iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116798

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01026476

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000007088.1	ENSTGUT00000007383.1	ENSTGUP00000007310.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.90e-66	215.8	185	227
UBD/Beta-Prp	1.60e-79	267.0	94	287

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvll 36
           gH+ ++tcl++      ++ ++l+s+s Dg+i++WD+  g++ 
   Q: 185  GHSKWITCLCWeplhinPEcRYLASASKDGSIRIWDTLMGRCD 227
           8***************9889****************9988886 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t kgh + vls+++sp+g+kl+sG + + i +wd  tg+ +  +
   Q: 94   CTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPQFTAKGHRHWVLSIAWSPDGKKLASGCKNSQIFLWDPATGSQIGRV 182
           5899************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           lsgh+++++c+++     +p++++l+s+s+D+ +r+Wd  +g++ + lt+ ht+sv+++++  +g  l s s+d+t+k+w  q g   r
   Q: 183  LSGHSKWITCLCWeplhiNPECRYLASASKDGSIRIWDTLMGRCDKILTS-HTQSVTCVKWGGDG-LLYSSSQDRTIKVWRSQDGVLCR 269
           **********8752222278999**************************9.************98.9********************** PP
   S: 217  tlnghtdnvksvrfspnder 236
           tl+gh  +v+ +++s  +++
   Q: 270  TLQGHAHWVNTMALS--TDY 287
           **************9..333 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

DVQRLLIQFR DEAGECLGSP FDVPVTITPD KLQLVCNALL QKDEPVPLAF FVHDAEIVAS 60
LEKTLAGQSV ETEKVLDIIY QPQAVFRVRA VTRCTSSLEG HTEAVISVAF SPTGKYLASG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGTGCAGC GGCTCCTGAT CCAGTTCCGC GATGAGGCAG GGGAGTGCCT GGGCTCCCCC 60
TTCGATGTCC CGGTCACCAT CACTCCGGAC AAGCTGCAGC TGGTCTGCAA CGCCCTCCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	57.08	1.00e-163	568.00
IUUC-Aml-001793	Ailuropoda melanoleuca	84.36	0.00e+00	852.00
IUUC-Atr-002507	Amborella trichopoda	57.14	3.00e-162	564.00
IUUC-Apl-003964	Anas platyrhynchos	93.17	0.00e+00	882.00
IUUC-Aly-006396	Arabidopsis lyrata	54.26	7.00e-158	549.00
IUUC-Ath-007278	Arabidopsis thaliana	54.47	9.00e-158	549.00
IUUC-Ago-007951	Ashbya gossypii	48.57	3.00e-130	457.00
IUUC-Acl-008298	Aspergillus clavatus	48.33	3.00e-121	428.00
IUUC-Afl-008581	Aspergillus flavus	52.51	3.00e-110	390.00
IUUC-Afu-008906	Aspergillus fumigatus	48.55	2.00e-122	431.00
IUUC-Ani-009189	Aspergillus nidulans	46.12	5.00e-119	421.00
IUUC-Ang-009630	Aspergillus niger	47.54	3.00e-125	441.00
IUUC-Aor-010038	Aspergillus oryzae	48.23	4.00e-128	451.00
IUUC-Ate-010278	Aspergillus terreus	47.00	6.00e-124	437.00
IUUC-Ame-011890	Astyanax mexicanus	82.45	0.00e+00	832.00
IUUC-Bgr-012011	Blumeria graminis	48.45	2.00e-131	461.00
IUUC-Bta-012964	Bos taurus	84.14	0.00e+00	850.00
IUUC-Bci-013592	Botrytis cinerea	45.42	7.00e-120	423.00
IUUC-Bdi-015035	Brachypodium distachyon	57.82	2.00e-166	578.00
IUUC-Bol-015501	Brassica oleracea	55.77	1.00e-159	555.00
IUUC-Bra-017642	Brassica rapa	55.34	4.00e-159	553.00
IUUC-Cel-018430	Caenorhabditis elegans	58.55	3.00e-163	567.00
IUUC-Cja-019125	Callithrix jacchus	85.20	0.00e+00	856.00
IUUC-Cfa-021013	Canis familiaris	84.99	0.00e+00	783.00
IUUC-Cpo-021743	Cavia porcellus	83.93	0.00e+00	850.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	43.74	5.00e-110	390.00
IUUC-Csa-024270	Chlorocebus sabaeus	85.20	0.00e+00	854.00
IUUC-Cin-025795	Ciona intestinalis	65.46	0.00e+00	674.00
IUUC-Csv-025953	Ciona savignyi	65.67	0.00e+00	677.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	51.72	6.00e-108	384.00
IUUC-Cne-026901	Cryptococcus neoformans	47.32	2.00e-133	468.00
IUUC-Cme-027281	Cyanidioschyzon merolae	47.03	1.00e-112	399.00
IUUC-Dre-028515	Danio rerio	81.61	0.00e+00	819.00
IUUC-Dno-029596	Dasypus novemcinctus	85.20	0.00e+00	851.00
IUUC-Dor-030494	Dipodomys ordii	85.14	0.00e+00	848.00
IUUC-Dse-031538	Dothistroma septosporum	49.38	3.00e-131	461.00
IUUC-Dme-031974	Drosophila melanogaster	60.60	5.00e-170	590.00
IUUC-Ete-032948	Echinops telfairi	89.00	5.00e-110	390.00
IUUC-Eca-033399	Equus caballus	85.35	0.00e+00	854.00
IUUC-Eeu-035013	Erinaceus europaeus	89.00	2.00e-109	388.00
IUUC-Fca-035860	Felis catus	85.41	0.00e+00	856.00
IUUC-Fal-037069	Ficedula albicollis	99.20	3.00e-147	513.00
IUUC-Fox-038059	Fusarium oxysporum	45.83	3.00e-124	438.00
IUUC-Fso-038445	Fusarium solani	46.88	7.00e-125	440.00
IUUC-Gmo-039319	Gadus morhua	77.23	0.00e+00	743.00
IUUC-Ggr-040095	Gaeumannomyces graminis	47.50	1.00e-121	429.00
IUUC-Gga-040303	Gallus gallus	93.63	3.00e-140	489.00
IUUC-Gac-042267	Gasterosteus aculeatus	80.38	0.00e+00	771.00
IUUC-Gma-044360	Glycine max	56.81	9.00e-165	572.00
IUUC-Ggo-044637	Gorilla gorilla	85.14	0.00e+00	851.00
IUUC-Hsa-046128	Homo sapiens	85.41	0.00e+00	860.00
IUUC-Hvu-047373	Hordeum vulgare	56.96	4.00e-164	570.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	83.89	0.00e+00	848.00
IUUC-Kpa-049274	Komagataella pastoris	45.79	1.00e-127	449.00
IUUC-Lch-049907	Latimeria chalumnae	85.71	0.00e+00	843.00
IUUC-Lpe-050778	Leersia perrieri	52.89	3.00e-147	514.00
IUUC-Loc-051889	Lepisosteus oculatus	83.09	0.00e+00	841.00
IUUC-Lma-053041	Leptosphaeria maculans	49.07	2.00e-116	412.00
IUUC-Laf-053598	Loxodonta africana	85.20	0.00e+00	855.00
IUUC-Mcc-055660	Macaca mulatta	85.20	0.00e+00	853.00
IUUC-Meu-056197	Macropus eugenii	74.41	0.00e+00	738.00
IUUC-Mor-056949	Magnaporthe oryzae	45.55	4.00e-116	411.00
IUUC-Mpo-057571	Magnaporthe poae	44.23	3.00e-63	235.00
IUUC-Mtr-058530	Medicago truncatula	58.30	2.00e-163	568.00
IUUC-Mla-059133	Melampsora laricipopulina	45.93	7.00e-124	437.00
IUUC-Mga-059252	Meleagris gallopavo	95.07	0.00e+00	727.00
IUUC-Mvi-060522	Microbotryum violaceum	48.78	6.00e-133	467.00
IUUC-Mmr-061117	Microcebus murinus	83.54	0.00e+00	842.00
IUUC-Mdo-062892	Monodelphis domestica	86.05	0.00e+00	858.00
IUUC-Mmu-064108	Mus musculus	85.20	0.00e+00	834.00
IUUC-Mac-064430	Musa acuminata	58.03	7.00e-167	579.00
IUUC-Mpu-065882	Mustela putorius furo	84.57	0.00e+00	849.00
IUUC-Mlu-068123	Myotis lucifugus	84.57	0.00e+00	855.00
IUUC-Nfi-068484	Neosartorya fischeri	48.55	1.00e-122	433.00
IUUC-Ncr-068649	Neurospora crassa	43.91	6.00e-112	397.00
IUUC-Nle-069140	Nomascus leucogenys	85.14	0.00e+00	853.00
IUUC-Opr-070220	Ochotona princeps	77.66	0.00e+00	738.00
IUUC-Ont-072643	Oreochromis niloticus	81.86	0.00e+00	825.00
IUUC-Ocu-074007	Oryctolagus cuniculus	84.99	0.00e+00	834.00
IUUC-Oba-075904	Oryza barthii	57.39	2.00e-166	578.00
IUUC-Obr-076280	Oryza brachyantha	57.17	9.00e-166	575.00
IUUC-Ogl-077425	Oryza glaberrima	57.60	6.00e-167	580.00
IUUC-Ogu-078586	Oryza glumaepatula	57.39	2.00e-166	578.00
IUUC-Oin-079489	Oryza indica	55.46	6.00e-158	550.00
IUUC-Olo-080766	Oryza longistaminata	57.26	3.00e-166	577.00
IUUC-Ome-081905	Oryza meridionalis	57.60	2.00e-166	578.00
IUUC-Oni-083022	Oryza nivara	57.39	9.00e-167	579.00
IUUC-Opu-083615	Oryza punctata	57.60	1.00e-166	578.00
IUUC-Oru-085076	Oryza rufipogon	57.39	1.00e-166	579.00
IUUC-Osa-085516	Oryza sativa	57.39	1.00e-166	579.00
IUUC-Ola-087290	Oryzias latipes	81.65	0.00e+00	823.00
IUUC-Olu-087898	Ostreococcus lucimarinus	56.24	8.00e-146	509.00
IUUC-Oga-088980	Otolemur garnettii	83.65	0.00e+00	846.00
IUUC-Oar-089580	Ovis aries	83.62	0.00e+00	735.00
IUUC-Ptr-090845	Pan troglodytes	84.93	0.00e+00	850.00
IUUC-Pan-092836	Papio anubis	85.20	0.00e+00	856.00
IUUC-Psi-093965	Pelodiscus sinensis	88.60	4.00e-59	218.00
IUUC-Pno-095052	Phaeosphaeria nodorum	48.12	3.00e-123	434.00
IUUC-Ppa-095432	Physcomitrella patens	57.78	2.00e-165	575.00
IUUC-Pfo-096963	Poecilia formosa	74.47	0.00e+00	717.00
IUUC-Pab-097716	Pongo abelii	81.53	0.00e+00	811.00
IUUC-Pop-099224	Populus trichocarpa	57.87	7.00e-167	579.00
IUUC-Pca-100682	Procavia capensis	82.82	1.00e-179	621.00
IUUC-Ppe-101819	Prunus persica	56.72	9.00e-162	562.00
IUUC-Pva-102338	Pteropus vampyrus	82.35	0.00e+00	634.00
IUUC-Pgr-103583	Puccinia graminis	53.19	9.00e-129	453.00
IUUC-Ptt-103737	Puccinia triticina	43.41	2.00e-96	346.00
IUUC-Pte-104150	Pyrenophora teres	50.23	3.00e-122	431.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	50.23	4.00e-122	431.00
IUUC-Rno-105987	Rattus norvegicus	85.17	0.00e+00	854.00
IUUC-Sce-106315	Saccharomyces cerevisiae	47.67	1.00e-128	452.00
IUUC-Sha-107273	Sarcophilus harrisii	85.41	0.00e+00	866.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	47.38	9.00e-120	423.00
IUUC-Spo-108092	Schizosaccharomyces pombe	50.34	2.00e-126	445.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	44.56	2.00e-116	412.00
IUUC-Smo-108855	Selaginella moellendorffii	55.44	7.00e-162	563.00
IUUC-Sit-110329	Setaria italica	57.39	3.00e-165	574.00
IUUC-Sly-111830	Solanum lycopersicum	59.10	2.00e-168	585.00
IUUC-Stu-112603	Solanum tuberosum	59.10	1.00e-168	585.00
IUUC-Sar-113504	Sorex araneus	82.98	5.00e-66	244.00
IUUC-Sbi-114560	Sorghum bicolor	57.39	4.00e-165	573.00
IUUC-Sre-115133	Sporisorium reilianum	39.59	3.00e-116	412.00
IUUC-Ssc-115903	Sus scrofa	84.99	0.00e+00	852.00
IUUC-Tru-118361	Takifugu rubripes	81.65	0.00e+00	829.00
IUUC-Tsy-118849	Tarsius syrichta	85.07	0.00e+00	848.00
IUUC-Tni-120094	Tetraodon nigroviridis	81.43	0.00e+00	825.00
IUUC-Tca-121634	Theobroma cacao	57.45	2.00e-163	568.00
IUUC-Tre-122051	Trichoderma reesei	47.29	4.00e-119	421.00
IUUC-Tvi-122322	Trichoderma virens	47.41	1.00e-122	432.00
IUUC-Tae-123133	Triticum aestivum	56.96	3.00e-164	571.00
IUUC-Tur-126766	Triticum urartu	50.67	3.00e-155	541.00
IUUC-Tme-127175	Tuber melanosporum	48.77	1.00e-127	449.00
IUUC-Tbe-127779	Tupaia belangeri	85.01	0.00e+00	765.00
IUUC-Ttr-128224	Tursiops truncatus	81.07	0.00e+00	741.00
IUUC-Uma-129537	Ustilago maydis	43.05	5.00e-120	424.00
IUUC-Vda-129927	Verticillium dahliae	45.61	1.00e-110	393.00
IUUC-Vpa-130658	Vicugna pacos	73.62	0.00e+00	713.00
IUUC-Vvi-131659	Vitis vinifera	57.14	1.00e-164	572.00
IUUC-Xtr-132918	Xenopus tropicalis	82.49	0.00e+00	820.00
IUUC-Xma-133700	Xiphophorus maculatus	82.91	0.00e+00	830.00
IUUC-Yli-134478	Yarrowia lipolytica	49.49	2.00e-136	478.00
IUUC-Zma-135835	Zea mays	54.97	1.00e-161	562.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence