iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066058

Ensembl Protein ID

ENSMPUP00000004584.1

UniProt Accession

M3XZT3; M3XZT3_MUSPF

Genbank Protein ID

ENSMPUP00000004584

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AEYP01029093

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000004619.1	ENSMPUT00000004663.1	ENSMPUP00000004584.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.90e-101	339.3	1	321

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
164	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m++++ ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tif
   Q: 1    MTGNAGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIF 78
           788999************************.****************.********************.........899********* PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc+++ ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + +++++    +++af
   Q: 79   FAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDAKTSAK----EEDAF 163
           ****************************************************************************9887....79*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLGA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmd 249
           **************************9.78999*********..******************************976665567777777 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
             +  ++l++i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 250  tDQGSNMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 321
           755568**********************************************************993...33344 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP 60
GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGGGCA ATGCTGGGGA GTGGTGCCTC ATGGAAAGCG ACCCCGGGGT CTTCACCGAG 60
CTCATTAAAG GATTCGGTGA GAGACAAGGG ACCGTCCTGG GCCGGGGGTC ACGGGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	46.99	4.00e-84	304.00
IUUC-Aml-001866	Ailuropoda melanoleuca	99.68	0.00e+00	652.00
IUUC-Atr-002966	Amborella trichopoda	46.84	4.00e-80	291.00
IUUC-Apl-003306	Anas platyrhynchos	86.31	1.00e-177	615.00
IUUC-Aca-004763	Anolis carolinensis	95.82	2.00e-180	624.00
IUUC-Aly-005581	Arabidopsis lyrata	48.33	3.00e-79	288.00
IUUC-Ath-007283	Arabidopsis thaliana	48.33	4.00e-82	297.00
IUUC-Ago-007999	Ashbya gossypii	33.33	1.00e-33	136.00
IUUC-Acl-008231	Aspergillus clavatus	43.15	2.00e-52	199.00
IUUC-Afl-008557	Aspergillus flavus	37.58	1.00e-54	206.00
IUUC-Afu-008988	Aspergillus fumigatus	45.00	2.00e-54	205.00
IUUC-Ani-009420	Aspergillus nidulans	37.81	1.00e-52	199.00
IUUC-Ang-009859	Aspergillus niger	40.82	4.00e-49	188.00
IUUC-Aor-010145	Aspergillus oryzae	37.58	1.00e-54	206.00
IUUC-Ate-010347	Aspergillus terreus	41.73	4.00e-53	201.00
IUUC-Ame-010791	Astyanax mexicanus	90.27	0.00e+00	630.00
IUUC-Bgr-012298	Blumeria graminis	37.50	4.00e-49	188.00
IUUC-Bta-013251	Bos taurus	99.36	0.00e+00	645.00
IUUC-Bci-013786	Botrytis cinerea	37.76	1.00e-57	216.00
IUUC-Bdi-014132	Brachypodium distachyon	48.77	2.00e-81	295.00
IUUC-Bol-015611	Brassica oleracea	49.70	1.00e-84	306.00
IUUC-Bra-017769	Brassica rapa	49.70	1.00e-84	306.00
IUUC-Cel-018604	Caenorhabditis elegans	47.13	6.00e-82	297.00
IUUC-Cja-019768	Callithrix jacchus	90.32	0.00e+00	627.00
IUUC-Cfa-020207	Canis familiaris	99.68	0.00e+00	652.00
IUUC-Cpo-021925	Cavia porcellus	95.53	2.00e-179	621.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.21	6.00e-74	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	98.72	0.00e+00	640.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	1.00e-42	166.00
IUUC-Cin-025771	Ciona intestinalis	54.18	1.00e-99	356.00
IUUC-Csv-026149	Ciona savignyi	57.68	1.00e-102	366.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.50	2.00e-51	196.00
IUUC-Cne-026955	Cryptococcus neoformans	37.87	5.00e-55	207.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.06	2.00e-48	186.00
IUUC-Dre-027409	Danio rerio	89.36	5.00e-179	619.00
IUUC-Dno-028921	Dasypus novemcinctus	99.04	0.00e+00	647.00
IUUC-Dor-030891	Dipodomys ordii	44.58	2.00e-34	140.00
IUUC-Dse-031170	Dothistroma septosporum	39.37	1.00e-58	219.00
IUUC-Dme-031677	Drosophila melanogaster	59.46	7.00e-115	406.00
IUUC-Ete-032707	Echinops telfairi	68.97	1.00e-119	422.00
IUUC-Eca-033776	Equus caballus	99.31	1.00e-171	595.00
IUUC-Eeu-035305	Erinaceus europaeus	79.26	1.00e-83	303.00
IUUC-Fca-035846	Felis catus	91.76	0.00e+00	634.00
IUUC-Fal-037597	Ficedula albicollis	96.18	6.00e-160	556.00
IUUC-Fox-037670	Fusarium oxysporum	42.86	2.00e-55	209.00
IUUC-Fso-038243	Fusarium solani	50.22	1.00e-54	206.00
IUUC-Gmo-038499	Gadus morhua	84.35	6.00e-162	563.00
IUUC-Ggr-039975	Gaeumannomyces graminis	42.17	6.00e-48	184.00
IUUC-Gga-040904	Gallus gallus	95.11	0.00e+00	648.00
IUUC-Gac-042058	Gasterosteus aculeatus	89.14	3.00e-171	593.00
IUUC-Gma-043763	Glycine max	48.37	4.00e-85	307.00
IUUC-Ggo-044699	Gorilla gorilla	93.16	1.00e-170	592.00
IUUC-Hsa-046227	Homo sapiens	99.04	0.00e+00	649.00
IUUC-Hvu-047359	Hordeum vulgare	47.42	1.00e-82	300.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	90.70	0.00e+00	633.00
IUUC-Lch-049829	Latimeria chalumnae	92.97	3.00e-176	610.00
IUUC-Lpe-050899	Leersia perrieri	48.26	6.00e-78	283.00
IUUC-Loc-052264	Lepisosteus oculatus	91.08	6.00e-174	603.00
IUUC-Lma-053110	Leptosphaeria maculans	38.41	2.00e-48	186.00
IUUC-Laf-053639	Loxodonta africana	99.68	0.00e+00	652.00
IUUC-Mcc-055506	Macaca mulatta	98.72	0.00e+00	640.00
IUUC-Meu-056267	Macropus eugenii	41.67	6.00e-46	179.00
IUUC-Mor-057001	Magnaporthe oryzae	45.38	5.00e-55	207.00
IUUC-Mpo-057608	Magnaporthe poae	40.64	1.00e-32	132.00
IUUC-Mtr-057731	Medicago truncatula	49.25	2.00e-85	308.00
IUUC-Mla-059016	Melampsora laricipopulina	43.28	1.00e-43	168.00
IUUC-Mga-060178	Meleagris gallopavo	95.72	2.00e-174	604.00
IUUC-Mvi-060353	Microbotryum violaceum	38.21	4.00e-54	204.00
IUUC-Mmr-060738	Microcebus murinus	99.04	0.00e+00	648.00
IUUC-Mdo-062266	Monodelphis domestica	98.04	1.00e-120	424.00
IUUC-Mmu-063619	Mus musculus	96.81	0.00e+00	636.00
IUUC-Mac-065301	Musa acuminata	50.16	4.00e-88	317.00
IUUC-Mlu-067292	Myotis lucifugus	98.08	0.00e+00	637.00
IUUC-Nfi-068275	Neosartorya fischeri	37.50	3.00e-55	208.00
IUUC-Ncr-068713	Neurospora crassa	38.68	4.00e-58	218.00
IUUC-Nle-069013	Nomascus leucogenys	98.40	0.00e+00	638.00
IUUC-Opr-070628	Ochotona princeps	87.35	4.00e-172	597.00
IUUC-Ont-072688	Oreochromis niloticus	89.84	7.00e-172	595.00
IUUC-Oan-073004	Ornithorhynchus anatinus	97.15	6.00e-143	499.00
IUUC-Ocu-074303	Oryctolagus cuniculus	100.00	0.00e+00	655.00
IUUC-Oba-075002	Oryza barthii	48.19	6.00e-82	297.00
IUUC-Obr-076392	Oryza brachyantha	49.21	7.00e-80	290.00
IUUC-Ogl-077271	Oryza glaberrima	48.19	6.00e-82	297.00
IUUC-Ogu-078493	Oryza glumaepatula	48.19	1.00e-82	299.00
IUUC-Oin-080084	Oryza indica	48.19	1.00e-82	299.00
IUUC-Olo-080803	Oryza longistaminata	47.89	3.00e-82	298.00
IUUC-Ome-081146	Oryza meridionalis	47.29	3.00e-81	295.00
IUUC-Oni-082146	Oryza nivara	48.19	1.00e-82	299.00
IUUC-Opu-083633	Oryza punctata	48.90	1.00e-78	286.00
IUUC-Oru-084789	Oryza rufipogon	48.19	1.00e-82	299.00
IUUC-Osa-086196	Oryza sativa	48.19	1.00e-82	299.00
IUUC-Ola-087126	Oryzias latipes	89.78	5.00e-168	583.00
IUUC-Olu-087665	Ostreococcus lucimarinus	41.67	4.00e-69	254.00
IUUC-Oga-089140	Otolemur garnettii	90.59	0.00e+00	630.00
IUUC-Oar-090296	Ovis aries	99.04	0.00e+00	646.00
IUUC-Ptr-090566	Pan troglodytes	99.04	0.00e+00	649.00
IUUC-Pan-092052	Papio anubis	98.72	0.00e+00	640.00
IUUC-Psi-093723	Pelodiscus sinensis	95.83	3.00e-166	577.00
IUUC-Pma-094568	Petromyzon marinus	61.11	1.00e-106	379.00
IUUC-Pno-095120	Phaeosphaeria nodorum	39.02	6.00e-50	191.00
IUUC-Ppa-095761	Physcomitrella patens	47.66	3.00e-84	305.00
IUUC-Pfo-096210	Poecilia formosa	89.14	1.00e-171	595.00
IUUC-Pab-098463	Pongo abelii	99.04	0.00e+00	647.00
IUUC-Pop-099423	Populus trichocarpa	48.96	1.00e-84	306.00
IUUC-Pca-100108	Procavia capensis	97.56	6.00e-143	499.00
IUUC-Ppe-101176	Prunus persica	50.90	7.00e-86	310.00
IUUC-Pva-102629	Pteropus vampyrus	96.18	4.00e-149	520.00
IUUC-Pgr-103419	Puccinia graminis	39.76	6.00e-57	214.00
IUUC-Pte-104207	Pyrenophora teres	44.38	7.00e-33	132.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.34	5.00e-57	214.00
IUUC-Rno-105579	Rattus norvegicus	87.00	3.00e-163	567.00
IUUC-Sha-106894	Sarcophilus harrisii	94.57	2.00e-156	544.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	38.87	4.00e-59	221.00
IUUC-Spo-108371	Schizosaccharomyces pombe	41.58	2.00e-59	221.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.41	2.00e-47	182.00
IUUC-Smo-109396	Selaginella moellendorffii	51.08	6.00e-88	317.00
IUUC-Sit-110630	Setaria italica	49.24	1.00e-85	310.00
IUUC-Sly-110972	Solanum lycopersicum	50.16	2.00e-80	292.00
IUUC-Stu-112185	Solanum tuberosum	49.40	1.00e-88	319.00
IUUC-Sar-113294	Sorex araneus	82.62	6.00e-165	573.00
IUUC-Sbi-113951	Sorghum bicolor	49.54	3.00e-86	311.00
IUUC-Ssc-115501	Sus scrofa	98.65	9.00e-176	608.00
IUUC-Tgu-117152	Taeniopygia guttata	95.83	6.00e-160	556.00
IUUC-Tru-118388	Takifugu rubripes	88.82	3.00e-171	594.00
IUUC-Tsy-119109	Tarsius syrichta	99.36	0.00e+00	649.00
IUUC-Tni-120048	Tetraodon nigroviridis	88.82	5.00e-172	596.00
IUUC-Tca-121750	Theobroma cacao	48.82	4.00e-88	318.00
IUUC-Tre-122130	Trichoderma reesei	39.33	2.00e-55	209.00
IUUC-Tvi-122284	Trichoderma virens	39.53	6.00e-53	200.00
IUUC-Tae-124082	Triticum aestivum	47.59	2.00e-83	302.00
IUUC-Tur-126366	Triticum urartu	42.72	4.00e-66	245.00
IUUC-Tme-127187	Tuber melanosporum	41.25	7.00e-58	217.00
IUUC-Tbe-127619	Tupaia belangeri	90.24	4.00e-145	507.00
IUUC-Ttr-128867	Tursiops truncatus	88.16	3.00e-124	437.00
IUUC-Vda-129912	Verticillium dahliae	37.37	2.00e-52	199.00
IUUC-Vpa-130552	Vicugna pacos	100.00	1.00e-126	446.00
IUUC-Vvi-130881	Vitis vinifera	50.74	1.00e-84	306.00
IUUC-Xtr-131934	Xenopus tropicalis	86.02	2.00e-174	604.00
IUUC-Xma-133312	Xiphophorus maculatus	89.14	2.00e-171	594.00
IUUC-Yli-134487	Yarrowia lipolytica	40.34	1.00e-48	186.00
IUUC-Zma-135462	Zea mays	43.69	1.00e-71	263.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence