iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	17220175

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.01	16.8	51	91

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 99   daglldrlpeeilveilkll.dkeellraarvcrrwqelas 138
           +++++d lpee+l+eil++l +++e  ++a+v+++w +l s
   Q: 51   KQTSIDVLPEECLFEILRRLpSGQERSACACVSKHWLNLLS 91
           67899***************88899***********97766 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Component of SCF(EBF1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). Regulator of the ethylene signaling cascade by modulating the stability of EIN3 and EIL1 proteins.

Protein Sequence
(Fasta)

MSGIFRFSGD EDCLLGGSMY LSPGSCPGVY YPARKRLRVA ATSFYSGFEE KQTSIDVLPE 60
ECLFEILRRL PSGQERSACA CVSKHWLNLL SSISRSEVNE SSVQDVEEGE GFLSRSLEGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAGTGGATC ATCCTTTTTA AAAATCGACA TCTCTCAAAT GTTTTTGTCA ACAATGCATG 60
TATTCTCTTC CTTCAATGTA TTCAGTCTTT TTCGTCAAAC CACATTTCAA AACTTTACGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0936--Ethylene signaling pathway
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

Pfam

PF00646--F-box
PF00560--LRR_1
PF13516--LRR_6

SMART

SM00256--FBOX
SM00367--LRR_CC

Gene Ontology

GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0009873--P:ethylene-activated signaling pathway
GO:0010105--P:negative regulation of ethylene-activated signaling pathway
GO:0016567--P:protein ubiquitination
GO:0009723--P:response to ethylene
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT5G25350

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002298	Ailuropoda melanoleuca	27.50	2.00e-29	123.00
IUUC-Aly-006167	Arabidopsis lyrata	85.60	0.00e+00	950.00
IUUC-Bol-015930	Brassica oleracea	84.10	0.00e+00	984.00
IUUC-Bra-017364	Brassica rapa	85.21	0.00e+00	999.00
IUUC-Dre-028464	Danio rerio	26.86	1.00e-27	117.00
IUUC-Dor-030835	Dipodomys ordii	36.54	8.00e-18	84.30
IUUC-Itr-048013	Ictidomys tridecemlineatus	27.43	6.00e-29	121.00
IUUC-Mpu-065742	Mustela putorius furo	27.50	8.00e-30	124.00
IUUC-Oga-088674	Otolemur garnettii	27.50	2.00e-29	123.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence