+m+G v++k+l++elLge+siae+++yldng++fvgsr+gdsQlvkl+++s+++gsy
   Q: 260  CHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGtVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSY 346
           *************************************************************************************** PP
   S: 348  vvilerfknlkpIvdlvvvdldrrgqgqvvtvsgaskdGslRvirlgigieelasvdlkgvigllslkstidestdnslvlafvset 434
           vv++e+f+nl+pIvd++vvdl+r+gqgq+vt+sga+k+GslR+ir+gigi+e+as+dl+g++gl++l+s+ +++td++lvl+fv++t
   Q: 347  VVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRETDDTLVLSFVGQT 433
           *************************************************************************************** PP
   S: 435  kvlnlntgeeledtelsgvlsdlqtlltqdvidykqllqvTsqsvrLvssqikrllkeWkaknleiigvassNteqvliaatsndlv 521
           +vl+ln gee+e+tel+g+++d+qt+++ +v +++ql+q+Ts+svrLvs++ k+l++eWk++++++i+vas+N++qv++a+ +++l+
   Q: 434  RVLMLN-GEEVEETELMGFVDDQQTFFCGNV-AHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAV-GRALY 517
           ******.************************.************************************************9.***** PP
   S: 522  yleigdgeldltstttlenevavldlinieddpnlsdleavglltdiskrililpdletiykeklggeiipRsilltefEnvtYlLi 608
           yl+i+++el+++s+t++e+eva+ld+++++d++ ls l+a+gl+tdis+ril+lp++e+++ke+lggeiipRsil+t+fE+ +YlL+
   Q: 518  YLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLC 604
           *************************************************************************************** PP
   S: 609  algdGalvsyildidtgdesdakksnlgtspgtlktfkslsttqvfassDrPtvIyssskkLvfSnVnlkeVqylCsldseaypdsl 695
           algdGal+++ l+i+tg +sd+kk++lgt+p++l+tf+slstt+vfa+sDrPtvIyss++kLvfSnVnlkeV+y+C+l+s++ypdsl
   Q: 605  ALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSL 691
           *************************************************************************************** PP
   S: 696  alanngslvigtvddiqklkiRsiplgeslrriayqesvitfgvisdrreldf.klklkalrnnasilalvpdiennklfsdglril 781
           alann++l+igt+d+iqkl+iR++pl+es+r+i+yqe++++fgv+s+r+e+++ +++++alr++as++al+++++++klfs++++ +
   Q: 692  ALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDtSGGTTALRPSASTQALSSSVSSSKLFSSSTAPH 778
           *****************************************************9********************************* PP
   S: 782  elseleenevnfllvlDkntfelllaqdlrewEtavsllSqklkdDseeyyvvktalvlpeenelkkgrilvfsvedslklkLltva 868
           e+s++ee+ev++ll++D++tfe+l+a+++ ++E+a+sl+S+kl++D+++y++v+ta+v+pee+e+k+gri+vf+++d+   kL+tva
   Q: 779  ETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDA-PGKLQTVA 864
           *****************************************************************************9.99****** PP
   S: 869  ekkvkgavidlvklNgkllaainseirlyewkvmgtdekelrkeCernntilaLtlktrkdfivVgDlmrsvtLllykdlegsfeEs 955
           ek+vkgav+++v++Ngklla+ins++rlyew    t+ekelr+eC+++n+i+aL+lkt++dfi+VgDlmrsv Ll+yk +eg+feE+
   Q: 865  EKEVKGAVYSMVEFNGKLLASINSTVRLYEW----TTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEI 947
           *******************************....**************************************************** PP
   S: 956  ardynlewmsaveilnddiflgaencgNlfvvkkdikagltdeerslleevgefrlgefvevfrfgtlvlqdvgerevnrssevifg 1042
           ard+n++wmsaveil+dd+flgaen++Nlfv++kd +a++tdeer++l+evg f+lgefv+vf++g+lv+q++ge++++++++v+fg
   Q: 948  ARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKD-SAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFG 1033
           ***********************************.*************************************************** PP
   S: 1043 tengeigvilrlrrellkflrnlestlkkvikrvakieHs...syRsFetekrterasgfvdgdLiesilDlsrdkavdilkvl.ye 1125
           t+ng+ig++++l+++++++l +++++l+kvik+v+kieHs    +RsF+te++te+a+gf+dgdLies+lD+sr+k+++++++l y+
   Q: 1034 TVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHShpsTWRSFHTERKTE

Organism

Papio anubis

Protein Sequence
(Fasta)

MSYNYVVTAQ KPTAVNGCVT GHFTSAEDLN LLIAKNTRLE IYVVTAEGLR PVKEVGMYGK 60
IAVMELFRPK GESKDLLFIL TAKYNACILE YKQSGESIDI ITRAHGNVQD RIGRPSETGI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTCGCGCTC GCGTCCCGAC GAGCCGCTCT AAGCCTCGAC ATGTCGTACA ACTACGTGGT 60
AACGGCCCAG AAGCCCACCG CCGTGAACGG CTGCGTGACC GGTGAGGCTG CCGGGGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004871--Cleavage/polyA-sp_fac_asu_C
IPR031297--DDB1
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom

Pfam

PF03178--CPSF_A

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005654--C:nucleoplasm
GO:0003684--F:damaged DNA binding
GO:0035518--P:histone H2A monoubiquitination
GO:0051702--P:interaction with symbiont
GO:0043066--P:negative regulation of apoptotic process
GO:0046726--P:positive regulation by virus of viral protein levels in host cell
GO:0045070--P:positive regulation of viral genome replication
GO:1902188--P:positive regulation of viral release from host cell
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1901990--P:regulation of mitotic cell cycle phase transition
GO:0070914--P:UV-damage excision repair
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000120	Aegilops tauschii	49.75	0.00e+00	1124.00
IUUC-Aml-002096	Ailuropoda melanoleuca	99.39	0.00e+00	2297.00
IUUC-Atr-002742	Amborella trichopoda	52.13	0.00e+00	1172.00
IUUC-Apl-003624	Anas platyrhynchos	96.36	0.00e+00	2187.00
IUUC-Aca-005085	Anolis carolinensis	96.42	0.00e+00	2231.00
IUUC-Aly-005857	Arabidopsis lyrata	52.39	0.00e+00	1175.00
IUUC-Ath-006658	Arabidopsis thaliana	52.30	0.00e+00	1173.00
IUUC-Acl-008149	Aspergillus clavatus	26.80	5.00e-104	372.00
IUUC-Afl-008549	Aspergillus flavus	28.05	2.00e-108	387.00
IUUC-Afu-009076	Aspergillus fumigatus	27.15	6.00e-115	409.00
IUUC-Ani-009302	Aspergillus nidulans	26.46	3.00e-88	320.00
IUUC-Ang-009636	Aspergillus niger	27.86	3.00e-82	300.00
IUUC-Aor-010073	Aspergillus oryzae	28.10	3.00e-113	403.00
IUUC-Ate-010422	Aspergillus terreus	27.07	2.00e-104	374.00
IUUC-Ame-011643	Astyanax mexicanus	81.13	0.00e+00	1838.00
IUUC-Bgr-012164	Blumeria graminis	26.14	7.00e-96	345.00
IUUC-Bta-012494	Bos taurus	99.21	0.00e+00	2293.00
IUUC-Bci-013957	Botrytis cinerea	26.33	2.00e-90	327.00
IUUC-Bdi-014186	Brachypodium distachyon	52.48	0.00e+00	1170.00
IUUC-Bol-015922	Brassica oleracea	52.91	0.00e+00	1187.00
IUUC-Bra-017300	Brassica rapa	52.91	0.00e+00	1181.00
IUUC-Cel-018239	Caenorhabditis elegans	37.07	0.00e+00	769.00
IUUC-Cja-019165	Callithrix jacchus	99.48	0.00e+00	2298.00
IUUC-Cfa-020406	Canis familiaris	99.39	0.00e+00	2297.00
IUUC-Cpo-022154	Cavia porcellus	98.60	0.00e+00	2278.00
IUUC-Cre-022557	Chlamydomonas reinhardtii	40.76	0.00e+00	777.00
IUUC-Csa-024061	Chlorocebus sabaeus	99.48	0.00e+00	2298.00
IUUC-Cho-024554	Choloepus hoffmanni	91.74	0.00e+00	927.00
IUUC-Cin-025466	Ciona intestinalis	61.62	0.00e+00	1464.00
IUUC-Csv-026370	Ciona savignyi	60.00	0.00e+00	1303.00
IUUC-Cgl-026595	Colletotrichum gloeosporioides	25.50	2.00e-96	347.00
IUUC-Cme-027342	Cyanidioschyzon merolae	27.50	8.00e-114	405.00
IUUC-Dre-027448	Danio rerio	90.73	0.00e+00	1014.00
IUUC-Dno-029794	Dasypus novemcinctus	98.80	0.00e+00	2155.00
IUUC-Dor-030789	Dipodomys ordii	85.27	0.00e+00	982.00
IUUC-Dse-031491	Dothistroma septosporum	27.79	7.00e-114	405.00
IUUC-Dme-031940	Drosophila melanogaster	60.57	0.00e+00	1357.00
IUUC-Ete-032913	Echinops telfairi	80.00	0.00e+00	851.00
IUUC-Eca-033777	Equus caballus	98.60	0.00e+00	2273.00
IUUC-Eeu-034900	Erinaceus europaeus	97.15	0.00e+00	1119.00
IUUC-Fca-035869	Felis catus	99.39	0.00e+00	2297.00
IUUC-Fal-036777	Ficedula albicollis	96.77	0.00e+00	2231.00
IUUC-Fox-037954	Fusarium oxysporum	26.51	2.00e-102	367.00
IUUC-Fso-038292	Fusarium solani	25.65	1.00e-106	381.00
IUUC-Gmo-038815	Gadus morhua	82.06	0.00e+00	962.00
IUUC-Ggr-039907	Gaeumannomyces graminis	25.39	1.00e-96	348.00
IUUC-Gga-040995	Gallus gallus	96.59	0.00e+00	2233.00
IUUC-Gac-042390	Gasterosteus aculeatus	90.05	0.00e+00	1988.00
IUUC-Gma-042904	Glycine max	51.83	0.00e+00	1129.00
IUUC-Ggo-044891	Gorilla gorilla	99.83	0.00e+00	2312.00
IUUC-Hsa-046709	Homo sapiens	99.48	0.00e+00	2298.00
IUUC-Hvu-047504	Hordeum vulgare	51.95	0.00e+00	1149.00
IUUC-Itr-048678	Ictidomys tridecemlineatus	99.30	0.00e+00	2296.00
IUUC-Lch-050565	Latimeria chalumnae	93.36	0.00e+00	2172.00
IUUC-Lpe-051260	Leersia perrieri	52.70	0.00e+00	1167.00
IUUC-Loc-052091	Lepisosteus oculatus	81.98	0.00e+00	1474.00
IUUC-Lma-053246	Leptosphaeria maculans	25.50	1.00e-101	364.00
IUUC-Laf-053502	Loxodonta africana	99.13	0.00e+00	2291.00
IUUC-Mcc-054802	Macaca mulatta	99.47	0.00e+00	2282.00
IUUC-Meu-056808	Macropus eugenii	96.04	0.00e+00	1451.00
IUUC-Mor-057253	Magnaporthe oryzae	25.42	6.00e-83	302.00
IUUC-Mpo-057562	Magnaporthe poae	25.14	5.00e-95	342.00
IUUC-Mtr-057743	Medicago truncatula	51.30	0.00e+00	1149.00
IUUC-Mla-059154	Melampsora laricipopulina	24.42	1.00e-78	288.00
IUUC-Mga-059824	Meleagris gallopavo	96.28	0.00e+00	2096.00
IUUC-Mvi-060279	Microbotryum violaceum	26.74	2.00e-107	384.00
IUUC-Mmr-061215	Microcebus murinus	98.87	0.00e+00	2277.00
IUUC-Mdo-062028	Monodelphis domestica	96.91	0.00e+00	1885.00
IUUC-Mmu-064327	Mus musculus	99.13	0.00e+00	2289.00
IUUC-Mac-065445	Musa acuminata	52.78	0.00e+00	1147.00
IUUC-Mpu-065814	Mustela putorius furo	96.07	0.00e+00	2194.00
IUUC-Mlu-067136	Myotis lucifugus	98.78	0.00e+00	2276.00
IUUC-Nfi-068355	Neosartorya fischeri	27.15	1.00e-108	387.00
IUUC-Ncr-068620	Neurospora crassa	25.10	1.00e-89	325.00
IUUC-Nle-069566	Nomascus leucogenys	99.30	0.00e+00	2270.00
IUUC-Opr-070915	Ochotona princeps	90.44	0.00e+00	1858.00
IUUC-Ont-071753	Oreochromis niloticus	90.92	0.00e+00	2108.00
IUUC-Oan-073187	Ornithorhynchus anatinus	97.49	0.00e+00	2041.00
IUUC-Ocu-074619	Oryctolagus cuniculus	99.48	0.00e+00	2300.00
IUUC-Oba-075091	Oryza barthii	45.47	0.00e+00	882.00
IUUC-Obr-076425	Oryza brachyantha	53.49	0.00e+00	1170.00
IUUC-Ogu-078794	Oryza glumaepatula	52.96	0.00e+00	1174.00
IUUC-Oin-079725	Oryza indica	53.04	0.00e+00	1163.00
IUUC-Olo-080842	Oryza longistaminata	51.70	0.00e+00	1073.00
IUUC-Ome-081818	Oryza meridionalis	53.04	0.00e+00	1177.00
IUUC-Oni-082879	Oryza nivara	52.26	0.00e+00	1150.00
IUUC-Opu-083361	Oryza punctata	52.27	0.00e+00	1165.00
IUUC-Oru-084781	Oryza rufipogon	52.96	0.00e+00	1174.00
IUUC-Osa-086293	Oryza sativa	52.96	0.00e+00	1174.00
IUUC-Ola-086881	Oryzias latipes	89.97	0.00e+00	2088.00
IUUC-Olu-087674	Ostreococcus lucimarinus	45.13	0.00e+00	946.00
IUUC-Oga-089056	Otolemur garnettii	99.13	0.00e+00	2292.00
IUUC-Oar-089457	Ovis aries	99.20	0.00e+00	2258.00
IUUC-Ptr-091179	Pan troglodytes	99.29	0.00e+00	2258.00
IUUC-Psi-093407	Pelodiscus sinensis	96.46	0.00e+00	2194.00
IUUC-Pma-094272	Petromyzon marinus	86.57	0.00e+00	1842.00
IUUC-Pno-094864	Phaeosphaeria nodorum	26.77	8.00e-111	395.00
IUUC-Ppa-095885	Physcomitrella patens	52.99	0.00e+00	1160.00
IUUC-Pfo-096083	Poecilia formosa	90.57	0.00e+00	2099.00
IUUC-Pab-098652	Pongo abelii	95.03	0.00e+00	2162.00
IUUC-Pop-099593	Populus trichocarpa	52.43	0.00e+00	1123.00
IUUC-Pca-100189	Procavia capensis	98.52	0.00e+00	1315.00
IUUC-Ppe-101987	Prunus persica	51.91	0.00e+00	1106.00
IUUC-Pva-102605	Pteropus vampyrus	99.21	0.00e+00	2290.00
IUUC-Pgr-103659	Puccinia graminis	24.46	1.00e-71	265.00
IUUC-Ptt-103884	Puccinia triticina	23.00	3.00e-57	217.00
IUUC-Pte-104233	Pyrenophora teres	26.96	1.00e-113	404.00
IUUC-Pyt-104454	Pyrenophora triticirepentis	27.11	2.00e-111	397.00
IUUC-Rno-106004	Rattus norvegicus	99.21	0.00e+00	2293.00
IUUC-Sha-106726	Sarcophilus harrisii	96.19	0.00e+00	2068.00
IUUC-Sja-107864	Schizosaccharomyces japonicus	23.57	4.00e-73	270.00
IUUC-Spo-108029	Schizosaccharomyces pombe	25.68	1.00e-98	354.00
IUUC-Ssl-108441	Sclerotinia sclerotiorum	25.26	4.00e-82	300.00
IUUC-Smo-108862	Selaginella moellendorffii	52.22	0.00e+00	1200.00
IUUC-Sit-109735	Setaria italica	53.49	0.00e+00	1166.00
IUUC-Sly-111520	Solanum lycopersicum	51.73	0.00e+00	1140.00
IUUC-Sar-113606	Sorex araneus	96.68	7.00e-138	484.00
IUUC-Sbi-114539	Sorghum bicolor	52.50	0.00e+00	1154.00
IUUC-Sre-114936	Sporisorium reilianum	24.90	4.00e-62	233.00
IUUC-Ssc-116038	Sus scrofa	99.21	0.00e+00	2292.00
IUUC-Tgu-117512	Taeniopygia guttata	96.68	0.00e+00	2232.00
IUUC-Tru-117593	Takifugu rubripes	89.44	0.00e+00	2075.00
IUUC-Tsy-119513	Tarsius syrichta	96.22	0.00e+00	1202.00
IUUC-Tni-120551	Tetraodon nigroviridis	84.61	0.00e+00	1696.00
IUUC-Tca-121505	Theobroma cacao	52.70	0.00e+00	1146.00
IUUC-Tre-122136	Trichoderma reesei	26.12	4.00e-101	363.00
IUUC-Tvi-122512	Trichoderma virens	25.22	2.00e-98	354.00
IUUC-Tae-122891	Triticum aestivum	51.87	0.00e+00	1150.00
IUUC-Tur-126451	Triticum urartu	52.33	0.00e+00	1045.00
IUUC-Tme-127057	Tuber melanosporum	28.80	1.00e-112	401.00
IUUC-Ttr-128891	Tursiops truncatus	94.03	0.00e+00	1473.00
IUUC-Uma-129583	Ustilago maydis	25.39	7.00e-54	206.00
IUUC-Vda-129870	Verticillium dahliae	25.16	2.00e-91	331.00
IUUC-Vpa-130117	Vicugna pacos	94.92	0.00e+00	1739.00
IUUC-Vvi-131033	Vitis vinifera	51.57	0.00e+00	1146.00
IUUC-Xtr-131987	Xenopus tropicalis	92.69	0.00e+00	2128.00
IUUC-Xma-134117	Xiphophorus maculatus	88.59	0.00e+00	2048.00
IUUC-Zma-134758	Zea mays	52.78	0.00e+00	1170.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence