iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105870

Ensembl Protein ID

ENSRNOP00000071806.1

UniProt Accession

A0A0G2K1E3; A0A0G2K1E3_RAT

Genbank Protein ID

ENSRNOP00000071806

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AC141526

Gene Name

Kmt2b

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000055525.1	ENSRNOT00000080842.1	ENSRNOP00000071806.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.50e-28	97.9	1249	1302

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++g+++k+l+eCe+Cr+++HpaCl++s ++++ ++ +  wiC+ C ++
   Q: 1249 KFCHVCGRKGRGSKHLLECERCRHAYHPACLGPS-YPTRATRRRrhWICSACVRC 1302
           58********************************.55554444444******876 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAAAAGGGSC PGPGSARGRF PGRPRGSGGG GGRGGRGSGA ERVRVALRRG GGAAGPGGAE 60
PGEDTALLRL LGLRRGLRRL RRLWAGARVQ RGRGRGRGRG WGPNRGCMPE EESSDGESEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCGG CGGCGGGCGG CGGCAGTTGC CCCCGGGCCT GGCTCCGCAC GGGGCCGCTT 60
CCCGGGCCGG CCGCGGGGTT CCGGCGGGGG CGGGGGCCGC GGCGGCCGAG GCAGCGGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0080182--P:histone H3-K4 trimethylation
GO:0007613--P:memory
GO:0009994--P:oocyte differentiation
GO:0001541--P:ovarian follicle development
GO:0030728--P:ovulation
GO:0051569--P:regulation of histone H3-K4 methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002367	Ailuropoda melanoleuca	87.76	0.00e+00	3105.00
IUUC-Aca-004718	Anolis carolinensis	54.86	0.00e+00	2103.00
IUUC-Ame-010705	Astyanax mexicanus	44.11	0.00e+00	927.00
IUUC-Bta-013578	Bos taurus	90.61	0.00e+00	2857.00
IUUC-Bdi-014882	Brachypodium distachyon	33.17	2.00e-27	117.00
IUUC-Bra-017422	Brassica rapa	33.81	4.00e-28	119.00
IUUC-Cja-019138	Callithrix jacchus	87.24	0.00e+00	3154.00
IUUC-Cfa-020020	Canis familiaris	89.17	0.00e+00	3068.00
IUUC-Cpo-021552	Cavia porcellus	88.69	0.00e+00	3170.00
IUUC-Csa-024216	Chlorocebus sabaeus	89.99	0.00e+00	2447.00
IUUC-Cho-024565	Choloepus hoffmanni	75.22	5.00e-163	569.00
IUUC-Dre-027440	Danio rerio	48.69	0.00e+00	782.00
IUUC-Dno-029583	Dasypus novemcinctus	87.65	0.00e+00	3133.00
IUUC-Dor-030903	Dipodomys ordii	87.43	0.00e+00	2146.00
IUUC-Dme-032023	Drosophila melanogaster	46.99	4.00e-92	334.00
IUUC-Eca-034026	Equus caballus	93.40	0.00e+00	1929.00
IUUC-Eeu-034687	Erinaceus europaeus	91.42	0.00e+00	1111.00
IUUC-Fca-036311	Felis catus	89.36	0.00e+00	3153.00
IUUC-Gmo-039265	Gadus morhua	45.00	0.00e+00	820.00
IUUC-Gac-042202	Gasterosteus aculeatus	49.01	0.00e+00	756.00
IUUC-Ggo-044791	Gorilla gorilla	91.64	0.00e+00	2089.00
IUUC-Hsa-046988	Homo sapiens	89.70	0.00e+00	2387.00
IUUC-Hvu-047762	Hordeum vulgare	36.57	4.00e-20	92.80
IUUC-Itr-048907	Ictidomys tridecemlineatus	91.05	0.00e+00	3288.00
IUUC-Lpe-051476	Leersia perrieri	31.39	4.00e-24	106.00
IUUC-Loc-052252	Lepisosteus oculatus	54.24	0.00e+00	786.00
IUUC-Laf-053703	Loxodonta africana	90.60	0.00e+00	2139.00
IUUC-Mcc-054782	Macaca mulatta	89.03	0.00e+00	2435.00
IUUC-Meu-056046	Macropus eugenii	78.61	0.00e+00	1865.00
IUUC-Mmr-061316	Microcebus murinus	88.04	0.00e+00	2787.00
IUUC-Mdo-062648	Monodelphis domestica	79.19	0.00e+00	2688.00
IUUC-Mmu-063579	Mus musculus	97.75	0.00e+00	3504.00
IUUC-Mac-064935	Musa acuminata	31.91	2.00e-30	127.00
IUUC-Mpu-066710	Mustela putorius furo	91.50	0.00e+00	2922.00
IUUC-Mlu-067559	Myotis lucifugus	88.26	0.00e+00	2413.00
IUUC-Nle-070085	Nomascus leucogenys	87.33	0.00e+00	2109.00
IUUC-Opr-071148	Ochotona princeps	85.04	0.00e+00	3136.00
IUUC-Ont-071626	Oreochromis niloticus	45.24	0.00e+00	904.00
IUUC-Ocu-074475	Oryctolagus cuniculus	87.56	0.00e+00	2103.00
IUUC-Obr-076458	Oryza brachyantha	34.30	5.00e-28	119.00
IUUC-Ogl-077851	Oryza glaberrima	36.02	3.00e-28	120.00
IUUC-Ogu-078706	Oryza glumaepatula	36.02	2.00e-28	120.00
IUUC-Oin-079802	Oryza indica	31.31	3.00e-23	103.00
IUUC-Osa-085421	Oryza sativa	36.02	4.00e-28	120.00
IUUC-Ola-086609	Oryzias latipes	51.68	0.00e+00	758.00
IUUC-Oga-088140	Otolemur garnettii	89.55	0.00e+00	3142.00
IUUC-Oar-089447	Ovis aries	90.66	0.00e+00	1995.00
IUUC-Ptr-090902	Pan troglodytes	89.70	0.00e+00	2392.00
IUUC-Pan-091930	Papio anubis	90.05	0.00e+00	2459.00
IUUC-Ppa-095221	Physcomitrella patens	36.54	3.00e-31	130.00
IUUC-Pfo-096884	Poecilia formosa	46.56	0.00e+00	902.00
IUUC-Pab-098404	Pongo abelii	76.58	0.00e+00	1610.00
IUUC-Pop-099585	Populus trichocarpa	33.83	1.00e-26	115.00
IUUC-Pca-100949	Procavia capensis	82.35	0.00e+00	1207.00
IUUC-Ppe-101920	Prunus persica	33.50	3.00e-28	120.00
IUUC-Pva-102634	Pteropus vampyrus	89.00	0.00e+00	3170.00
IUUC-Sit-110552	Setaria italica	34.33	1.00e-28	121.00
IUUC-Sar-113289	Sorex araneus	87.26	0.00e+00	1739.00
IUUC-Ssc-115509	Sus scrofa	88.55	0.00e+00	3111.00
IUUC-Tru-117736	Takifugu rubripes	44.98	0.00e+00	836.00
IUUC-Tca-121624	Theobroma cacao	33.66	3.00e-28	120.00
IUUC-Tae-124647	Triticum aestivum	36.57	3.00e-20	93.20
IUUC-Tbe-127825	Tupaia belangeri	85.47	0.00e+00	1385.00
IUUC-Ttr-128754	Tursiops truncatus	91.76	0.00e+00	1214.00
IUUC-Xtr-132838	Xenopus tropicalis	49.28	0.00e+00	1007.00
IUUC-Xma-133119	Xiphophorus maculatus	43.47	0.00e+00	987.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence