iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.70e-22	77.0	461	499
UBD/Beta-Prp	6.00e-46	157.9	421	750

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tl.lvsGsdDgtikvWDlrtgvll 36
           H ++v++++f  ++  l +++++dD+tikvWD  tgv+ 
   Q: 461  HVGGVNDISFstPNkQLcVITCGDDKTIKVWDAATGVKR 499
           999*******98664334799***********9999875 PP

UBD/Beta-Prp

   S: 14   tcvkfspdksllatgsrdgtikvwdvttgkl...lrslsgheaevtavkfspdgk..ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp.. 104
           + v +spd+sl+ +++ ++ +++++++ g       ++  h ++v++++fs   k    +t+++D+tikvwd  tg   ht++ghe+ v+s+  +   
   Q: 421  NRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDmrqHLEIDAHVGGVNDISFSTPNKqlCVITCGDDKTIKVWDAATGVKRHTFEGHEAPVYSVCPHYke 518
           55778**********************9998333334589***********88777899********************************8555443 PP
   S: 105  sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGsl..Dr..tvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsg 198
           + +++ s+  d  i+ w  ++     + +++  ++ ++++++ dg  l+s+++  D+  ++  W+ + g + rt +g h++s   ++fd ++++ +++
   Q: 519  NIQFIFSTALDGKIKAWLYDNMGSRVDYDAPG-RWCTTMAYSADGTRLFSCGTskDGesFIVEWNESEGAVKRTYQGFHKRSLGVVQFDTTKNRYLAA 615
           88***************999877777566655.5999999***9*999998652243336777999******************************** PP
   S: 199  sldgtvklwdlqtgecvrtlnght..dnvksvrfspnderlvsgssDgsiriW.dlrsgdllktlqlhn............................s 265
           ++d ++k+wd+ + + + +  g    +   ++rf +++ +l++ + +++i+i  +++   ll+t+++                               
   Q: 616  GDDFSIKFWDMDAVQLLTAIDGDGglQASPRIRFNKEGSLLAVSGNENVIKIMaNSDGLRLLHTFENISsesskpainsiaaaaaaaatsaghadrsA 713
           ************99988888887644555669999*****************88999**********9988999998888788887777777777777 PP
   S: 266  svisvavlsfgdnvl......vlgsedskvniwklkk 296
           +v+s+++++ + +++      ++ ++++k +iwkl++
   Q: 714  NVVSIQGMNGDSRNMvdvkpvITEESNDKSKIWKLTE 750
           7777777666655556777777777899999999986 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Transcriptional corepressor. May repress the expression of root-promoting genes in the top half of the embryo to allow proper differentiation of the shoot pole during the transition stage of embryogenesis. Regulates the expression of PLT1 and PLT2. Negative regulator of jasmonate responses. Negative regulator of auxin responses. Negative regulator of multiple floral organ identity genes (PubMed:23034631). Required for ovule development (PubMed:25378179).

Protein Sequence
(Fasta)

MSSLSRELVF LILQFLDEEK FKETVHKLEQ ESGFFFNMKY FEDEVHNGNW DEVEKYLSGF 60
TKVDDNRYSM KIFFEIRKQK YLEALDKHDR PKAVDILVKD LKVFSTFNEE LFKEITQLLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGAGAGA GAGAGAGAGA AGAAGAAGCT TTTTAATTTA GTTTTGCTTT CTTTCAAGTT 60
TCCTTTTTTC GATAGAGAGA AAAAGAGTCC AAAAATCAAT CCATCACCTC TTTCGTCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1184--Jasmonic acid signaling pathway
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR006595--CTLH_C
IPR006594--LisH
IPR027728--Topless_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50897--CTLH
PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00668--CTLH
SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0042803--F:protein homodimerization activity
GO:0009867--P:jasmonic acid mediated signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0010072--P:primary shoot apical meristem specification
GO:0009733--P:response to auxin
GO:0006351--P:transcription, DNA-templated
GO:0010051--P:xylem and phloem pattern formation

KEGG

ath:AT1G15750

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002737	Amborella trichopoda	77.79	0.00e+00	1741.00
IUUC-Aly-005995	Arabidopsis lyrata	99.38	0.00e+00	2194.00
IUUC-Bol-015359	Brassica oleracea	96.46	0.00e+00	2135.00
IUUC-Bra-016893	Brassica rapa	96.99	0.00e+00	2125.00
IUUC-Mac-065382	Musa acuminata	77.99	0.00e+00	1789.00
IUUC-Ppa-095814	Physcomitrella patens	68.78	0.00e+00	1542.00
IUUC-Ppe-101370	Prunus persica	85.48	0.00e+00	1974.00
IUUC-Sly-111739	Solanum lycopersicum	82.59	0.00e+00	1892.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence