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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046939
UUCD1 version UUC-HoS-00024
Ensembl Protein ID ENSP00000345984.6
UniProt Accession O43734; B2RAY9; E1P555; Q5R3A3; Q7Z6Q1; Q7Z6Q2; Q7Z6Q3; Q9H5W2; Q9H6Y3; Q9NS14; Q9UG72; CIKS_HUMAN
Genbank Protein ID AAF67445.1; AAF67446.1; AAF67447.1; AAG15367.1; AAG15407.1; BAB15117.1; BAB15507.1; BAG37036.1; CAB43390.1; CAA15506.1; CAA15507.1; CAD92596.1; CAD92597.1; CAD92597.1; CAI22298.1; CAI22298.1; CAI22297.1; CAI22297.1; EAW48285.1; EAW48287.1; AAH02823.1; ENSP00000345984
Protein Name Adapter protein CIKS; Connection to IKK and SAPK/JNK; Nuclear factor NF-kappa-B activator 1; TRAF3-interacting protein 2
Genbank Nucleotide ID AF136405; AF136406; AF136407; AF274303; AF272151; AK025351; AK026602; AK314415; AL050289; AL008730; AL008730; AL008730; AL008730; Z97989; Z97989; AL008730; Z97989; AL008730; CH471051; CH471051; BC002823; BI856094
Gene Name TRAF3IP2; C6orf2; C6orf4; C6orf5; C6orf6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000056972.18 ENST00000359831.8 ENSP00000352889.4
ENSG00000056972.18 ENST00000340026.10 ENSP00000345984.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/U-box U-box 19825828
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6.
 Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6.
Protein Sequence
(Fasta)
MPPQLQETRM NRSIPVEVDE SEPYPSQLLK PIPEYSPEEE SEPPAPNIRN MAPNSLSAPT 60
MLHNSSGDFS QAHSTLKLAN HQRPVSRQVT CLRTQVLEDS EDSFCRRHPG LGKAFPSGCS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046939|E3,U-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGCAATGCT GATGTTTTAA GCAGTTAGAG GAGGTGGAAG AAGCTCGACT CCCTCTTCTT 60
CCCCATTATC TGCCCACAAT CCCCTCCTTT GGAGCTGCTA ATGATTACTA ATTCTTAACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046939|E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR013568--SEFIR_dom
IPR000157--TIR_dom
PROSITE

PS51534--SEFIR
Pfam

PF08357--SEFIR
Gene Ontology

GO:0005622--C:intracellular
GO:0001783--P:B cell apoptotic process
GO:0006959--P:humoral immune response
GO:0048305--P:immunoglobulin secretion
GO:0035556--P:intracellular signal transduction
GO:0002230--P:positive regulation of defense response to virus by host
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
KEGG hsa:10758
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002194 Ailuropoda melanoleuca 84.37 0.00e+00 803.00
IUUC-Apl-003292 Anas platyrhynchos 65.16 2.00e-135 475.00
IUUC-Aca-005173 Anolis carolinensis 52.08 1.00e-129 456.00
IUUC-Ame-010632 Astyanax mexicanus 52.31 3.00e-49 187.00
IUUC-Bta-012676 Bos taurus 83.01 0.00e+00 827.00
IUUC-Bol-016235 Brassica oleracea 29.41 2.00e-02 35.00
IUUC-Bra-017363 Brassica rapa 29.41 1.90e-02 35.00
IUUC-Cja-019819 Callithrix jacchus 92.42 0.00e+00 954.00
IUUC-Cfa-020618 Canis familiaris 80.70 0.00e+00 724.00
IUUC-Cpo-021337 Cavia porcellus 81.42 0.00e+00 835.00
IUUC-Csa-023655 Chlorocebus sabaeus 95.58 0.00e+00 977.00
IUUC-Cho-024547 Choloepus hoffmanni 78.48 0.00e+00 751.00
IUUC-Dre-028655 Danio rerio 47.31 3.00e-45 175.00
IUUC-Dno-029255 Dasypus novemcinctus 84.33 0.00e+00 836.00
IUUC-Dor-030858 Dipodomys ordii 79.72 0.00e+00 723.00
IUUC-Ete-032597 Echinops telfairi 66.78 1.00e-90 327.00
IUUC-Eca-033990 Equus caballus 87.94 0.00e+00 894.00
IUUC-Eeu-034594 Erinaceus europaeus 81.36 0.00e+00 818.00
IUUC-Fca-035932 Felis catus 86.44 0.00e+00 900.00
IUUC-Fal-037433 Ficedula albicollis 54.90 5.00e-136 478.00
IUUC-Gmo-039640 Gadus morhua 55.83 7.00e-39 152.00
IUUC-Gga-040229 Gallus gallus 53.60 1.00e-137 483.00
IUUC-Gac-041660 Gasterosteus aculeatus 57.46 1.00e-52 199.00
IUUC-Gma-043508 Glycine max 28.75 1.40e-01 32.30
IUUC-Ggo-044913 Gorilla gorilla 89.67 0.00e+00 947.00
IUUC-Itr-047865 Ictidomys tridecemlineatus 92.36 4.00e-134 470.00
IUUC-Lch-049621 Latimeria chalumnae 52.33 1.00e-88 320.00
IUUC-Loc-052498 Lepisosteus oculatus 41.06 4.00e-60 225.00
IUUC-Laf-053734 Loxodonta africana 83.54 0.00e+00 827.00
IUUC-Mcc-054884 Macaca mulatta 95.30 0.00e+00 983.00
IUUC-Meu-056225 Macropus eugenii 61.96 2.00e-89 323.00
IUUC-Mga-059442 Meleagris gallopavo 58.19 9.00e-130 457.00
IUUC-Mmr-061017 Microcebus murinus 89.88 0.00e+00 982.00
IUUC-Mdo-062163 Monodelphis domestica 72.13 0.00e+00 693.00
IUUC-Mmu-064394 Mus musculus 77.80 0.00e+00 759.00
IUUC-Mpu-066777 Mustela putorius furo 84.25 0.00e+00 891.00
IUUC-Mlu-068135 Myotis lucifugus 84.96 0.00e+00 849.00
IUUC-Nle-070002 Nomascus leucogenys 93.66 0.00e+00 939.00
IUUC-Opr-070530 Ochotona princeps 69.82 0.00e+00 644.00
IUUC-Ont-071530 Oreochromis niloticus 53.06 5.00e-50 190.00
IUUC-Oan-073155 Ornithorhynchus anatinus 86.11 5.00e-83 300.00
IUUC-Ocu-074761 Oryctolagus cuniculus 73.81 0.00e+00 700.00
IUUC-Ola-086465 Oryzias latipes 55.90 2.00e-44 171.00
IUUC-Oga-088791 Otolemur garnettii 88.32 0.00e+00 931.00
IUUC-Oar-090442 Ovis aries 81.59 0.00e+00 829.00
IUUC-Ptr-091482 Pan troglodytes 99.13 0.00e+00 1015.00
IUUC-Pan-092343 Papio anubis 89.61 0.00e+00 883.00
IUUC-Psi-093042 Pelodiscus sinensis 58.59 1.00e-165 576.00
IUUC-Pfo-097008 Poecilia formosa 59.77 3.00e-48 184.00
IUUC-Pab-098135 Pongo abelii 98.43 0.00e+00 1014.00
IUUC-Pca-100508 Procavia capensis 80.33 0.00e+00 787.00
IUUC-Pva-103048 Pteropus vampyrus 87.41 0.00e+00 918.00
IUUC-Rno-105238 Rattus norvegicus 74.43 0.00e+00 714.00
IUUC-Sha-107315 Sarcophilus harrisii 70.58 0.00e+00 703.00
IUUC-Ssc-116085 Sus scrofa 84.60 0.00e+00 828.00
IUUC-Tgu-116885 Taeniopygia guttata 65.63 3.00e-133 468.00
IUUC-Tru-118396 Takifugu rubripes 59.24 6.00e-55 206.00
IUUC-Tni-120375 Tetraodon nigroviridis 57.65 2.00e-56 211.00
IUUC-Tbe-128139 Tupaia belangeri 94.57 5.00e-117 414.00
IUUC-Ttr-128651 Tursiops truncatus 82.87 0.00e+00 816.00
IUUC-Vpa-130559 Vicugna pacos 76.05 0.00e+00 721.00
IUUC-Xtr-132354 Xenopus tropicalis 50.57 2.00e-70 259.00
IUUC-Xma-134194 Xiphophorus maculatus 60.34 2.00e-43 169.00
Created Date 25-Jun-2017

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