iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-10	40.8	3107	3138

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtc....lafsdtllvsGsdDgtikvWDl 30
           gHtd vtc    +a+  +++vsGs+D t+ +WDl
   Q: 3107 GHTDTVTCatasIAY--HIIVSGSRDRTCIIWDL 3138
           8*******7766677..89**************8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MNMVKRIMGR PRQEECSPQD NALGLMHLRR LFTELCHPPR HMTQKEQEEK LYMMLPVFNR 60
VFGNAPPSTM TEKFSDLLQF TTQVSRLMVT EIRRRASNKS TEAASRAIVQ FLEINQSEEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCCCCGCG GCCCGGCCCG GCCTTGATGG AGAGGAGCAG CCCGTGCAGC GCCGAGGCTG 60
AGGCGGCGGC GGGGACCCGG CGAGGGAGAA GACGCGGCAG AAGGGACCCG GGGGGAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000409--BEACH_dom
IPR013320--ConA-like_dom
IPR031570--DUF4704
IPR023362--PH-BEACH_dom
IPR011993--PH_dom-like
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50197--BEACH
PS51783--PH_BEACH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS50178--ZF_FYVE

Pfam

PF02138--Beach
PF15787--DUF4704
PF01363--FYVE
PF14844--PH_BEACH

SMART

SM01026--Beach
SM00064--FYVE
SM00320--WD40

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0005829--C:cytosol
GO:0097635--C:extrinsic component of autophagosome membrane
GO:0016234--C:inclusion body
GO:0005635--C:nuclear envelope
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:0016605--C:PML body
GO:0005545--F:1-phosphatidylinositol binding
GO:0003831--F:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0046872--F:metal ion binding
GO:0035973--P:aggrephagy

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000317	Aegilops tauschii	33.55	8.00e-176	612.00
IUUC-Aml-002094	Ailuropoda melanoleuca	94.84	0.00e+00	6718.00
IUUC-Atr-002879	Amborella trichopoda	37.71	1.00e-175	612.00
IUUC-Apl-003581	Anas platyrhynchos	90.07	0.00e+00	4909.00
IUUC-Aca-005386	Anolis carolinensis	89.71	0.00e+00	6443.00
IUUC-Aly-006119	Arabidopsis lyrata	33.86	4.00e-177	617.00
IUUC-Ath-007645	Arabidopsis thaliana	46.89	1.00e-167	585.00
IUUC-Afu-009064	Aspergillus fumigatus	37.98	9.00e-166	578.00
IUUC-Ani-009310	Aspergillus nidulans	36.56	1.00e-160	561.00
IUUC-Aor-010079	Aspergillus oryzae	36.67	2.00e-166	580.00
IUUC-Ame-011607	Astyanax mexicanus	80.94	0.00e+00	5585.00
IUUC-Bta-012997	Bos taurus	94.36	0.00e+00	6629.00
IUUC-Bci-013784	Botrytis cinerea	36.75	5.00e-165	576.00
IUUC-Bdi-015031	Brachypodium distachyon	34.21	2.00e-175	611.00
IUUC-Bol-016599	Brassica oleracea	46.41	3.00e-162	567.00
IUUC-Bra-017709	Brassica rapa	46.25	5.00e-162	566.00
IUUC-Cja-019272	Callithrix jacchus	94.56	0.00e+00	6695.00
IUUC-Cfa-020073	Canis familiaris	94.39	0.00e+00	6653.00
IUUC-Cpo-021455	Cavia porcellus	93.32	0.00e+00	6568.00
IUUC-Csa-023097	Chlorocebus sabaeus	93.85	0.00e+00	6684.00
IUUC-Cin-025176	Ciona intestinalis	27.54	2.00e-18	86.30
IUUC-Csv-026108	Ciona savignyi	36.76	3.00e-98	352.00
IUUC-Cgl-026670	Colletotrichum gloeosporioides	35.31	1.00e-144	508.00
IUUC-Dre-027703	Danio rerio	83.15	0.00e+00	5828.00
IUUC-Dor-030567	Dipodomys ordii	84.39	0.00e+00	2031.00
IUUC-Dme-031959	Drosophila melanogaster	47.33	0.00e+00	2737.00
IUUC-Ete-032373	Echinops telfairi	88.99	0.00e+00	2709.00
IUUC-Eca-033575	Equus caballus	94.44	0.00e+00	6704.00
IUUC-Eeu-034853	Erinaceus europaeus	83.58	0.00e+00	2180.00
IUUC-Fca-036304	Felis catus	94.70	0.00e+00	6660.00
IUUC-Fal-037019	Ficedula albicollis	90.71	0.00e+00	6456.00
IUUC-Fox-038015	Fusarium oxysporum	34.84	5.00e-153	535.00
IUUC-Fso-038249	Fusarium solani	35.82	7.00e-150	526.00
IUUC-Gmo-039503	Gadus morhua	78.56	0.00e+00	5537.00
IUUC-Ggr-039900	Gaeumannomyces graminis	40.33	7.00e-152	533.00
IUUC-Gac-041618	Gasterosteus aculeatus	80.79	0.00e+00	5714.00
IUUC-Gma-043242	Glycine max	34.53	2.00e-176	615.00
IUUC-Ggo-044679	Gorilla gorilla	91.99	0.00e+00	6493.00
IUUC-Hsa-046586	Homo sapiens	94.75	0.00e+00	6735.00
IUUC-Hvu-047814	Hordeum vulgare	34.11	8.00e-177	616.00
IUUC-Itr-048396	Ictidomys tridecemlineatus	94.38	0.00e+00	5528.00
IUUC-Lpe-050828	Leersia perrieri	34.48	3.00e-178	621.00
IUUC-Loc-052434	Lepisosteus oculatus	85.93	0.00e+00	6094.00
IUUC-Lma-053017	Leptosphaeria maculans	32.80	5.00e-135	476.00
IUUC-Laf-054408	Loxodonta africana	94.68	0.00e+00	6717.00
IUUC-Mcc-055652	Macaca mulatta	94.64	0.00e+00	6734.00
IUUC-Meu-056743	Macropus eugenii	78.59	0.00e+00	2731.00
IUUC-Mor-057120	Magnaporthe oryzae	35.84	2.00e-163	571.00
IUUC-Mtr-058732	Medicago truncatula	38.18	5.00e-177	617.00
IUUC-Mla-058974	Melampsora laricipopulina	32.27	2.00e-138	488.00
IUUC-Mvi-060546	Microbotryum violaceum	30.88	7.00e-157	549.00
IUUC-Mmr-061760	Microcebus murinus	88.98	0.00e+00	6169.00
IUUC-Mdo-062645	Monodelphis domestica	92.23	0.00e+00	6518.00
IUUC-Mmu-063588	Mus musculus	97.28	0.00e+00	6952.00
IUUC-Mac-064551	Musa acuminata	39.05	5.00e-173	603.00
IUUC-Mpu-066073	Mustela putorius furo	94.76	0.00e+00	6665.00
IUUC-Mlu-067641	Myotis lucifugus	94.34	0.00e+00	6685.00
IUUC-Nfi-068471	Neosartorya fischeri	37.01	5.00e-166	580.00
IUUC-Nle-070009	Nomascus leucogenys	94.64	0.00e+00	6715.00
IUUC-Opr-070689	Ochotona princeps	91.12	0.00e+00	5782.00
IUUC-Ont-071427	Oreochromis niloticus	81.75	0.00e+00	5713.00
IUUC-Oan-073118	Ornithorhynchus anatinus	83.68	0.00e+00	5794.00
IUUC-Ocu-074702	Oryctolagus cuniculus	95.01	0.00e+00	6762.00
IUUC-Oba-075831	Oryza barthii	34.68	5.00e-177	616.00
IUUC-Obr-076728	Oryza brachyantha	34.35	2.00e-176	615.00
IUUC-Ogl-077922	Oryza glaberrima	34.68	6.00e-177	616.00
IUUC-Ogu-079001	Oryza glumaepatula	34.59	3.00e-176	614.00
IUUC-Oin-079929	Oryza indica	38.20	1.00e-164	573.00
IUUC-Olo-080662	Oryza longistaminata	34.97	5.00e-177	617.00
IUUC-Ome-081733	Oryza meridionalis	34.76	7.00e-178	619.00
IUUC-Oni-082641	Oryza nivara	34.68	9.00e-177	615.00
IUUC-Opu-083564	Oryza punctata	34.97	1.00e-177	619.00
IUUC-Oru-084403	Oryza rufipogon	34.68	7.00e-177	616.00
IUUC-Osa-085957	Oryza sativa	36.08	2.00e-45	176.00
IUUC-Ola-086856	Oryzias latipes	78.98	0.00e+00	5565.00
IUUC-Oga-088908	Otolemur garnettii	94.94	0.00e+00	2990.00
IUUC-Oar-089625	Ovis aries	93.49	0.00e+00	6548.00
IUUC-Ptr-091209	Pan troglodytes	94.64	0.00e+00	6733.00
IUUC-Pan-092751	Papio anubis	94.50	0.00e+00	6714.00
IUUC-Psi-092951	Pelodiscus sinensis	90.81	0.00e+00	6521.00
IUUC-Ppa-095361	Physcomitrella patens	35.43	0.00e+00	634.00
IUUC-Pfo-097102	Poecilia formosa	80.42	0.00e+00	5685.00
IUUC-Pab-098485	Pongo abelii	94.36	0.00e+00	6702.00
IUUC-Pop-099807	Populus trichocarpa	37.69	2.00e-178	621.00
IUUC-Pca-100146	Procavia capensis	86.56	0.00e+00	1402.00
IUUC-Ppe-101277	Prunus persica	37.44	0.00e+00	634.00
IUUC-Pva-102502	Pteropus vampyrus	84.58	0.00e+00	3145.00
IUUC-Ptt-103873	Puccinia triticina	32.88	2.00e-111	398.00
IUUC-Sha-106751	Sarcophilus harrisii	82.05	0.00e+00	5711.00
IUUC-Sja-107759	Schizosaccharomyces japonicus	39.04	6.00e-149	523.00
IUUC-Spo-108108	Schizosaccharomyces pombe	40.21	7.00e-153	536.00
IUUC-Ssl-108524	Sclerotinia sclerotiorum	37.97	3.00e-164	572.00
IUUC-Smo-109485	Selaginella moellendorffii	32.46	0.00e+00	642.00
IUUC-Sit-110811	Setaria italica	34.11	0.00e+00	630.00
IUUC-Sly-110936	Solanum lycopersicum	36.10	1.00e-176	615.00
IUUC-Sar-113013	Sorex araneus	80.83	0.00e+00	1375.00
IUUC-Sbi-114421	Sorghum bicolor	42.84	2.00e-174	608.00
IUUC-Sre-115137	Sporisorium reilianum	32.83	3.00e-135	477.00
IUUC-Ssc-116100	Sus scrofa	93.99	0.00e+00	6683.00
IUUC-Tgu-117182	Taeniopygia guttata	90.37	0.00e+00	6423.00
IUUC-Tru-117859	Takifugu rubripes	81.00	0.00e+00	5627.00
IUUC-Tsy-119315	Tarsius syrichta	94.84	0.00e+00	4185.00
IUUC-Tni-120784	Tetraodon nigroviridis	80.29	0.00e+00	5565.00
IUUC-Tca-121423	Theobroma cacao	36.89	3.00e-174	607.00
IUUC-Tre-121988	Trichoderma reesei	36.74	7.00e-160	559.00
IUUC-Tvi-122476	Trichoderma virens	37.61	4.00e-161	563.00
IUUC-Tur-126221	Triticum urartu	33.68	4.00e-176	613.00
IUUC-Tme-126944	Tuber melanosporum	40.59	5.00e-157	550.00
IUUC-Tbe-127827	Tupaia belangeri	88.29	0.00e+00	2667.00
IUUC-Ttr-128368	Tursiops truncatus	94.50	0.00e+00	6728.00
IUUC-Vda-129813	Verticillium dahliae	35.80	2.00e-152	534.00
IUUC-Vpa-130252	Vicugna pacos	94.73	0.00e+00	4303.00
IUUC-Vvi-131663	Vitis vinifera	37.87	2.00e-177	618.00
IUUC-Xtr-132689	Xenopus tropicalis	85.27	0.00e+00	6175.00
IUUC-Xma-133273	Xiphophorus maculatus	81.67	0.00e+00	4764.00
IUUC-Zma-135580	Zea mays	42.52	1.00e-172	602.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence