iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108147

UUCD1 version

UUC-ScP-00048

Ensembl Protein ID

SPBC336.01.1:pep

UniProt Accession

Q9USU3; FBH1_SCHPO

Genbank Protein ID

AAK58077.1; CAC44128.1

Protein Name

F-box DNA helicase protein 1

Genbank Nucleotide ID

AF380117; CU329671

Gene Name

fbh1; fdh; fdh1; SPBC336.01

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC336.01	SPBC336.01.1	SPBC336.01.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	19836238; 15147268

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	29.67	5.00e-41	167.00	IUUC-Hsa-046650

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Involved in ATP-dependent DNA-unwinding in a 3' to 5' direction, and ATP-ase activities stimulated by the single-stranded DNA-binding protein ssb1. Essential for viability and normal growth of stationary phase cells and in the absence of either srs2 or rqh1 DNA helicase (PubMed:16135799, PubMed:9228070). Involved in DNA recombination repair of strand breaks and stalled or collapsed replication forks, on the rhp51-dependent pathway: promotes rhp51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:16135800, PubMed:19546232). Ubiquitination and DNA helicase activities are essential for controlling rhp51-dependent recombination in the absence of rad22. Plays a role in the processing of toxic recombination intermediates. Promotes proper chromosome segregation (PubMed:16135799, PubMed:16135800, PubMed:9228070, PubMed:19546232).

Protein Sequence
(Fasta)

MSAQHLHSCK FYRLPLEIIP LICRFLSVQD IQSFIRVFPS FQTILDSSND LFWKKKNYEL 60
RIRRNRLLRG SYAAGVSSSA MNGFVNGTQI SSTPAEREYY SKSDEIKNIC GLPPGPMKVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAGATTGG ATTTATTTTA ATGTTCGTTG CTCATTCATA AACTAGTTCT GGTATTTTTA 60
CTACTCTTAA ATTTGCACAT ACCCAACCAA CAAGCAATTC TTCTAATGCA ATTTGTTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR014017--DNA_helicase_UvrD-like_C
IPR000212--DNA_helicase_UvrD/REP
IPR001810--F-box_dom
IPR027417--P-loop_NTPase

PROSITE

PS50181--FBOX

Pfam

PF13361--UvrD_C

Gene Ontology

GO:0005829--C:cytosol
GO:0043224--C:nuclear SCF ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0017117--C:single-stranded DNA-dependent ATP-dependent DNA helicase complex
GO:0005524--F:ATP binding
GO:0030674--F:protein binding, bridging
GO:0003697--F:single-stranded DNA binding
GO:1990518--F:single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity
GO:0006310--P:DNA recombination
GO:0000724--P:double-strand break repair via homologous recombination
GO:0016567--P:protein ubiquitination
GO:0000018--P:regulation of DNA recombination
GO:0060542--P:regulation of strand invasion
GO:0031297--P:replication fork processing
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

spo:SPBC336.01

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000743	Aegilops tauschii	33.33	2.00e-05	41.20
IUUC-Aml-001396	Ailuropoda melanoleuca	28.67	2.00e-43	169.00
IUUC-Atr-002826	Amborella trichopoda	41.67	5.00e-08	51.60
IUUC-Apl-003317	Anas platyrhynchos	28.10	2.00e-44	172.00
IUUC-Aca-004498	Anolis carolinensis	29.43	6.00e-44	171.00
IUUC-Aly-005981	Arabidopsis lyrata	31.91	6.10e-02	30.40
IUUC-Ath-007293	Arabidopsis thaliana	32.77	3.00e-08	52.80
IUUC-Ani-009226	Aspergillus nidulans	31.91	1.00e-06	47.00
IUUC-Ate-010526	Aspergillus terreus	28.72	3.00e-05	42.40
IUUC-Ame-011808	Astyanax mexicanus	27.48	3.00e-22	97.40
IUUC-Bta-013250	Bos taurus	28.95	3.00e-43	168.00
IUUC-Bol-015348	Brassica oleracea	42.03	2.00e-07	49.70
IUUC-Cja-019638	Callithrix jacchus	29.30	2.00e-43	169.00
IUUC-Cfa-020195	Canis familiaris	28.93	6.00e-44	171.00
IUUC-Cpo-022269	Cavia porcellus	28.54	6.00e-38	150.00
IUUC-Cre-022611	Chlamydomonas reinhardtii	33.75	7.00e-05	41.20
IUUC-Csa-024060	Chlorocebus sabaeus	29.14	2.00e-43	169.00
IUUC-Cho-025003	Choloepus hoffmanni	32.22	1.00e-31	130.00
IUUC-Cin-025694	Ciona intestinalis	38.75	2.00e-11	61.60
IUUC-Dre-028083	Danio rerio	30.42	3.00e-44	172.00
IUUC-Dno-029203	Dasypus novemcinctus	28.11	3.00e-35	142.00
IUUC-Dor-030477	Dipodomys ordii	28.42	3.00e-23	102.00
IUUC-Ete-032861	Echinops telfairi	28.70	1.00e-41	163.00
IUUC-Eca-033205	Equus caballus	29.10	3.00e-44	171.00
IUUC-Eeu-034784	Erinaceus europaeus	28.03	3.00e-41	161.00
IUUC-Fca-035797	Felis catus	28.37	3.00e-42	165.00
IUUC-Gmo-038855	Gadus morhua	35.86	3.00e-35	141.00
IUUC-Gga-040326	Gallus gallus	29.47	6.00e-44	171.00
IUUC-Gac-042240	Gasterosteus aculeatus	28.97	5.00e-43	167.00
IUUC-Ggo-045050	Gorilla gorilla	27.57	1.00e-35	143.00
IUUC-Hsa-046650	Homo sapiens	29.67	5.00e-43	168.00
IUUC-Itr-047965	Ictidomys tridecemlineatus	26.91	5.00e-16	76.60
IUUC-Lch-050231	Latimeria chalumnae	25.37	2.00e-16	79.00
IUUC-Loc-051884	Lepisosteus oculatus	27.54	8.00e-43	167.00
IUUC-Lma-052982	Leptosphaeria maculans	31.78	4.00e-05	42.00
IUUC-Laf-053843	Loxodonta africana	28.62	2.00e-42	166.00
IUUC-Mcc-055570	Macaca mulatta	29.24	2.00e-43	169.00
IUUC-Meu-056798	Macropus eugenii	33.14	2.00e-12	66.20
IUUC-Mor-057259	Magnaporthe oryzae	31.71	9.50e-01	26.60
IUUC-Mtr-057915	Medicago truncatula	28.21	2.00e-07	50.10
IUUC-Mga-059648	Meleagris gallopavo	28.55	2.00e-43	168.00
IUUC-Mmr-060757	Microcebus murinus	29.58	7.00e-45	174.00
IUUC-Mdo-061913	Monodelphis domestica	29.55	6.00e-42	164.00
IUUC-Mmu-064337	Mus musculus	28.88	2.00e-42	166.00
IUUC-Mac-064479	Musa acuminata	26.50	4.00e-08	52.00
IUUC-Mpu-066483	Mustela putorius furo	28.90	1.00e-43	170.00
IUUC-Mlu-068204	Myotis lucifugus	29.53	8.00e-30	124.00
IUUC-Ncr-068735	Neurospora crassa	36.05	1.00e-08	53.90
IUUC-Nle-070053	Nomascus leucogenys	28.74	8.00e-43	167.00
IUUC-Opr-070588	Ochotona princeps	33.73	9.00e-34	137.00
IUUC-Ont-072655	Oreochromis niloticus	30.04	4.00e-46	177.00
IUUC-Oan-073351	Ornithorhynchus anatinus	29.39	6.00e-42	164.00
IUUC-Ocu-074465	Oryctolagus cuniculus	29.05	1.00e-43	169.00
IUUC-Obr-076710	Oryza brachyantha	42.11	1.00e-07	50.80
IUUC-Oin-079176	Oryza indica	22.84	1.00e-06	45.80
IUUC-Olu-087831	Ostreococcus lucimarinus	30.14	6.00e-51	194.00
IUUC-Oga-089088	Otolemur garnettii	28.96	7.00e-43	167.00
IUUC-Oar-089870	Ovis aries	29.11	1.00e-43	169.00
IUUC-Ptr-090957	Pan troglodytes	29.14	5.00e-43	167.00
IUUC-Pan-092632	Papio anubis	29.14	2.00e-43	169.00
IUUC-Psi-093035	Pelodiscus sinensis	28.07	8.00e-40	157.00
IUUC-Pma-094253	Petromyzon marinus	40.62	1.10e+00	26.20
IUUC-Pno-094870	Phaeosphaeria nodorum	39.29	5.00e-04	38.10
IUUC-Ppa-095660	Physcomitrella patens	36.17	2.00e-08	53.10
IUUC-Pfo-096902	Poecilia formosa	27.45	2.00e-35	142.00
IUUC-Pab-098206	Pongo abelii	28.97	2.00e-43	169.00
IUUC-Pop-098801	Populus trichocarpa	34.38	6.00e-07	48.10
IUUC-Pca-100238	Procavia capensis	27.07	1.00e-23	103.00
IUUC-Ppe-101748	Prunus persica	26.50	1.00e-06	47.00
IUUC-Pva-103182	Pteropus vampyrus	29.12	1.00e-41	163.00
IUUC-Pte-104033	Pyrenophora teres	41.07	1.00e-04	40.00
IUUC-Pyt-104599	Pyrenophora triticirepentis	41.07	9.00e-05	40.40
IUUC-Rno-105141	Rattus norvegicus	28.88	4.00e-43	167.00
IUUC-Sce-106341	Saccharomyces cerevisiae	39.19	2.00e-06	46.20
IUUC-Sha-106827	Sarcophilus harrisii	29.82	3.00e-42	165.00
IUUC-Sja-107882	Schizosaccharomyces japonicus	59.61	0.00e+00	1068.00
IUUC-Ssl-108584	Sclerotinia sclerotiorum	29.87	1.00e-03	37.00
IUUC-Sly-111170	Solanum lycopersicum	29.91	8.00e-10	56.60
IUUC-Sre-115025	Sporisorium reilianum	40.59	4.00e-53	201.00
IUUC-Ssc-116188	Sus scrofa	28.87	2.00e-45	175.00
IUUC-Tgu-116612	Taeniopygia guttata	33.22	3.00e-34	137.00
IUUC-Tsy-119560	Tarsius syrichta	27.50	6.00e-05	41.60
IUUC-Tni-120734	Tetraodon nigroviridis	30.73	8.00e-45	173.00
IUUC-Tca-121338	Theobroma cacao	36.62	6.00e-07	48.10
IUUC-Tre-122089	Trichoderma reesei	35.64	4.00e-07	48.10
IUUC-Tae-124429	Triticum aestivum	33.33	7.70e-01	26.60
IUUC-Tme-127009	Tuber melanosporum	34.18	4.00e-05	42.00
IUUC-Tbe-127431	Tupaia belangeri	29.23	5.00e-38	151.00
IUUC-Ttr-128744	Tursiops truncatus	29.01	3.00e-43	168.00
IUUC-Uma-129536	Ustilago maydis	40.98	8.00e-54	203.00
IUUC-Vpa-130123	Vicugna pacos	43.33	5.00e-08	51.20
IUUC-Vvi-131025	Vitis vinifera	38.89	6.00e-06	44.70
IUUC-Xtr-132902	Xenopus tropicalis	29.60	6.00e-45	174.00
IUUC-Xma-133978	Xiphophorus maculatus	34.26	7.00e-34	137.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence