iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UEV	E2_UEV	18178771; 17586653

Classification

Family	E-value	Score	Start	End
E2/UEV	1.50e-66	223.6	67	164

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UEV

   S: 48   ltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevndsnGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           +   I    +t++egrIyqlklf++k+YPekPPtvrf+s++nma+vn+++Gvvdp+++++LanW+rey++e++lvqlkke+ +++nrkl+qPpeG++f
   Q: 67   VVTEINFMSQTVHEGRIYQLKLFCDKDYPEKPPTVRFHSRVNMACVNHETGVVDPKKFGLLANWQREYTMEDILVQLKKEMSTSHNRKLVQPPEGTCF 164
           5566777889**************************************************************************************97 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Has no ubiquitin ligase activity on its own. The heterodimer with UBC catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. May play a role in the control of progress through the cell cycle and differentiation. Involved in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Protein Sequence
(Fasta)

MTLGSGGSSV VVPRNFRLLE ELERGEKGIG DGTVSYGMDD GDDIYMRSWT GTIIGPHNIM 60
PLLLLLVVTE INFMSQTVHE GRIYQLKLFC DKDYPEKPPT VRFHSRVNMA CVNHETGVVD 120

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Nucleotide Sequence
(Fasta)

AAATTTGACC CTCCCATTTT AGCTTTCTGT CTATTCACCA GATTCTCTCT ATTCGATTCT 60
CCCTTTACTT CTTCTCGTCT CTCTTCTCTG CTCGTCAGAT CTCAAAATCA ATCGGATATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0070534--P:protein K63-linked ubiquitination

KEGG

ath:AT3G52560

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005402	Arabidopsis lyrata	87.20	2.00e-78	283.00
IUUC-Bol-015323	Brassica oleracea	86.59	5.00e-77	278.00
IUUC-Bra-018041	Brassica rapa	86.59	5.00e-77	278.00
IUUC-Meu-056842	Macropus eugenii	42.05	5.00e-14	71.20
IUUC-Pop-099786	Populus trichocarpa	83.54	7.00e-75	271.00
IUUC-Ptt-104008	Puccinia triticina	39.02	5.00e-21	92.40
IUUC-Sly-111205	Solanum lycopersicum	83.54	7.00e-75	271.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence