iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040326

UUCD1 version

UUC-GaG-00379

Ensembl Protein ID

ENSGALP00000013249.3

UniProt Accession

F1ND48; A1YKW0; FBH1_CHICK

Genbank Protein ID

ABM05617.1; ENSGALP00000013249

Protein Name

F-box DNA helicase 1; F-box only protein 18

Genbank Nucleotide ID

EF066526; AADN03001147

Gene Name

FBXO18; FBH1; FBX18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000008162.3	ENSGALT00000013264.3	ENSGALP00000013249.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	50.91	0.00e+00	990.00	IUUC-Hsa-046650
E3 adaptor/Cullin RING/SCF/F-box	29.47	6.00e-43	171.00	IUUC-Spo-108147

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gallus gallus

Functional Description
(View)

3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17283053). Also promotes cell death and DNA double-strand breakage in response to replication stress: promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress.

Protein Sequence
(Fasta)

MHLTADDCEA LSRSTEGLSS LTQPLNQRRS RGDVNRGLQP THRTRTQPGA QGRQKNIMDY 60
FKVSQRQQAV AGRTKDISIK EEVLDPFFAE DDESSISSVM ETSGDSSSFL ENEYMGNSRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCACCTTA CAGCTGATGA CTGTGAAGCT CTCAGTCGGA GCACTGAAGG TTTATCCTCC 60
CTGACACAGC CATTGAATCA AAGGCGAAGC AGAGGAGATG TCAACAGGGG CCTCCAACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014017--DNA_helicase_UvrD-like_C
IPR000212--DNA_helicase_UvrD/REP
IPR001810--F-box_dom
IPR027417--P-loop_NTPase

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13361--UvrD_C

SMART

SM00256--FBOX

Gene Ontology

GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0043138--F:3'-5' DNA helicase activity
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0003678--F:DNA helicase activity
GO:0015616--F:DNA translocase activity
GO:0003690--F:double-stranded DNA binding
GO:0003697--F:single-stranded DNA binding
GO:0008219--P:cell death
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000737--P:DNA catabolic process, endonucleolytic
GO:0000724--P:double-strand break repair via homologous recombination
GO:0035562--P:negative regulation of chromatin binding
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001934--P:positive regulation of protein phosphorylation
GO:0016567--P:protein ubiquitination
GO:0031297--P:replication fork processing
GO:0048478--P:replication fork protection
GO:0072429--P:response to intra-S DNA damage checkpoint signaling

KEGG

gga:416687

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000424	Aegilops tauschii	43.48	6.00e-04	40.40
IUUC-Aml-001396	Ailuropoda melanoleuca	50.24	0.00e+00	978.00
IUUC-Atr-002826	Amborella trichopoda	34.04	1.00e-03	39.30
IUUC-Apl-003317	Anas platyrhynchos	74.61	0.00e+00	1515.00
IUUC-Aca-004498	Anolis carolinensis	54.44	0.00e+00	1010.00
IUUC-Ath-007293	Arabidopsis thaliana	39.06	1.00e-04	42.40
IUUC-Ani-009226	Aspergillus nidulans	26.14	5.00e-04	40.00
IUUC-Ate-010526	Aspergillus terreus	35.06	1.00e-03	38.50
IUUC-Ame-011808	Astyanax mexicanus	53.13	3.00e-117	414.00
IUUC-Bta-013250	Bos taurus	50.14	0.00e+00	970.00
IUUC-Bol-015348	Brassica oleracea	41.54	1.00e-04	42.70
IUUC-Cja-019638	Callithrix jacchus	51.26	0.00e+00	1004.00
IUUC-Cfa-020195	Canis familiaris	56.00	0.00e+00	980.00
IUUC-Cpo-022269	Cavia porcellus	49.23	0.00e+00	923.00
IUUC-Cre-022611	Chlamydomonas reinhardtii	37.80	5.00e-10	60.10
IUUC-Csa-024060	Chlorocebus sabaeus	55.63	0.00e+00	947.00
IUUC-Cho-025003	Choloepus hoffmanni	56.65	2.00e-132	466.00
IUUC-Cin-025694	Ciona intestinalis	27.06	5.00e-30	125.00
IUUC-Dre-028083	Danio rerio	43.70	0.00e+00	799.00
IUUC-Dno-029203	Dasypus novemcinctus	48.42	0.00e+00	904.00
IUUC-Dor-030477	Dipodomys ordii	60.15	1.00e-138	487.00
IUUC-Ete-032861	Echinops telfairi	50.58	0.00e+00	971.00
IUUC-Eca-033205	Equus caballus	50.96	0.00e+00	1016.00
IUUC-Eeu-034784	Erinaceus europaeus	55.51	0.00e+00	749.00
IUUC-Fca-035797	Felis catus	49.86	0.00e+00	982.00
IUUC-Gmo-038855	Gadus morhua	43.04	1.00e-117	417.00
IUUC-Gac-042240	Gasterosteus aculeatus	39.79	0.00e+00	676.00
IUUC-Ggo-045050	Gorilla gorilla	48.70	0.00e+00	915.00
IUUC-Hsa-046650	Homo sapiens	50.82	0.00e+00	980.00
IUUC-Itr-047965	Ictidomys tridecemlineatus	57.65	3.00e-124	437.00
IUUC-Lch-050231	Latimeria chalumnae	41.93	2.00e-160	559.00
IUUC-Loc-051884	Lepisosteus oculatus	45.83	0.00e+00	880.00
IUUC-Lma-053267	Leptosphaeria maculans	22.84	1.00e-03	38.90
IUUC-Laf-053843	Loxodonta africana	50.82	0.00e+00	981.00
IUUC-Mcc-055570	Macaca mulatta	51.35	0.00e+00	1010.00
IUUC-Meu-056798	Macropus eugenii	47.54	2.00e-104	374.00
IUUC-Mtr-057915	Medicago truncatula	39.39	2.00e-03	38.50
IUUC-Mga-059648	Meleagris gallopavo	93.76	0.00e+00	1805.00
IUUC-Mmr-060757	Microcebus murinus	50.19	0.00e+00	947.00
IUUC-Mdo-061913	Monodelphis domestica	52.76	0.00e+00	918.00
IUUC-Mmu-064337	Mus musculus	50.62	0.00e+00	998.00
IUUC-Mac-064479	Musa acuminata	41.10	3.00e-04	40.80
IUUC-Mpu-066483	Mustela putorius furo	50.48	0.00e+00	991.00
IUUC-Mlu-068204	Myotis lucifugus	48.62	0.00e+00	932.00
IUUC-Ncr-068735	Neurospora crassa	27.08	5.00e-04	40.00
IUUC-Nle-070053	Nomascus leucogenys	51.06	0.00e+00	976.00
IUUC-Opr-070588	Ochotona princeps	49.33	0.00e+00	929.00
IUUC-Ont-072655	Oreochromis niloticus	43.42	0.00e+00	668.00
IUUC-Oan-073351	Ornithorhynchus anatinus	49.85	0.00e+00	983.00
IUUC-Ocu-074465	Oryctolagus cuniculus	50.29	0.00e+00	939.00
IUUC-Oba-075140	Oryza barthii	43.18	1.00e-03	37.70
IUUC-Obr-076710	Oryza brachyantha	40.00	5.00e-04	40.40
IUUC-Ogu-078861	Oryza glumaepatula	43.18	1.00e-03	37.70
IUUC-Oin-079568	Oryza indica	48.72	8.00e-04	37.00
IUUC-Olo-080505	Oryza longistaminata	48.48	4.50e-02	35.00
IUUC-Oni-082634	Oryza nivara	43.18	8.00e-04	38.10
IUUC-Opu-083155	Oryza punctata	48.78	1.00e-03	38.50
IUUC-Oru-084992	Oryza rufipogon	43.18	8.00e-04	38.10
IUUC-Olu-087831	Ostreococcus lucimarinus	34.58	3.00e-69	257.00
IUUC-Oga-089088	Otolemur garnettii	50.72	0.00e+00	965.00
IUUC-Oar-089870	Ovis aries	50.10	0.00e+00	958.00
IUUC-Ptr-090957	Pan troglodytes	50.58	0.00e+00	981.00
IUUC-Pan-092632	Papio anubis	51.35	0.00e+00	970.00
IUUC-Psi-093035	Pelodiscus sinensis	59.69	0.00e+00	1202.00
IUUC-Pno-094870	Phaeosphaeria nodorum	28.57	3.00e-03	37.40
IUUC-Ppa-095660	Physcomitrella patens	40.54	3.00e-04	41.20
IUUC-Pfo-096902	Poecilia formosa	41.47	1.00e-178	620.00
IUUC-Pab-098206	Pongo abelii	50.29	0.00e+00	936.00
IUUC-Pop-098801	Populus trichocarpa	38.46	1.00e-04	42.40
IUUC-Pca-100238	Procavia capensis	47.25	0.00e+00	891.00
IUUC-Ppe-101748	Prunus persica	37.50	2.00e-03	38.50
IUUC-Pva-103182	Pteropus vampyrus	50.53	0.00e+00	971.00
IUUC-Pte-104033	Pyrenophora teres	36.73	4.00e-03	37.00
IUUC-Pyt-104599	Pyrenophora triticirepentis	36.73	3.00e-03	37.40
IUUC-Rno-105141	Rattus norvegicus	50.73	0.00e+00	1002.00
IUUC-Sce-106341	Saccharomyces cerevisiae	29.07	5.00e-05	42.70
IUUC-Sha-106827	Sarcophilus harrisii	49.32	0.00e+00	959.00
IUUC-Sja-107882	Schizosaccharomyces japonicus	29.39	4.00e-43	169.00
IUUC-Spo-108147	Schizosaccharomyces pombe	29.47	2.00e-43	171.00
IUUC-Ssl-108584	Sclerotinia sclerotiorum	27.63	4.70e-02	33.50
IUUC-Sly-111170	Solanum lycopersicum	39.06	1.50e-02	34.30
IUUC-Sre-115025	Sporisorium reilianum	32.06	2.00e-37	150.00
IUUC-Ssc-116188	Sus scrofa	58.14	0.00e+00	788.00
IUUC-Tgu-116612	Taeniopygia guttata	72.71	0.00e+00	744.00
IUUC-Tsy-119560	Tarsius syrichta	49.80	1.00e-67	251.00
IUUC-Tni-120734	Tetraodon nigroviridis	43.74	0.00e+00	672.00
IUUC-Tca-121338	Theobroma cacao	37.50	6.00e-04	40.00
IUUC-Tre-122089	Trichoderma reesei	30.11	5.00e-04	39.70
IUUC-Tme-127009	Tuber melanosporum	25.00	1.00e-03	38.90
IUUC-Tbe-127431	Tupaia belangeri	51.53	0.00e+00	857.00
IUUC-Ttr-128744	Tursiops truncatus	49.18	0.00e+00	932.00
IUUC-Uma-129536	Ustilago maydis	31.16	3.00e-38	154.00
IUUC-Vda-129824	Verticillium dahliae	54.29	6.20e-02	32.00
IUUC-Vpa-130123	Vicugna pacos	81.08	1.00e-33	138.00
IUUC-Vvi-131025	Vitis vinifera	39.06	4.00e-04	40.80
IUUC-Xtr-132902	Xenopus tropicalis	47.01	0.00e+00	909.00
IUUC-Xma-133978	Xiphophorus maculatus	42.44	4.00e-145	508.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence