iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091226

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Mitochondrial E3 ubiquitin protein ligase 1

Genbank Nucleotide ID

AACZ03009684

Gene Name

MUL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000000288.3	ENSPTRT00000000569.3	ENSPTRP00000000497.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.72	0.00e+00	726.00	IUUC-Hsa-046597

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MESGGRPSLC QFILLGTTSV VTAALYSVYR QKARVSQELK GAKKVHLGED LKSILSEAPG 60
KCVPYAVIEG AVRSVKETLN SQFVENCKGV IQRLTLQEHK MVWNRTTHLW NDCSKIIHQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGTTCCGGC GTCGTGCGTC ATCGCTGGGC GACTGATTTC GAGTTTCCGG TCAGGTTAGG 60
CTAGGGGGTG CGGTCCTGGT CGGAAGGAGG GGGAGAGTCG GGGGTCATCA GGCCTATCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR022170--GIDE
IPR001841--Znf_RING

PROSITE

PS50089--ZF_RING_2

Pfam

PF12483--GIDE

Gene Ontology

GO:0030424--C:axon
GO:0031307--C:integral component of mitochondrial outer membrane
GO:0043025--C:neuronal cell body
GO:0005777--C:peroxisome
GO:0016874--F:ligase activity
GO:0004871--F:signal transducer activity
GO:0019789--F:SUMO transferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007257--P:activation of JUN kinase activity
GO:0071360--P:cellular response to exogenous dsRNA
GO:0000266--P:mitochondrial fission
GO:0051646--P:mitochondrion localization
GO:0030308--P:negative regulation of cell growth
GO:0071650--P:negative regulation of chemokine (C-C motif) ligand 5 production
GO:0050689--P:negative regulation of defense response to virus by host
GO:0010637--P:negative regulation of mitochondrial fusion
GO:0051898--P:negative regulation of protein kinase B signaling
GO:0060339--P:negative regulation of type I interferon-mediated signaling pathway
GO:1903861--P:positive regulation of dendrite extension
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0090141--P:positive regulation of mitochondrial fission
GO:1904925--P:positive regulation of mitophagy in response to mitochondrial depolarization
GO:0033235--P:positive regulation of protein sumoylation
GO:0031648--P:protein destabilization
GO:0050821--P:protein stabilization
GO:0051881--P:regulation of mitochondrial membrane potential
GO:1901028--P:regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000342	Aegilops tauschii	25.00	1.00e-12	68.60
IUUC-Aml-002287	Ailuropoda melanoleuca	92.61	0.00e+00	651.00
IUUC-Atr-002698	Amborella trichopoda	24.30	9.00e-09	54.30
IUUC-Aca-005039	Anolis carolinensis	37.79	2.00e-63	235.00
IUUC-Aly-006181	Arabidopsis lyrata	28.37	4.00e-22	98.60
IUUC-Ath-007438	Arabidopsis thaliana	28.65	5.00e-23	101.00
IUUC-Ame-010671	Astyanax mexicanus	61.93	5.00e-132	463.00
IUUC-Bta-012407	Bos taurus	80.45	3.00e-166	577.00
IUUC-Bdi-014735	Brachypodium distachyon	24.85	2.00e-17	83.20
IUUC-Bol-015493	Brassica oleracea	26.93	1.00e-23	103.00
IUUC-Bra-016933	Brassica rapa	26.65	7.00e-20	91.30
IUUC-Cja-019709	Callithrix jacchus	97.82	0.00e+00	654.00
IUUC-Cfa-020818	Canis familiaris	93.75	0.00e+00	665.00
IUUC-Cpo-022490	Cavia porcellus	92.90	0.00e+00	637.00
IUUC-Csa-023259	Chlorocebus sabaeus	99.72	0.00e+00	726.00
IUUC-Cho-024730	Choloepus hoffmanni	94.32	0.00e+00	687.00
IUUC-Cin-025301	Ciona intestinalis	30.82	3.00e-44	172.00
IUUC-Dre-028644	Danio rerio	62.22	7.00e-134	469.00
IUUC-Dno-028925	Dasypus novemcinctus	91.76	0.00e+00	680.00
IUUC-Dor-030692	Dipodomys ordii	92.05	0.00e+00	643.00
IUUC-Dme-031761	Drosophila melanogaster	30.72	4.00e-33	135.00
IUUC-Ete-032329	Echinops telfairi	82.10	1.00e-155	541.00
IUUC-Eca-034008	Equus caballus	89.49	0.00e+00	667.00
IUUC-Eeu-034895	Erinaceus europaeus	75.64	3.00e-121	427.00
IUUC-Fca-036104	Felis catus	93.47	0.00e+00	667.00
IUUC-Fal-036900	Ficedula albicollis	73.47	1.00e-139	489.00
IUUC-Gmo-039049	Gadus morhua	58.81	7.00e-107	380.00
IUUC-Gga-040254	Gallus gallus	71.88	7.00e-147	513.00
IUUC-Gac-042277	Gasterosteus aculeatus	60.23	6.00e-134	469.00
IUUC-Gma-043979	Glycine max	26.89	2.00e-20	92.80
IUUC-Ggo-045509	Gorilla gorilla	99.72	0.00e+00	726.00
IUUC-Hsa-046597	Homo sapiens	99.72	0.00e+00	726.00
IUUC-Hvu-047335	Hordeum vulgare	25.00	9.00e-18	83.60
IUUC-Itr-048691	Ictidomys tridecemlineatus	93.75	0.00e+00	654.00
IUUC-Lch-050344	Latimeria chalumnae	68.75	7.00e-147	513.00
IUUC-Lpe-051343	Leersia perrieri	27.80	6.00e-14	71.60
IUUC-Loc-052376	Lepisosteus oculatus	67.05	1.00e-149	522.00
IUUC-Laf-054414	Loxodonta africana	94.03	0.00e+00	689.00
IUUC-Mcc-054604	Macaca mulatta	99.43	0.00e+00	725.00
IUUC-Meu-056087	Macropus eugenii	85.23	1.00e-173	602.00
IUUC-Mtr-057779	Medicago truncatula	27.06	9.00e-20	90.90
IUUC-Mga-060188	Meleagris gallopavo	73.08	3.00e-144	504.00
IUUC-Mmr-060704	Microcebus murinus	96.31	0.00e+00	704.00
IUUC-Mdo-062842	Monodelphis domestica	84.94	2.00e-166	578.00
IUUC-Mmu-064324	Mus musculus	89.49	1.00e-178	618.00
IUUC-Mpu-065940	Mustela putorius furo	89.77	9.00e-180	622.00
IUUC-Mlu-067028	Myotis lucifugus	92.61	0.00e+00	682.00
IUUC-Nle-069254	Nomascus leucogenys	91.81	0.00e+00	666.00
IUUC-Opr-070827	Ochotona princeps	87.78	0.00e+00	651.00
IUUC-Ont-072008	Oreochromis niloticus	62.22	2.00e-138	485.00
IUUC-Oan-072935	Ornithorhynchus anatinus	78.98	3.00e-167	580.00
IUUC-Ocu-074526	Oryctolagus cuniculus	92.33	0.00e+00	637.00
IUUC-Oba-075954	Oryza barthii	27.80	8.00e-14	70.90
IUUC-Obr-076592	Oryza brachyantha	26.96	8.00e-22	97.80
IUUC-Ogl-077732	Oryza glaberrima	27.33	1.00e-21	97.10
IUUC-Ogu-078565	Oryza glumaepatula	27.80	7.00e-14	71.20
IUUC-Oin-080188	Oryza indica	27.33	1.00e-21	97.10
IUUC-Olo-080705	Oryza longistaminata	24.90	1.00e-12	67.80
IUUC-Ome-081154	Oryza meridionalis	27.48	6.00e-14	71.60
IUUC-Oni-082201	Oryza nivara	27.80	8.00e-14	70.90
IUUC-Opu-083497	Oryza punctata	26.67	5.00e-14	71.60
IUUC-Oru-084332	Oryza rufipogon	27.80	8.00e-14	70.90
IUUC-Osa-086059	Oryza sativa	27.80	3.00e-14	72.40
IUUC-Ola-087288	Oryzias latipes	58.24	2.00e-126	444.00
IUUC-Oga-088402	Otolemur garnettii	94.32	0.00e+00	692.00
IUUC-Oar-089851	Ovis aries	91.98	2.00e-88	317.00
IUUC-Pan-092575	Papio anubis	99.15	0.00e+00	724.00
IUUC-Psi-094062	Pelodiscus sinensis	76.99	1.00e-165	575.00
IUUC-Pma-094501	Petromyzon marinus	35.59	9.00e-45	174.00
IUUC-Ppa-095285	Physcomitrella patens	25.86	5.00e-16	78.60
IUUC-Pfo-096146	Poecilia formosa	56.82	2.00e-121	428.00
IUUC-Pab-098524	Pongo abelii	99.43	0.00e+00	725.00
IUUC-Pop-099864	Populus trichocarpa	27.15	5.00e-19	88.20
IUUC-Pca-100314	Procavia capensis	92.61	0.00e+00	681.00
IUUC-Ppe-101663	Prunus persica	25.15	6.00e-17	81.30
IUUC-Pva-102947	Pteropus vampyrus	92.33	0.00e+00	679.00
IUUC-Rno-105024	Rattus norvegicus	89.77	0.00e+00	629.00
IUUC-Sha-107500	Sarcophilus harrisii	67.89	2.00e-125	441.00
IUUC-Smo-109194	Selaginella moellendorffii	26.99	1.00e-19	90.10
IUUC-Sit-109922	Setaria italica	25.73	8.00e-21	94.40
IUUC-Sly-111826	Solanum lycopersicum	26.35	8.00e-20	91.30
IUUC-Stu-112907	Solanum tuberosum	25.97	7.00e-19	87.80
IUUC-Sar-113522	Sorex araneus	90.38	4.00e-168	583.00
IUUC-Sbi-114536	Sorghum bicolor	27.33	1.00e-22	100.00
IUUC-Ssc-115445	Sus scrofa	94.03	0.00e+00	645.00
IUUC-Tgu-116551	Taeniopygia guttata	72.44	1.00e-136	478.00
IUUC-Tru-118407	Takifugu rubripes	57.10	8.00e-116	409.00
IUUC-Tsy-118794	Tarsius syrichta	91.76	0.00e+00	671.00
IUUC-Tni-120128	Tetraodon nigroviridis	65.25	5.00e-94	337.00
IUUC-Tca-121508	Theobroma cacao	27.38	1.00e-21	96.70
IUUC-Tae-125185	Triticum aestivum	25.65	2.00e-21	96.70
IUUC-Tur-126470	Triticum urartu	25.36	2.00e-21	95.90
IUUC-Tbe-127432	Tupaia belangeri	95.45	0.00e+00	646.00
IUUC-Ttr-128573	Tursiops truncatus	90.06	0.00e+00	649.00
IUUC-Vpa-130583	Vicugna pacos	92.63	1.00e-176	611.00
IUUC-Vvi-131710	Vitis vinifera	26.20	6.00e-17	81.60
IUUC-Xtr-132009	Xenopus tropicalis	61.30	3.00e-135	474.00
IUUC-Xma-134121	Xiphophorus maculatus	57.79	2.00e-126	445.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence