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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063988
UUCD1 version UUC-MuM-00854
Ensembl Protein ID ENSMUSP00000114968.1
UniProt Accession Q922V4; O55039; PLRG1_MOUSE
Genbank Protein ID AAC04388.1; BAC36104.1; BAC36115.1; BAC36675.1; AAH06750.1; ENSMUSP00000114968
Protein Name Pleiotropic regulator 1
Genbank Nucleotide ID AF044334; AK075993; AK076007; AK077197; BC006750; BC052895
Gene Name Plrg1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027998.11 ENSMUST00000150268.7 ENSMUSP00000114968.1
ENSMUSG00000027998.11 ENSMUST00000122128.1 ENSMUSP00000113614.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.50e-44 147.6 201 237
UBD/Beta-Prp 5.30e-67 227.2 296 489
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH ++v+c+a  ++   +v+Gs D tik+WDl +g+l
   Q: 201  GHLGWVRCIAVePGnQWFVTGSADRTIKIWDLASGKL 237
           8***********77799***************99987 PP
   

   UBD/Beta-Prp
   S: 19   spdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgd 107
           +p  ++l+t srd+t ++wdv+t+  +++lsgh+++v++v+++  ++ ++tgs D ti++wdl +gk+ +tl++h++sv+++ ++p  +
   Q: 296  HPTLDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPLLY 384
           67778999999999999999999999999999999999999999999999999999999999999999999999999999999999999 PP
   S: 108  klvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.......tgghtdsvyslsfd 189
           +++sGs d+ i+ w+ + g  ++  lsgh++++n+++v+  + +lvsG++++t+ lWd +tg   ++        + + ++ +   +fd
   Q: 385  TFASGSPDN-IKQWKFPDGGFIQ-NLSGHNAIINTLAVNA-DGVLVSGADNGTMHLWDWRTGYNFQRVhaavqpgSLDSESGIFACAFD 470
           999999665.9999999999999.9999999999999999.678999999999999999999999888766665533355566666699 PP
   S: 190  sngkelvsgsldgtvklwd 208
           ++  +l+++  d+t+k++ 
   Q: 471  RSESRLLTAEADKTIKVYR 489
           9999999999999999996 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
 Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.
Protein Sequence
(Fasta)
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT 60
SKENLKEKGP QNATDSYPHK QYPANQGQDV EYLVTGTHPY PAGPGVALTA DTKIQRMPSE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063988|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTTAGCGTC ACGTCCGGCG ACGGGCCCCA ATCTCCGGAA AGAGCTGCCG AATAGTGGCG 60
GCGTTTTCTG CGGCGATTAT TTGAGTTCCT TCGCTGCTGG AGGGGTAGAC TAAACGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063988|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005662--C:DNA replication factor A complex
GO:0001650--C:fibrillar center
GO:0031965--C:nuclear membrane
GO:0016607--C:nuclear speck
GO:0071011--C:precatalytic spliceosome
GO:0000974--C:Prp19 complex
GO:0000398--P:mRNA splicing, via spliceosome
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0034504--P:protein localization to nucleus
KEGG mmu:53317
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000084 Aegilops tauschii 47.20 7.00e-128 450.00
IUUC-Aml-001605 Ailuropoda melanoleuca 95.13 0.00e+00 1015.00
IUUC-Atr-002757 Amborella trichopoda 49.49 2.00e-129 456.00
IUUC-Apl-003198 Anas platyrhynchos 88.57 0.00e+00 952.00
IUUC-Aca-004683 Anolis carolinensis 87.98 0.00e+00 937.00
IUUC-Aly-005775 Arabidopsis lyrata 55.81 2.00e-127 449.00
IUUC-Ath-007460 Arabidopsis thaliana 60.53 8.00e-125 440.00
IUUC-Ago-007884 Ashbya gossypii 49.71 2.00e-106 379.00
IUUC-Acl-008153 Aspergillus clavatus 64.33 1.00e-127 449.00
IUUC-Afl-008384 Aspergillus flavus 64.94 1.00e-128 452.00
IUUC-Afu-009045 Aspergillus fumigatus 64.94 1.00e-128 452.00
IUUC-Ani-009229 Aspergillus nidulans 62.32 6.00e-128 450.00
IUUC-Ang-009812 Aspergillus niger 65.30 2.00e-122 431.00
IUUC-Aor-010059 Aspergillus oryzae 64.94 1.00e-128 452.00
IUUC-Ate-010351 Aspergillus terreus 63.66 1.00e-135 476.00
IUUC-Ame-011613 Astyanax mexicanus 58.56 8.00e-154 536.00
IUUC-Bgr-012042 Blumeria graminis 64.02 2.00e-134 472.00
IUUC-Bta-012406 Bos taurus 94.16 0.00e+00 1001.00
IUUC-Bci-013760 Botrytis cinerea 64.04 2.00e-133 468.00
IUUC-Bdi-014776 Brachypodium distachyon 51.17 7.00e-131 460.00
IUUC-Bol-016189 Brassica oleracea 53.90 5.00e-127 447.00
IUUC-Bra-018044 Brassica rapa 54.15 9.00e-128 450.00
IUUC-Cel-018651 Caenorhabditis elegans 53.89 2.00e-156 545.00
IUUC-Cja-019974 Callithrix jacchus 95.53 0.00e+00 1025.00
IUUC-Cfa-021085 Canis familiaris 94.76 0.00e+00 1016.00
IUUC-Cpo-021458 Cavia porcellus 94.37 0.00e+00 1012.00
IUUC-Cre-022880 Chlamydomonas reinhardtii 60.49 5.00e-124 437.00
IUUC-Csa-023883 Chlorocebus sabaeus 96.11 0.00e+00 1030.00
IUUC-Cho-024623 Choloepus hoffmanni 93.53 0.00e+00 979.00
IUUC-Cin-025190 Ciona intestinalis 60.42 0.00e+00 642.00
IUUC-Csv-026367 Ciona savignyi 60.38 0.00e+00 657.00
IUUC-Cgl-026499 Colletotrichum gloeosporioides 56.73 6.00e-140 490.00
IUUC-Cne-027069 Cryptococcus neoformans 63.44 2.00e-126 445.00
IUUC-Cme-027233 Cyanidioschyzon merolae 30.17 5.00e-36 145.00
IUUC-Dre-028260 Danio rerio 77.67 0.00e+00 831.00
IUUC-Dno-029112 Dasypus novemcinctus 95.53 0.00e+00 1024.00
IUUC-Dor-031118 Dipodomys ordii 93.90 0.00e+00 788.00
IUUC-Dse-031493 Dothistroma septosporum 46.77 4.00e-127 448.00
IUUC-Dme-032138 Drosophila melanogaster 59.84 1.00e-171 596.00
IUUC-Ete-032411 Echinops telfairi 82.75 0.00e+00 820.00
IUUC-Eca-033521 Equus caballus 94.17 0.00e+00 1011.00
IUUC-Eeu-035249 Erinaceus europaeus 80.44 0.00e+00 656.00
IUUC-Fca-036358 Felis catus 94.37 0.00e+00 1011.00
IUUC-Fal-036933 Ficedula albicollis 89.15 0.00e+00 952.00
IUUC-Fox-037713 Fusarium oxysporum 57.32 2.00e-139 489.00
IUUC-Fso-038380 Fusarium solani 64.33 6.00e-139 487.00
IUUC-Gmo-039133 Gadus morhua 78.60 0.00e+00 831.00
IUUC-Ggr-039915 Gaeumannomyces graminis 66.67 3.00e-132 465.00
IUUC-Gga-041176 Gallus gallus 87.02 0.00e+00 939.00
IUUC-Gac-042344 Gasterosteus aculeatus 76.74 0.00e+00 827.00
IUUC-Gma-043328 Glycine max 50.10 1.00e-132 466.00
IUUC-Ggo-044478 Gorilla gorilla 95.91 0.00e+00 1028.00
IUUC-Hsa-046037 Homo sapiens 96.11 0.00e+00 1030.00
IUUC-Hvu-047349 Hordeum vulgare 50.31 6.00e-132 464.00
IUUC-Itr-048390 Ictidomys tridecemlineatus 95.73 0.00e+00 1027.00
IUUC-Kpa-049343 Komagataella pastoris 58.46 5.00e-118 417.00
IUUC-Lch-049830 Latimeria chalumnae 83.14 0.00e+00 894.00
IUUC-Lpe-051442 Leersia perrieri 48.87 5.00e-129 454.00
IUUC-Loc-051794 Lepisosteus oculatus 81.69 0.00e+00 848.00
IUUC-Lma-053137 Leptosphaeria maculans 44.92 4.00e-127 448.00
IUUC-Laf-053471 Loxodonta africana 94.15 0.00e+00 1003.00
IUUC-Mcc-055627 Macaca mulatta 95.91 0.00e+00 1028.00
IUUC-Meu-056148 Macropus eugenii 80.98 0.00e+00 862.00
IUUC-Mor-056960 Magnaporthe oryzae 66.26 1.00e-136 479.00
IUUC-Mtr-057816 Medicago truncatula 47.24 4.00e-126 444.00
IUUC-Mla-059031 Melampsora laricipopulina 65.72 3.00e-127 448.00
IUUC-Mga-059337 Meleagris gallopavo 87.35 0.00e+00 939.00
IUUC-Mvi-060217 Microbotryum violaceum 64.78 7.00e-129 454.00
IUUC-Mmr-061018 Microcebus murinus 95.73 0.00e+00 1024.00
IUUC-Mdo-062863 Monodelphis domestica 89.73 0.00e+00 932.00
IUUC-Mac-064459 Musa acuminata 50.10 7.00e-122 430.00
IUUC-Mpu-066559 Mustela putorius furo 94.95 0.00e+00 1018.00
IUUC-Mlu-067361 Myotis lucifugus 91.59 0.00e+00 965.00
IUUC-Nfi-068492 Neosartorya fischeri 65.24 1.00e-128 452.00
IUUC-Ncr-068808 Neurospora crassa 60.32 1.00e-136 479.00
IUUC-Nle-069875 Nomascus leucogenys 96.30 0.00e+00 1032.00
IUUC-Opr-070462 Ochotona princeps 95.49 1.00e-153 536.00
IUUC-Ont-071365 Oreochromis niloticus 76.94 0.00e+00 829.00
IUUC-Oan-072708 Ornithorhynchus anatinus 89.69 0.00e+00 964.00
IUUC-Ocu-074594 Oryctolagus cuniculus 95.15 0.00e+00 1016.00
IUUC-Oba-075570 Oryza barthii 59.33 8.00e-127 447.00
IUUC-Obr-076366 Oryza brachyantha 64.41 5.00e-91 327.00
IUUC-Ogl-077153 Oryza glaberrima 59.61 2.00e-126 445.00
IUUC-Ogu-078540 Oryza glumaepatula 59.61 4.00e-127 447.00
IUUC-Oin-079612 Oryza indica 58.79 3.00e-125 442.00
IUUC-Olo-081077 Oryza longistaminata 58.79 3.00e-125 442.00
IUUC-Ome-081236 Oryza meridionalis 58.24 1.00e-124 439.00
IUUC-Oni-082499 Oryza nivara 59.61 4.00e-127 447.00
IUUC-Opu-083499 Oryza punctata 58.79 4.00e-125 441.00
IUUC-Oru-084276 Oryza rufipogon 59.61 4.00e-127 447.00
IUUC-Osa-085849 Oryza sativa 59.61 4.00e-127 447.00
IUUC-Ola-086655 Oryzias latipes 76.16 0.00e+00 818.00
IUUC-Olu-087637 Ostreococcus lucimarinus 58.98 9.00e-119 420.00
IUUC-Oga-087934 Otolemur garnettii 95.35 0.00e+00 1016.00
IUUC-Oar-090185 Ovis aries 93.20 0.00e+00 991.00
IUUC-Ptr-091198 Pan troglodytes 96.30 0.00e+00 1032.00
IUUC-Pan-092622 Papio anubis 96.11 0.00e+00 1030.00
IUUC-Psi-093320 Pelodiscus sinensis 88.78 0.00e+00 951.00
IUUC-Pma-094638 Petromyzon marinus 76.12 0.00e+00 826.00
IUUC-Pno-094826 Phaeosphaeria nodorum 47.51 1.00e-107 383.00
IUUC-Ppa-095576 Physcomitrella patens 64.31 3.00e-124 438.00
IUUC-Pfo-096894 Poecilia formosa 77.22 0.00e+00 832.00
IUUC-Pab-098020 Pongo abelii 96.11 0.00e+00 1032.00
IUUC-Pop-099180 Populus trichocarpa 48.32 7.00e-128 450.00
IUUC-Pca-100909 Procavia capensis 89.14 0.00e+00 803.00
IUUC-Ppe-101346 Prunus persica 48.32 3.00e-127 448.00
IUUC-Pva-102167 Pteropus vampyrus 77.48 0.00e+00 782.00
IUUC-Pgr-103516 Puccinia graminis 50.41 4.00e-130 457.00
IUUC-Ptt-103738 Puccinia triticina 50.73 1.00e-131 462.00
IUUC-Pte-104352 Pyrenophora teres 53.23 4.00e-131 461.00
IUUC-Pyt-104632 Pyrenophora triticirepentis 53.73 4.00e-132 464.00
IUUC-Rno-105291 Rattus norvegicus 98.44 0.00e+00 1050.00
IUUC-Sce-106204 Saccharomyces cerevisiae 50.45 4.00e-103 368.00
IUUC-Sha-106943 Sarcophilus harrisii 88.78 0.00e+00 922.00
IUUC-Sja-107659 Schizosaccharomyces japonicus 65.40 1.00e-129 456.00
IUUC-Spo-108049 Schizosaccharomyces pombe 64.01 7.00e-134 470.00
IUUC-Smo-109043 Selaginella moellendorffii 61.68 9.00e-127 446.00
IUUC-Sit-110431 Setaria italica 57.87 2.00e-130 459.00
IUUC-Sly-111391 Solanum lycopersicum 48.63 9.00e-121 427.00
IUUC-Stu-112364 Solanum tuberosum 55.26 1.00e-95 342.00
IUUC-Sar-113450 Sorex araneus 96.85 0.00e+00 712.00
IUUC-Sbi-113829 Sorghum bicolor 49.80 2.00e-129 455.00
IUUC-Sre-115153 Sporisorium reilianum 61.47 5.00e-121 427.00
IUUC-Ssc-116274 Sus scrofa 93.77 0.00e+00 1007.00
IUUC-Tgu-117417 Taeniopygia guttata 89.28 0.00e+00 952.00
IUUC-Tru-117615 Takifugu rubripes 75.78 0.00e+00 781.00
IUUC-Tsy-119480 Tarsius syrichta 96.28 0.00e+00 1023.00
IUUC-Tni-119847 Tetraodon nigroviridis 75.34 0.00e+00 810.00
IUUC-Tca-121287 Theobroma cacao 47.64 7.00e-126 444.00
IUUC-Tre-122010 Trichoderma reesei 65.50 3.00e-143 501.00
IUUC-Tvi-122475 Trichoderma virens 64.33 9.00e-142 496.00
IUUC-Tae-124397 Triticum aestivum 50.51 2.00e-133 468.00
IUUC-Tur-126116 Triticum urartu 42.38 5.00e-100 358.00
IUUC-Tme-126992 Tuber melanosporum 65.85 6.00e-136 477.00
IUUC-Tbe-127803 Tupaia belangeri 84.35 0.00e+00 725.00
IUUC-Ttr-128933 Tursiops truncatus 94.94 0.00e+00 1013.00
IUUC-Uma-129447 Ustilago maydis 60.00 6.00e-117 414.00
IUUC-Vda-129780 Verticillium dahliae 64.12 3.00e-138 484.00
IUUC-Vpa-130557 Vicugna pacos 89.52 9.00e-118 417.00
IUUC-Vvi-130918 Vitis vinifera 48.46 3.00e-122 431.00
IUUC-Xtr-132409 Xenopus tropicalis 84.33 0.00e+00 875.00
IUUC-Xma-133420 Xiphophorus maculatus 77.33 0.00e+00 836.00
IUUC-Yli-134362 Yarrowia lipolytica 48.04 3.00e-121 428.00
IUUC-Zma-135804 Zea mays 59.00 3.00e-125 441.00
Created Date 25-Jun-2017

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