iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-017707

Ensembl Protein ID

Bra021611.1-P

UniProt Accession

M4DYL5; M4DYL5_BRARP

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra021611	Bra021611.1	Bra021611.1-P

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.20e-167	559.4	442	929

Active Site

Position(s)	Description	Evidence
623	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnve 91
           YD Qi ++G++ q+kl+ a+v+ vG g+lGcE+lKn++l+Gv     g++tv+D+d +e+snl+rqFLfr++++g+ K+ vaa a++ +np+ n+e
   Q: 442  YDAQISVFGAKLQKKLEDARVFTVGSGALGCEFLKNMALMGVscggqGKLTVTDDDIIEKSNLSRQFLFRDWNIGQAKSTVAASAAAAINPKFNIE 537
           ************************************************************************************************ PP
   S: 92   aheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaae 184
           a ++++ +++e+++   F ++++vVv+aldn+ ar++v+++cl+ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p +++
   Q: 538  ALQNRVGAETENVFddaFWENLTVVVNALDNVNARLYVDSRCLYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNID 633
           ************99********************************************************************************** PP
   S: 185  htiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtks 268
           h+++wa            + +n +l+   + ++       ++ +e+++++ + l++e+ enf+++ ++a+  f+ ++ n +kql+  f+ d  t+ 
   Q: 634  HCLTWArsefegllektpAEVNAYLSSPVEYTNSMMSAGDAQARETLERIVECLEKEKCENFQDCLNWARLRFEDYFVNRVKQLIYTFPEDAATST 729
           ***********999999977777777777777777777788888899999999999**************************************** PP
   S: 269  kspfwv.........................................................sfcsnaealqvpekvekdeevvkasap....ly 303
           ++pfw+                                                          f++ ++a+ v +  + + ++ +++++      
   Q: 730  GAPFWSapkrfprplqysssdpsllnfitatailraetfgipvpewtknpkeaaeavdsvivpDFEPRKDAKIVTDEKATSLTTASVDDAtvinDL 825
           ************************************************999999999999999888888877776666666666666666799999 PP
   S: 304  lllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfepl 395
           ++++ l r++  ++  ++ ++fekddd   ++d++  +an+ra +++i++ +d+ + k iag+iipaiat +a+  Gl+++E++Kv++g  k e++
   Q: 826  IAKLELCRLNLSPDFRMKPVQFEKDDDTnyHMDVISGLANMRARNYSIPE-VDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKVLDGghKVEAY 920
           9999999*******************************************.***************************************9***** PP
   S: 396  knfflfdae 404
           +n+f ++a+
   Q: 921  RNTFANLAL 929
           ****99875 PP

Organism

Brassica rapa

Protein Sequence
(Fasta)

MLESVSASSP IKKRRIDNST IAASVVQHMA FGNNSNRQEI DEDLHSRQLA VYGRETMRRL 60
FASNVLVSGM HGLGAEIAKN LILAGVKSVT LHDERVVELW DLSSNFVFSE DDVGKNRADA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTTGAAT CAGTTTCAGC ATCGTCGCCG ATCAAGAAAC GCCGTATCGA TAACTCTACG 60
ATCGCAGCTT CCGTCGTCCA GCACATGGCT TTCGGGAATA ACTCGAACCG TCAGGAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ang-009737	Aspergillus niger	45.28	0.00e+00	803.00
IUUC-Bci-013721	Botrytis cinerea	46.26	0.00e+00	798.00
IUUC-Bol-015161	Brassica oleracea	97.82	0.00e+00	2111.00
IUUC-Cel-018260	Caenorhabditis elegans	37.86	0.00e+00	657.00
IUUC-Cho-024682	Choloepus hoffmanni	36.71	8.00e-102	365.00
IUUC-Cin-025790	Ciona intestinalis	44.15	0.00e+00	863.00
IUUC-Csv-026084	Ciona savignyi	42.53	0.00e+00	847.00
IUUC-Cne-026960	Cryptococcus neoformans	45.67	0.00e+00	872.00
IUUC-Ggr-039823	Gaeumannomyces graminis	45.52	0.00e+00	865.00
IUUC-Mla-059176	Melampsora laricipopulina	46.92	0.00e+00	859.00
IUUC-Ola-087002	Oryzias latipes	44.93	0.00e+00	872.00
IUUC-Pma-094214	Petromyzon marinus	47.37	4.00e-36	143.00
IUUC-Pno-095154	Phaeosphaeria nodorum	44.14	0.00e+00	847.00
IUUC-Pgr-103336	Puccinia graminis	46.01	0.00e+00	823.00
IUUC-Ptt-103939	Puccinia triticina	45.91	0.00e+00	826.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	44.42	0.00e+00	853.00
IUUC-Uma-129387	Ustilago maydis	45.62	0.00e+00	823.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence