iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Dme-031807

UUCD1 version

UUC-DrM-00567

Ensembl Protein ID

FBpp0071067

UniProt Accession

Q7JW03; Q7JW03_DROME

Genbank Protein ID

AAF46318.1; AAF46319.1; AAL28785.1; AAM49879.1; AAN09227.1; ADG53169.1; ADG53170.1; ADG53171.1; ADG53172.1; ADG53173.1; ADG53174.1; ADG53175.1; ADG53176.1; ADG53177.1; ADG53178.1; ADG53179.1; ADG53180.1; ADG53181.1; ADG53182.1; ADG53183.1; ADG53184.1; ADG53185.1; ADG53186.1; ADG53187.1; ADG53188.1

Protein Name

CG2257; LD13772p; LD17992p; Ubiquitin conjugating enzyme E2H, isoform A; Ubiquitin conjugating enzyme E2H, isoform B; Ubiquitin conjugating enzyme E2H, isoform C

Genbank Nucleotide ID

AE014298; AE014298; AY061237; AY118510; AE014298; GQ306696; GQ306697; GQ306698; GQ306699; GQ306700; GQ306701; GQ306702; GQ306703; GQ306704; GQ306705; GQ306706; GQ306707; GQ306708; GQ306709; GQ306710; GQ306711; GQ306712; GQ306713; GQ306714; GQ306715

Gene Name

UbcE2H; Ubc-E2H; CG2257; Dmel_CG2257

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0029996	FBtr0071112	FBpp0071067

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	9.70e-35	119.4	31	142

Active Site

Position(s)	Description	Evidence
87	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 27   ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsilkeeekWspalsvesvlls.iqsllaepnpesplneea 122
           l+e++v+++Gp++tpYeggv+k+++++p++YPfk+P++ f++ki+hPn++e+ G+vCl++++  ++W++ +++++++ s + +ll+ pnp +pln +a
   Q: 31   LNEFHVKFFGPTETPYEGGVWKVRVYLPDNYPFKSPSIGFVNKIYHPNIDESsGTVCLDVIN--QAWTALYDLSNIFESfLPQLLTYPNPVDPLNRDA 126
           789************************************************99********9..*************66378999************* PP
   S: 123  aellkknreeykkkvr 138
           a l+ +++eey++kv 
   Q: 127  AALYLHEPEEYHRKVA 142
           *************985 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MSSPSAGKRR MDNDVIKLIE SKHEVTILGG LNEFHVKFFG PTETPYEGGV WKVRVYLPDN 60
YPFKSPSIGF VNKIYHPNID ESSGTVCLDV INQAWTALYD LSNIFESFLP QLLTYPNPVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCATCAATG GTCACACTCT GCAGGCGCTG GTCACACTAC AAATTTTCCA AGTCTTTCAT 60
ATTCCGGAAA ACAAAACAAA ATTAATTAAG TAATTAGACA CGAAGTATCT AGGAAAATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0046331--P:lateral inhibition
GO:0000209--P:protein polyubiquitination
GO:0019233--P:sensory perception of pain
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG2257

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000745	Aegilops tauschii	59.35	8.00e-50	188.00
IUUC-Aml-001260	Ailuropoda melanoleuca	78.69	7.00e-71	258.00
IUUC-Atr-002471	Amborella trichopoda	60.67	7.00e-52	195.00
IUUC-Apl-003547	Anas platyrhynchos	78.18	5.00e-60	222.00
IUUC-Aca-005224	Anolis carolinensis	78.18	6.00e-61	225.00
IUUC-Aly-005836	Arabidopsis lyrata	55.84	8.00e-50	188.00
IUUC-Ath-007534	Arabidopsis thaliana	55.84	1.00e-49	188.00
IUUC-Ago-007727	Ashbya gossypii	57.05	2.00e-49	187.00
IUUC-Acl-008119	Aspergillus clavatus	55.95	7.00e-53	198.00
IUUC-Afl-008412	Aspergillus flavus	62.07	1.00e-42	164.00
IUUC-Afu-008925	Aspergillus fumigatus	54.86	1.00e-49	188.00
IUUC-Ani-009294	Aspergillus nidulans	56.60	1.00e-49	187.00
IUUC-Ang-009805	Aspergillus niger	59.38	9.00e-53	198.00
IUUC-Aor-010201	Aspergillus oryzae	52.53	9.00e-45	171.00
IUUC-Ate-010441	Aspergillus terreus	62.93	4.00e-43	166.00
IUUC-Ame-010807	Astyanax mexicanus	60.11	1.00e-49	187.00
IUUC-Bta-012802	Bos taurus	78.69	7.00e-71	258.00
IUUC-Bdi-014415	Brachypodium distachyon	60.65	9.00e-52	194.00
IUUC-Bol-016385	Brassica oleracea	58.00	4.00e-49	186.00
IUUC-Bra-017669	Brassica rapa	55.62	1.00e-49	187.00
IUUC-Cel-018412	Caenorhabditis elegans	68.42	9.00e-62	228.00
IUUC-Cja-019571	Callithrix jacchus	63.95	1.00e-50	191.00
IUUC-Cfa-020811	Canis familiaris	78.69	7.00e-71	258.00
IUUC-Cpo-021889	Cavia porcellus	72.68	1.00e-62	231.00
IUUC-Cre-022956	Chlamydomonas reinhardtii	58.71	2.00e-51	194.00
IUUC-Csa-023289	Chlorocebus sabaeus	78.69	7.00e-71	258.00
IUUC-Cho-024517	Choloepus hoffmanni	60.11	3.00e-43	166.00
IUUC-Cin-025571	Ciona intestinalis	61.29	1.00e-48	184.00
IUUC-Cgl-026627	Colletotrichum gloeosporioides	67.74	1.00e-50	191.00
IUUC-Cne-027006	Cryptococcus neoformans	59.70	1.00e-47	182.00
IUUC-Cme-027171	Cyanidioschyzon merolae	61.04	5.00e-52	196.00
IUUC-Dre-027450	Danio rerio	77.60	1.00e-70	258.00
IUUC-Dno-029838	Dasypus novemcinctus	78.69	7.00e-71	258.00
IUUC-Dor-031119	Dipodomys ordii	78.69	7.00e-71	258.00
IUUC-Dse-031243	Dothistroma septosporum	60.76	2.00e-55	207.00
IUUC-Ete-032437	Echinops telfairi	60.66	4.00e-51	192.00
IUUC-Eca-034123	Equus caballus	78.03	2.00e-65	239.00
IUUC-Eeu-034543	Erinaceus europaeus	82.35	2.00e-29	120.00
IUUC-Fca-035502	Felis catus	78.69	7.00e-71	258.00
IUUC-Fal-037054	Ficedula albicollis	78.18	1.00e-61	228.00
IUUC-Fox-037912	Fusarium oxysporum	68.69	4.00e-39	152.00
IUUC-Fso-038148	Fusarium solani	60.26	2.00e-49	187.00
IUUC-Gmo-038858	Gadus morhua	77.05	5.00e-75	272.00
IUUC-Ggr-039749	Gaeumannomyces graminis	66.94	8.00e-48	181.00
IUUC-Gga-040942	Gallus gallus	78.69	7.00e-71	258.00
IUUC-Gac-042079	Gasterosteus aculeatus	77.60	4.00e-76	275.00
IUUC-Gma-043019	Glycine max	61.29	1.00e-52	198.00
IUUC-Hsa-046545	Homo sapiens	78.69	7.00e-71	258.00
IUUC-Hvu-047260	Hordeum vulgare	58.00	9.00e-49	185.00
IUUC-Itr-048474	Ictidomys tridecemlineatus	78.69	7.00e-71	258.00
IUUC-Kpa-049144	Komagataella pastoris	65.15	6.00e-48	182.00
IUUC-Lch-050589	Latimeria chalumnae	73.22	7.00e-62	228.00
IUUC-Lpe-051335	Leersia perrieri	60.65	2.00e-51	193.00
IUUC-Loc-052829	Lepisosteus oculatus	78.69	2.00e-69	254.00
IUUC-Lma-052971	Leptosphaeria maculans	59.85	2.00e-44	171.00
IUUC-Laf-053526	Loxodonta africana	77.60	2.00e-69	254.00
IUUC-Mcc-055611	Macaca mulatta	78.69	7.00e-71	258.00
IUUC-Meu-056722	Macropus eugenii	47.88	1.00e-28	117.00
IUUC-Mor-057278	Magnaporthe oryzae	66.15	2.00e-50	190.00
IUUC-Mpo-057484	Magnaporthe poae	67.27	6.00e-44	168.00
IUUC-Mtr-058579	Medicago truncatula	57.59	2.00e-52	197.00
IUUC-Mla-058926	Melampsora laricipopulina	62.91	6.00e-55	205.00
IUUC-Mga-059801	Meleagris gallopavo	78.69	7.00e-71	258.00
IUUC-Mvi-060244	Microbotryum violaceum	62.58	3.00e-55	206.00
IUUC-Mmr-061205	Microcebus murinus	78.69	7.00e-71	258.00
IUUC-Mdo-062038	Monodelphis domestica	73.45	4.00e-33	131.00
IUUC-Mmu-063974	Mus musculus	78.69	7.00e-71	258.00
IUUC-Mac-065158	Musa acuminata	61.94	4.00e-54	202.00
IUUC-Mpu-066759	Mustela putorius furo	78.69	7.00e-71	258.00
IUUC-Mlu-067674	Myotis lucifugus	77.84	1.00e-61	228.00
IUUC-Nfi-068618	Neosartorya fischeri	59.57	3.00e-48	183.00
IUUC-Ncr-068712	Neurospora crassa	68.07	4.00e-49	186.00
IUUC-Nle-069926	Nomascus leucogenys	78.69	7.00e-71	258.00
IUUC-Opr-070598	Ochotona princeps	78.69	7.00e-71	258.00
IUUC-Ont-071893	Oreochromis niloticus	77.60	2.00e-75	273.00
IUUC-Oan-073273	Ornithorhynchus anatinus	78.18	2.00e-61	227.00
IUUC-Ocu-074357	Oryctolagus cuniculus	85.82	9.00e-68	248.00
IUUC-Oba-075055	Oryza barthii	60.65	2.00e-51	193.00
IUUC-Obr-076538	Oryza brachyantha	60.00	4.00e-51	192.00
IUUC-Ogl-077784	Oryza glaberrima	60.65	2.00e-51	193.00
IUUC-Ogu-078045	Oryza glumaepatula	60.65	2.00e-51	193.00
IUUC-Oin-079163	Oryza indica	60.65	2.00e-51	193.00
IUUC-Olo-080847	Oryza longistaminata	58.04	3.00e-44	170.00
IUUC-Ome-081586	Oryza meridionalis	56.29	5.00e-49	186.00
IUUC-Oni-082913	Oryza nivara	60.65	2.00e-51	193.00
IUUC-Opu-083651	Oryza punctata	60.65	2.00e-51	193.00
IUUC-Oru-084980	Oryza rufipogon	60.65	2.00e-51	193.00
IUUC-Osa-085334	Oryza sativa	61.97	8.00e-49	184.00
IUUC-Ola-087423	Oryzias latipes	78.14	7.00e-76	275.00
IUUC-Oga-088412	Otolemur garnettii	78.69	7.00e-71	258.00
IUUC-Oar-090282	Ovis aries	76.61	6.00e-62	229.00
IUUC-Ptr-090470	Pan troglodytes	78.69	7.00e-71	258.00
IUUC-Pan-092552	Papio anubis	78.69	7.00e-71	258.00
IUUC-Psi-093516	Pelodiscus sinensis	72.83	1.00e-62	231.00
IUUC-Pno-094800	Phaeosphaeria nodorum	67.31	3.00e-41	160.00
IUUC-Ppa-095962	Physcomitrella patens	58.60	2.00e-51	193.00
IUUC-Pfo-097374	Poecilia formosa	78.14	4.00e-70	256.00
IUUC-Pab-098112	Pongo abelii	78.69	7.00e-71	258.00
IUUC-Pop-099923	Populus trichocarpa	60.65	1.00e-52	197.00
IUUC-Pca-100436	Procavia capensis	68.09	3.00e-53	199.00
IUUC-Ppe-101144	Prunus persica	60.65	2.00e-52	197.00
IUUC-Pva-102776	Pteropus vampyrus	78.14	7.00e-69	251.00
IUUC-Pgr-103325	Puccinia graminis	64.71	1.00e-51	194.00
IUUC-Ptt-104010	Puccinia triticina	60.90	3.00e-45	173.00
IUUC-Pte-104024	Pyrenophora teres	55.81	4.00e-52	196.00
IUUC-Pyt-104715	Pyrenophora triticirepentis	64.39	5.00e-50	189.00
IUUC-Rno-105699	Rattus norvegicus	78.14	9.00e-70	254.00
IUUC-Sce-106165	Saccharomyces cerevisiae	60.94	3.00e-44	170.00
IUUC-Sha-106524	Sarcophilus harrisii	78.18	2.00e-61	226.00
IUUC-Sja-107813	Schizosaccharomyces japonicus	62.25	2.00e-52	197.00
IUUC-Spo-108105	Schizosaccharomyces pombe	62.58	2.00e-53	201.00
IUUC-Ssl-108543	Sclerotinia sclerotiorum	53.55	8.00e-44	168.00
IUUC-Smo-109023	Selaginella moellendorffii	62.67	3.00e-53	200.00
IUUC-Sit-110211	Setaria italica	60.00	7.00e-51	193.00
IUUC-Sly-111324	Solanum lycopersicum	60.78	1.00e-52	198.00
IUUC-Stu-112455	Solanum tuberosum	57.59	6.00e-52	195.00
IUUC-Sar-113572	Sorex araneus	61.21	2.00e-38	150.00
IUUC-Sbi-114111	Sorghum bicolor	60.00	3.00e-51	193.00
IUUC-Sre-115027	Sporisorium reilianum	61.39	1.00e-56	211.00
IUUC-Ssc-116221	Sus scrofa	77.46	2.00e-63	233.00
IUUC-Tgu-116965	Taeniopygia guttata	78.18	3.00e-61	226.00
IUUC-Tru-118743	Takifugu rubripes	79.78	1.00e-77	281.00
IUUC-Tni-120422	Tetraodon nigroviridis	80.65	1.00e-69	254.00
IUUC-Tca-121140	Theobroma cacao	60.13	2.00e-53	200.00
IUUC-Tre-122110	Trichoderma reesei	64.89	4.00e-49	186.00
IUUC-Tvi-122592	Trichoderma virens	66.67	2.00e-47	180.00
IUUC-Tae-125866	Triticum aestivum	59.35	8.00e-51	192.00
IUUC-Tur-126414	Triticum urartu	59.35	9.00e-50	188.00
IUUC-Tme-127020	Tuber melanosporum	62.96	5.00e-38	149.00
IUUC-Tbe-128053	Tupaia belangeri	63.64	1.00e-42	164.00
IUUC-Ttr-128734	Tursiops truncatus	78.69	7.00e-71	258.00
IUUC-Uma-129334	Ustilago maydis	61.25	5.00e-57	212.00
IUUC-Vda-129953	Verticillium dahliae	58.58	4.00e-53	199.00
IUUC-Vpa-130729	Vicugna pacos	78.18	3.00e-61	226.00
IUUC-Vvi-131055	Vitis vinifera	60.00	1.00e-52	198.00
IUUC-Xtr-132368	Xenopus tropicalis	78.69	8.00e-71	258.00
IUUC-Xma-133864	Xiphophorus maculatus	78.14	4.00e-70	256.00
IUUC-Yli-134339	Yarrowia lipolytica	57.86	2.00e-55	207.00
IUUC-Zma-135047	Zea mays	59.33	1.00e-50	191.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence