iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046216

UUCD1 version

UUC-HoS-01180

Ensembl Protein ID

ENSP00000348838.4

UniProt Accession

O00762; A6NP33; E1P5N7; G3XAB7; UBE2C_HUMAN

Genbank Protein ID

AAB53362.1; AAP35964.1; EAW75804.1; EAW75805.1; EAW75806.1; EAW75807.1; AAH07656.1; AAH16292.1; AAH50736.1; ENSP00000335674

Protein Name

Ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 ubiquitin-conjugating enzyme C; E2 ubiquitin-conjugating enzyme C; UbcH10; Ubiquitin carrier protein C; Ubiquitin-protein ligase C

Genbank Nucleotide ID

U73379; BT007300; AL050348; CH471077; CH471077; CH471077; BC007656; BC016292; BC050736; BI858659

Gene Name

UBE2C; UBCH10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000175063.16	ENST00000356455.8	ENSP00000348838.4
ENSG00000175063.16	ENST00000335046.7	ENSP00000335674.3
ENSG00000175063.16	ENST00000243893.10	ENSP00000243893.6
ENSG00000175063.16	ENST00000352551.9	ENSP00000333975.5
ENSG00000175063.16	ENST00000405520.5	ENSP00000385878.2
ENSG00000175063.16	ENST00000617055.4	ENSP00000479486.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20704751; 19465892; 15749827

Classification

Family	E-value	Score	Start	End
E2/UBC	4.90e-45	154.4	34	166

Active Site

Position(s)	Description	Evidence
114	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           Rl++el++l+ +  +gisa p+++ +l++w  +i G ++t+Ye+  +kl++efp+ YP+++P+vkflt+++hPnv+++G++Cl+ilk  ekW
   Q: 34   RLQQELMTLMMSGDKGISAFPESD-NLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILK--EKW 122
           9***********************.9************************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkv 137
           s+ ++v+++llsiqsll epn++spln++aael+k+   ++kk +
   Q: 123  SALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPT-AFKKYL 166
           ********************************997655.488765 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Protein Sequence
(Fasta)

MASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF 60
KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCCATTGA TTGGTCGACG CCCCCAGAGG GTTACAATTC AAACGCGGGC GGGCGGGCCC 60
GCAGTCCTGC AGTTGCAGTC GTGTTCTCCG AGTTCCTGTC TCTCTGCCAA CGCCGCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0010458--P:exit from mitosis
GO:0010994--P:free ubiquitin chain polymerization
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0031536--P:positive regulation of exit from mitosis
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:11065

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001924	Ailuropoda melanoleuca	95.58	2.00e-94	337.00
IUUC-Atr-002885	Amborella trichopoda	60.90	4.00e-53	200.00
IUUC-Aly-006086	Arabidopsis lyrata	58.79	6.00e-53	199.00
IUUC-Ath-006897	Arabidopsis thaliana	58.33	1.00e-51	195.00
IUUC-Acl-008223	Aspergillus clavatus	66.14	6.00e-39	153.00
IUUC-Afl-008675	Aspergillus flavus	54.22	2.00e-38	151.00
IUUC-Afu-008997	Aspergillus fumigatus	65.35	9.00e-38	149.00
IUUC-Ani-009470	Aspergillus nidulans	55.42	9.00e-39	152.00
IUUC-Ang-009648	Aspergillus niger	58.78	2.00e-38	151.00
IUUC-Aor-009977	Aspergillus oryzae	57.25	3.00e-31	127.00
IUUC-Ate-010318	Aspergillus terreus	51.14	5.00e-38	150.00
IUUC-Ame-011302	Astyanax mexicanus	76.47	7.00e-75	272.00
IUUC-Bta-013101	Bos taurus	97.21	1.00e-99	354.00
IUUC-Bci-013787	Botrytis cinerea	56.71	9.00e-45	172.00
IUUC-Bdi-014144	Brachypodium distachyon	68.57	9.00e-57	212.00
IUUC-Bol-015613	Brassica oleracea	57.40	4.00e-53	200.00
IUUC-Bra-017249	Brassica rapa	57.99	5.00e-53	200.00
IUUC-Cfa-020588	Canis familiaris	97.77	9.00e-97	345.00
IUUC-Cpo-021384	Cavia porcellus	97.21	7.00e-100	355.00
IUUC-Csa-023437	Chlorocebus sabaeus	98.88	1.00e-104	371.00
IUUC-Cho-024330	Choloepus hoffmanni	98.29	1.00e-67	247.00
IUUC-Cin-025365	Ciona intestinalis	56.88	1.00e-32	131.00
IUUC-Csv-025933	Ciona savignyi	62.07	2.00e-59	221.00
IUUC-Cgl-026494	Colletotrichum gloeosporioides	57.14	2.00e-44	171.00
IUUC-Cme-027266	Cyanidioschyzon merolae	51.61	1.00e-37	149.00
IUUC-Dre-027375	Danio rerio	76.47	2.00e-74	271.00
IUUC-Dno-029921	Dasypus novemcinctus	94.97	1.00e-93	335.00
IUUC-Dor-030209	Dipodomys ordii	93.85	4.00e-95	340.00
IUUC-Dse-031516	Dothistroma septosporum	54.67	4.00e-38	150.00
IUUC-Dme-031942	Drosophila melanogaster	66.43	3.00e-55	207.00
IUUC-Ete-032827	Echinops telfairi	84.69	5.00e-41	158.00
IUUC-Eca-034073	Equus caballus	98.32	4.00e-97	346.00
IUUC-Eeu-034854	Erinaceus europaeus	74.86	6.00e-68	249.00
IUUC-Fca-035666	Felis catus	98.32	4.00e-97	346.00
IUUC-Fal-037652	Ficedula albicollis	88.57	3.00e-54	202.00
IUUC-Fox-037793	Fusarium oxysporum	55.49	1.00e-43	168.00
IUUC-Fso-038151	Fusarium solani	57.41	8.00e-45	172.00
IUUC-Gmo-038894	Gadus morhua	77.22	9.00e-61	225.00
IUUC-Ggr-039730	Gaeumannomyces graminis	60.29	8.00e-35	139.00
IUUC-Gga-040537	Gallus gallus	88.24	2.00e-71	260.00
IUUC-Gac-041346	Gasterosteus aculeatus	71.59	7.00e-62	229.00
IUUC-Gma-043989	Glycine max	58.08	2.00e-54	204.00
IUUC-Ggo-045594	Gorilla gorilla	98.90	4.00e-104	369.00
IUUC-Hvu-047797	Hordeum vulgare	69.40	6.00e-54	203.00
IUUC-Itr-048402	Ictidomys tridecemlineatus	98.32	4.00e-97	346.00
IUUC-Kpa-049294	Komagataella pastoris	58.64	8.00e-49	186.00
IUUC-Lch-049761	Latimeria chalumnae	70.95	1.00e-72	265.00
IUUC-Lpe-051089	Leersia perrieri	62.82	3.00e-55	207.00
IUUC-Loc-052297	Lepisosteus oculatus	77.65	1.00e-73	270.00
IUUC-Lma-053214	Leptosphaeria maculans	50.32	9.00e-43	165.00
IUUC-Laf-054468	Loxodonta africana	95.58	4.00e-101	360.00
IUUC-Mcc-055338	Macaca mulatta	98.88	1.00e-104	371.00
IUUC-Meu-056147	Macropus eugenii	92.18	1.00e-93	335.00
IUUC-Mor-057239	Magnaporthe oryzae	53.61	2.00e-41	161.00
IUUC-Mpo-057491	Magnaporthe poae	61.76	2.00e-43	168.00
IUUC-Mtr-057687	Medicago truncatula	59.64	4.00e-48	184.00
IUUC-Mla-058880	Melampsora laricipopulina	65.00	8.00e-51	192.00
IUUC-Mga-059929	Meleagris gallopavo	88.78	8.00e-50	187.00
IUUC-Mvi-060528	Microbotryum violaceum	57.06	3.00e-46	177.00
IUUC-Mmr-060747	Microcebus murinus	98.14	6.00e-86	309.00
IUUC-Mdo-062343	Monodelphis domestica	93.89	1.00e-94	338.00
IUUC-Mmu-063563	Mus musculus	95.53	1.00e-97	348.00
IUUC-Mac-064823	Musa acuminata	64.54	2.00e-53	201.00
IUUC-Mpu-065746	Mustela putorius furo	96.69	3.00e-95	340.00
IUUC-Mlu-067388	Myotis lucifugus	95.58	5.00e-94	336.00
IUUC-Nfi-068577	Neosartorya fischeri	62.32	2.00e-38	151.00
IUUC-Ncr-068803	Neurospora crassa	56.96	2.00e-38	151.00
IUUC-Opr-070902	Ochotona princeps	93.33	5.00e-94	336.00
IUUC-Ont-071672	Oreochromis niloticus	69.71	2.00e-64	238.00
IUUC-Oan-073728	Ornithorhynchus anatinus	81.93	3.00e-38	149.00
IUUC-Ocu-074566	Oryctolagus cuniculus	92.78	5.00e-91	326.00
IUUC-Oba-075538	Oryza barthii	67.18	1.00e-51	194.00
IUUC-Obr-076757	Oryza brachyantha	69.57	4.00e-36	142.00
IUUC-Ogu-078467	Oryza glumaepatula	65.75	1.00e-55	209.00
IUUC-Oin-079533	Oryza indica	66.41	5.00e-51	192.00
IUUC-Olo-080673	Oryza longistaminata	67.94	4.00e-52	196.00
IUUC-Ome-081483	Oryza meridionalis	67.14	5.00e-55	206.00
IUUC-Oni-082321	Oryza nivara	65.75	1.00e-55	209.00
IUUC-Opu-083245	Oryza punctata	65.71	1.00e-53	202.00
IUUC-Oru-084641	Oryza rufipogon	62.99	5.00e-54	203.00
IUUC-Osa-085992	Oryza sativa	65.75	1.00e-55	209.00
IUUC-Ola-086807	Oryzias latipes	72.47	6.00e-72	263.00
IUUC-Olu-087834	Ostreococcus lucimarinus	70.80	8.00e-56	208.00
IUUC-Oga-088699	Otolemur garnettii	95.60	7.00e-102	362.00
IUUC-Oar-089542	Ovis aries	96.69	3.00e-95	340.00
IUUC-Ptr-091069	Pan troglodytes	100.00	1.00e-105	375.00
IUUC-Pan-092533	Papio anubis	97.79	3.00e-103	367.00
IUUC-Psi-093581	Pelodiscus sinensis	67.47	2.00e-58	218.00
IUUC-Pma-094607	Petromyzon marinus	72.35	5.00e-71	259.00
IUUC-Pno-094829	Phaeosphaeria nodorum	54.05	1.00e-42	165.00
IUUC-Ppa-095861	Physcomitrella patens	66.43	2.00e-55	208.00
IUUC-Pfo-096836	Poecilia formosa	70.11	6.00e-67	246.00
IUUC-Pab-098707	Pongo abelii	100.00	1.00e-105	375.00
IUUC-Pop-099870	Populus trichocarpa	66.43	6.00e-54	203.00
IUUC-Pca-100661	Procavia capensis	97.21	5.00e-99	352.00
IUUC-Ppe-101289	Prunus persica	57.14	3.00e-54	204.00
IUUC-Pva-103235	Pteropus vampyrus	93.30	1.00e-88	318.00
IUUC-Pte-104292	Pyrenophora teres	58.65	5.00e-43	166.00
IUUC-Rno-105501	Rattus norvegicus	96.09	2.00e-98	350.00
IUUC-Sce-106133	Saccharomyces cerevisiae	62.79	1.00e-37	148.00
IUUC-Sha-107205	Sarcophilus harrisii	93.62	3.00e-77	280.00
IUUC-Sja-108009	Schizosaccharomyces japonicus	56.98	6.00e-50	189.00
IUUC-Spo-108136	Schizosaccharomyces pombe	54.97	2.00e-50	191.00
IUUC-Ssl-108394	Sclerotinia sclerotiorum	56.71	1.00e-44	172.00
IUUC-Smo-109459	Selaginella moellendorffii	64.71	3.00e-52	197.00
IUUC-Sit-110754	Setaria italica	66.43	4.00e-55	207.00
IUUC-Sly-111137	Solanum lycopersicum	65.49	2.00e-53	201.00
IUUC-Stu-112305	Solanum tuberosum	65.28	8.00e-54	202.00
IUUC-Sbi-114299	Sorghum bicolor	63.38	1.00e-51	195.00
IUUC-Ssc-115625	Sus scrofa	97.77	4.00e-97	346.00
IUUC-Tru-118289	Takifugu rubripes	75.58	1.00e-36	143.00
IUUC-Tni-120070	Tetraodon nigroviridis	73.28	6.00e-57	212.00
IUUC-Tca-121158	Theobroma cacao	59.28	2.00e-54	204.00
IUUC-Tre-121973	Trichoderma reesei	57.23	1.00e-44	172.00
IUUC-Tvi-122496	Trichoderma virens	56.89	1.00e-44	172.00
IUUC-Tae-123596	Triticum aestivum	65.75	4.00e-56	210.00
IUUC-Tur-126818	Triticum urartu	64.66	3.00e-42	163.00
IUUC-Tme-127044	Tuber melanosporum	65.69	6.00e-42	163.00
IUUC-Ttr-128548	Tursiops truncatus	76.54	4.00e-68	250.00
IUUC-Vda-129840	Verticillium dahliae	55.09	2.00e-43	168.00
IUUC-Vvi-131685	Vitis vinifera	60.84	1.00e-55	208.00
IUUC-Xtr-132953	Xenopus tropicalis	79.33	3.00e-82	297.00
IUUC-Xma-134093	Xiphophorus maculatus	70.11	5.00e-67	246.00
IUUC-Yli-134548	Yarrowia lipolytica	57.23	4.00e-51	194.00
IUUC-Zma-135182	Zea mays	65.71	2.00e-54	204.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence