iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-20	73.3	254	288

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgv 34
           gHt  vt  +f +++++v+Gs Dg++k WD++ g+
   Q: 254  GHTKTVTYARFmDSHTIVTGSTDGSLKQWDIDNGR 288
           8**********86699**************98775 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Functions in association with RUP2 as repressor of UV-B-induced photomorphogenesis mediated by UVR8 and HY5. Plays a crucial negative feedback regulatory role downstream of UVR8-COP1 to inhibit UVR8 function, balance UV-B-specific responses and ensure normal plant growth. Is involved in the regulation of photoperiodic flowering and vegetative development.

Protein Sequence
(Fasta)

MEALFCSEIP NNNIRSSIND LSSSSSYTWP MIMTSSSSSS SSPTIMNIEN IPRCDWDLSL 60
SAVVSSASTG SDAIGAIEFD PTGEIIATGG IARKIRSYRL SSLLESRDDH VTASESYICT 120

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Nucleotide Sequence
(Fasta)

CACATTTTTT GTTTTCGTCA ACAAACAAAC CACTTTATAG CTTATATATA CACATCACAC 60
ACACATATGA ATGTGATGTT AATATAGTTT CGTGTGGACC TAACTAAAAC TAGTCGTAAC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0287--Flowering
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0009908--P:flower development
GO:0043496--P:regulation of protein homodimerization activity
GO:0010218--P:response to far red light
GO:0010114--P:response to red light
GO:0010224--P:response to UV-B

KEGG

ath:AT5G52250

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005955	Arabidopsis lyrata	95.06	3.00e-180	623.00
IUUC-Bol-015816	Brassica oleracea	83.19	7.00e-147	512.00
IUUC-Bra-016672	Brassica rapa	83.68	1.00e-153	535.00
IUUC-Cre-022579	Chlamydomonas reinhardtii	35.61	3.00e-43	167.00
IUUC-Opu-083787	Oryza punctata	45.17	1.00e-73	269.00
IUUC-Ppa-095874	Physcomitrella patens	38.32	6.00e-58	218.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence