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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045774
UUCD1 version UUC-HoS-00360
Ensembl Protein ID ENSP00000339109.3
UniProt Accession Q9H1A4; Q2M3H8; Q9BSE6; Q9H8D0; APC1_HUMAN
Genbank Protein ID CAC19484.1; AAH05089.1; AAI04903.1; AAI04905.1; BAB14687.1
Protein Name Anaphase-promoting complex subunit 1; Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein
Genbank Nucleotide ID AJ278357; BC005089; BC104902; BC104904; AK023807
Gene Name ANAPC1; TSG24
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000153107.11 ENST00000427997.5 ENSP00000396695.1
ENSG00000153107.11 ENST00000341068.7 ENSP00000339109.3
ENSG00000153107.11 ENST00000451367.3 ENSP00000405375.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C APC_C 21107322; 16763193
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 26.53 7.00e-41 165.00 IUUC-Sce-106246
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MSNFYEERTT MIAARDLQEF VPFGRDHCKH HPNALNLQLR QLQPASELWS SDGAAGLVGS 60
LQEVTIHEKQ KESWQLRKGV SEIGEDVDYD EELYVAGNMV IWSKGSKSQA LAVYKAFTVD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045774|E3,APC_C|Homo sapiens
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Nucleotide Sequence
(Fasta)
TCCCAAAGTG CTGGGATTAC AGGCGCGAGT GGCCGCTGGG GTTCTTAACT TGGGTCTTTG 60
AATCGCCTTA AGAAGTGTCT CTGAATCTGG GAATTGCAAG CAACGTTTCT GTGAGGACCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045774|E3,APC_C|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR024990--Apc1
Pfam

PF12859--ANAPC1
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
KEGG hsa:64682
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000288 Aegilops tauschii 26.92 1.00e-08 54.30
IUUC-Aml-002294 Ailuropoda melanoleuca 96.01 0.00e+00 3639.00
IUUC-Atr-002881 Amborella trichopoda 32.51 3.00e-165 577.00
IUUC-Apl-003588 Anas platyrhynchos 85.47 0.00e+00 3131.00
IUUC-Aca-005361 Anolis carolinensis 83.49 0.00e+00 3219.00
IUUC-Aly-005680 Arabidopsis lyrata 28.05 7.00e-141 495.00
IUUC-Ath-007479 Arabidopsis thaliana 30.27 2.00e-177 617.00
IUUC-Ago-007943 Ashbya gossypii 26.36 3.00e-49 191.00
IUUC-Acl-008141 Aspergillus clavatus 36.84 1.00e-120 429.00
IUUC-Afl-008487 Aspergillus flavus 37.07 5.00e-116 413.00
IUUC-Afu-008897 Aspergillus fumigatus 31.37 3.00e-126 447.00
IUUC-Ani-009232 Aspergillus nidulans 35.83 5.00e-112 400.00
IUUC-Ang-009699 Aspergillus niger 37.14 1.00e-111 399.00
IUUC-Aor-009943 Aspergillus oryzae 37.07 5.00e-116 413.00
IUUC-Ate-010554 Aspergillus terreus 37.53 1.00e-119 426.00
IUUC-Ame-011373 Astyanax mexicanus 67.65 0.00e+00 2597.00
IUUC-Bgr-011994 Blumeria graminis 34.64 1.00e-123 439.00
IUUC-Bta-013227 Bos taurus 95.18 0.00e+00 3546.00
IUUC-Bci-013591 Botrytis cinerea 33.58 1.00e-133 471.00
IUUC-Bdi-015048 Brachypodium distachyon 34.84 2.00e-134 473.00
IUUC-Bol-016448 Brassica oleracea 30.25 7.00e-171 595.00
IUUC-Bra-017688 Brassica rapa 31.73 6.00e-149 522.00
IUUC-Cel-018707 Caenorhabditis elegans 28.09 1.00e-78 289.00
IUUC-Cja-019608 Callithrix jacchus 98.41 0.00e+00 3787.00
IUUC-Cfa-021133 Canis familiaris 97.22 0.00e+00 3699.00
IUUC-Cpo-022097 Cavia porcellus 95.28 0.00e+00 3659.00
IUUC-Cre-022722 Chlamydomonas reinhardtii 41.67 3.00e-16 80.90
IUUC-Csa-024077 Chlorocebus sabaeus 99.38 0.00e+00 3823.00
IUUC-Cho-024372 Choloepus hoffmanni 90.35 0.00e+00 694.00
IUUC-Cin-025169 Ciona intestinalis 47.20 2.00e-86 312.00
IUUC-Csv-026053 Ciona savignyi 33.89 2.00e-123 437.00
IUUC-Cgl-026415 Colletotrichum gloeosporioides 30.72 3.00e-110 394.00
IUUC-Cne-026772 Cryptococcus neoformans 32.51 2.00e-101 365.00
IUUC-Cme-027221 Cyanidioschyzon merolae 32.10 4.00e-16 82.40
IUUC-Dre-028168 Danio rerio 66.53 0.00e+00 2553.00
IUUC-Dno-029251 Dasypus novemcinctus 92.43 0.00e+00 2668.00
IUUC-Dor-031058 Dipodomys ordii 81.40 0.00e+00 1164.00
IUUC-Dse-031374 Dothistroma septosporum 35.64 1.00e-79 291.00
IUUC-Dme-031637 Drosophila melanogaster 36.03 0.00e+00 907.00
IUUC-Ete-032785 Echinops telfairi 91.60 0.00e+00 1443.00
IUUC-Eca-034301 Equus caballus 97.17 0.00e+00 3689.00
IUUC-Eeu-034448 Erinaceus europaeus 87.30 0.00e+00 1173.00
IUUC-Fca-036327 Felis catus 97.27 0.00e+00 3713.00
IUUC-Fal-037242 Ficedula albicollis 84.60 0.00e+00 2909.00
IUUC-Fox-037815 Fusarium oxysporum 37.33 9.00e-55 209.00
IUUC-Fso-038155 Fusarium solani 32.17 6.00e-118 420.00
IUUC-Gmo-039055 Gadus morhua 62.88 0.00e+00 1306.00
IUUC-Ggr-039950 Gaeumannomyces graminis 31.47 2.00e-120 428.00
IUUC-Gga-040699 Gallus gallus 81.31 0.00e+00 3138.00
IUUC-Gac-041384 Gasterosteus aculeatus 62.70 0.00e+00 2282.00
IUUC-Gma-043887 Glycine max 30.26 2.00e-172 600.00
IUUC-Hvu-047197 Hordeum vulgare 38.03 5.00e-96 345.00
IUUC-Itr-048307 Ictidomys tridecemlineatus 93.30 0.00e+00 3312.00
IUUC-Kpa-049213 Komagataella pastoris 34.88 3.00e-107 384.00
IUUC-Lch-050625 Latimeria chalumnae 77.26 0.00e+00 2934.00
IUUC-Lpe-050901 Leersia perrieri 30.80 2.00e-143 504.00
IUUC-Loc-052539 Lepisosteus oculatus 80.63 0.00e+00 1512.00
IUUC-Lma-052970 Leptosphaeria maculans 31.81 4.00e-104 374.00
IUUC-Laf-054144 Loxodonta africana 95.73 0.00e+00 3696.00
IUUC-Mcc-054940 Macaca mulatta 99.38 0.00e+00 3823.00
IUUC-Meu-056069 Macropus eugenii 57.71 1.00e-74 273.00
IUUC-Mor-057218 Magnaporthe oryzae 34.88 8.00e-125 442.00
IUUC-Mpo-057455 Magnaporthe poae 29.51 2.60e-02 33.50
IUUC-Mtr-058775 Medicago truncatula 30.85 2.00e-179 624.00
IUUC-Mla-059122 Melampsora laricipopulina 31.18 2.00e-100 362.00
IUUC-Mga-059663 Meleagris gallopavo 81.87 0.00e+00 3042.00
IUUC-Mvi-060259 Microbotryum violaceum 31.90 3.00e-100 361.00
IUUC-Mmr-060620 Microcebus murinus 97.28 0.00e+00 3718.00
IUUC-Mdo-062149 Monodelphis domestica 89.57 0.00e+00 3454.00
IUUC-Mmu-063698 Mus musculus 92.39 0.00e+00 3598.00
IUUC-Mac-065285 Musa acuminata 38.09 9.00e-110 391.00
IUUC-Mpu-066489 Mustela putorius furo 97.27 0.00e+00 3739.00
IUUC-Mlu-067969 Myotis lucifugus 95.79 0.00e+00 3657.00
IUUC-Nfi-068325 Neosartorya fischeri 34.34 2.00e-123 438.00
IUUC-Ncr-068817 Neurospora crassa 34.01 7.00e-110 393.00
IUUC-Nle-069961 Nomascus leucogenys 99.50 0.00e+00 3165.00
IUUC-Opr-071086 Ochotona princeps 89.08 0.00e+00 815.00
IUUC-Ont-071831 Oreochromis niloticus 64.84 0.00e+00 2447.00
IUUC-Oan-073375 Ornithorhynchus anatinus 82.85 0.00e+00 724.00
IUUC-Ocu-073892 Oryctolagus cuniculus 96.91 0.00e+00 3745.00
IUUC-Oba-075880 Oryza barthii 35.27 3.00e-93 337.00
IUUC-Obr-076384 Oryza brachyantha 32.59 2.00e-158 554.00
IUUC-Ogl-077165 Oryza glaberrima 35.87 1.00e-135 478.00
IUUC-Ogu-078764 Oryza glumaepatula 30.39 1.00e-120 428.00
IUUC-Oin-079711 Oryza indica 34.54 1.00e-154 541.00
IUUC-Olo-080715 Oryza longistaminata 41.22 1.00e-90 328.00
IUUC-Ome-081131 Oryza meridionalis 33.33 3.00e-103 370.00
IUUC-Oni-082223 Oryza nivara 34.18 1.00e-104 375.00
IUUC-Opu-083985 Oryza punctata 39.81 2.00e-127 451.00
IUUC-Oru-085031 Oryza rufipogon 32.46 3.00e-100 360.00
IUUC-Osa-085599 Oryza sativa 36.76 7.00e-125 441.00
IUUC-Ola-087375 Oryzias latipes 63.95 0.00e+00 2400.00
IUUC-Olu-087875 Ostreococcus lucimarinus 33.12 3.00e-142 500.00
IUUC-Oga-088815 Otolemur garnettii 95.22 0.00e+00 3633.00
IUUC-Oar-090326 Ovis aries 95.32 0.00e+00 3525.00
IUUC-Ptr-091143 Pan troglodytes 99.71 0.00e+00 3403.00
IUUC-Pan-091945 Papio anubis 99.33 0.00e+00 3821.00
IUUC-Psi-092955 Pelodiscus sinensis 84.80 0.00e+00 2155.00
IUUC-Pma-094473 Petromyzon marinus 51.13 0.00e+00 1865.00
IUUC-Pno-094991 Phaeosphaeria nodorum 37.32 2.00e-97 350.00
IUUC-Ppa-095617 Physcomitrella patens 32.15 6.00e-170 592.00
IUUC-Pfo-096119 Poecilia formosa 63.86 0.00e+00 2437.00
IUUC-Pab-098265 Pongo abelii 98.88 0.00e+00 2454.00
IUUC-Pop-099429 Populus trichocarpa 33.23 7.00e-166 578.00
IUUC-Pca-100116 Procavia capensis 78.93 0.00e+00 984.00
IUUC-Ppe-102034 Prunus persica 35.49 4.00e-158 552.00
IUUC-Pva-102425 Pteropus vampyrus 91.63 0.00e+00 2826.00
IUUC-Pgr-103486 Puccinia graminis 30.16 2.00e-100 361.00
IUUC-Pte-104231 Pyrenophora teres 30.59 2.00e-99 358.00
IUUC-Pyt-104725 Pyrenophora triticirepentis 31.84 3.00e-110 394.00
IUUC-Rno-106106 Rattus norvegicus 92.95 0.00e+00 3590.00
IUUC-Sce-106246 Saccharomyces cerevisiae 26.23 2.00e-39 159.00
IUUC-Sha-107371 Sarcophilus harrisii 86.87 0.00e+00 3331.00
IUUC-Sja-107837 Schizosaccharomyces japonicus 31.20 6.00e-70 259.00
IUUC-Spo-108151 Schizosaccharomyces pombe 30.74 2.00e-97 351.00
IUUC-Smo-109131 Selaginella moellendorffii 32.05 3.00e-146 513.00
IUUC-Sit-109833 Setaria italica 35.13 2.00e-97 350.00
IUUC-Sly-111174 Solanum lycopersicum 38.79 3.00e-131 462.00
IUUC-Sar-113322 Sorex araneus 84.75 0.00e+00 906.00
IUUC-Sre-115207 Sporisorium reilianum 31.71 2.00e-95 345.00
IUUC-Ssc-115572 Sus scrofa 96.22 0.00e+00 3259.00
IUUC-Tgu-117040 Taeniopygia guttata 83.60 0.00e+00 3139.00
IUUC-Tru-118159 Takifugu rubripes 64.39 0.00e+00 2433.00
IUUC-Tsy-119288 Tarsius syrichta 83.02 0.00e+00 1215.00
IUUC-Tni-119889 Tetraodon nigroviridis 59.01 0.00e+00 1427.00
IUUC-Tca-120982 Theobroma cacao 33.28 8.00e-156 545.00
IUUC-Tre-122017 Trichoderma reesei 31.77 4.00e-122 433.00
IUUC-Tvi-122340 Trichoderma virens 32.37 2.00e-123 437.00
IUUC-Tae-122989 Triticum aestivum 30.92 3.00e-173 603.00
IUUC-Tme-127169 Tuber melanosporum 31.67 1.00e-122 435.00
IUUC-Tbe-127596 Tupaia belangeri 85.94 0.00e+00 798.00
IUUC-Ttr-128376 Tursiops truncatus 94.70 0.00e+00 3571.00
IUUC-Uma-129513 Ustilago maydis 29.92 5.00e-89 323.00
IUUC-Vda-129898 Verticillium dahliae 30.07 3.00e-95 344.00
IUUC-Vpa-130495 Vicugna pacos 90.84 0.00e+00 3450.00
IUUC-Vvi-131656 Vitis vinifera 36.87 7.00e-136 478.00
IUUC-Xtr-132770 Xenopus tropicalis 77.93 0.00e+00 2939.00
IUUC-Xma-133490 Xiphophorus maculatus 71.46 0.00e+00 1134.00
IUUC-Yli-134525 Yarrowia lipolytica 32.28 3.00e-103 370.00
IUUC-Zma-134774 Zea mays 30.61 6.00e-110 392.00
Created Date 25-Jun-2017

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