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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Ath-007182
UUCD1 version UUC-ArT-01610
Ensembl Protein ID AT4G16144.1
UniProt Accession Q5PNU3; AMSH3_ARATH
Genbank Protein ID AEE83701.1; AAV85709.1
Protein Name AMSH-like ubiquitin thioesterase 3; Deubiquitinating enzyme AMSH3
Genbank Nucleotide ID Z97340; BT020354
Gene Name AMSH3; At4g16144; FCAALL
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT4G16144 AT4G16144.1 AT4G16144.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexPINAHINT
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/JAMM JAMM 20543027
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description



     Zinc metalloprotease that cleaves 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, but is not implicated in protein degradation by the 26S proteasome, deneddylation, or desumoylation. Required for intracellular trafficking (e.g. trafficking from the Golgi to the vacuole and the vacuolar trafficking of endocytosed cargo), endocytosis and vacuole biogenesis.
Zinc metalloprotease that cleaves 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, but is not implicated in protein degradation by the 26S proteasome, deneddylation, or desumoylation. Required for intracellular trafficking (e.g. trafficking from the Golgi to the vacuole and the vacuolar trafficking of endocytosed cargo), endocytosis and vacuole biogenesis.
Protein Sequence
(Fasta)
MKIDLNKVAR EIEVDNRIPL RNYYRIADNL LRQASIYREE KNVVDLYIML LRYSSLISET 60
IPFHRDYQAS LPQERLGSRK RLRAVINELE SLKPEFNQLV DKLNRVEDES RQDGSDLPVV 120
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Protein Fasta Sequence



>IUUC-Ath-007182|DUB,JAMM|Arabidopsis thaliana
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Nucleotide Sequence
(Fasta)
TTTATTCCAC TTGATATAAT ATTGCAACTC CACACAATTC GATCATCAGC TGGTTGAAAC 60
CACTTAATAG TTCCATAAGA TATCATTCCA CATTGAAAAT TTCAAATATA CCCCTAAAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ath-007182|DUB,JAMM|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0645--Protease
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0926--Vacuole
KW-0862--Zinc

Interpro

IPR000555--JAMM/MPN+_dom
IPR015063--USP8_dimer

Pfam

PF01398--JAB
PF08969--USP8_dimer

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005774--C:vacuolar membrane
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0006897--P:endocytosis
GO:0046907--P:intracellular transport
GO:0090316--P:positive regulation of intracellular protein transport
GO:0044090--P:positive regulation of vacuole organization
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0015031--P:protein transport
GO:0007033--P:vacuole organization

KEGG ath:AT4G16144
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aly-005808 Arabidopsis lyrata 94.80 0.00e+00 781.00
IUUC-Bol-015371 Brassica oleracea 85.15 0.00e+00 667.00
IUUC-Bra-017428 Brassica rapa 84.52 0.00e+00 677.00
IUUC-Cel-018572 Caenorhabditis elegans 33.33 5.00e-03 35.40
IUUC-Cne-026908 Cryptococcus neoformans 48.15 1.00e-01 30.40
IUUC-Gma-044253 Glycine max 57.42 3.00e-127 447.00
IUUC-Mmr-061347 Microcebus murinus 34.41 1.00e-11 62.00
IUUC-Ola-087457 Oryzias latipes 28.21 1.00e-07 48.10
IUUC-Pop-098795 Populus trichocarpa 60.24 1.00e-134 472.00
IUUC-Tae-124652 Triticum aestivum 45.54 6.00e-73 267.00
Created Date 25-Jun-2017

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