iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
HINT	Mentha
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	16339806

Classification

Family	E-value	Score	Start	End
E2/UBC	3.00e-26	92.7	9	132

Active Site

Position(s)	Description	Evidence
87	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk.......eeek 91
           Rl+ke+ +l k+p+++++a+p+ + d+ ew+++++G e+tp++gg++  +i+fp++YP+kPP ++++t+  ++ + ++ k+Cls+ +       ++e 
   Q: 9    RLQKEYRALCKEPVSHVVARPSPN-DILEWHYVLEGSEGTPFAGGFYYGKIKFPPEYPYKPPGITMTTP--NGRFMTQKKICLSMSDfdmaftvHPES 103
           9**********************9.9******************************************9..99*************888899999*** PP
   S: 92   Wspalsvesvllsiqsllaepnpesplne 120
           W+p++sv+s+l+++ s++ +  p  +  +
   Q: 104  WNPMWSVSSILTGLLSFMMDTSPTTGSVN 132
           ******************88766655443 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.

Protein Sequence
(Fasta)

MAEKACIKRL QKEYRALCKE PVSHVVARPS PNDILEWHYV LEGSEGTPFA GGFYYGKIKF 60
PPEYPYKPPG ITMTTPNGRF MTQKKICLSM SDFDMAFTVH PESWNPMWSV SSILTGLLSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGTTTTG TCTCACTACT AATCACTAGT TTTTTTTCTT CTTCTGCAGC TATTTTTTTT 60
ATATTTCATG AAGAGAAGGA AAAATTGATT CCAAGAACCG GCACAGATTC TTTGATGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT1G17280

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003156	Amborella trichopoda	65.74	7.00e-91	325.00
IUUC-Aly-005734	Arabidopsis lyrata	95.06	2.00e-135	473.00
IUUC-Bol-016116	Brassica oleracea	85.66	6.00e-118	415.00
IUUC-Bra-017777	Brassica rapa	88.07	2.00e-121	426.00
IUUC-Lpe-050949	Leersia perrieri	58.54	6.00e-82	296.00
IUUC-Oba-075200	Oryza barthii	58.94	4.00e-81	293.00
IUUC-Ogl-077398	Oryza glaberrima	57.72	6.00e-79	286.00
IUUC-Ogu-078362	Oryza glumaepatula	58.94	4.00e-81	293.00
IUUC-Oin-079625	Oryza indica	58.94	4.00e-81	293.00
IUUC-Olo-080620	Oryza longistaminata	47.17	2.00e-57	214.00
IUUC-Ome-081187	Oryza meridionalis	58.94	5.00e-81	293.00
IUUC-Oni-082271	Oryza nivara	58.94	4.00e-81	293.00
IUUC-Opu-083487	Oryza punctata	58.94	8.00e-81	292.00
IUUC-Oru-085263	Oryza rufipogon	58.94	4.00e-81	293.00
IUUC-Osa-085694	Oryza sativa	58.94	4.00e-81	293.00
IUUC-Ppe-102054	Prunus persica	77.87	7.00e-110	388.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence