iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006675

UUCD1 version

UUC-ArT-01508

Ensembl Protein ID

AT5G44280.2

UniProt Accession

Q9FKW0; RNG1A_ARATH

Genbank Protein ID

BAB10113.1; AED95085.1; AT5G44280.1

Protein Name

Putative E3 ubiquitin-protein ligase RING1a; Polycomb complex protein RING1a; Protein RING1a; RING-type E3 ubiquitin transferase RING1a; Ring finger protein 434

Genbank Nucleotide ID

AB011475; CP002688; AK228896

Gene Name

RING1A; RF434; At5g44280; K9L2.3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G44280	AT5G44280.1	AT5G44280.1
AT5G44280	AT5G44280.2	AT5G44280.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20933424
ULD/UDP/UFD/RAWUL	RAWUL	24465219

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/RAWUL	3.40e-21	76.4	412	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsklkkkylrcsarltVkhlkkflaeklklsssyevdllce............dev................LednetLeeik 70
           i+++L++l++++++d   l+++yl+c+++l Vk+l++f+a++++l+++ ev+ll++              +                LednetL+++k
   Q: 412  IHVKLVSLDTKCIPD---LPQPYLCCRPTLLVKQLREFVALQIHLKTE-EVELLVTrrrvgedaaienL-PavtpasaaaskdemlsLEDNETLSRLK 504
           89*************...******************************.*******9888888777750.15555555566666689*********** PP
   S: 71   yifiwkkegpLvLqYr 86
           ++fi+++e++L+++Yr
   Q: 505  IDFISSHEQHLIIAYR 520
           ***************9 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

As part of the PRC1-like complex, repress class I KNOX gene expression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.

Protein Sequence
(Fasta)

MSVKNNSFSS AEIPDVADQP RDRFNPEATQ DLQEKDETKE EKEGDEEVKH DEAEEDQEVV 60
KPNDAEEDDD GDDAEEDEEE EVEAEEDEEA EEEEEEEEEE EEEEEDSKER SPSSISGDQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATATCGGCAC CGAACCAAAA ACACAAACGA AGCAGAACAA GAAGAAGAAG AAGAATAGAG 60
AGAGACGTAG AGAGAGAGAG ACAAAGGCTG AGCCTTTTGG GTTTCTCTTA GAGAGAAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0035102--C:PRC1 complex
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0001709--P:cell fate determination
GO:0016569--P:covalent chromatin modification
GO:0010076--P:maintenance of floral meristem identity
GO:0010077--P:maintenance of inflorescence meristem identity
GO:0010492--P:maintenance of shoot apical meristem identity
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0016567--P:protein ubiquitination
GO:0006351--P:transcription, DNA-templated

KEGG

ath:AT5G44280

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005911	Arabidopsis lyrata	88.46	4.00e-169	587.00
IUUC-Bol-015993	Brassica oleracea	70.21	2.00e-111	395.00
IUUC-Bra-017150	Brassica rapa	78.77	4.00e-62	231.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence