iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089925

Ensembl Protein ID

ENSOARP00000016491.1

UniProt Accession

W5Q1A5; W5Q1A5_SHEEP

Genbank Protein ID

ENSOARP00000016491

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01092989

Gene Name

KLHL3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000015370.1	ENSOART00000016726.1	ENSOARP00000016491.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.50e-22	77.9	50	116
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	6.00e-09	35.1	149	175

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv++v +++e++ah++vLaa+S++F a+f+++++esk  +++eikdv+ + ++ l++++Yt +++ +
   Q: 50   CDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESK-AKKIEIKDVDGQTLSKLIDYIYTAEIEVT 116
           8*************************************.************************99876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfi 27
           + Nclgi++fAd ++c+dL ++a+ ++
   Q: 149  PTNCLGIRAFADVHTCTDLLQQANAYA 175
           78*********************9995 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MDGESIKPSS QPLIQTGDDE KNQRTVTVNP AHMGKAFKVM NELRSKQLLC DVMIVAEDVE 60
IEAHRVVLAA CSPYFCAMFT GDMSESKAKK IEIKDVDGQT LSKLIDYIYT AEIEVTEENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCTCCTGCT GGTTGGCTGG GAGAACCGAG CAGAACAGAG CTAGGATCCT CCGGTACAGA 60
CACAGCTCAG CAGCTGCCAC CCCAGCTGGG CCTCACACAA TGGACGGGGA AAGGTAGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0072156--P:distal tubule morphogenesis
GO:0050801--P:ion homeostasis
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0070294--P:renal sodium ion absorption

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001632	Ailuropoda melanoleuca	98.80	0.00e+00	1187.00
IUUC-Apl-003965	Anas platyrhynchos	94.87	0.00e+00	1107.00
IUUC-Aca-004912	Anolis carolinensis	94.06	0.00e+00	1099.00
IUUC-Ate-010500	Aspergillus terreus	25.56	1.00e-19	90.90
IUUC-Ame-010670	Astyanax mexicanus	81.47	0.00e+00	943.00
IUUC-Bta-013354	Bos taurus	99.83	0.00e+00	1196.00
IUUC-Bol-016582	Brassica oleracea	28.83	1.00e-12	68.60
IUUC-Bra-017771	Brassica rapa	29.55	6.00e-13	69.70
IUUC-Cel-018136	Caenorhabditis elegans	42.62	4.00e-131	461.00
IUUC-Cja-019183	Callithrix jacchus	93.60	0.00e+00	1022.00
IUUC-Cfa-020465	Canis familiaris	97.26	0.00e+00	1160.00
IUUC-Cpo-022115	Cavia porcellus	98.12	0.00e+00	1176.00
IUUC-Csa-024219	Chlorocebus sabaeus	98.47	0.00e+00	1183.00
IUUC-Csv-026032	Ciona savignyi	60.57	0.00e+00	702.00
IUUC-Cgl-026620	Colletotrichum gloeosporioides	30.42	8.00e-25	107.00
IUUC-Dre-028524	Danio rerio	75.08	0.00e+00	954.00
IUUC-Dno-029075	Dasypus novemcinctus	99.11	0.00e+00	1142.00
IUUC-Dor-030156	Dipodomys ordii	89.29	0.00e+00	751.00
IUUC-Ete-033064	Echinops telfairi	83.27	0.00e+00	865.00
IUUC-Eca-033887	Equus caballus	97.28	0.00e+00	1172.00
IUUC-Eeu-035244	Erinaceus europaeus	78.95	0.00e+00	933.00
IUUC-Fca-035375	Felis catus	98.29	0.00e+00	1182.00
IUUC-Fal-037119	Ficedula albicollis	96.23	0.00e+00	1070.00
IUUC-Fso-038219	Fusarium solani	40.32	2.00e-10	57.00
IUUC-Gga-041094	Gallus gallus	95.99	0.00e+00	1103.00
IUUC-Gac-042585	Gasterosteus aculeatus	76.13	0.00e+00	910.00
IUUC-Ggo-045485	Gorilla gorilla	98.47	0.00e+00	1186.00
IUUC-Hsa-046717	Homo sapiens	98.30	0.00e+00	1182.00
IUUC-Itr-048605	Ictidomys tridecemlineatus	98.46	0.00e+00	1174.00
IUUC-Lch-050246	Latimeria chalumnae	86.88	0.00e+00	1004.00
IUUC-Laf-053700	Loxodonta africana	98.62	0.00e+00	1172.00
IUUC-Mcc-054732	Macaca mulatta	99.21	0.00e+00	1021.00
IUUC-Mga-059994	Meleagris gallopavo	94.90	0.00e+00	994.00
IUUC-Mdo-062923	Monodelphis domestica	97.28	0.00e+00	1172.00
IUUC-Mmu-063842	Mus musculus	96.93	0.00e+00	1158.00
IUUC-Mpu-066380	Mustela putorius furo	97.79	0.00e+00	1177.00
IUUC-Mlu-067922	Myotis lucifugus	98.44	0.00e+00	1162.00
IUUC-Nle-069761	Nomascus leucogenys	98.13	0.00e+00	1180.00
IUUC-Opr-070287	Ochotona princeps	88.96	0.00e+00	1043.00
IUUC-Ont-071654	Oreochromis niloticus	80.42	0.00e+00	952.00
IUUC-Ocu-074957	Oryctolagus cuniculus	97.95	0.00e+00	1166.00
IUUC-Ola-086853	Oryzias latipes	78.12	0.00e+00	905.00
IUUC-Oga-088559	Otolemur garnettii	97.96	0.00e+00	1183.00
IUUC-Ptr-091487	Pan troglodytes	98.30	0.00e+00	1182.00
IUUC-Pan-091705	Papio anubis	98.47	0.00e+00	1183.00
IUUC-Psi-093478	Pelodiscus sinensis	91.84	0.00e+00	1051.00
IUUC-Pfo-097450	Poecilia formosa	80.59	0.00e+00	896.00
IUUC-Pab-097618	Pongo abelii	98.13	0.00e+00	1179.00
IUUC-Pca-100739	Procavia capensis	89.33	0.00e+00	664.00
IUUC-Sha-106935	Sarcophilus harrisii	99.47	0.00e+00	759.00
IUUC-Ssc-115599	Sus scrofa	98.80	0.00e+00	1177.00
IUUC-Tgu-117001	Taeniopygia guttata	95.41	0.00e+00	1085.00
IUUC-Tru-118078	Takifugu rubripes	79.55	0.00e+00	946.00
IUUC-Tsy-119161	Tarsius syrichta	85.71	0.00e+00	900.00
IUUC-Tni-120888	Tetraodon nigroviridis	76.44	0.00e+00	886.00
IUUC-Tbe-127285	Tupaia belangeri	82.77	0.00e+00	674.00
IUUC-Ttr-128884	Tursiops truncatus	82.16	3.00e-152	531.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence