iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afl-008547

Ensembl Protein ID

EED48826

UniProt Accession

B8NPH7; B8NPH7_ASPFN

Genbank Protein ID

EED48826.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

EQ963481

Gene Name

AFLA_130490

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AFLA_130490	EED48826	EED48826

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-53	181.1	177	656
UBD/Alpha-Helix/UBA	7.80e-18	63.5	524	562

Active Site

Position(s)	Description	Evidence
186	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
611	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel...................wkskkkavsprellkalkkeae 82
           tGl NlgN+CY+ Sv+QcL+ +pe+++ + + ++e+ + +  ++p ++l ++l+kl   +                      ++k   p ++++ +++ +e
   Q: 177  TGLANLGNSCYLSSVIQCLFDLPEFQQRYRH-ENEEPPLT--DSPAEDLETQLRKLADGIlsgrysradmdvivapdspEVPRQKGLVPAMFKHLVGRGHE 274
           7*****************************9.66665655..57999999*******9996666666666665544433366777**************** PP
   S: 83   efsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetk 183
           efs+++qqDa Efl +l++ ++ +                            +  n s  ++ F + ++++++c  c++v  + ++   +s+pvp ++   
   Q: 275  EFSTMKQQDAFEFLLHLFKLINLSR---------------------------HPDNLSSPTHSFMFAMEQRLQCVCCKKVRYKVDEQDNVSIPVPARRLAL 348
           *******************998777...........................6788999999*********************************999776 PP
   S: 184  ke...........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspeekq 272
           +            +l dcL++ t+ee ++    + c++c +k   +k+ ++++lP+ L+++  Rf  +  +++++k++  v++ +e Ldlsp+++s +++ 
   Q: 349  PDdttstgqfapvTLFDCLDASTSEEVVD----LVCPSCGSKDGFSKRSSFRTLPQQLVINARRF--ELINWVPTKLDIPVDVSEEpLDLSPYLSSGQKEG 443
           6699999*********************9....9*******************************..6677*************************44444 PP
   S: 273  ke................................................................................................... 274
           +e                                                                                                   
   Q: 444  EEllpdidaskrdfvpnqyaldqllsmgfprarsekalyttgnsdfeaamnwlfahledpdidepltiseirgggtdashdpakvaqlvemgidesrakra 544
           44666666666666666666666666666666666666666666667777777777777777777777777777777777777777777777777777777 PP
   S: 275  ..............................................kkkYeLiavvvHsG.slssGHYvayvkn.....ekgkWllfdDskVtevkeeevl 323
                                                         + +Y+L ++v+H+G s++ GHYva+v++     ++ +W+ f+D+kV +    ++ 
   Q: 545  lgatggdvnraidwvfshpeadaegygresnthsdgcprnlgssdvPARYKLRSIVCHKGsSVHAGHYVAFVRKtlpgqNEPCWVMFNDEKVVKA--GDIH 643
           8888888888888888888888888888888888899999999999****************************887655556********9888..4555 PP
   S: 324  eetgstaYvlfYkr 337
           e++ + aY++f+ r
   Q: 644  EMK-KYAYLYFFSR 656
           533.6******987 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           d  k++qlveMG+d+++a++aL a+++++++A+++++++
   Q: 524  DPAKVAQLVEMGIDESRAKRALGATGGDVNRAIDWVFSH 562
           6679*********************************97 PP

Organism

Aspergillus flavus

Protein Sequence
(Fasta)

MTIDGVLNAM SFSKREEVKA WEQEFVPCEH TLCLNQQESR NIGSKDLSQC SMCDLKENLW 60
LCLECGNLGC GRSQFGGIGG NSHALAHADR TSHAIAVKLG SITADGSADI YCYKCNEERT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCATTG ATGGAGTCCT AAATGCGATG TCATTCTCAA AACGAGAGGA GGTAAAGGCC 60
TGGGAGCAGG AGTTCGTTCC TTGTGAACAC ACCCTCTGCC TGAATCAACA GGAATCCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

afv:AFLA_130490

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	32.65	2.00e-93	335.00
IUUC-Aml-002104	Ailuropoda melanoleuca	35.67	1.00e-113	402.00
IUUC-Atr-002580	Amborella trichopoda	36.01	1.00e-98	352.00
IUUC-Apl-003774	Anas platyrhynchos	35.87	7.00e-118	416.00
IUUC-Aca-005368	Anolis carolinensis	36.29	8.00e-118	416.00
IUUC-Aly-005727	Arabidopsis lyrata	36.46	3.00e-108	384.00
IUUC-Ath-006974	Arabidopsis thaliana	36.56	2.00e-109	387.00
IUUC-Ago-007890	Ashbya gossypii	35.86	2.00e-99	355.00
IUUC-Acl-008057	Aspergillus clavatus	72.64	0.00e+00	1010.00
IUUC-Afu-008805	Aspergillus fumigatus	66.46	0.00e+00	923.00
IUUC-Ani-009441	Aspergillus nidulans	64.18	0.00e+00	828.00
IUUC-Ang-009720	Aspergillus niger	71.34	0.00e+00	945.00
IUUC-Aor-010111	Aspergillus oryzae	100.00	0.00e+00	1371.00
IUUC-Ate-010531	Aspergillus terreus	64.76	0.00e+00	857.00
IUUC-Ame-011893	Astyanax mexicanus	36.63	6.00e-95	340.00
IUUC-Bgr-012183	Blumeria graminis	54.30	0.00e+00	717.00
IUUC-Bta-013179	Bos taurus	35.49	4.00e-112	397.00
IUUC-Bci-013858	Botrytis cinerea	58.79	0.00e+00	808.00
IUUC-Bdi-014904	Brachypodium distachyon	35.99	2.00e-94	338.00
IUUC-Bol-015536	Brassica oleracea	37.25	3.00e-110	390.00
IUUC-Bra-017619	Brassica rapa	36.96	1.00e-110	392.00
IUUC-Cel-018625	Caenorhabditis elegans	32.53	6.00e-78	283.00
IUUC-Cja-019063	Callithrix jacchus	35.48	6.00e-111	393.00
IUUC-Cfa-020976	Canis familiaris	36.60	1.00e-117	415.00
IUUC-Cpo-022265	Cavia porcellus	36.45	9.00e-117	412.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	33.88	6.00e-65	239.00
IUUC-Csa-024177	Chlorocebus sabaeus	37.48	3.00e-105	374.00
IUUC-Cho-024702	Choloepus hoffmanni	32.47	2.00e-75	275.00
IUUC-Cin-025411	Ciona intestinalis	34.24	1.00e-94	338.00
IUUC-Csv-026347	Ciona savignyi	32.62	2.00e-92	331.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	57.32	0.00e+00	749.00
IUUC-Cne-026831	Cryptococcus neoformans	45.80	2.00e-153	534.00
IUUC-Cme-027335	Cyanidioschyzon merolae	41.26	1.00e-54	206.00
IUUC-Dre-027982	Danio rerio	34.83	5.00e-97	347.00
IUUC-Dno-029034	Dasypus novemcinctus	36.59	7.00e-116	409.00
IUUC-Dor-030479	Dipodomys ordii	35.22	1.00e-56	213.00
IUUC-Dse-031467	Dothistroma septosporum	52.14	0.00e+00	698.00
IUUC-Dme-032075	Drosophila melanogaster	38.41	1.00e-111	395.00
IUUC-Ete-032865	Echinops telfairi	33.15	2.00e-95	341.00
IUUC-Eca-034059	Equus caballus	35.63	1.00e-112	399.00
IUUC-Eeu-035304	Erinaceus europaeus	35.61	1.00e-112	398.00
IUUC-Fca-035515	Felis catus	35.76	2.00e-114	404.00
IUUC-Fal-037271	Ficedula albicollis	37.30	4.00e-118	417.00
IUUC-Fox-037745	Fusarium oxysporum	57.93	0.00e+00	783.00
IUUC-Fso-038158	Fusarium solani	58.58	0.00e+00	774.00
IUUC-Gmo-039071	Gadus morhua	34.37	4.00e-99	353.00
IUUC-Ggr-040098	Gaeumannomyces graminis	57.78	0.00e+00	747.00
IUUC-Gga-040635	Gallus gallus	35.88	4.00e-117	413.00
IUUC-Gac-042528	Gasterosteus aculeatus	35.79	3.00e-103	367.00
IUUC-Gma-042656	Glycine max	34.44	3.00e-102	364.00
IUUC-Ggo-044602	Gorilla gorilla	36.04	3.00e-115	407.00
IUUC-Hsa-045959	Homo sapiens	36.04	3.00e-115	407.00
IUUC-Hvu-047563	Hordeum vulgare	36.53	9.00e-100	355.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	35.71	4.00e-114	403.00
IUUC-Kpa-049156	Komagataella pastoris	41.43	2.00e-145	507.00
IUUC-Lch-049648	Latimeria chalumnae	37.11	3.00e-111	394.00
IUUC-Lpe-051523	Leersia perrieri	34.62	2.00e-97	348.00
IUUC-Loc-052072	Lepisosteus oculatus	33.66	1.00e-102	365.00
IUUC-Lma-053216	Leptosphaeria maculans	58.38	0.00e+00	754.00
IUUC-Laf-054327	Loxodonta africana	35.90	5.00e-114	403.00
IUUC-Mcc-055443	Macaca mulatta	35.90	8.00e-115	406.00
IUUC-Meu-056361	Macropus eugenii	35.59	5.00e-71	260.00
IUUC-Mor-057106	Magnaporthe oryzae	58.07	0.00e+00	786.00
IUUC-Mpo-057589	Magnaporthe poae	57.57	0.00e+00	748.00
IUUC-Mtr-058680	Medicago truncatula	37.39	1.00e-109	389.00
IUUC-Mla-058903	Melampsora laricipopulina	43.92	2.00e-160	557.00
IUUC-Mga-059669	Meleagris gallopavo	35.73	6.00e-114	403.00
IUUC-Mvi-060476	Microbotryum violaceum	44.38	5.00e-150	523.00
IUUC-Mmr-060575	Microcebus murinus	35.81	1.00e-113	402.00
IUUC-Mdo-062183	Monodelphis domestica	35.43	1.00e-113	402.00
IUUC-Mmu-063592	Mus musculus	35.76	2.00e-114	405.00
IUUC-Mac-065446	Musa acuminata	32.04	8.00e-92	329.00
IUUC-Mpu-066082	Mustela putorius furo	36.79	4.00e-117	413.00
IUUC-Mlu-067345	Myotis lucifugus	35.61	1.00e-111	395.00
IUUC-Nfi-068558	Neosartorya fischeri	70.95	0.00e+00	999.00
IUUC-Ncr-068960	Neurospora crassa	59.94	0.00e+00	770.00
IUUC-Nle-070173	Nomascus leucogenys	36.74	8.00e-118	416.00
IUUC-Opr-070556	Ochotona princeps	36.28	1.00e-113	402.00
IUUC-Ont-071502	Oreochromis niloticus	35.23	1.00e-103	368.00
IUUC-Oan-072959	Ornithorhynchus anatinus	41.78	1.00e-45	174.00
IUUC-Ocu-074861	Oryctolagus cuniculus	36.65	1.00e-116	412.00
IUUC-Oba-075109	Oryza barthii	34.54	5.00e-100	357.00
IUUC-Obr-076292	Oryza brachyantha	34.59	4.00e-95	340.00
IUUC-Ogl-077065	Oryza glaberrima	35.50	1.00e-105	375.00
IUUC-Ogu-078776	Oryza glumaepatula	34.50	4.00e-103	367.00
IUUC-Oin-080048	Oryza indica	35.17	3.00e-104	371.00
IUUC-Olo-080711	Oryza longistaminata	33.38	2.00e-96	344.00
IUUC-Ome-081506	Oryza meridionalis	34.21	8.00e-99	352.00
IUUC-Oni-082320	Oryza nivara	34.54	7.00e-100	356.00
IUUC-Opu-083801	Oryza punctata	34.26	1.00e-94	338.00
IUUC-Oru-085139	Oryza rufipogon	34.54	4.00e-100	357.00
IUUC-Osa-085713	Oryza sativa	35.64	1.00e-106	379.00
IUUC-Ola-086951	Oryzias latipes	33.61	1.00e-96	345.00
IUUC-Olu-087822	Ostreococcus lucimarinus	33.14	1.00e-87	316.00
IUUC-Oga-088625	Otolemur garnettii	35.44	2.00e-113	401.00
IUUC-Oar-089995	Ovis aries	35.53	9.00e-112	395.00
IUUC-Ptr-090640	Pan troglodytes	36.97	5.00e-117	413.00
IUUC-Pan-091974	Papio anubis	35.89	2.00e-114	404.00
IUUC-Psi-093957	Pelodiscus sinensis	36.02	3.00e-117	414.00
IUUC-Pma-094242	Petromyzon marinus	38.96	4.00e-66	243.00
IUUC-Pno-094835	Phaeosphaeria nodorum	58.52	0.00e+00	741.00
IUUC-Ppa-095901	Physcomitrella patens	37.30	2.00e-114	404.00
IUUC-Pfo-097148	Poecilia formosa	35.09	1.00e-102	365.00
IUUC-Pab-098068	Pongo abelii	35.68	3.00e-96	344.00
IUUC-Pop-098943	Populus trichocarpa	35.51	2.00e-103	368.00
IUUC-Pca-100738	Procavia capensis	34.57	1.00e-90	325.00
IUUC-Ppe-101315	Prunus persica	34.54	2.00e-101	361.00
IUUC-Pva-102154	Pteropus vampyrus	35.08	2.00e-110	391.00
IUUC-Pgr-103343	Puccinia graminis	44.32	2.00e-126	444.00
IUUC-Ptt-103928	Puccinia triticina	36.63	4.00e-115	407.00
IUUC-Pte-104306	Pyrenophora teres	58.31	0.00e+00	721.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	58.46	0.00e+00	733.00
IUUC-Rno-105801	Rattus norvegicus	35.99	6.00e-116	409.00
IUUC-Sce-106304	Saccharomyces cerevisiae	35.47	7.00e-111	392.00
IUUC-Sha-107635	Sarcophilus harrisii	35.86	3.00e-114	404.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	42.49	2.00e-145	508.00
IUUC-Spo-108144	Schizosaccharomyces pombe	40.96	2.00e-146	510.00
IUUC-Smo-108703	Selaginella moellendorffii	36.73	2.00e-105	374.00
IUUC-Sit-110728	Setaria italica	34.69	2.00e-106	378.00
IUUC-Sly-111523	Solanum lycopersicum	36.48	5.00e-112	396.00
IUUC-Sar-113733	Sorex araneus	40.80	6.00e-60	223.00
IUUC-Sbi-114419	Sorghum bicolor	35.17	6.00e-104	369.00
IUUC-Sre-115225	Sporisorium reilianum	42.84	1.00e-148	518.00
IUUC-Ssc-115686	Sus scrofa	35.71	7.00e-114	403.00
IUUC-Tgu-117346	Taeniopygia guttata	36.39	3.00e-113	400.00
IUUC-Tru-118627	Takifugu rubripes	33.87	8.00e-104	369.00
IUUC-Tsy-119278	Tarsius syrichta	34.24	3.00e-88	318.00
IUUC-Tni-120658	Tetraodon nigroviridis	33.56	1.00e-93	335.00
IUUC-Tca-121585	Theobroma cacao	35.21	1.00e-102	365.00
IUUC-Tre-122043	Trichoderma reesei	58.13	0.00e+00	739.00
IUUC-Tvi-122303	Trichoderma virens	57.40	0.00e+00	750.00
IUUC-Tae-123798	Triticum aestivum	35.32	5.00e-104	370.00
IUUC-Tur-126732	Triticum urartu	32.65	8.00e-93	333.00
IUUC-Tme-126909	Tuber melanosporum	56.35	0.00e+00	747.00
IUUC-Tbe-127261	Tupaia belangeri	30.65	2.00e-70	258.00
IUUC-Ttr-128295	Tursiops truncatus	30.77	3.00e-81	295.00
IUUC-Uma-129599	Ustilago maydis	42.35	1.00e-148	518.00
IUUC-Vda-129688	Verticillium dahliae	57.58	0.00e+00	736.00
IUUC-Vpa-130170	Vicugna pacos	29.44	2.00e-72	265.00
IUUC-Vvi-131116	Vitis vinifera	35.16	1.00e-100	359.00
IUUC-Xtr-131953	Xenopus tropicalis	34.75	2.00e-104	372.00
IUUC-Xma-133837	Xiphophorus maculatus	35.23	8.00e-103	366.00
IUUC-Yli-134510	Yarrowia lipolytica	45.91	1.00e-158	551.00
IUUC-Zma-135786	Zea mays	34.88	9.00e-101	359.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence