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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108202
Ensembl Protein ID SPCC74.03c.1:pep
UniProt Accession O74536; SNF1_SCHPO
Genbank Protein ID CAA20833.1
Protein Name SNF1-like protein kinase ssp2
Genbank Nucleotide ID CU329672
Gene Name ssp2; SPCC74.03c
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPCC74.03c SPCC74.03c.1 SPCC74.03c.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProt
Protein Expression/Proteomics
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 12672455
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 3.60e-05 21.9 305 344
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlve.MGFdreealqaLraa.nnnleaAveyLld 40
           d+ ++ +l e MGF+++ +++aLr+  nn + +A ++L++
   Q: 305  DSRIVSKLGEaMGFSEDYIVEALRSDeNNEVKEAYNLLHE 344
           66778888899**************99*********9986 PP
   
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Serine/threonine protein kinase essential for release from glucose repression via the phosphorylation of scr1 upon glucose deprivation (PubMed:22140232). Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes (PubMed:22375066). The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation through TBP recruitment to the promoters (By similarity). Regulates proper cell cycle exit and sexual differentiation (PubMed:22375066). Regulates also ste11 levels under nitrogen deprivation (PubMed:22375066).
 Serine/threonine protein kinase essential for release from glucose repression via the phosphorylation of scr1 upon glucose deprivation (PubMed:22140232). Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes (PubMed:22375066). The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation through TBP recruitment to the promoters (By similarity). Regulates proper cell cycle exit and sexual differentiation (PubMed:22375066). Regulates also ste11 levels under nitrogen deprivation (PubMed:22375066).
Protein Sequence
(Fasta)
MQPQEVDLME NSTMRNGARV LPPEAISKRH IGPYIIRETL GEGSFGKVKL ATHYKTQQKV 60
ALKFISRQLL KKSDMHMRVE REISYLKLLR HPHIIKLYDV ITTPTDIVMV IEYAGGELFD 120
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Protein Fasta Sequence


>IUUC-Spo-108202|UBD,UBA|Schizosaccharomyces pombe
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Nucleotide Sequence
(Fasta)
GACACAACTA AGGATGTATA CTATGGCTTT GCCTTCTACC AAATTATATA TTTATCTCAC 60
ACTCTGAAAT TTAAGCCTTG CTATTAAGGA AAAAAAGATT TTATCAATAA ACTTTCAATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Spo-108202|UBD,UBA|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0119--Carbohydrate metabolism
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR013896--SNF1_UBA
IPR015940--UBA
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA
Pfam

PF16579--AdenylateSensor
PF00069--Pkinase
PF08587--UBA_2
SMART

SM00220--S_TKc
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0044732--C:mitotic spindle pole body
GO:0031588--C:nucleotide-activated protein kinase complex
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0031593--F:polyubiquitin binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:2000766--P:negative regulation of cytoplasmic translation
GO:1904262--P:negative regulation of TORC1 signaling
GO:0046015--P:regulation of transcription by glucose
KEGG spo:SPCC74.03c
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000713 Aegilops tauschii 53.74 2.00e-106 377.00
IUUC-Aml-001907 Ailuropoda melanoleuca 40.08 9.00e-99 352.00
IUUC-Atr-002770 Amborella trichopoda 58.68 2.00e-106 377.00
IUUC-Apl-003395 Anas platyrhynchos 41.31 5.00e-100 356.00
IUUC-Aca-004480 Anolis carolinensis 40.35 2.00e-107 380.00
IUUC-Aly-006289 Arabidopsis lyrata 54.70 2.00e-108 384.00
IUUC-Ath-007014 Arabidopsis thaliana 44.91 2.00e-109 387.00
IUUC-Ago-007957 Ashbya gossypii 46.01 1.00e-141 494.00
IUUC-Acl-008103 Aspergillus clavatus 59.77 5.00e-117 413.00
IUUC-Afl-008555 Aspergillus flavus 58.60 2.00e-115 408.00
IUUC-Afu-008949 Aspergillus fumigatus 52.97 3.00e-116 410.00
IUUC-Ani-009408 Aspergillus nidulans 59.59 2.00e-116 410.00
IUUC-Ang-009551 Aspergillus niger 59.48 3.00e-117 414.00
IUUC-Aor-010176 Aspergillus oryzae 58.60 2.00e-115 407.00
IUUC-Ate-010287 Aspergillus terreus 61.13 7.00e-116 409.00
IUUC-Ame-011019 Astyanax mexicanus 41.13 2.00e-107 380.00
IUUC-Bgr-012045 Blumeria graminis 48.56 3.00e-130 456.00
IUUC-Bta-012786 Bos taurus 40.28 4.00e-99 353.00
IUUC-Bci-013774 Botrytis cinerea 55.96 2.00e-124 437.00
IUUC-Bdi-014319 Brachypodium distachyon 54.65 5.00e-108 382.00
IUUC-Bol-016242 Brassica oleracea 55.85 1.00e-108 384.00
IUUC-Bra-016750 Brassica rapa 55.85 1.00e-108 384.00
IUUC-Cel-018518 Caenorhabditis elegans 42.35 1.00e-110 392.00
IUUC-Cja-019386 Callithrix jacchus 41.29 1.00e-107 381.00
IUUC-Cfa-020177 Canis familiaris 39.10 3.00e-97 347.00
IUUC-Cpo-021805 Cavia porcellus 41.29 7.00e-108 382.00
IUUC-Cre-022915 Chlamydomonas reinhardtii 53.48 1.00e-89 320.00
IUUC-Csa-024267 Chlorocebus sabaeus 41.29 2.00e-107 380.00
IUUC-Cho-024859 Choloepus hoffmanni 38.10 6.00e-94 335.00
IUUC-Cin-025550 Ciona intestinalis 42.44 2.00e-108 384.00
IUUC-Csv-026139 Ciona savignyi 43.50 9.00e-113 398.00
IUUC-Cgl-026480 Colletotrichum gloeosporioides 37.82 1.00e-63 236.00
IUUC-Cne-027044 Cryptococcus neoformans 48.41 4.00e-114 403.00
IUUC-Cme-027289 Cyanidioschyzon merolae 55.66 4.00e-104 369.00
IUUC-Dre-027749 Danio rerio 41.54 5.00e-105 372.00
IUUC-Dno-030006 Dasypus novemcinctus 40.47 1.00e-99 354.00
IUUC-Dor-030578 Dipodomys ordii 41.10 5.00e-107 379.00
IUUC-Dse-031507 Dothistroma septosporum 59.09 2.00e-127 447.00
IUUC-Dme-031704 Drosophila melanogaster 38.26 3.00e-103 367.00
IUUC-Ete-033055 Echinops telfairi 39.69 2.00e-99 353.00
IUUC-Eca-034239 Equus caballus 39.18 5.00e-97 346.00
IUUC-Eeu-034949 Erinaceus europaeus 40.05 8.00e-78 282.00
IUUC-Fca-035754 Felis catus 39.12 3.00e-96 343.00
IUUC-Fal-037363 Ficedula albicollis 40.35 3.00e-99 353.00
IUUC-Fox-038073 Fusarium oxysporum 39.76 1.00e-130 458.00
IUUC-Fso-038236 Fusarium solani 39.94 5.00e-129 452.00
IUUC-Gmo-039633 Gadus morhua 41.26 3.00e-110 390.00
IUUC-Ggr-039987 Gaeumannomyces graminis 57.65 3.00e-125 440.00
IUUC-Gga-040546 Gallus gallus 42.13 3.00e-108 383.00
IUUC-Gac-041822 Gasterosteus aculeatus 40.75 5.00e-108 382.00
IUUC-Gma-042824 Glycine max 59.62 7.00e-109 385.00
IUUC-Ggo-044797 Gorilla gorilla 40.47 1.00e-99 354.00
IUUC-Hsa-045867 Homo sapiens 40.28 3.00e-99 353.00
IUUC-Hvu-047406 Hordeum vulgare 54.52 7.00e-109 385.00
IUUC-Itr-048134 Ictidomys tridecemlineatus 41.29 7.00e-108 382.00
IUUC-Kpa-049190 Komagataella pastoris 47.42 1.00e-141 494.00
IUUC-Lch-049623 Latimeria chalumnae 40.94 3.00e-100 357.00
IUUC-Lpe-051392 Leersia perrieri 57.75 5.00e-108 382.00
IUUC-Loc-052362 Lepisosteus oculatus 40.75 8.00e-107 378.00
IUUC-Lma-053054 Leptosphaeria maculans 48.21 6.00e-139 486.00
IUUC-Laf-053799 Loxodonta africana 40.86 2.00e-102 364.00
IUUC-Mcc-055862 Macaca mulatta 41.29 1.00e-107 381.00
IUUC-Meu-056525 Macropus eugenii 39.80 3.00e-77 280.00
IUUC-Mor-057170 Magnaporthe oryzae 57.69 4.00e-125 440.00
IUUC-Mpo-057302 Magnaporthe poae 57.65 3.00e-125 440.00
IUUC-Mtr-058309 Medicago truncatula 58.36 8.00e-106 375.00
IUUC-Mla-059058 Melampsora laricipopulina 45.20 1.00e-118 418.00
IUUC-Mga-059206 Meleagris gallopavo 41.31 1.00e-100 358.00
IUUC-Mvi-060337 Microbotryum violaceum 44.87 4.00e-115 406.00
IUUC-Mmr-061761 Microcebus murinus 40.28 4.00e-99 353.00
IUUC-Mdo-062160 Monodelphis domestica 41.04 1.00e-108 385.00
IUUC-Mmu-063406 Mus musculus 41.88 5.00e-110 389.00
IUUC-Mac-064518 Musa acuminata 56.18 9.00e-104 369.00
IUUC-Mpu-066326 Mustela putorius furo 40.65 3.00e-100 357.00
IUUC-Mlu-068227 Myotis lucifugus 39.67 3.00e-98 350.00
IUUC-Nfi-068493 Neosartorya fischeri 59.18 8.00e-117 412.00
IUUC-Ncr-068665 Neurospora crassa 40.84 3.00e-138 483.00
IUUC-Nle-070158 Nomascus leucogenys 41.29 1.00e-107 381.00
IUUC-Opr-070272 Ochotona princeps 38.74 1.00e-94 338.00
IUUC-Ont-072027 Oreochromis niloticus 41.45 8.00e-107 379.00
IUUC-Oan-073322 Ornithorhynchus anatinus 38.11 1.00e-95 342.00
IUUC-Ocu-074188 Oryctolagus cuniculus 39.01 3.00e-95 340.00
IUUC-Oba-075436 Oryza barthii 56.36 9.00e-109 385.00
IUUC-Obr-076507 Oryza brachyantha 57.75 1.00e-108 384.00
IUUC-Ogl-077718 Oryza glaberrima 44.30 2.00e-105 374.00
IUUC-Ogu-078349 Oryza glumaepatula 56.36 8.00e-109 385.00
IUUC-Oin-079889 Oryza indica 41.05 3.00e-106 377.00
IUUC-Olo-080521 Oryza longistaminata 56.36 8.00e-109 385.00
IUUC-Ome-081630 Oryza meridionalis 56.07 2.00e-108 383.00
IUUC-Oni-082211 Oryza nivara 56.36 4.00e-109 386.00
IUUC-Opu-083617 Oryza punctata 57.75 2.00e-108 384.00
IUUC-Oru-084252 Oryza rufipogon 56.36 8.00e-109 385.00
IUUC-Osa-085548 Oryza sativa 56.36 8.00e-109 385.00
IUUC-Ola-086366 Oryzias latipes 41.18 2.00e-106 377.00
IUUC-Olu-087861 Ostreococcus lucimarinus 58.04 5.00e-105 372.00
IUUC-Oga-088003 Otolemur garnettii 40.28 3.00e-99 353.00
IUUC-Oar-089933 Ovis aries 40.28 4.00e-99 353.00
IUUC-Ptr-090718 Pan troglodytes 40.28 3.00e-99 353.00
IUUC-Pan-092526 Papio anubis 39.96 4.00e-99 353.00
IUUC-Psi-094034 Pelodiscus sinensis 40.35 5.00e-98 349.00
IUUC-Pma-094666 Petromyzon marinus 44.76 5.00e-76 276.00
IUUC-Pno-095030 Phaeosphaeria nodorum 61.76 8.00e-129 451.00
IUUC-Ppa-095615 Physcomitrella patens 42.62 3.00e-110 390.00
IUUC-Pfo-097050 Poecilia formosa 41.34 1.00e-107 381.00
IUUC-Pab-098519 Pongo abelii 40.28 3.00e-99 353.00
IUUC-Pop-100042 Populus trichocarpa 59.81 1.00e-109 388.00
IUUC-Pca-101104 Procavia capensis 48.46 1.00e-89 321.00
IUUC-Ppe-101642 Prunus persica 59.94 2.00e-108 384.00
IUUC-Pva-102470 Pteropus vampyrus 40.90 8.00e-105 372.00
IUUC-Pgr-103406 Puccinia graminis 67.16 7.00e-102 362.00
IUUC-Ptt-103713 Puccinia triticina 38.06 4.00e-88 317.00
IUUC-Pte-104259 Pyrenophora teres 47.37 2.00e-135 474.00
IUUC-Pyt-104752 Pyrenophora triticirepentis 47.74 3.00e-136 477.00
IUUC-Rno-104960 Rattus norvegicus 41.29 2.00e-107 381.00
IUUC-Sce-106290 Saccharomyces cerevisiae 46.92 6.00e-146 509.00
IUUC-Sha-107603 Sarcophilus harrisii 39.28 7.00e-99 352.00
IUUC-Sja-107772 Schizosaccharomyces japonicus 63.75 0.00e+00 714.00
IUUC-Ssl-108535 Sclerotinia sclerotiorum 57.60 7.00e-125 439.00
IUUC-Smo-109309 Selaginella moellendorffii 44.81 8.00e-109 385.00
IUUC-Sit-109745 Setaria italica 57.36 1.00e-107 381.00
IUUC-Sly-110890 Solanum lycopersicum 45.03 1.00e-108 384.00
IUUC-Stu-112144 Solanum tuberosum 48.98 3.00e-104 370.00
IUUC-Sar-113521 Sorex araneus 36.25 4.00e-72 263.00
IUUC-Sbi-114764 Sorghum bicolor 40.95 3.00e-108 383.00
IUUC-Sre-115141 Sporisorium reilianum 72.93 9.00e-124 435.00
IUUC-Ssc-115732 Sus scrofa 39.18 5.00e-97 346.00
IUUC-Tgu-117190 Taeniopygia guttata 40.35 4.00e-99 353.00
IUUC-Tru-118735 Takifugu rubripes 40.53 6.00e-109 385.00
IUUC-Tsy-119503 Tarsius syrichta 42.08 2.00e-97 347.00
IUUC-Tni-119833 Tetraodon nigroviridis 40.90 1.00e-104 372.00
IUUC-Tca-121386 Theobroma cacao 60.25 1.00e-108 384.00
IUUC-Tre-122070 Trichoderma reesei 41.45 1.00e-134 471.00
IUUC-Tvi-122305 Trichoderma virens 40.46 1.00e-130 457.00
IUUC-Tae-124621 Triticum aestivum 53.97 6.00e-108 382.00
IUUC-Tur-126416 Triticum urartu 53.97 1.00e-107 381.00
IUUC-Tme-127174 Tuber melanosporum 37.71 7.00e-102 362.00
IUUC-Tbe-127501 Tupaia belangeri 44.72 4.00e-75 275.00
IUUC-Ttr-129224 Tursiops truncatus 38.93 1.00e-95 342.00
IUUC-Uma-129372 Ustilago maydis 72.93 7.00e-123 432.00
IUUC-Vda-129819 Verticillium dahliae 37.78 4.00e-111 393.00
IUUC-Vpa-130220 Vicugna pacos 40.49 5.00e-99 352.00
IUUC-Vvi-131649 Vitis vinifera 58.99 1.00e-107 381.00
IUUC-Xtr-132954 Xenopus tropicalis 41.65 3.00e-109 386.00
IUUC-Xma-134082 Xiphophorus maculatus 41.34 2.00e-107 380.00
IUUC-Yli-134422 Yarrowia lipolytica 46.92 1.00e-139 488.00
IUUC-Zma-135621 Zea mays 54.70 6.00e-109 386.00
Created Date 25-Jun-2017

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