• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045729
UUCD1 version UUC-HoS-00710
Ensembl Protein ID ENSP00000280098.4
UniProt Accession Q6IQ16; SPOPL_HUMAN
Genbank Protein ID AAH71613.1
Protein Name Speckle-type POZ protein-like; HIB homolog 2; Roadkill homolog 2
Genbank Nucleotide ID BC071613
Gene Name SPOPL
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000144228.8 ENST00000280098.8 ENSP00000280098.4
ENSG00000144228.8 ENST00000430968.5 ENSP00000410201.1
ENSG00000144228.8 ENST00000420679.1 ENSP00000396006.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDMenthaInWeb_IM
Disease-associated Variation
GWASdbGWAS Central
Post-translational Modifications (PTMs)
PhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 3.30e-28 99.5 200 266
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.30e-07 30.9 299 326
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +D+ + v g+ef+ahk+vLaa+S+vF+a+f++e+eesk k++vei+d++pevf+++++F+Ytg++++ 
   Q: 200  TDCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESK-KNRVEINDLDPEVFKEMMRFIYTGRAPNL 266
           7*************************************.*************************9986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfil 28
           +eN+++ l +Adl+++++Lk +a+dfi+
   Q: 299  VENVADTLVLADLHSAEQLKAQAIDFIN 326
           79*************************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.
 Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.
Protein Sequence
(Fasta)
MSREPTPPLP GDMSTGPIAE SWCYTQVKVV KFSYMWTINN FSFCREEMGE VLKSSTFSSG 60
PSDKMKWCLR VNPKGLDDES KDYLSLYLLL VSCPKSEVRA KFKFSLLNAK REETKAMESQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045729|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTCGTAACT CGGAAGCCGG AGCCCAGACG GGCCCGCGGC GGGGGGGTGG GGGCTGCGCG 60
GGGGCGGGAG TGGCGGAGGT GGCCGCCCCT GGCGGCGGGT TTGTTTATCC CGGGGAAGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045729|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000210--BTB/POZ_dom
IPR002083--MATH/TRAF_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR008974--TRAF-like
PROSITE

PS50097--BTB
PS50144--MATH
Pfam

PF00651--BTB
PF00917--MATH
SMART

SM00225--BTB
SM00061--MATH
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0031397--P:negative regulation of protein ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
KEGG hsa:339745
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000119 Aegilops tauschii 33.23 3.00e-42 165.00
IUUC-Aml-001309 Ailuropoda melanoleuca 98.47 0.00e+00 766.00
IUUC-Atr-002922 Amborella trichopoda 29.84 6.00e-42 164.00
IUUC-Apl-003864 Anas platyrhynchos 95.41 0.00e+00 764.00
IUUC-Aca-005320 Anolis carolinensis 92.86 0.00e+00 737.00
IUUC-Ath-007670 Arabidopsis thaliana 28.35 4.00e-38 152.00
IUUC-Ate-010494 Aspergillus terreus 36.36 2.00e-07 49.70
IUUC-Ame-011843 Astyanax mexicanus 90.31 0.00e+00 731.00
IUUC-Bta-013528 Bos taurus 93.11 0.00e+00 709.00
IUUC-Bol-015218 Brassica oleracea 30.51 6.00e-43 168.00
IUUC-Bra-016833 Brassica rapa 30.91 4.00e-43 169.00
IUUC-Cja-019227 Callithrix jacchus 96.43 0.00e+00 766.00
IUUC-Cfa-020990 Canis familiaris 98.72 0.00e+00 768.00
IUUC-Cpo-021660 Cavia porcellus 99.49 0.00e+00 815.00
IUUC-Csa-023569 Chlorocebus sabaeus 96.88 4.00e-162 563.00
IUUC-Cho-024732 Choloepus hoffmanni 87.76 0.00e+00 685.00
IUUC-Dre-027880 Danio rerio 91.07 0.00e+00 734.00
IUUC-Dno-029399 Dasypus novemcinctus 97.70 0.00e+00 778.00
IUUC-Dor-030177 Dipodomys ordii 86.70 0.00e+00 646.00
IUUC-Ete-032759 Echinops telfairi 90.82 0.00e+00 719.00
IUUC-Eca-033858 Equus caballus 98.98 0.00e+00 770.00
IUUC-Eeu-035156 Erinaceus europaeus 99.08 0.00e+00 670.00
IUUC-Fca-036500 Felis catus 98.72 0.00e+00 768.00
IUUC-Fal-037023 Ficedula albicollis 95.41 0.00e+00 764.00
IUUC-Fox-037845 Fusarium oxysporum 36.14 3.00e-10 58.90
IUUC-Gmo-038605 Gadus morhua 91.58 0.00e+00 737.00
IUUC-Gga-040204 Gallus gallus 95.41 0.00e+00 764.00
IUUC-Gac-042260 Gasterosteus aculeatus 91.84 0.00e+00 740.00
IUUC-Gma-043055 Glycine max 30.38 5.00e-43 168.00
IUUC-Ggo-045160 Gorilla gorilla 99.74 0.00e+00 816.00
IUUC-Hvu-047528 Hordeum vulgare 30.96 4.00e-40 158.00
IUUC-Itr-048153 Ictidomys tridecemlineatus 99.23 0.00e+00 815.00
IUUC-Lch-050036 Latimeria chalumnae 91.33 0.00e+00 706.00
IUUC-Lpe-050805 Leersia perrieri 31.34 2.00e-45 176.00
IUUC-Loc-052332 Lepisosteus oculatus 89.97 0.00e+00 722.00
IUUC-Lma-053180 Leptosphaeria maculans 20.86 8.00e-07 48.90
IUUC-Laf-053691 Loxodonta africana 97.45 0.00e+00 780.00
IUUC-Mcc-055808 Macaca mulatta 99.74 0.00e+00 816.00
IUUC-Mtr-058012 Medicago truncatula 30.35 5.00e-43 168.00
IUUC-Mga-059990 Meleagris gallopavo 95.41 0.00e+00 764.00
IUUC-Mmr-061748 Microcebus murinus 98.72 0.00e+00 810.00
IUUC-Mdo-062472 Monodelphis domestica 90.48 0.00e+00 681.00
IUUC-Mmu-063522 Mus musculus 96.43 0.00e+00 771.00
IUUC-Mac-064772 Musa acuminata 31.34 2.00e-42 166.00
IUUC-Mpu-065894 Mustela putorius furo 92.57 0.00e+00 751.00
IUUC-Mlu-067879 Myotis lucifugus 97.96 0.00e+00 763.00
IUUC-Nle-069115 Nomascus leucogenys 100.00 0.00e+00 817.00
IUUC-Ont-072569 Oreochromis niloticus 91.58 0.00e+00 737.00
IUUC-Oan-073449 Ornithorhynchus anatinus 92.86 0.00e+00 741.00
IUUC-Ocu-073817 Oryctolagus cuniculus 98.98 0.00e+00 813.00
IUUC-Oba-075042 Oryza barthii 33.04 5.00e-44 172.00
IUUC-Obr-076906 Oryza brachyantha 33.43 2.00e-38 153.00
IUUC-Ogl-077426 Oryza glaberrima 33.04 2.00e-44 172.00
IUUC-Ogu-078825 Oryza glumaepatula 31.62 5.00e-40 160.00
IUUC-Oin-079531 Oryza indica 33.63 4.00e-42 165.00
IUUC-Olo-080313 Oryza longistaminata 37.59 5.00e-39 155.00
IUUC-Ome-081371 Oryza meridionalis 32.83 4.00e-39 155.00
IUUC-Oni-082862 Oryza nivara 33.24 2.00e-42 167.00
IUUC-Opu-083831 Oryza punctata 31.81 9.00e-39 154.00
IUUC-Oru-084513 Oryza rufipogon 32.15 5.00e-34 139.00
IUUC-Osa-085702 Oryza sativa 33.04 1.00e-40 160.00
IUUC-Ola-086485 Oryzias latipes 90.08 0.00e+00 724.00
IUUC-Oga-087982 Otolemur garnettii 92.86 0.00e+00 728.00
IUUC-Oar-089667 Ovis aries 97.96 0.00e+00 761.00
IUUC-Ptr-090729 Pan troglodytes 100.00 0.00e+00 817.00
IUUC-Pan-091988 Papio anubis 99.49 0.00e+00 815.00
IUUC-Psi-093103 Pelodiscus sinensis 95.66 0.00e+00 766.00
IUUC-Pfo-096279 Poecilia formosa 83.21 0.00e+00 649.00
IUUC-Pab-098431 Pongo abelii 100.00 0.00e+00 817.00
IUUC-Pop-099010 Populus trichocarpa 30.11 1.00e-33 137.00
IUUC-Pca-100373 Procavia capensis 77.23 1.00e-135 476.00
IUUC-Ppe-101816 Prunus persica 30.08 7.00e-36 145.00
IUUC-Pva-102660 Pteropus vampyrus 98.72 0.00e+00 768.00
IUUC-Rno-105020 Rattus norvegicus 88.92 0.00e+00 727.00
IUUC-Sha-107038 Sarcophilus harrisii 95.41 0.00e+00 762.00
IUUC-Sit-110155 Setaria italica 35.11 1.00e-38 153.00
IUUC-Ssc-116199 Sus scrofa 93.88 0.00e+00 716.00
IUUC-Tgu-116755 Taeniopygia guttata 94.90 0.00e+00 754.00
IUUC-Tru-118288 Takifugu rubripes 89.03 0.00e+00 716.00
IUUC-Tni-119955 Tetraodon nigroviridis 88.83 0.00e+00 719.00
IUUC-Tre-122160 Trichoderma reesei 34.25 1.00e-10 60.10
IUUC-Tvi-122498 Trichoderma virens 31.19 2.00e-11 63.20
IUUC-Tae-123958 Triticum aestivum 33.23 3.00e-42 165.00
IUUC-Tur-126285 Triticum urartu 37.26 3.00e-42 165.00
IUUC-Ttr-129261 Tursiops truncatus 98.21 0.00e+00 764.00
IUUC-Vpa-130728 Vicugna pacos 98.53 0.00e+00 655.00
IUUC-Xtr-132576 Xenopus tropicalis 87.98 2.00e-178 618.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved