iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053948

UUCD1 version

UUC-LoA-01017

Ensembl Protein ID

ENSLAFP00000025689.1

UniProt Accession

G3UCY1; G3UCY1_LOXAF

Protein Name

Uncharacterized protein

Gene Name

UBA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000002798.3	ENSLAFT00000002799.3	ENSLAFP00000002343.3
ENSLAFG00000002798.3	ENSLAFT00000029582.1	ENSLAFP00000025689.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.30e-235	780.2	451	930

Active Site

Position(s)	Description	Evidence
632	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q++++G++ qekl+++k++lvGag++GcEllKn++++G+     g+i v+Dmdt+e+snlnrqFLfr++dv k K+++aa+a++++
   Q: 451  YDGQVAVFGSDVQEKLGKQKYFLVGAGAIGCELLKNFAMIGLgcgegGEIVVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVHQM 539
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np+++v +h++++ +++e+i+   Ff+++d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+i+ lte+ys+s+dpp+k+
   Q: 540  NPHIQVMSHQNRVGPDTERIYdddFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKS 628
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           iP+ctlk++pna+eht++wa            + +n++l ++++++e++ +l+ ++++e++++v+++l+ ++++++++++++a++++++
   Q: 629  IPICTLKNFPNAIEHTLQWArdefeglfkqpaENVNQYL-TDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHT 716
           ***************************************.999999******************************************* PP
   S: 248  ttinsikqllksfecdivtkskspfwv.........................................sfcsnaealqvp........e 287
           ++ n+i+qll++f++d++t+s++pfw+                                          + ++ +a+qvp        +
   Q: 717  QYCNNIRQLLHNFPPDQLTSSGAPFWSgpkrcphpltfdvnnplhldyvaaanlfaqtygltgsqdrtAVSTLLQAVQVPeftpksgvK 805
           ****************************************************************9999666666777766555555556 PP
   S: 288  kvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipai 369
            +++d+e ++a+a+     l+ l+ +l   +k +g k++ ++fekddds  ++d++ aa+nlrae+++i+p +d+++ k iag+iipai
   Q: 806  IHVSDQELQSANASvddsrLEELKGTLPAPDKLPGFKMYPIDFEKDDDSnfHMDFIVAASNLRAENYDIPP-ADRHKSKLIAGKIIPAI 893
           6666666666666688889****************************************************.***************** PP
   S: 370  attnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           att+a+v Gl+++E++Kvv+g  + + +kn fl++a+
   Q: 894  ATTTAAVVGLVCLELYKVVQGhqQLDSYKNGFLNLAL 930
           *********************9999********9875 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSSSPLSKKR RVSGPDPKPG SNCSPAHSVL SEVPSVPTNG MAKNGSEADI DEGLYSRQLY 60
VLGHEAMKRL QTSSVLVSGL RGLGVEIAKN IILGGVKAVT LHDQGTAQWA DLSSQFYLRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAGCT CGCCGCTGTC CAAGAAACGT CGCGTGTCCG GGCCTGATCC AAAGCCAGGT 60
TCTAACTGCT CCCCTGCTCA CTCCGTGCTG TCTGAAGTAC CCTCGGTGCC AACCAACGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005829--C:cytosol
GO:0030057--C:desmosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0000792--C:heterochromatin
GO:0005765--C:lysosomal membrane
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0030867--C:rough endoplasmic reticulum membrane
GO:0005524--F:ATP binding
GO:0003723--F:RNA binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0006974--P:cellular response to DNA damage stimulus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	46.80	0.00e+00	853.00
IUUC-Aml-001311	Ailuropoda melanoleuca	92.94	0.00e+00	2012.00
IUUC-Atr-002684	Amborella trichopoda	46.78	0.00e+00	884.00
IUUC-Aca-004620	Anolis carolinensis	78.64	0.00e+00	1729.00
IUUC-Aly-005515	Arabidopsis lyrata	45.03	0.00e+00	895.00
IUUC-Ath-006891	Arabidopsis thaliana	45.23	0.00e+00	899.00
IUUC-Ago-007873	Ashbya gossypii	53.89	0.00e+00	1033.00
IUUC-Acl-008181	Aspergillus clavatus	53.33	0.00e+00	1034.00
IUUC-Afl-008455	Aspergillus flavus	55.09	0.00e+00	1010.00
IUUC-Afu-009065	Aspergillus fumigatus	52.98	0.00e+00	1048.00
IUUC-Ani-009371	Aspergillus nidulans	52.90	0.00e+00	1017.00
IUUC-Ang-009737	Aspergillus niger	53.55	0.00e+00	1040.00
IUUC-Aor-010007	Aspergillus oryzae	55.09	0.00e+00	1009.00
IUUC-Ate-010466	Aspergillus terreus	53.30	0.00e+00	1066.00
IUUC-Ame-010933	Astyanax mexicanus	77.62	0.00e+00	1659.00
IUUC-Bgr-012281	Blumeria graminis	53.43	0.00e+00	1056.00
IUUC-Bta-012767	Bos taurus	93.38	0.00e+00	2029.00
IUUC-Bci-013721	Botrytis cinerea	55.46	0.00e+00	1009.00
IUUC-Bdi-014843	Brachypodium distachyon	46.14	0.00e+00	865.00
IUUC-Bol-015665	Brassica oleracea	43.53	0.00e+00	877.00
IUUC-Bra-017252	Brassica rapa	44.23	0.00e+00	884.00
IUUC-Cel-018260	Caenorhabditis elegans	48.99	0.00e+00	929.00
IUUC-Cja-019152	Callithrix jacchus	94.05	0.00e+00	2038.00
IUUC-Cfa-020622	Canis familiaris	91.97	0.00e+00	1944.00
IUUC-Cpo-022526	Cavia porcellus	93.76	0.00e+00	2004.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	44.93	0.00e+00	826.00
IUUC-Csa-023780	Chlorocebus sabaeus	93.86	0.00e+00	2035.00
IUUC-Cho-024896	Choloepus hoffmanni	87.87	5.00e-119	422.00
IUUC-Cin-025790	Ciona intestinalis	62.31	0.00e+00	1318.00
IUUC-Csv-026084	Ciona savignyi	59.67	0.00e+00	1307.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	53.57	0.00e+00	1080.00
IUUC-Cne-026960	Cryptococcus neoformans	55.36	0.00e+00	1093.00
IUUC-Cme-027290	Cyanidioschyzon merolae	43.59	0.00e+00	806.00
IUUC-Dre-028149	Danio rerio	77.24	0.00e+00	1688.00
IUUC-Dno-028884	Dasypus novemcinctus	94.23	0.00e+00	2043.00
IUUC-Dor-030229	Dipodomys ordii	89.41	0.00e+00	1923.00
IUUC-Dse-031524	Dothistroma septosporum	52.18	0.00e+00	1048.00
IUUC-Dme-032045	Drosophila melanogaster	59.19	0.00e+00	1229.00
IUUC-Ete-032544	Echinops telfairi	86.86	0.00e+00	894.00
IUUC-Eca-033330	Equus caballus	94.52	0.00e+00	2048.00
IUUC-Fca-036255	Felis catus	94.33	0.00e+00	2021.00
IUUC-Fal-037445	Ficedula albicollis	50.00	0.00e+00	891.00
IUUC-Fox-038007	Fusarium oxysporum	55.62	2.00e-162	565.00
IUUC-Fso-038339	Fusarium solani	55.31	0.00e+00	1049.00
IUUC-Gmo-039338	Gadus morhua	73.71	0.00e+00	1586.00
IUUC-Ggr-039823	Gaeumannomyces graminis	54.78	0.00e+00	1099.00
IUUC-Gga-040365	Gallus gallus	48.88	0.00e+00	808.00
IUUC-Gac-041773	Gasterosteus aculeatus	73.52	0.00e+00	1579.00
IUUC-Gma-043198	Glycine max	45.44	0.00e+00	869.00
IUUC-Ggo-045336	Gorilla gorilla	94.33	0.00e+00	2019.00
IUUC-Hsa-045982	Homo sapiens	94.23	0.00e+00	2016.00
IUUC-Hvu-047418	Hordeum vulgare	46.56	0.00e+00	874.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	94.05	0.00e+00	2041.00
IUUC-Kpa-049112	Komagataella pastoris	50.88	0.00e+00	986.00
IUUC-Lch-050371	Latimeria chalumnae	78.38	0.00e+00	1745.00
IUUC-Lpe-051299	Leersia perrieri	44.27	0.00e+00	872.00
IUUC-Loc-052936	Lepisosteus oculatus	79.04	0.00e+00	1730.00
IUUC-Lma-053315	Leptosphaeria maculans	52.91	0.00e+00	1073.00
IUUC-Mcc-055843	Macaca mulatta	94.14	0.00e+00	2045.00
IUUC-Meu-056258	Macropus eugenii	85.54	0.00e+00	1863.00
IUUC-Mor-057269	Magnaporthe oryzae	54.24	0.00e+00	1069.00
IUUC-Mpo-057435	Magnaporthe poae	54.63	0.00e+00	1061.00
IUUC-Mtr-058572	Medicago truncatula	45.23	0.00e+00	863.00
IUUC-Mla-059176	Melampsora laricipopulina	57.08	0.00e+00	1088.00
IUUC-Mvi-060437	Microbotryum violaceum	53.69	0.00e+00	1046.00
IUUC-Mmr-061405	Microcebus murinus	92.34	0.00e+00	1984.00
IUUC-Mdo-062032	Monodelphis domestica	83.60	0.00e+00	1828.00
IUUC-Mmu-063280	Mus musculus	92.53	0.00e+00	1991.00
IUUC-Mac-065505	Musa acuminata	46.69	0.00e+00	876.00
IUUC-Mpu-066409	Mustela putorius furo	93.67	0.00e+00	2033.00
IUUC-Mlu-067217	Myotis lucifugus	92.44	0.00e+00	2003.00
IUUC-Nfi-068407	Neosartorya fischeri	53.18	0.00e+00	1028.00
IUUC-Ncr-068698	Neurospora crassa	54.67	0.00e+00	1086.00
IUUC-Nle-070072	Nomascus leucogenys	89.04	0.00e+00	1896.00
IUUC-Ont-071671	Oreochromis niloticus	76.20	0.00e+00	1652.00
IUUC-Ocu-074544	Oryctolagus cuniculus	93.10	0.00e+00	2025.00
IUUC-Oba-075120	Oryza barthii	46.20	0.00e+00	870.00
IUUC-Obr-076557	Oryza brachyantha	47.15	0.00e+00	863.00
IUUC-Ogl-077887	Oryza glaberrima	46.20	0.00e+00	872.00
IUUC-Ogu-078305	Oryza glumaepatula	43.94	0.00e+00	868.00
IUUC-Oin-080154	Oryza indica	43.94	0.00e+00	867.00
IUUC-Olo-081089	Oryza longistaminata	44.13	0.00e+00	868.00
IUUC-Ome-081942	Oryza meridionalis	46.10	0.00e+00	870.00
IUUC-Oni-082365	Oryza nivara	46.20	0.00e+00	872.00
IUUC-Opu-083977	Oryza punctata	46.59	0.00e+00	874.00
IUUC-Oru-084469	Oryza rufipogon	44.04	0.00e+00	870.00
IUUC-Osa-085949	Oryza sativa	46.40	0.00e+00	879.00
IUUC-Ola-087002	Oryzias latipes	75.53	0.00e+00	1649.00
IUUC-Olu-087687	Ostreococcus lucimarinus	43.52	0.00e+00	788.00
IUUC-Oga-088594	Otolemur garnettii	94.05	0.00e+00	2006.00
IUUC-Oar-090068	Ovis aries	92.92	0.00e+00	2017.00
IUUC-Pan-092114	Papio anubis	94.33	0.00e+00	2047.00
IUUC-Pma-094214	Petromyzon marinus	58.72	8.00e-55	206.00
IUUC-Pno-095154	Phaeosphaeria nodorum	52.62	0.00e+00	1080.00
IUUC-Ppa-095416	Physcomitrella patens	45.62	0.00e+00	882.00
IUUC-Pfo-097184	Poecilia formosa	75.81	0.00e+00	1644.00
IUUC-Pab-097861	Pongo abelii	93.95	0.00e+00	2001.00
IUUC-Pop-098934	Populus trichocarpa	44.69	0.00e+00	897.00
IUUC-Pca-100347	Procavia capensis	89.64	0.00e+00	1599.00
IUUC-Ppe-102012	Prunus persica	44.13	0.00e+00	884.00
IUUC-Pva-102584	Pteropus vampyrus	94.05	0.00e+00	2058.00
IUUC-Pgr-103336	Puccinia graminis	55.64	0.00e+00	1041.00
IUUC-Ptt-103939	Puccinia triticina	55.12	0.00e+00	1053.00
IUUC-Pte-104200	Pyrenophora teres	53.26	0.00e+00	1078.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	54.58	0.00e+00	1069.00
IUUC-Rno-105462	Rattus norvegicus	93.29	0.00e+00	1983.00
IUUC-Sce-106245	Saccharomyces cerevisiae	51.79	0.00e+00	1054.00
IUUC-Sha-107142	Sarcophilus harrisii	85.07	0.00e+00	1874.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	54.82	0.00e+00	1113.00
IUUC-Spo-108034	Schizosaccharomyces pombe	53.42	0.00e+00	1049.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	54.34	0.00e+00	1032.00
IUUC-Smo-109211	Selaginella moellendorffii	46.36	0.00e+00	880.00
IUUC-Sit-110281	Setaria italica	46.31	0.00e+00	889.00
IUUC-Sly-111237	Solanum lycopersicum	46.86	0.00e+00	861.00
IUUC-Stu-112001	Solanum tuberosum	46.56	0.00e+00	856.00
IUUC-Sar-113737	Sorex araneus	92.82	0.00e+00	2009.00
IUUC-Sbi-114089	Sorghum bicolor	45.93	0.00e+00	888.00
IUUC-Sre-115148	Sporisorium reilianum	54.40	0.00e+00	1071.00
IUUC-Ssc-115777	Sus scrofa	94.15	0.00e+00	2035.00
IUUC-Tru-118742	Takifugu rubripes	75.72	0.00e+00	1595.00
IUUC-Tsy-119485	Tarsius syrichta	95.71	4.00e-171	594.00
IUUC-Tni-120401	Tetraodon nigroviridis	75.91	0.00e+00	1597.00
IUUC-Tca-121436	Theobroma cacao	44.63	0.00e+00	883.00
IUUC-Tre-122009	Trichoderma reesei	53.04	0.00e+00	1014.00
IUUC-Tvi-122259	Trichoderma virens	54.71	0.00e+00	1010.00
IUUC-Tae-125113	Triticum aestivum	46.84	0.00e+00	853.00
IUUC-Tur-126189	Triticum urartu	46.49	0.00e+00	852.00
IUUC-Tme-127055	Tuber melanosporum	53.52	0.00e+00	997.00
IUUC-Tbe-127487	Tupaia belangeri	95.34	0.00e+00	1038.00
IUUC-Ttr-128331	Tursiops truncatus	93.29	0.00e+00	2009.00
IUUC-Uma-129387	Ustilago maydis	54.38	0.00e+00	1068.00
IUUC-Vda-129977	Verticillium dahliae	54.95	0.00e+00	998.00
IUUC-Vvi-130857	Vitis vinifera	45.01	0.00e+00	891.00
IUUC-Xtr-132026	Xenopus tropicalis	63.98	0.00e+00	1269.00
IUUC-Xma-133805	Xiphophorus maculatus	75.81	0.00e+00	1623.00
IUUC-Yli-134547	Yarrowia lipolytica	53.36	0.00e+00	1077.00
IUUC-Zma-135052	Zea mays	46.36	0.00e+00	893.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence